Research graph
References from Organelle-anchored translation factories: the roles of neuronal RNA-binding protein condensates in organizing local protein synthesis in neurological diseases. Local targets link to admitted publications; unresolved targets remain external evidence.
Localized molecular chaperone synthesis maintains neuronal dendrite proteostasis
10.1038/s41467-024-55055-7 · 2024 · External reference
Biomolecular condensates: organizers of cellular biochemistry
10.1038/nrm.2017.7 · 2017 · External reference
Post-translational modification of cysteines: a key determinant of endoplasmic reticulum-mitochondria contacts (MERCs)
2021 · External reference
Multi-organelle-mediated mRNA localization in neurons and links to disease
10.1016/j.gde.2025.102332 · 2025 · External reference
Membrane-associated RNA-binding proteins orchestrate organelle-coupled translation
10.1016/j.tcb.2018.10.005 · 2019 · External reference
PERK-ATAD3A interaction provides a subcellular safe haven for protein synthesis during ER stress
10.1126/science.adp7114 · 2024 · External reference
Redox regulation of UPR signalling and mitochondrial ER contact sites
10.1007/s00018-024-05286-0 · 2024 · External reference
Late endosomes act as mRNA translation platforms and sustain mitochondria in axons
10.1016/j.cell.2018.11.030 · 2019 · External reference
The integrated stress response: From mechanism to disease
10.1126/science.aat5314 · 2020 · External reference
Local protein synthesis at synapses: a driver for synapse diversification
10.1111/jnc.70308 · 2025 · External reference
Mitochondria at the neuronal presynapse in health and disease
10.1038/nrn.2017.170 · 2018 · External reference
BORC/kinesin-1 ensemble drives polarized transport of lysosomes into the axon
10.1073/pnas.1616363114 · 2017 · External reference
RNA transport and local translation in neurodevelopmental and neurodegenerative disease
10.1038/s41593-020-00785-2 · 2021 · External reference
mRNA transport & local translation in neurons
10.1016/j.conb.2017.05.005 · 2017 · External reference
Local protein synthesis is a ubiquitous feature of neuronal pre- AND postsynaptic compartments
10.1126/science.aau3644 · 2019 · External reference
Neuronal mitochondria transport Pink1 mRNA via synaptojanin 2 to support local mitophagy
10.1016/j.neuron.2022.01.035 · 2022 · External reference
Insulin signalling regulates Pink1 mRNA localization via modulation of AMPK activity to support PINK1 function in neurons
10.1038/s42255-024-01007-w · 2024 · External reference
ER stress and the unfolded protein response in neurodegeneration
10.1038/nrneurol.2017.99 · 2017 · External reference
Synapsin condensation controls synaptic vesicle sequestering and dynamics
10.1038/s41467-023-42372-6 · 2023 · External reference
Local translation in neurons: visualization and function
10.1038/s41594-019-0263-5 · 2019 · External reference
The central dogma decentralized: new perspectives on RNA function and local translation in neurons
10.1016/j.neuron.2013.10.036 · 2013 · External reference
Proteomic mapping of cytosol-facing outer mitochondrial and ER membranes in living human cells by proximity biotinylation
10.7554/elife.24463 · 2017 · External reference
Axonal mRNA localization and local protein synthesis in nervous system assembly, maintenance and repair
10.1038/nrn3210 · 2012 · External reference
Neuronal RNA granules: movers and makers
10.1016/j.neuron.2006.08.021 · 2006 · External reference
Proteostasis and RNA binding proteins in synaptic plasticity and in the pathogenesis of neuropsychiatric disorders
10.1155/2016/3857934 · 2016 · External reference
Better together: interorganellar communication in the regulation of proteostasis
2024 · External reference
Axonal endoplasmic reticulum tubules control local translation via P180/RRBP1-mediated ribosome interactions
10.1016/j.devcel.2024.05.005 · 2024 · External reference
Studying endosomes in cultured neurons by live-cell imaging
10.1016/bs.mcb.2015.07.002 · 2016 · External reference
The PERK arm of the unfolded protein response regulates mitochondrial morphology during acute endoplasmic reticulum stress
10.1016/j.celrep.2018.02.055 · 2018 · External reference
