Research graph
References from Hemoglobin-based oxygen carrier: what we have learned and where we are heading?. Local targets link to admitted publications; unresolved targets remain external evidence.
Anesthesia in cases of poor surgical risk: some suggestions for decreasing the risk
10.1097/00000542-194209000-00032 · 1942 · External reference
On the use of Ringer-Locke solutions containing hemoglobin as a substitute for normal blood in mammals
10.1002/jcp.1030050309 · 1934 · External reference
First-in-human phase 1 trial of hemoglobin vesicles as artificial red blood cells developed for use as a transfusion alternative
10.1182/bloodadvances.2022007977 · 2022 · External reference
A broad diversity in oxygen affinity to haemoglobin
10.1038/s41598-020-73560-9 · 2020 · External reference
The effect of rigid red blood cells on platelet adhesion in blood flow and implications in sickle cell disease
10.1182/blood-2019-128733 · 2019 · External reference
A therapeutic oxygen carrier isolated from Arenicola marina decreased P. gingivalis induced inflammation and tissue destruction
10.1038/s41598-020-71593-8 · 2020 · External reference
Regulatory mechanisms of hemoglobin oxygen affinity in acidosis and alkalosis
10.1172/jci106540 · 1971 · External reference
A phase I single blind clinical trial of a new oxygen transport agent (MP4), human hemoglobin modified with maleimide-activated polyethylene glycol
2005 · External reference
Hemoglobin-based oxygen carriers: from mechanisms of toxicity and clearance to rational drug design
10.1016/j.molmed.2010.07.006 · 2010 · External reference
10.1007/978-3-030-95975-3_28
10.1007/978-3-030-95975-3_28 · 2022 · External reference
Fluid resuscitation for hemorrhagic shock in tactical combat casualty care: TCCC guidelines change 14-01–2 June 2014
2014 · External reference
A phase I study of oxidized raffinose cross-linked human hemoglobin
10.1097/00003246-200007000-00017 · 2000 · External reference
Perfluorocarbon-based oxygen carriers: review of products and trials
10.1111/j.1525-1594.2009.00944.x · 2010 · External reference
Stop the bleed”: a U.S. Military installation’s model for implementation of a rapid hemorrhage control program
10.1093/milmed/usy185 · 2019 · External reference
Hemoglobin-based oxygen carriers: where are we now in 2023?
10.3390/medicina59020396 · 2023 · External reference
Unresolved reference
2022 · External reference
The anti-tumoral effects of the oxygen carrier YQ23 in a triple-negative breast cancer syngeneic model
10.21037/tcr-20-2768 · 2021 · External reference
Unresolved reference
2022 · External reference
Unresolved reference
2025 · External reference
Unresolved reference
2021 · External reference
Transfusion practices among patients who did and did not predonate autologous blood before elective cardiac surgery
1999 · External reference
Unresolved reference
2023 · External reference
Unresolved reference
2025 · External reference
Unresolved reference
2022 · External reference
Red blood cell storage time and transfusion: current practice, concerns and future perspectives
2017 · External reference
Red blood cells stored 35 days or more are associated with adverse outcomes in high-risk patients
10.1111/trf.13559 · 2016 · External reference
Severe anemia associated with increased risk of death and myocardial ischemia in patients declining blood transfusion
10.1111/trf.14768 · 2018 · External reference
Blood management in high-risk surgery
10.1001/jama.2021.25299 · 2022 · External reference
A multicenter, randomized, controlled clinical trial of transfusion requirements in critical care
10.1056/nejm199902113400601 · 1999 · External reference
Unresolved reference
2022 · External reference
Large-scale in vitro production of red blood cells from human peripheral blood mononuclear cells
10.1182/bloodadvances.2019000689 · 2019 · External reference
10.1007/978-3-030-95975-3_18
10.1007/978-3-030-95975-3_18 · 2022 · External reference
A hemoglobin-based multifunctional therapeutic: polynitroxylated pegylated hemoglobin
10.1111/j.1525-1594.2011.01307.x · 2012 · External reference
Ensuring a safe and sufficient global blood supply
10.1056/nejmp2403596 · 2024 · External reference
Blood substitutes: basic science, translational studies and clinical trials
10.3389/fmedt.2022.989829 · 2022 · External reference
HBOC-201 as an alternative to blood transfusion: efficacy and safety evaluation in a multicenter phase III trial in elective orthopedic surgery
2008 · External reference
10.1007/978-3-030-95975-3_12
10.1007/978-3-030-95975-3_12 · 2022 · External reference
Unresolved reference
2024 · External reference
Open and remotely accessible neuroplatform for research in wetware computing
10.3389/frai.2024.1376042 · 2024 · External reference
