Research graph
References from Review of in vitro approaches for assessing the toxicity of chemical stressors across diverse physiological systems. Local targets link to admitted publications; unresolved targets remain external evidence.
hERG block potencies for 5 positive control drugs obtained per ICH E14/S7B Q&As best practices: impact of recording temperature and drug loss
10.1016/j.vascn.2022.107193 · 2022 · External reference
Alternative (non-animal) methods for cosmetics testing: current status and future prospects—2010
10.1007/s00204-011-0693-2 · 2011 · External reference
10.1007/978-3-030-66376-6_11
10.1007/978-3-030-66376-6_11 · 2021 · External reference
Strategies for the early detection of drug-induced hepatic steatosis in preclinical drug safety evaluation studies
10.1016/j.tox.2010.10.006 · 2011 · External reference
Editor’s highlight: mechanistic toxicity tests based on an adverse outcome pathway network for hepatic steatosis
10.1093/toxsci/kfx121 · 2017 · External reference
A comparative evaluation of in vitro skin sensitisation tests: the human cell-line activation test (h-CLAT) versus the local lymph node assay (LLNA)
10.1177/026119291003800403 · 2010 · External reference
Microphysiological system with continuous analysis of albumin for hepatotoxicity modeling and drug screening
10.1016/j.jiec.2021.03.035 · 2021 · External reference
Profiling of the Tox21 chemical collection for mitochondrial function to identify compounds that acutely decrease mitochondrial membrane potential
10.1289/ehp.1408642 · 2015 · External reference
Systematic study of mitochondrial toxicity of environmental chemicals using quantitative high throughput screening
10.1021/tx4001754 · 2013 · External reference
Alzheimer’s disease: the impact of age-related changes in reproductive hormones: the role of hypothalamic-pituitary-gonadal hormones in the normal structure and functioning of the brain
10.1007/s00018-004-4380-4 · 2005 · External reference
Functional characterization of GABAA receptor-mediated modulation of cortical neuron network activity in microelectrode array recordings
10.1371/journal.pone.0186147 · 2017 · External reference
Recommendation on test readiness criteria for new approach methods in toxicology: exemplified for developmental neurotoxicity
10.14573/altex.1712081 · 2018 · External reference
Antioxidant enzyme activities and lipid peroxidation in the freshwater cladoceran Daphnia magna exposed to redox cycling compounds
10.1016/j.cca.2005.01.013 · 2005 · External reference
A human iPSC-based in vitro neural network formation assay to investigate neurodevelopmental toxicity of pesticides
10.14573/altex.2206031 · 2023 · External reference
Is dietary mercury of neurotoxicological concern to wild polar bears (Ursus maritimus)?
10.1897/08-251.1 · 2009 · External reference
An interspecies comparison of mercury inhibition on muscarinic acetylcholine receptor binding in the cerebral cortex and cerebellum
10.1016/j.taap.2004.09.009 · 2005 · External reference
Biology of oligodendrocyte and myelin in the mammalian central nervous system
10.1152/physrev.2001.81.2.871 · 2001 · External reference
Project TENDR: targeting environmental neuro-developmental risks the TENDR consensus statement
10.1289/ehp358 · 2016 · External reference
Multiplicity of nuclear receptor activation by PFOA and PFOS in primary human and rodent hepatocytes
10.1016/j.tox.2011.06.012 · 2011 · External reference
Intestinal microbiota regulate xenobiotic metabolism in the liver
10.1371/journal.pone.0006958 · 2009 · External reference
Diseases, disorders, and comorbidities of interoception
10.1016/j.tins.2020.09.009 · 2021 · External reference
Endocrine-disrupting potential of bisphenol A, bisphenol a dimethacrylate, 4-n-nonylphenol, and 4-n-octylphenol in vitro: new data and a brief review
10.1289/ehp.9368 · 2007 · External reference
How useful are clinical liver function tests in in vitro human hepatotoxicity assays?