Emerging roles of mitochondria in synaptic transmission and neurodegeneration
10.1016/j.cophys.2018.03.009 · 2018 · External reference
RNA granules hitchhike on lysosomes for long-distance transport, using annexin A11 as a molecular tether
10.1016/j.cell.2019.08.050 · 2019 · External reference
Axonal transport: cargo-specific mechanisms of motility and regulation
10.1016/j.neuron.2014.10.019 · 2014 · External reference
Annexin A11 mutations are associated with nuclear envelope dysfunction in vivo and in human tissues
10.1093/brain/awae226 · 2025 · External reference
Axonal transport deficits and neurodegenerative diseases
10.1038/nrn3380 · 2013 · External reference
Multiple modes of protein-protein interactions promote RNP granule assembly
10.1016/j.jmb.2018.08.005 · 2018 · External reference
Phase separation and pathologic transitions of RNP condensates in neurons: implications for amyotrophic lateral sclerosis, frontotemporal dementia and other neurodegenerative disorders
10.3389/fnmol.2023.1242925 · 2023 · External reference
ANXA11 biomolecular condensates facilitate protein-lipid phase coupling on lysosomal membranes
10.1038/s41467-025-58142-5 · 2025 · External reference
Hitting the mark: localization of mRNA and biomolecular condensates in health and disease
10.1002/wrna.1807 · 2023 · External reference
There’s something wrong with my MAM; the ER-mitochondria axis and neurodegenerative diseases
10.1016/j.tins.2016.01.008 · 2016 · External reference
PERK signaling promotes mitochondrial elongation by remodeling membrane phosphatidic acid
10.15252/embj.2023113908 · 2023 · External reference
Local translation in axons: when membraneless RNP granules meet membrane-bound organelles
10.3389/fmolb.2019.00129 · 2019 · External reference
Spatiotemporally-resolved mapping of RNA binding proteins via functional proximity labeling reveals a mitochondrial mRNA anchor promoting stress recovery
10.1038/s41467-021-25259-2 · 2021 · External reference
Structural basis of mRNA binding by the human FERRY Rab5 effector complex
10.1016/j.molcel.2023.05.009 · 2023 · External reference
The coordination of local translation, membranous organelle trafficking, and synaptic plasticity in neurons
10.3389/fcell.2021.711446 · 2021 · External reference
Neurogenetic disorders associated with mutations in the FERRY complex: A novel disease class?
10.1242/bio.061808 · 2025 · External reference
Navigating the landscape of mitochondrial-ER communication in health and disease
10.3389/fmolb.2024.1356500 · 2024 · External reference
Endoplasmic reticulum-mitochondria contacts: function of the junction
10.1038/nrm3440 · 2012 · External reference
Seeing the unseen: the hidden world of slow axonal transport
10.1177/1073858413498306 · 2014 · External reference
The Rab5 effector FERRY links early endosomes with mRNA localization
10.1016/j.molcel.2023.05.012 · 2023 · External reference
Dynamic axonal translation in developing and mature visual circuits
10.1016/j.cell.2016.05.029 · 2016 · External reference
Mitochondria coordinate sites of axon branching through localized intra-axonal protein synthesis
10.1016/j.celrep.2013.11.022 · 2013 · External reference
Dendritic protein synthesis in the normal and diseased brain
10.1016/j.neuroscience.2012.12.003 · 2013 · External reference
Coupling axonal mRNA transport and local translation to organelle maintenance and function
10.1016/j.ceb.2022.01.008 · 2022 · External reference
PERK is required at the ER-mitochondrial contact sites to convey apoptosis after ROS-based ER stress
10.1038/cdd.2012.74 · 2012 · External reference
Mitochondria and endoplasmic reticulum contact site as a regulator of proteostatic stress responses in neurodegenerative diseases
10.1002/bies.70016 · 2025 · External reference
Contacts between the endoplasmic reticulum and other membranes in neurons
10.1073/pnas.1701078114 · 2017 · External reference
Neuronal endoplasmic reticulum architecture and roles in axonal physiology
10.1016/j.mcn.2023.103822 · 2023 · External reference
Mitochondria and other organelles in neural development and their potential as therapeutic targets in neurodegenerative diseases
10.3389/fnins.2022.853911 · 2022 · External reference
