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References from Astragaloside IV Attenuates Cardiac Aging Through Restoring Mitochondrial Dynamics Homeostasis by Promoting SIRT3 ‐Mediated DRP1 Deacetylation. Local targets link to admitted publications; unresolved targets remain external evidence.
Global, Regional, and National Burden of Stroke and Its Risk Factors, 1990–2019: A Systematic Analysis for the Global Burden of Disease Study 2019
10.1016/s1474-4422(21)00252-0 · 2021 · External reference
Potential Clinical Implications of Senotherapies for Cardiovascular Disease
10.1253/circj.cj-23-0657 · 2024 · External reference
Cardiac Cell Senescence: Molecular Mechanisms, Key Proteins and Therapeutic Targets
10.1038/s41420-023-01792-5 · 2024 · External reference
Cardiomyocyte Senescence and Cellular Communications Within Myocardial Microenvironments
10.3389/fendo.2020.00280 · 2020 · External reference
Cardiac Aging: From Basic Research to Therapeutics
10.1155/2021/9570325 · 2021 · External reference
Mitochondria at the Crossroads of Aging and Cardiovascular Disease
10.1016/j.lfs.2025.124127 · 2025 · External reference
Astaxanthin Prevented Acute Alcoholic Cardiomyopathy by Maintenance of Mitophagy‐Mediated Mitochondrial Homeostasis
10.1111/jcmm.70714 · 2025 · External reference
Exosomal miR‐9‐5p Derived From iPSC‐MSCs Ameliorates Doxorubicin‐Induced Cardiomyopathy by Inhibiting Cardiomyocyte Senescence
10.1186/s12951-024-02421-8 · 2024 · External reference
Effects of Aging and Exercise Training on Mitochondrial Function and Apoptosis in the Rat Heart
10.1007/s00424-020-02357-6 · 2020 · External reference
Increased Drp1 Acetylation by Lipid Overload Induces Cardiomyocyte Death and Heart Dysfunction
10.1161/circresaha.119.315252 · 2020 · External reference
SIRT3 Activation a Promise in Drug Development? New Insights Into SIRT3 Biology and Its Implications on the Drug Discovery Process
10.1021/acs.jmedchem.3c01979 · 2024 · External reference
Mitochondrial Sirtuin 3: New Emerging Biological Function and Therapeutic Target
10.7150/thno.45922 · 2020 · External reference
The Role of Mitochondrial Sirtuins in Health and Disease
10.1016/j.freeradbiomed.2016.04.197 · 2016 · External reference
Alterations in Mitochondrial Dynamics With Age‐Related Sirtuin1/Sirtuin3 Deficiency Impair Cardiomyocyte Contractility
10.1111/acel.13419 · 2021 · External reference
SIRT3 Deficiency Exacerbates p53/Parkin‐Mediated Mitophagy Inhibition and Promotes Mitochondrial Dysfunction: Implication for Aged Hearts
2018 · External reference
Sirt3 Attenuates Post‐Infarction Cardiac Injury via Inhibiting Mitochondrial Fission and Normalization of AMPK‐Drp1 Pathways
10.1016/j.cellsig.2018.09.009 · 2019 · External reference
Protective Effects of Astragaloside IV on Endoplasmic Reticulum Stress‐Induced Renal Tubular Epithelial Cells Apoptosis in Type 2 Diabetic Nephropathy Rats
10.1016/j.biopha.2018.10.041 · 2019 · External reference
Protective Effects of AS‐IV on Diabetic Cardiomyopathy by Improving Myocardial Lipid Metabolism in Rat Models of T2DM
10.1016/j.biopha.2020.110081 · 2020 · External reference
Astragalus mongholicus : A Review of Its Anti‐Fibrosis Properties
10.3389/fphar.2022.976561 · 2022 · External reference
Astragaloside IV Prevents Memory Impairment in D‐Galactose‐Induced Aging Rats via the AGEs/RAGE/ NF‐κB Axis
10.1016/j.arcmed.2021.05.005 · 2022 · External reference
Astragaloside IV Improves the Quality of in Vitro Postovulatory Aged Oocytes by Decreasing Oxidative Stress in Mice
10.1016/j.theriogenology.2025.117573 · 2025 · External reference
Astragaloside IV Inhibits Astrocyte Senescence: Implication in Parkinson's Disease
10.1186/s12974-020-01791-8 · 2020 · External reference
SIRT3‐Mediated Deacetylation of DRP1(K711) Prevents Mitochondrial Dysfunction in Parkinson's Disease
2025 · External reference
Coenzyme Q10 Prevents Oxidative Stress and Fibrosis in Isoprenaline Induced Cardiac Remodeling in Aged Rats
10.1186/s40360-017-0136-7 · 2017 · External reference
Trimetazidine and l‐Carnitine Prevent Heart Aging and Cardiac Metabolic Impairment in Rats via Regulating Cardiac Metabolic Substrates
10.1016/j.exger.2018.12.019 · 2019 · External reference
Elucidation of the Potential Molecular Mechanisms of Buyang Huanwu Decoction in Delaying Cardiac Aging: Based on Network Pharmacology, Bioinformatics, and in Vivo/in Vitro Experimental Validation
10.1016/j.jep.2025.120624 · 2025 · External reference
Hallmarks and Mechanisms of Cellular Senescence in Aging and Disease