10.1016/j.tiv.2014.03.006 · 2014 · External reference
Myelin breakdown in human Huntington’s disease: multi-modal evidence from diffusion MRI and quantitative magnetization transfer
10.1016/j.neuroscience.2017.05.042 · 2019 · External reference
Cell painting, a high-content image-based assay for morphological profiling using multiplexed fluorescent dyes
10.1038/nprot.2016.105 · 2016 · External reference
Screening chemicals for estrogen receptor bioactivity using a computational model
10.1021/acs.est.5b02641 · 2015 · External reference
Evaluation of potential sodium-iodide symporter (NIS) inhibitors using a secondary Fischer rat thyroid follicular cell (FRTL-5) radioactive iodide uptake (RAIU) assay
10.1007/s00204-020-02664-y · 2020 · External reference
Evaluation of per- and polyfluoroalkyl substances (PFAS) in vitro toxicity testing for developmental neurotoxicity
10.1021/acs.chemrestox.2c00344 · 2023 · External reference
Current approaches to the interpretation of bioactivity data from a neural network formation assay to inform developmental neurotoxicity potential of chemical exposure
10.1016/j.yrtph.2025.106008 · 2026 · External reference
Impact of endocrine disrupting chemicals on neurodevelopment: the need for better testing strategies for endocrine disruption-induced developmental neurotoxicity
10.1080/17446651.2022.2044788 · 2022 · External reference
Interpretation of liver enzymes
10.1016/j.cvsm.2006.11.009 · 2007 · External reference
An in vitro approach for lipolysis measurement using high-resolution mass spectrometry and partial least squares based analysis
10.1016/j.aca.2016.10.043 · 2017 · External reference
Chronic exposure to perfluorooctane sulfonate induces behavior defects and neurotoxicity through oxidative damages, in vivo and in vitro
10.1371/journal.pone.0113453 · 2014 · External reference
Novel clinical biomarkers for drug-induced liver injury
10.1124/dmd.121.000732 · 2022 · External reference
Human IPSC-derived model to study myelin disruption
10.3390/ijms22179473 · 2021 · External reference
The role of mitochondrial dysfunction in cardiovascular disease: a brief review
10.1080/07853890.2017.1417631 · 2018 · External reference
Inhibition of the urea cycle by the environmental contaminant 2,3,7,8-tetrachlorodibenzo-p-dioxin increases serum ammonia levels in mice
10.1016/j.jbc.2023.105500 · 2024 · External reference
Developmental neurotoxicity of different pesticides in PC-12 cells in vitro
10.1016/j.taap.2017.03.027 · 2017 · External reference
Quantitative analysis of cell proliferation by a dye dilution assay: application to cell lines and cocultures
10.1002/cyto.a.23105 · 2017 · External reference
Unresolved reference
External reference
Unresolved reference
External reference
In vitro bioassays for the study of endocrine-disrupting food additives and contaminants
10.1016/j.trac.2010.10.009 · 2011 · External reference
Developmental neurotoxicity testing: recommendations for developing alternative methods for the screening and prioritization of chemicals
10.14573/altex.2011.1.009 · 2010 · External reference
External scientific report on the interpretation of data from the developmental neurotoxicity in vitro testing assays for use in integrated approaches for testing and assessment
10.2903/sp.efsa.2021.en-6924 · 2021 · External reference
Optimization of human neural progenitor cells for an imaging-based high-throughput phenotypic profiling assay for developmental neurotoxicity screening
10.3389/ftox.2021.803987 · 2021 · External reference
In vitro exposure to xenoestrogens induces growth hormone transcription and release via estrogen receptor-dependent pathways in rat pituitary GH3 cells
10.1016/j.steroids.2009.03.002 · 2009 · External reference
Alterations of myelin content in Parkinson’s disease: A cross-sectional neuroimaging study
