References

A comparison of classical and 21st century genotoxicity tools: a proof of concept study of 18 chemicals comparing in vitro micronucleus, ToxTracker and genomics-based methods (TGx-DDI, whole genome clustering and connectivity mapping)

10.1002/em.22418 · 2021 · External reference

Cyclophosphamide: review of its mutagenicity for an assessment of potential germ cell risks

10.1016/0027-5107(95)00039-l · 1995 · External reference

Optimization of the HepaRG cell model for drug metabolism and toxicity studies

10.1016/j.tiv.2012.05.008 · 2012 · External reference

A novel genotoxin-specific qPCR array based on the metabolically competent human HepaRG™ cell line as a rapid and reliable tool for improved in vitro hazard assessment

10.1007/s00204-018-2172-5 · 2018 · External reference

Towards better prediction of xenobiotic genotoxicity: CometChip technology coupled with a 3D model of HepaRG human liver cells

10.1007/s00204-022-03292-4 · 2022 · External reference

Assessment of TGx-DDI genes for genotoxicity in a comprehensive panel of chemicals

10.1080/15376516.2024.2335966 · 2024 · External reference

Identification and characterization of E2F7, a novel mammalian E2F family member capable of blocking cellular proliferation

10.1074/jbc.m308105200 · 2003 · External reference

Integrated genotoxicity testing of three anti-infective drugs using the TGx-DDI transcriptomic biomarker and high-throughput CometChip® assay in TK6 cells

10.3389/ftox.2022.991590 · 2022 · External reference

Flow cytometric micronucleus assay and TGx-DDI transcriptomic biomarker analysis of ten genotoxic and non-genotoxic chemicals in human HepaRG™ cells

10.1186/s41021-019-0139-2 · 2020 · External reference

A modern genotoxicity testing paradigm: integration of the high-throughput CometChip® and the TGx-DDI transcriptomic biomarker in human HepaRG™ cell cultures

10.3389/fpubh.2021.694834 · 2021 · External reference

Current methods in risk assessment of genotoxic chemicals

10.1016/j.fct.2016.09.012 · 2017 · External reference

E2F7, a novel target, is up-regulated by p53 and mediates DNA damage-dependent transcriptional repression

10.1101/gad.184911.111 · 2012 · External reference

A high-throughput and highly automated genotoxicity screening assay

10.14573/altex.2102121 · 2022 · External reference

Thymidine kinase+/- mammalian cell mutagenicity assays for assessment of nanomaterials

10.3389/ftox.2022.864753 · 2022 · External reference

Non-coplanar and coplanar polychlorinated biphenyls potentiate genotoxicity of aflatoxin B1 in a human hepatocyte line by enhancing CYP1A2 and CYP3A4 expression

10.1016/j.envpol.2018.12.041 · 2019 · External reference

Assessment of the performance of the TGx-DDI biomarker to detect DNA damage-inducing agents using quantitative RT-PCR in TK6 cells

10.1002/em.22257 · 2019 · External reference

Genotoxicity of aflatoxin B1 and ochratoxin a after simultaneous application of the in vivo micronucleus and comet assay

10.1016/j.fct.2014.12.003 · 2015 · External reference

Human CYP3A4-mediated toxification of the pyrrolizidine alkaloid lasiocarpine

10.1016/j.fct.2019.05.019 · 2019 · External reference

Application of a new approach methodology (NAM)-based strategy for genotoxicity assessment of data-poor compounds

10.3389/ftox.2023.1098432 · 2023 · External reference

Reduction of misleading (“false”) positive results in mammalian cell genotoxicity assays. I. Choice of cell type

10.1016/j.mrgentox.2011.10.014 · 2012 · External reference

Interaction of aflatoxin B2 with rat liver DNA and histones in vivo

10.1093/carcin/2.12.1371 · 1981 · External reference

Advances in drug-induced liver injury research: in vitro models, mechanisms, omics and gene modulation techniques

10.1186/s13578-024-01317-2 · 2024 · External reference

Application of HepaRG cells for genotoxicity assessment: a review

10.1080/26896583.2024.2331956 · 2024 · External reference

Artichoke induces genetic toxicity and decreases ethyl methanesulfonate-related DNA damage in Chinese hamster ovary cells

10.1089/jmf.2012.0032 · 2012 · External reference

Differential toxic effects of food contaminant mixtures in HepaRG cells after single or repeated treatments

10.1016/j.mrgentox.2020.503161 · 2020 · External reference

Use of cyclophosphamide as a positive control in dominant lethal and micronucleus assays

10.1016/0165-1161(95)00038-0 · 1995 · External reference

Review of transcriptomic biomarkers that predict in vitro genotoxicity in human cell lines

10.1002/em.70004 · 2025 · External reference

Evaluation of pyrrolizidine alkaloid-induced genotoxicity using metabolically competent TK6 cell lines

10.1016/j.fct.2020.111662 · 2020 · External reference

Qualification of the human reconstructed intestine micronuclei cytome assay for site-of-contact genotoxic hazard identification

10.1016/j.namjnl.2025.100015 · 2025 · External reference

Tissue-specific in vivo genetic toxicity of nine polycyclic aromatic hydrocarbons assessed using the muta™mouse transgenic rodent assay