In vitro neurons learn and exhibit sentience when embodied in a simulated game-world
10.1016/j.neuron.2022.09.001 · 2022 · External reference
DCL-Hb for trauma patients with severe hemorrhagic shock: the European “on-scene” multicenter study
10.1007/s00134-002-1622-x · 2003 · External reference
Artificial blood: the history and current perspectives of blood substitutes
10.15190/d.2020.1 · 2020 · External reference
Unraveling the reactions of nitric oxide, nitrite, and hemoglobin in physiology and therapeutics
10.1161/01.atv.0000204350.44226.9a · 2006 · External reference
Polymerized human cord hemoglobin assisted with ascorbic acid as a red blood cell substitute alleviating oxidative stress for blood transfusion
10.3389/fbioe.2023.1151975 · 2023 · External reference
A novel cross-linked hemoglobin-based oxygen carrier, YQ23, extended the golden hour for uncontrolled hemorrhagic shock in rats and miniature pigs
10.3389/fphar.2021.652716 · 2021 · External reference
A novel cross-linked haemoglobin-based oxygen carrier is beneficial to sepsis in rats
10.1080/21691401.2019.1602049 · 2019 · External reference
Superior survival of ex vivo cultured human reticulocytes following transfusion into mice
10.3324/haematol.2016.154443 · 2017 · External reference
Preparation of artificial red blood cells (hemoglobin vesicles) using the rotation-revolution mixer for high encapsulation efficiency
10.1021/acsbiomaterials.1c00424 · 2021 · External reference
Current status of red blood cell manufacturing in 3D culture and bioreactors
10.5045/br.2023.2023008 · 2023 · External reference
Preoperative anemia versus blood transfusion: which is the culprit for worse outcomes in cardiac surgery?
10.1016/j.jtcvs.2018.03.109 · 2018 · External reference
Computational design of serine hydrolases
10.1126/science.adu2454 · 2025 · External reference
First-in-human use of a marine oxygen carrier (M101) for organ preservation: a safety and proof-of-principle study
10.1111/ajt.15798 · 2020 · External reference
Evaluation of the efficacy of HEMO(2)life®, a marine OXYgen carrier for organ preservation (OxyOp2) in renal transplantation: study protocol for a multicenter randomized trial
10.1186/s13063-023-07302-3 · 2023 · External reference
Oxygen carrier YQ23 can enhance the chemotherapeutic drug responses of chemoresistant esophageal tumor xenografts
10.1007/s00280-015-2897-2 · 2015 · External reference
Generation of red blood cells from human pluripotent stem cells: an update
10.3390/cells12111554 · 2023 · External reference
Beneficial effects of novel cross-linked hemoglobin YQ23 on hemorrhagic shock in rats and pigs
10.1016/j.jss.2016.11.045 · 2017 · External reference
10.1007/978-3-030-95975-3
10.1007/978-3-030-95975-3 · 2022 · External reference
Combating hypoxemia in COVID-19 patients with a natural oxygen carrier, HEMO(2)life® (M101)
10.1016/j.mehy.2020.110421 · 2021 · External reference
Anemia and perioperative red blood cell transfusion: a matter of tolerance
10.1097/01.ccm.0000214317.26717.73 · 2006 · External reference
First pig liver transplanted into a person lasts for 10 days
10.1038/d41586-024-00853-8 · 2024 · External reference
Artificial oxygen carriers, from nanometer- to micrometer-sized particles, made of hemoglobin composites substituting for red blood cells
10.1016/j.partic.2021.08.010 · 2022 · External reference
Splenic development and injury in premature lambs supported by the artificial placenta
10.1016/j.jpedsurg.2019.02.041 · 2019 · External reference
Thriving in oxygen while preventing ROS overproduction: no two systems are created equal
10.3389/fphys.2022.874321 · 2022 · External reference
PEGylated carboxyhemoglobin bovine (sanguinate): results of a phase I clinical trial
10.1111/aor.12341 · 2014 · External reference
Unresolved reference
2022 · External reference
Therapeutic delivery of oxygen using artificial oxygen carriers demonstrates the possibility of treating a wide range of diseases
10.1186/s12951-024-03060-9 · 2025 · External reference
Current perspectives of artificial oxygen carriers as red blood cell substitutes: a review of old to cutting-edge technologies using in vitro and in vivo assessments
10.1007/s40005-022-00590-y · 2023 · External reference
Human polymerized hemoglobin for the treatment of hemorrhagic shock when blood is unavailable: the USA multicenter trial
10.1016/j.jamcollsurg.2008.09.023 · 2009 · External reference
Unresolved reference
2025 · External reference
Autologous blood donations prior to elective cardiac surgery: safety and effect on subsequent blood use
10.1001/jama.1989.03430140081029 · 1989 · External reference
Erythromer (EM), a nanoscale bio-synthetic artificial red cell: proof of concept and in vivo efficacy results
10.1182/blood.v128.22.1027.1027 · 2016 · External reference