10.1371/journal.pone.0163774 · 2016 · External reference
An in vitro model of hepatic steatosis using lipid loaded induced pluripotent stem cell derived hepatocyte like cells
10.14440/jbm.2020.330 · 2020 · External reference
Effects on in vitro exposure of beluga whale splenocytes and thymocytes to heavy metals
10.1002/etc.5620150815 · 1996 · External reference
Immune functions in beluga whales (Delphinapterus leucas): evaluation of phagocytosis and respiratory burst with peripheral blood leukocytes using flow cytometry
10.1016/0165-2427(94)05399-d · 1995 · External reference
Immune functions in beluga whales (Delphinapterus leucas): evaluation of natural killer cell activity
10.1016/s0165-2427(97)00035-4 · 1997 · External reference
First observations of a potential association between accumulation of PFAS in the CNS and markers of Alzheimer’s disease
10.1093/gerona/glad208 · 2023 · External reference
Using a liver cell culture from epinephelus coioides as a model to evaluate the nonylphenol-induced oxidative stress
10.1016/j.marpolbul.2017.06.049 · 2017 · External reference
Translational immunologic safety evaluation: a perspective
10.3109/1547691x.2012.712067 · 2013 · External reference
Effects of polar bear and killer whale derived contaminant cocktails on marine mammal immunity
10.1021/acs.est.7b03532 · 2017 · External reference
Role of oxidative stress in cardiovascular diseases
10.1097/00004872-200018060-00002 · 2000 · External reference
Cardiac metabolism in heart failure
10.1161/circresaha.113.300376 · 2013 · External reference
Structural and functional screening in human induced-pluripotent stem cell-derived cardiomyocytes accurately identifies cardiotoxicity of multiple drug types
10.1016/j.taap.2015.03.008 · 2015 · External reference
In vitro models for studying chronic drug-induced liver injury
10.3390/ijms231911428 · 2022 · External reference
Application of a nonradioactive assay for high throughput screening for inhibition of thyroid hormone uptake via the transmembrane transporter MCT8
10.1016/j.tiv.2017.01.014 · 2017 · External reference
Biomarkers of immunotoxicity for environmental and public health research
10.3390/ijerph8051388 · 2011 · External reference
Endocrine disrupting chemicals: effects on pituitary, thyroid and adrenal glands
10.1007/s12020-022-03076-x · 2022 · External reference
Pyrethroid pesticide-induced alterations in dopamine transporter function
10.1016/j.taap.2005.06.003 · 2006 · External reference
Unresolved reference
2006 · External reference
Unresolved reference
2011 · External reference
Unresolved reference
2006 · External reference
Cytotoxicity burst? Differentiating specific from nonspecific effects in Tox21 in vitro reporter gene assays
10.1289/ehp6664 · 2020 · External reference
Differential effects of oleic and palmitic acids on lipid droplet-mitochondria interaction in the hepatic cell line HepG2
10.3389/fnut.2021.775382 · 2021 · External reference
Advancing endocrine disruptors via in vitro evaluation: recognizing the significance of OECD and USEPA guidelines, embracing new assessment methods, and the urgent need for a comprehensive battery of tests
10.3390/toxics12030183 · 2024 · External reference
Methods: implementation of in vitro and ex vivo phagocytosis and respiratory burst function assessments in safety testing
10.3109/1547691x.2012.736427 · 2013 · External reference
Nonclinical human cardiac new approach methodologies (NAMs) predict vanoxerine-induced proarrhythmic potential
10.3390/jcdd12080285 · 2025 · External reference
Serum vaccine antibody concentrations in children exposed to perfluorinated compounds
10.1001/jama.2011.2034 · 2012 · External reference
Neurobehavioural effects of developmental toxicity
10.1016/s1474-4422(13)70278-3 · 2014 · External reference
In vitro myelotoxicity of environmental contaminants
10.1016/s1382-6689(98)00029-5 · 1998 · External reference