10.1016/j.taap.2015.11.010 · 2016 · External reference

Relevance of in vitro transcriptomics for in vivo mode of action assessment

10.1021/acs.chemrestox.0c00313 · 2021 · External reference

Aflatoxin B1 and M1: biological properties and their involvement in cancer development

10.3390/toxins10060214 · 2018 · External reference

Genotoxicity assessment: opportunities, challenges and perspectives for quantitative evaluations of dose-response data

10.1007/s00204-023-03553-w · 2023 · External reference

The current limitations of in vitro genotoxicity testing and their relevance to the in vivo situation

10.1016/j.fct.2016.08.035 · 2017 · External reference

Genotoxicity: damage to DNA and its consequences

10.1007/978-3-7643-8336-7_4 · 2009 · External reference

Metabolic activation of polycyclic aromatic hydrocarbons to mutagens in the ames test by various animal species including man

10.1016/0027-5107(89)90115-2 · 1989 · External reference

In vitro/in vivo effects of mesna on the genotoxicity and toxicity of cyclophosphamide—a study aimed at clarifying the mechanism of Mesna’s anticarcinogenic activity

10.1016/0378-4274(88)90007-0 · 1988 · External reference

Metabolomic analysis to discriminate drug-induced liver injury (DILI) phenotypes

10.1007/s00204-021-03114-z · 2021 · External reference

Improved functionality of hepatic spheroids cultured in acoustic levitation compared to existing 2D and 3D models

10.1038/s41598-024-72059-x · 2024 · External reference

Organotypic 3D HepaRG liver model for assessment of drug-induced cholestasis

10.1007/978-1-4939-9420-5_20 · 2019 · External reference

High content imaging and analysis enable quantitative in situ assessment of CYP3A4 using cryopreserved differentiated HepaRG cells

10.1155/2014/291054 · 2014 · External reference

Functional relevance of the histone γH2Ax in the response to DNA damaging agents

10.1073/pnas.1105866108 · 2011 · External reference

In vitro metabolism of aflatoxin B2 by animal and human liver

1978 · External reference

Deciphering per- and polyfluoroalkyl substances mode of action: comparative gene expression analysis in human liver spheroids

10.1093/toxsci/kfaf023 · 2025 · External reference

Quantitative evaluation of genotoxicity data for risk assessment and regulatory decision-making: time for a paradigm shift

10.1016/j.envint.2026.110070 · 2026 · External reference

Mechanistic toxicity profiling of chemicals: a comparative study in 2D and 3D HepaRG models using high-content analysis

10.1016/j.tox.2025.154280 · 2026 · External reference

High-throughput micronucleus assay using three-dimensional HepaRG spheroids for in vitro genotoxicity testing

10.1007/s00204-023-03461-z · 2023 · External reference

In vitro hepatic 3D cell models and their application in genetic toxicology: a systematic review

10.1016/j.mrgentox.2024.503835 · 2024 · External reference

Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles

10.1073/pnas.0506580102 · 2005 · External reference

Micro-mold design controls the 3D morphological evolution of self-assembling multicellular microtissues

10.1089/ten.tea.2013.0297 · 2014 · External reference

Genotoxicity of aflatoxins and their precursors in human cells

10.1016/j.toxlet.2018.02.007 · 2018 · External reference

Unlocking the power of transcriptomic biomarkers in qualitative and quantitative genotoxicity assessment of chemicals

10.1021/acs.chemrestox.3c00318 · 2024 · External reference

Novel prediction models for genotoxicity based on biomarker genes in human HepaRG™ cells

10.14573/altex.2206201 · 2023 · External reference

Genotoxicity testing: progress and prospects for the next decade

10.1080/17425255.2017.1375097 · 2017 · External reference

An adverse outcome pathway network for chemically induced oxidative stress leading to (non)genotoxic carcinogenesis

10.1021/acs.chemrestox.2c00396 · 2023 · External reference

Mutagenicity of aflatoxins related to their metabolism and carcinogenic potential

10.1073/pnas.73.7.2241 · 1976 · External reference

Formation of DHP-derived DNA adducts from metabolic activation of the prototype heliotridine-type pyrrolizidine alkaloid, lasiocarpine

10.1016/j.canlet.2005.01.023 · 2006 · External reference

Amelioration of cyclophosphamide-induced DNA damage, oxidative stress, and hepato- and neurotoxicity by piper longum extract in rats: the role of γH2AX and 8-OHdG

10.3389/fphar.2023.1147823 · 2023 · External reference

Mutagenicity of pyrrolizidine alkaloids in the Salmonella/mammalian-microsome test

10.1016/0165-1218(79)90152-6 · 1979 · External reference

A trichostatin a expression signature identified by TempO-Seq targeted whole transcriptome profiling

10.1371/journal.pone.0178302 · 2017 · External reference

A critical appraisal of the sensitivity of in vivo genotoxicity assays in detecting human carcinogens

10.1093/mutage/gey005 · 2018 · External reference

Determination of potential thresholds for N-ethyl-N-nitrosourea and ethyl methanesulfonate based on a multi-endpoint genotoxicity assessment platform in rats

10.1007/s11356-022-21605-z · 2022 · External reference