Cellular dynamics in pig-to-human kidney xenotransplantation
10.1016/j.medj.2024.05.003 · 2024 · External reference
An extra-uterine system to physiologically support the extreme premature lamb
10.1038/ncomms15112 · 2017 · External reference
Outcome of patients who refuse transfusion after cardiac surgery: a natural experiment with severe blood conservation
10.1001/archinternmed.2012.2449 · 2012 · External reference
Towards manufactured red blood cells for the treatment of inherited anemia
10.3324/haematol.2020.268847 · 2021 · External reference
Unresolved reference
2022 · External reference
Phase I study of the safety and pharmacologic effects of diaspirin cross-linked hemoglobin solution
10.1097/00003246-199612000-00011 · 1996 · External reference
A hemoglobin-based oxygen carrier sensitized cisplatin based chemotherapy in hepatocellular carcinoma
10.18632/oncotarget.19672 · 2017 · External reference
Assessing the global burden of hemorrhage: the global blood supply, deficits, and potential solutions
10.1177/20503121211054995 · 2021 · External reference
The influence of the storage lesion(s) on pediatric red cell transfusion
10.1097/mop.0000000000000224 · 2015 · External reference
Unresolved reference
2022 · External reference
Hemoglobin and the paracrine and endocrine functions of nitric oxide
10.1056/nejmcibr023045 · 2003 · External reference
Integrative multi-omics profiling in human decedents receiving pig heart xenografts
10.1038/s41591-024-02972-1 · 2024 · External reference
Hemoglobin-based oxygen carriers: current state-of-the-art and novel molecules
10.1097/shk.0000000000001009 · 2019 · External reference
Polynitroxylated pegylated hemoglobin: a novel neuroprotective hemoglobin for acute volume-limited fluid resuscitation after combined traumatic brain injury and hemorrhagic hypotension in mice
10.1097/ccm.0b013e318206b1fa · 2011 · External reference
Milestones for clinical translation of the artificial placenta
10.1016/j.siny.2022.101408 · 2022 · External reference
Machine perfusion of donor organs for transplantation
10.1111/aor.13894 · 2021 · External reference
Current status of artificial O2 carriers
10.1016/j.atc.2005.01.004 · 2005 · External reference
An immortalized adult human erythroid line facilitates sustainable and scalable generation of functional red cells
10.1038/ncomms14750 · 2017 · External reference
Oxygen-carrying blood substitutes: a microvascular perspective
10.1517/14712598.4.7.1147 · 2004 · External reference
Methemoglobin—it’s not just blue: a concise review
10.1002/ajh.20738 · 2007 · External reference
Unresolved reference
2025 · External reference
Mini-review on the properties and possible applications of therapeutic oxygen carrier Hemarina-M101
10.1016/j.transci.2020.103016 · 2021 · External reference
Joint trauma system clinical practice guideline (JTS CPG): prehospital blood transfusion. 30 October 2020
10.55460/p685-l7r7 · 2021 · External reference
The role of pet blood bank UK
10.1111/vnj.12142 · 2014 · External reference
Polynitroxylated PEGylated hemoglobin protects pig brain neocortical gray and white matter after traumatic brain injury and hemorrhagic shock
10.3389/fmedt.2023.1074643 · 2023 · External reference
Unresolved reference
2022 · External reference
De novo design of protein structure and function with RFdiffusion
10.1038/s41586-023-06415-8 · 2023 · External reference
Pet owners’ awareness of animal blood banks and their motivations towards animal blood donation
10.1136/vr.105139 · 2019 · External reference
OxyVita? Hb: a step forward in delivering oxygen carrying capacity for therapeutic applications
10.1142/9789811228698_0042 · 2020 · External reference
OxyVita(®)C, a next-generation haemoglobin-based oxygen carrier, with coagulation capacity (OVCCC). modified lyophilization/spray-drying process: proteins protection
10.1080/21691401.2017.1339052 · 2017 · External reference
Unresolved reference
2022 · External reference
Blood shortages and donation in China
10.1016/s0140-6736(16)30416-0 · 2016 · External reference
Unresolved reference
2022 · External reference
There will be blood
10.1126/science.adr4067 · 2024 · External reference
The protective effect of a novel cross-linked hemoglobin-based oxygen carrier on hypoxia injury of acute mountain sickness in rabbits and goats
10.3389/fphys.2021.690190 · 2021 · External reference
Perfluorocarbon-based oxygen carriers: what is new in 2024?
10.1016/j.jatmed.2024.02.003 · 2024 · External reference
Preparation and exchange transfusion effect of a double polymerization human umbilical cord haemoglobin of red blood cell substitute
10.1080/21691401.2023.2201599 · 2023 · External reference
Controlled oxygen delivery to power tissue regeneration
10.1038/s41467-024-48719-x · 2024 · External reference