Review of evidence of environmental impacts of animal research and testing
10.3390/environments1010014 · 2014 · External reference
Effect of toxicants on fatty acid metabolism in HepG2 cells
10.3389/fphar.2018.00257 · 2018 · External reference
Tissue macrophages: origin, heterogeneity, biological functions, diseases and therapeutic targets
10.1038/s41392-025-02124-y · 2025 · External reference
10.5829/idosi.wjfms.2012.04.01.6138
10.5829/idosi.wjfms.2012.04.01.6138 · 2012 · External reference
High-throughput H295R steroidogenesis assay: utility as an alternative and a statistical approach to characterize effects on steroidogenesis
10.1093/toxsci/kfx274 · 2018 · External reference
Development of a screening approach to detect thyroid disrupting chemicals that inhibit the human sodium iodide symporter (NIS)
10.1016/j.tiv.2016.12.006 · 2017 · External reference
Transthyretin-binding activity of complex mixtures representing the composition of thyroid-hormone disrupting contaminants in house dust and human serum
10.1289/ehp5911 · 2020 · External reference
Testing for developmental neurotoxicity using a battery of in vitro assays for key cellular events in neurodevelopment
10.1016/j.taap.2018.04.001 · 2018 · External reference
Molecular and functional characterization of different brain sphere models for use in neurotoxicity testing on microelectrode arrays
10.3390/cells12091270 · 2023 · External reference
A general procedure to select calibration drugs for lab-specific validation and calibration of proarrhythmia risk prediction models: an illustrative example using the CiPA model
10.1016/j.vascn.2020.106890 · 2020 · External reference
Immunotoxicology: challenges in the 21st century and in vitro opportunities
10.14573/altex.2013.4.411 · 2013 · External reference
Adverse cardiac effects of cancer therapies: cardiotoxicity and arrhythmia
10.1038/s41569-020-0348-1 · 2020 · External reference
Unresolved reference
1998 · External reference
Interference of endocrine disrupters with thyroid hormone receptor-dependent transactivation
10.1093/toxsci/kfp086 · 2009 · External reference
Toxic, bioaccumulative and persistent chemicals in Central and Eastern Europe—state-of-the-art report
2000 · External reference
Generation of human nociceptor-enriched sensory neurons for the study of pain-related dysfunctions
10.1093/stcltm/szac031 · 2022 · External reference
Screening the ToxCast Phase 1 chemical library for inhibition of deiodinase type 1 activity
10.1093/toxsci/kfx279 · 2018 · External reference
Cardiac voltage-gated ion channels in safety pharmacology: review of the landscape leading to the CiPA initiative
10.1016/j.vascn.2017.04.002 · 2017 · External reference
Serum polyfluoroalkyl chemicals are associated with risk of cardiovascular diseases in national US population
10.1016/j.envint.2018.05.051 · 2018 · External reference
Low concentrations of bisphenol A induce lipid accumulation mediated by the production of reactive oxygen species in the mitochondria of HepG2 cells
10.1016/j.tiv.2012.03.017 · 2012 · External reference
Ligand binding assays at equilibrium: validation and interpretation
10.1111/j.1476-5381.2009.00604.x · 2010 · External reference
Recent insights into T-cell receptor-mediated signalling pathways for T-cell activation and development
10.1038/s12276-020-0435-8 · 2020 · External reference
In vitro approaches to investigate the effect of chemicals on antibody production: the case study of PFASs
10.1007/s00204-025-03993-6 · 2025 · External reference
Application of T-cell proliferation assay
2020 · External reference
Effects of selective serotonin reuptake inhibitors on three sex steroids in aromatase enzyme inhibition and H295R assays
10.1016/j.tiv.2015.07.005 · 2015 · External reference
Are new approach methodologies (NAMs) the holy grail of toxicology?
