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References from Co-exposure to high temperature and mono(2-ethylhexyl) phthalate inhibits mouse antral follicle growth and estradiol synthesis: phthalate-heat interactions in the ovary. Local targets link to admitted publications; unresolved targets remain external evidence.
Heat stress impairs in vitro development of preantral follicles of cattle
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Oxidative and endoplasmic reticulum stress defense mechanisms of bovine granulosa cells exposed to heat stress
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10.1186/s12889-025-21677-9 · 2025 · External reference
Heat-related emergency hospitalizations for respiratory diseases in the Medicare population
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A dose-response study following in utero and lactational exposure to di-(2-ethylhexyl)-phthalate (DEHP): non-monotonic dose-response and low dose effects on rat brain aromatase activity
10.1016/j.tox.2006.07.022 · 2006 · External reference
Effects of heat stress on ovarian development and the expression of HSP genes in mice
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Elevated temperature (heat stress) in vitro reduces androstenedione and estradiol and increases progesterone secretion by follicular cells from bovine dominant follicles
10.1016/j.domaniend.2005.02.017 · 2005 · External reference
Warming modulates the effects of the endocrine disruptor progestin levonorgestrel on the zebrafish fitness, ovary maturation kinetics and reproduction success
10.1016/j.envpol.2017.05.090 · 2017 · External reference
Molecular mechanisms of action of FSH
10.3389/fendo.2019.00305 · 2019 · External reference
Organ-ovary crosstalk as a vital determinant of women’s health
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Co-treatment of mouse antral follicles with 17beta-estradiol interferes with Mono-2-ethylhexyl phthalate (MEHP)-induced atresia and altered apoptosis gene expression
10.1016/j.reprotox.2014.01.002 · 2014 · External reference
Endocrine-disrupting chemicals in ovarian function: effects on steroidogenesis, metabolism and nuclear receptor signaling
10.1530/rep-11-0136 · 2011 · External reference
Combined effects of increased temperature and endocrine disrupting pollutants on sex determination, survival, and development across generations
10.1038/s41598-017-09631-1 · 2017 · External reference
Non-monotonic dose effects of in utero exposure to di(2-ethylhexyl) phthalate (DEHP) on testicular and serum testosterone and anogenital distance in male mouse fetuses
10.1016/j.reprotox.2012.09.006 · 2012 · External reference
The role of estrogen in folliculogenesis
10.1016/s0303-7207(99)00038-6 · 1999 · External reference
Follicular fluid concentrations of phthalate metabolites are associated with altered intrafollicular reproductive hormones in women undergoing in vitro fertilization
10.1016/j.fertnstert.2019.01.021 · 2019 · External reference
Follicular fluid and urinary concentrations of phthalate metabolites among infertile women and associations with in vitro fertilization parameters
10.1016/j.reprotox.2016.04.005 · 2016 · External reference
Biology of the cell cycle inhibitor p21(CDKN1A): molecular mechanisms and relevance in chemical toxicology
10.1007/s00204-014-1430-4 · 2015 · External reference
Impact of ambient temperature on ovarian reserve
10.1016/j.fertnstert.2021.05.091 · 2021 · External reference
Biphasic effects of postnatal exposure to diethylhexylphthalate on the timing of puberty in male rats
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Extreme heat and occupational health risks
10.1146/annurev-publhealth-060222-034715 · 2024 · External reference
Di-(2-ethylhexyl) phthalate and mono-(2-ethylhexyl) phthalate inhibit growth and reduce estradiol levels of antral follicles in vitro
10.1016/j.taap.2009.10.011 · 2010 · External reference
Mono(2-ethylhexyl) phthalate accelerates early folliculogenesis and inhibits steroidogenesis in cultured mouse whole ovaries and antral follicles
10.1095/biolreprod.115.129148 · 2015 · External reference
The effects of phthalates on the ovary
10.3389/fendo.2015.00008 · 2015 · External reference
Phthalate diesters and their metabolites in human breast milk, blood or serum, and urine as biomarkers of exposure in vulnerable populations
10.1289/ehp.10788 · 2008 · External reference
Relationship between phthalates exposure, risk of decreased ovarian reserve, and oxidative stress levels
