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References from A high-throughput method to computationally develop candidate adverse outcome pathways in humans: a proof of concept with insecticides and Parkinson’s Disease. Local targets link to admitted publications; unresolved targets remain external evidence.
Unresolved reference
2025 · External reference
The neurotoxicity of pesticides: implications for Parkinson’s disease
10.1016/j.chemosphere.2025.144348 · 2025 · External reference
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Gene ontology: tool for the unification of biology
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Unresolved reference
2017 · External reference
Application of radiation omics in the development of adverse outcome pathway networks: an example of radiation-induced cardiovascular disease
10.1080/09553002.2022.2110325 · 2022 · External reference
Unresolved reference
2026 · External reference
Bgee in 2024: focus on curated single-cell RNA-seq datasets, and query tools
10.1093/nar/gkae1118 · 2025 · External reference
Linking bisphenol S to adverse outcome pathways using a combined text mining and systems biology approach
10.1289/ehp4200 · 2019 · External reference
Adverse outcome pathway (AOP) framework for predicting toxic mechanisms in E-cigarette-induced lung injury
10.1016/j.ecoenv.2025.118703 · 2025 · External reference
Comparative toxicogenomics database’s 20th anniversary: update 2025
10.1093/nar/gkae883 · 2025 · External reference
The cell ontology 2016: enhanced content, modularization, and ontology interoperability
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Organophosphorus compounds and MAPK signaling pathways
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TREM2 expression level is critical for microglial state, metabolic capacity and efficacy of TREM2 agonism
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The human phenotype ontology in 2024: phenotypes around the world
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The physiological and pharmacological role of basic fibroblast growth factor in the dopaminergic nigrostriatal system
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Pesticides and Parkinson’s disease: causal relationship at the population and individual level?
10.1007/s00702-025-03054-3 · 2026 · External reference
Ligands of peroxisome proliferator-activated receptor-alpha promote glutamate transporter-1 endocytosis in astrocytes
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Strength of ERK1/2 MAPK activation determines its effect on myelin and axonal integrity in the adult CNS
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ERK1/ERK2 MAPK signaling is required to increase myelin thickness independent of oligodendrocyte differentiation and initiation of myelination
10.1523/jneurosci.0137-12.2012 · 2012 · External reference
AOP-helpFinder 3.0: from text mining to network visualization of key event relationships, and knowledge integration from multiple sources
10.1093/bioinformatics/btaf381 · 2025 · External reference
A single-cell type transcriptomics map of human tissues
10.1126/sciadv.abh2169 · 2021 · External reference
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10.1007/s00204-019-02613-4 · 2020 · External reference
Perinatal exposure to pesticides alters synaptic plasticity signaling and induces behavioral deficits associated with neurodevelopmental disorders
10.1007/s10565-022-09697-2 · 2023 · External reference
PPARα inhibits astrocyte inflammation activation by restoring autophagic flux after transient brain ischemia
10.3390/biomedicines11030973 · 2023 · External reference
Lost in translation: animal models and clinical trials in cancer treatment
2014 · External reference
The reactome pathway knowledgebase 2024
10.1093/nar/gkad1025 · 2024 · External reference
The environmental health language collaborative (EHLC) adverse outcome pathway (AOP) standards workshop report
10.12688/f1000research.175826.1 · 2026 · External reference
The FAIR AOP roadmap for 2025: advancing findability, accessibility, interoperability, and re-usability of adverse outcome pathways
10.1016/j.comtox.2025.100368 · 2025 · External reference
The 2021 update of the EPA’s adverse outcome pathway database
10.1038/s41597-021-00962-3 · 2021 · External reference
Uberon, an integrative multi-species anatomy ontology
10.1186/gb-2012-13-1-r5 · 2012 · External reference
Unresolved reference
2017 · External reference
Accelerating adverse outcome pathway development using publicly available data sources
10.1007/s40572-016-0079-y · 2016 · External reference
Exploring and retrieving sequence and metadata for species across the tree of life with NCBI datasets
10.1038/s41597-024-03571-y · 2024 · External reference
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10.48550/arxiv.1403.2805 · 2014 · External reference
Integration of adverse outcome pathways, causal networks and ‘omics to support chemical hazard assessment
10.3389/ftox.2022.786057 · 2022 · External reference
The DisGeNET knowledge platform for disease genomics: 2019 update
10.1093/nar/gkz1021 · 2020 · External reference
The monarch initiative in 2024: an analytic platform integrating phenotypes, genes and diseases across species
10.1093/nar/gkad1082 · 2024 · External reference
Unresolved reference
2022 · External reference
From causal networks to adverse outcome pathways: a developmental neurotoxicity case study
10.3389/ftox.2022.815754 · 2022 · External reference
10.25678/000h0t
10.25678/000h0t · 2026 · External reference
A curated gene and biological system annotation of adverse outcome pathways related to human health
10.1038/s41597-023-02321-w · 2023 · External reference
10.21105/joss.00037 · 2016 · Admitted local publication
A pragmatic approach to adverse outcome pathway development and evaluation
10.1093/toxsci/kfab113 · 2021 · External reference
The gene ontology knowledgebase in 2023
10.1093/genetics/iyad031 · 2023 · External reference
The next generation blueprint of computational toxicology at the U.S. Environmental Protection Agency
10.1093/toxsci/kfz058 · 2019 · External reference
Fibroblast growth factor (FGF)-2 and FGF receptor 3 are required for the development of the substantia nigra, and FGF-2 plays a crucial role for the rescue of dopaminergic neurons after 6-hydroxydopamine lesion
10.1523/jneurosci.4493-06.2007 · 2007 · External reference
Bax ablation prevents dopaminergic neurodegeneration in the 1-methyl- 4-phenyl-1,2,3,6-tetrahydropyridine mouse model of Parkinson’s disease
10.1073/pnas.051633998 · 2001 · External reference
FGF–FGFR signaling in Parkinson’s disease: mechanistic links to ferroptosis and neuroprotection
10.3390/brainsci16020151 · 2026 · External reference
Toward a global understanding of chemical pollution: a first comprehensive analysis of national and regional chemical inventories
10.1021/acs.est.9b06379 · 2020 · External reference
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10.1007/978-3-319-24277-4 · 2016 · External reference
Unresolved reference
2023 · External reference
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10.21105/joss.01686 · 2019 · External reference
Unresolved reference
2026 · External reference
Unresolved reference
2023 · External reference
Unresolved reference
2025 · External reference
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10.32614/rj-2017-058 · 2017 · External reference
Molecular mechanisms of excitotoxicity and their relevance to the pathogenesis of neurodegenerative diseases—an update
10.1038/s41401-025-01576-w · 2025 · External reference
White matter changes in Parkinson’s disease
10.1038/s41531-023-00592-z · 2023 · External reference
AOP-networkFinder—a versatile tool for the reconstruction and visualization of Adverse Outcome Pathway networks from AOP-Wiki
10.1093/bioadv/vbaf007 · 2025 · External reference
Recent advance in the relationship between excitatory amino acid transporters and Parkinson’s disease
10.1155/2016/8941327 · 2016 · External reference