10.1093/toxsci/kfaf113 · 2025 · External reference
Directional thyroid hormone distribution via the blood stream to target sites
10.1016/j.mce.2017.02.037 · 2017 · External reference
Regulation of granulocyte and macrophage populations of murine bone marrow cells by G-CSF and CD137 protein
10.1371/journal.pone.0015565 · 2010 · External reference
Inhibition of hERG K channels by verapamil at physiological temperature: implications for the CiPA initiative
10.1016/j.vascn.2024.107562 · 2024 · External reference
Abnormal liver enzymes: a review for clinicians
10.4254/wjh.v13.i11.1688 · 2021 · External reference
Free fatty acid transport across adipocytes is mediated by an unknown membrane protein pump
10.1152/ajpendo.00259.2007 · 2007 · External reference
Establishment of neurotoxicity assessment using microelectrode array (MEA) with hiPSC-derived neurons and evaluation of new psychoactive substances (NPS)
10.15283/ijsc21217 · 2022 · External reference
CaFFEE: a program for evaluating time courses of Ca2+ dependent signal changes of complex cells loaded with fluorescent indicator dyes
10.14573/altex.2003191 · 2020 · External reference
Biomarkers in immunology: their impact on immune function and response
10.1016/j.abst.2025.03.001 · 2025 · External reference
Optimization of the IL-2 Luc assay for immunosuppressive drugs: a novel in vitro immunotoxicity test with high sensitivity and predictivity
10.1007/s00204-021-03101-4 · 2021 · External reference
An international validation study of the interleukin-2 luciferase leukocyte toxicity test (IL-2 Luc LTT) to evaluate potential immunosuppressive chemicals and its performance after use with the interleukin-2 luciferase assay (IL-2 Luc assay)
10.1007/s00204-021-03101-4 · 2023 · External reference
Development and validation of a computational model for androgen receptor activity
10.1021/acs.chemrestox.6b00347 · 2017 · External reference
Neurodevelopmental toxicity assessment of flame retardants using a human DNT in vitro testing battery
10.1007/s10565-021-09603-2 · 2022 · External reference
Pregnane X receptor mediates steatotic effects of propiconazole and tebuconazole in human liver cell lines
10.1007/s00204-019-02445-2 · 2019 · External reference
Scientific validation of human neurosphere assays for developmental neurotoxicity evaluation
10.3389/ftox.2022.816370 · 2022 · External reference
Unresolved reference
2005 · External reference
Functional assays are mandatory for a correct prediction of immunotoxic properties of compounds in vitro
10.1016/j.fct.2008.10.025 · 2009 · External reference
Do in vitro assays in rat primary neurons predict drug-induced seizure liability in humans?
10.1016/j.taap.2018.03.028 · 2018 · External reference
Toxicity testing in the 21st century: a vision and a strategy
10.1080/10937404.2010.483176 · 2010 · External reference
In vivo and in vitro changes in neurochemical parameters related to mercury concentrations from specific brain regions of polar bears (Ursus maritimus)
10.1002/etc.2685 · 2014 · External reference
Key hepatoprotective roles of mitochondria in liver regeneration
10.1152/ajpgi.00220.2022 · 2023 · External reference
Evaluation and prevalidation of an immunotoxicity test based on human whole-blood cytokine release
10.1177/026119290203000605 · 2002 · External reference
More than additive effects on liver triglyceride accumulation by combinations of steatotic and non-steatotic pesticides in HepaRG cells
10.1007/s00204-021-02997-2 · 2021 · External reference
3D primary hepatocyte culture systems for analyses of liver diseases, drug metabolism, and toxicity: emerging culture paradigms and applications
10.1002/biot.201800347 · 2019 · External reference
A dual mixture of persistent organic pollutants modifies carbohydrate metabolism in the human hepatic cell line HepaRG
10.1016/j.envres.2019.108628 · 2019 · External reference