10.1177/07482337241229761 · 2024 · External reference
The multifaceted role of cell cycle regulators in the coordination of growth and metabolism
10.1111/febs.15586 · 2021 · External reference
Ambient temperature, heat exposure and diminished ovarian reserve among women undergoing assisted reproductive technologies
10.1016/j.ecoenv.2025.118870 · 2025 · External reference
Determination of five phthalate monoesters in human urine using gas chromatography-mass spectrometry
10.1007/s00128-010-0051-8 · 2010 · External reference
Impact of real-life environmental exposures on reproduction: phthalates disrupt female reproductive health: a call for enhanced investigation into mixtures
10.1530/rep-24-0117 · 2025 · External reference
Heat stress induces a biphasic thermoregulatory response in mice
10.1152/ajpregu.00046.2004 · 2005 · External reference
Extreme cold or warm events can potentially exacerbate chemical toxicity to the marine medaka fish Oryzias melastigma
10.1016/j.aquatox.2022.106226 · 2022 · External reference
Effects of chronic heat stress on granulosa cell apoptosis and follicular atresia in mouse ovary
10.1186/s40104-016-0116-6 · 2016 · External reference
Dysregulation of steroid metabolome in follicular fluid links phthalate exposure to diminished ovarian reserve of childbearing-age women
10.1016/j.envpol.2023.121730 · 2023 · External reference
The association of serum phthalate metabolites with biomarkers of ovarian reserve in women of childbearing age
10.1016/j.ecoenv.2022.113909 · 2022 · External reference
Phthalate metabolites in paired human serum and whole blood
10.1016/j.scitotenv.2022.153792 · 2022 · External reference
Mechanisms of and potential medications for oxidative stress in ovarian granulosa cells: a review
10.3390/ijms24119205 · 2023 · External reference
Heat stress impairs mice granulosa cell function by diminishing steroids production and inducing apoptosis
10.1007/s11010-015-2610-0 · 2016 · External reference
Urinary phthalate metabolites and ovarian reserve among women seeking infertility care
10.1093/humrep/dev292 · 2016 · External reference
A novel mouse model of heatstroke accounting for ambient temperature and relative humidity
10.1186/s40560-021-00546-8 · 2021 · External reference
Differential actions of FSH and LH during folliculogenesis
10.1016/s1472-6483(10)60347-1 · 2007 · External reference
The effect of temperature gradients on endocrine signaling and antioxidant gene expression during Chironomus riparius development
10.1016/j.scitotenv.2013.10.052 · 2014 · External reference
Occupational exposure to phthalates in relation to gender, consumer practices and body composition
10.1007/s11356-016-7394-6 · 2016 · External reference
Heat-shock protein 70 antagonizes apoptosis-inducing factor
10.1038/ncb0901-839 · 2001 · External reference
Effect of Mono-(2-ethylhexyl) phthalate on steroid production of human granulosa cells
10.1016/j.taap.2009.05.022 · 2009 · External reference
Impact of heat stress on estrus expression and follicle size in estrus under field conditions in dairy cows
10.1016/j.theriogenology.2017.07.004 · 2017 · External reference
Heat stress diminishes gonadotropin receptor expression and enhances susceptibility to apoptosis of rat granulosa cells
10.1530/rep.1.00502 · 2005 · External reference
The combined impact of chemical and non-chemical stressors on adverse health outcomes: an overview of reviews from the epidemiological literature and experimental animal studies
10.1038/s41370-026-00862-x · 2026 · External reference
Mono-(2-ethylhexyl) phthalate induces oxidative stress and inhibits growth of mouse ovarian antral follicles
10.1095/biolreprod.112.102467 · 2012 · External reference
Leaching of phthalates from medical supplies and their implications for exposure
10.1021/acs.est.2c09182 · 2023 · External reference
Associations between phthalate metabolites and cytokines in the follicular fluid of women undergoing in vitro fertilization
10.1016/j.ecoenv.2023.115616 · 2023 · External reference
Endocrine disruption from plastic pollution and warming interact to increase the energetic cost of growth in a fish
2022 · External reference
Natural and technologic hazardous material releases during and after natural disasters: a review
10.1016/s0048-9697(03)00446-7 · 2004 · External reference
Mechanisms of follicular atresia: focus on apoptosis, autophagy, and ferroptosis
10.3389/fendo.2025.1603467 · 2025 · External reference