Roles of mTOR signaling in brain development
10.5607/en.2015.24.3.177 · 2015 · External reference
Inhibition of neurite outgrowth and enhanced effects compared to baseline toxicity in SH-SY5Y cells
10.1007/s00204-022-03237-x · 2022 · External reference
Evaluation of elevated liver enzymes
10.1016/j.cld.2012.03.006 · 2012 · External reference
Phagocytosis: measurement by flow cytometry
10.1016/s0022-1759(00)00237-4 · 2000 · External reference
Development and utilization of a unique in vitro antigen presentation co-culture model for detection of immunomodulating substances
10.1016/j.tiv.2018.06.025 · 2018 · External reference
Modeling chemotherapy induced peripheral neuropathy (CIPN) in vitro: Prospects and limitations
10.1016/j.expneurol.2019.113140 · 2020 · External reference
Proposed key characteristics of neurotoxic chemicals
10.1016/j.neuro.2025.103370 · 2026 · External reference
Bioluminescent assay for the quantification of cellular glycogen levels
10.1021/acsomega.4c04190 · 2024 · External reference
Role of mitochondrial inner membrane permeabilization in necrotic cell death, apoptosis, and autophagy
10.1089/152308602760598918 · 2002 · External reference
T-screen and yeast assay for detecting thyroid-disrupting activities of cadmium, mercury, and zinc
10.1007/s11356-016-6095-5 · 2016 · External reference
Sediment pollutant exposures caused hepatotoxicity and disturbed glycogenesis
10.1016/j.ecoenv.2023.114559 · 2023 · External reference
Assessment of indicators in a human liver cell line HL-7702 for tetracycline toxicity in farm soil
10.3390/agronomy12030730 · 2022 · External reference
Toxicity of organic and inorganic mercury species in differentiated human neurons and human astrocytes
10.1016/j.jtemb.2015.06.008 · 2015 · External reference
Human neuronal signaling and communication assays to assess functional neurotoxicity
10.1007/s00204-020-02956-3 · 2021 · External reference
Differentiation of human induced pluripotent stem cells into mature and myelinating schwann cells
10.1089/ten.tec.2022.0186 · 2023 · External reference
Binding affinity and biological activity of gonadotropin-releasing hormone agonists in isolated pituitary cells
10.1210/endo-111-3-730 · 1982 · External reference
Polychlorinated biphenyl-induced neurotoxicity in organotypic cocultures of developing rat ventral mesencephalon and striatum
10.1093/toxsci/kfm027 · 2007 · External reference
Serum metabolome and targeted bile acid profiling reveals potential novel biomarkers for drug-induced liver injury
10.1097/md.0000000000016717 · 2019 · External reference
Identification of neural-relevant toxcast high-throughput assay intended gene targets: applicability to neurotoxicity and neurotoxicant putative molecular initiating events
10.1016/j.neuro.2024.07.001 · 2024 · External reference
In vitro test battery for testing molecular initiating events in chemical-induced cholestasis
10.1016/j.tox.2025.154210 · 2025 · External reference
Neutrophils in the activation and regulation of innate and adaptive immunity
10.1038/nri3024 · 2011 · External reference
Literature review and appraisal on alternative neurotoxicity testing methods
10.2903/sp.efsa.2018.en-1410 · 2018 · External reference
Establishment of an a priori protocol for the implementation and interpretation of an in-vitro testing battery for the assessment of developmental neurotoxicity
10.2903/sp.efsa.2020.en-1938 · 2020 · External reference
Lipid droplet accumulation and impaired fat efflux in polarized hepatic cells: consequences of ethanol metabolism
10.1155/2012/978136 · 2012 · External reference
Dopaminergic dysbalance in distinct basal ganglia neurocircuits: implications for the pathophysiology of Parkinson’s disease, schizophrenia and attention deficit hyperactivity disorder
10.1007/bf03033354 · 2006 · External reference
Emerging three-dimensional hepatic models in relation to traditional two-dimensional in vitro assays for evaluating drug metabolism and hepatoxicity
10.1016/j.medidd.2020.100060 · 2020 · External reference
New approach methodologies for the endocrine activity toolbox: environmental assessment for fish and amphibians
10.1002/etc.5584 · 2023 · External reference
Effects of perfluorooctanoic acid (PFOA) on gene expression profiles via nuclear receptors in HepaRG cells: comparative study with in vitro transactivation assays
10.1016/j.tox.2023.153577 · 2023 · External reference
Mechanism-based testing strategy using in vitro approaches for identification of thyroid hormone disrupting chemicals
10.1016/j.tiv.2013.02.012 · 2013 · External reference
Evaluation of functional and binding assays in cells expressing either recombinant or endogenous hERG channel
10.1016/j.vascn.2005.10.003 · 2006 · External reference
Role of environmental toxicants on neurodegenerative disorders
10.3389/ftox.2022.837579 · 2022 · External reference
Interactions of the GnRH receptor with heterotrimeric G proteins
10.1016/j.yfrne.2012.11.001 · 2013 · External reference
Microelectrode array recordings of cardiac action potentials as a high throughput method to evaluate pesticide toxicity
10.1016/j.tiv.2005.08.014 · 2006 · External reference
10.1007/978-1-4939-9228-7_8
10.1007/978-1-4939-9228-7_8 · 2019 · External reference
Functional alteration of natural killer cells and cytotoxic T lymphocytes upon asbestos exposure and in malignant mesothelioma patients
10.1155/2015/238431 · 2015 · External reference
Evaluating chemicals for thyroid disruption: Opportunities and challenges with in vitro testing and adverse outcome pathway approaches
10.1289/ehp5297 · 2019 · External reference
The CPT1a inhibitor, etomoxir induces severe oxidative stress at commonly used concentrations
10.1038/s41598-018-24676-6 · 2018 · External reference
Unresolved reference
2014 · External reference
10.1787/9789264304741-en
10.1787/9789264304741-en · 2018 · External reference
10.1787/9789264265295-en
10.1787/9789264265295-en · 2021 · External reference
Detailed review paper on in vitro test addressing immunotoxicity with a focus on immunosuppression
2022 · External reference
10.1787/91964ef3-en
10.1787/91964ef3-en · 2023 · External reference
Unresolved reference
2024 · External reference
10.1787/9789264122642-en
10.1787/9789264122642-en · 2025 · External reference
Unresolved reference
2025 · External reference
10.1787/765aaada-en
10.1787/765aaada-en · External reference
The pathophysiology of cholestasis and its relevance to clinical practice
10.1002/cld.894 · 2020 · External reference
Force-controlled patch clamp of beating cardiac cells
10.1021/nl504438z · 2015 · External reference
Workshop report: FDA workshop on improving cardiotoxicity assessment with human-relevant platforms
10.1161/circresaha.119.315378 · 2019 · External reference
Human induced pluripotent stem cell-cardiomyocytes for cardiotoxicity assessment: a comparative study of arrhythmia inducing drugs with multi-electrode array analysis
10.4196/kjpp.24.413 · 2025 · External reference
Development of a thyroperoxidase inhibition assay for high-throughput screening
10.1021/tx400310w · 2014 · External reference
Induction of human cytochrome P450 enzyme activities by metabolism disrupting chemicals in the hepatic cell line HepaRG
10.1016/j.tox.2025.154300 · 2026 · External reference
Prevalidation of a CFU-GM assay model for predicting acute neutropenia
10.1016/s0887-2333(01)00085-6 · 2001 · External reference
Development of a quantitative 96-well method to image glycogen storage in primary rat hepatocytes
10.1007/s11010-010-0438-1 · 2010 · External reference
Prediction of liver injury induced by chemicals in human with a multiparametric assay on isolated mouse liver mitochondria
10.1093/toxsci/kfs197 · 2012 · External reference
Dietary flavonoids modulate PCB-induced oxidative stress, CYP1A1 induction, and AhR-DNA binding in endothelial cells
10.1093/toxsci/kfg227 · 2003 · External reference
Novel treatment strategy for patients with urea cycle disorders: pharmacological chaperones enhance enzyme stability and activity in patient-derived liver disease models
10.1002/jimd.70043 · 2025 · External reference
10.1016/c2010-1-67850-9
10.1016/c2010-1-67850-9 · 2024 · External reference
An integrated platform for simultaneous multi-well field potential recording and Fura-2-based calcium transient ratiometry in human induced pluripotent stem cell (hiPSC)-derived cardiomyocytes
10.1016/j.vascn.2015.04.005 · 2015 · External reference
Morphological profiling of environmental chemicals enables efficient and untargeted exploration of combination effects
10.1016/j.scitotenv.2022.155058 · 2022 · External reference
Fatty acid oxidation disorders
10.1146/annurev.physiol.64.082201.154705 · 2002 · External reference
Towards regulation of endocrine disrupting chemicals in water resources using bioassays – a guide to developing a testing strategy
10.1016/j.envres.2021.112483 · 2022 · External reference
An estrogenic municipal effluent decreased fathead minnow reproduction to a near stop
10.1016/j.chemosphere.2024.143957 · 2025 · External reference
The ins and outs of MHC class II–mediated antigen processing and presentation
10.1038/nri3818 · 2015 · External reference
An integrated approach for early in vitro seizure prediction utilizing hiPSC neurons and human ion channel assays
10.1093/toxsci/kfad087 · 2023 · External reference
The relevance of chemical interactions with CYP17 enzyme activity: assessment using a novel in vitro assay
10.1016/j.taap.2013.01.033 · 2013 · External reference
Phagocytosis: a fundamental process in immunity
10.1155/2017/9042851 · 2017 · External reference
Xenobiotic-metabolizing enzyme and transporter gene expression in primary cultures of human hepatocytes modulated by Toxcast chemicals
10.1080/10937404.2010.483949 · 2010 · External reference
Characterizing the reproducibility in using a liver microphysiological system for assaying drug toxicity, metabolism, and accumulation
10.1111/cts.12969 · 2021 · External reference
10.1007/978-1-4939-6346-1_2
10.1007/978-1-4939-6346-1_2 · 2016 · External reference
Development and characterization of a human embryonic stem cell-derived 3D neural tissue model for neurotoxicity testing
10.1016/j.tiv.2016.10.001 · 2017 · External reference
In vitro assay of thyroid disruptors affecting TSH-stimulated adenylate cyclase activity
10.1007/bf03348190 · 2003 · External reference
Analysis of motor neurons differentiated from human induced pluripotent stem cells for the use in cell-based botulinum neurotoxin activity assays
10.3390/toxins12050276 · 2020 · External reference
Omnisphero: a high-content image analysis (HCA) approach for phenotypic developmental neurotoxicity (DNT) screenings of organoid neurosphere cultures in vitro
10.1007/s00204-016-1852-2 · 2017 · External reference
Endothelial dysfunction in adipose triglyceride lipase deficiency
10.1016/j.bbalip.2014.03.005 · 2014 · External reference
Functional embryonic cardiomyocytes after disruption of the L-type α1C (Cav 1.2) calcium channel gene in the mouse
10.1074/jbc.m006467200 · 2000 · External reference
The cardiac muscle cell
10.1002/(sici)1521-1878(200002)22:2<188::aid-bies10>3.0.co;2-t · 2000 · External reference
Long-term hepatotoxicity model using rat hepatocytes in micro-hollow fiber reactor
10.1016/j.bej.2006.12.010 · 2007 · External reference
Environmental pollutants and their effects on human health
10.1016/j.heliyon.2023.e19496 · 2023 · External reference
The impact of environmental toxins on cardiovascular diseases
10.1016/j.cpcardiol.2023.102120 · 2024 · External reference
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