10.1038/s41420-025-02655-x · 2025 · External reference
Cellular Senescence: From Mechanisms to Current Biomarkers and Senotherapies
10.1124/pharmrev.122.000622 · 2023 · External reference
Cellular Senescence: A Key Therapeutic Target in Aging and Diseases
10.1172/jci158450 · 2022 · External reference
Inhibition and Rescue of Hyperglycemia‐Induced Cellular Senescence by Mitochondrial Transfer From Enucleated Mesenchymal Stem Cell‐Derived Microvesicles for Chronic Wound Healing
2025 · External reference
Mitochondrial Homeostasis and Cellular Senescence
10.3390/cells8070686 · 2019 · External reference
GDF11 Alleviates Secondary Brain Injury After Intracerebral Hemorrhage via Attenuating Mitochondrial Dynamic Abnormality and Dysfunction
10.1038/s41598-021-83545-x · 2021 · External reference
The Aging Heart
10.1042/cs20171156 · 2018 · External reference
Cardiac Aging: Molecular Mechanisms and Therapeutic Interventions
10.1016/j.phrs.2025.107954 · 2025 · External reference
Astragaloside IV Attenuate MI‐Induced Myocardial Fibrosis and Cardiac Remodeling by Inhibiting ROS/Caspase‐1/GSDMD Signaling Pathway
10.1080/15384101.2022.2093598 · 2022 · External reference
Cardiomyocyte Senescence and the Potential Therapeutic Role of Senolytics in the Heart
10.20517/jca.2024.06 · 2024 · External reference
p53 in Senescence—It's a Marathon, Not a Sprint
10.1111/febs.16325 · 2023 · External reference
Mitochondrial Dysfunction Drives Cellular Senescence: Molecular Mechanisms of Inter‐Organelle Communication
10.1016/j.exger.2025.112913 · 2025 · External reference
TRIM28‐Mediated Excessive Oxidative Stress Induces Cellular Senescence in Granulosa Cells and Contributes to Premature Ovarian Insufficiency In Vitro and In Vivo
10.3390/antiox13030308 · 2024 · External reference
Mitochondrial Quality Control Mechanisms as Molecular Targets in Cardiac Ageing
10.1038/s41569-018-0059-z · 2018 · External reference
Senescence Mechanisms and Targets in the Heart
10.1093/cvr/cvab161 · 2022 · External reference
Regulatory Mechanisms of Mitochondrial Function and Cardiac Aging
10.3390/ijms21041359 · 2020 · External reference
A Senescent Cell Bystander Effect: Senescence‐Induced Senescence
10.1111/j.1474-9726.2012.00795.x · 2012 · External reference
Mitochondrial Dynamics and Its Involvement in Disease
10.1146/annurev-pathmechdis-012419-032711 · 2020 · External reference
Aging Shifts Mitochondrial Dynamics Toward Fission to Promote Germline Stem Cell Loss
10.1111/acel.13191 · 2020 · External reference
Future Perspectives on the Roles of Mitochondrial Dynamics in the Heart in Obesity and Aging
10.1016/j.lfs.2024.122575 · 2024 · External reference
Heart of the Matter: Mitochondrial Dynamics and Genome Alterations in Cardiac Aging
10.1016/j.mad.2025.112044 · 2025 · External reference
Constitutive Activation of ERK1/2 Signaling Protects Against Myocardial Ischemia via Inhibition of Mitochondrial Fragmentation in the Aging Heart
10.21037/atm-21-503 · 2021 · External reference
Gui‐Pi‐Tang Defers Skeletal Muscle and Cardiac Muscle Aging by Promoting Mitochondrial Remodeling
10.2147/dddt.s509046 · 2025 · External reference
Spermine Alleviates Myocardial Cell Aging by Inhibiting Mitochondrial Oxidative Stress Damage
10.1016/j.ejphar.2025.177477 · 2025 · External reference
Astragaloside IV Ameliorates Diabetic Nephropathy by Modulating the Mitochondrial Quality Control Network
10.1371/journal.pone.0182558 · 2017 · External reference
Peroxisome Proliferator‐Activated Receptor‐γ Coactivator‐1α Inhibits Vascular Calcification Through Sirtuin 3‐Mediated Reduction of Mitochondrial Oxidative Stress
10.1089/ars.2018.7620 · 2019 · External reference
Camkii Induces Permeability Transition Through Drp1 Phosphorylation During Chronic β‐AR Stimulation
10.1038/ncomms13189 · 2016 · External reference
Early ERK1/2 Activation Promotes DRP1‐Dependent Mitochondrial Fission Necessary for Cell Reprogramming
10.1038/ncomms11124 · 2016 · External reference
AMP‐Activated Protein Kinase Mediates Mitochondrial Fission in Response to Energy Stress
10.1126/science.aab4138 · 2016 · External reference
Targeting Lactylation Reinforces NK Cell Cytotoxicity Within the Tumor Microenvironment
10.1038/s41590-025-02178-8 · 2025 · External reference
Drp1‐Dependent Mitochondrial Fission in Cardiovascular Disease
10.1038/s41401-020-00518-y · 2021 · External reference
Posttranslational Modifications of Mitochondrial Fission and Fusion Proteins in Cardiac Physiology and Pathophysiology
10.1152/ajpcell.00523.2018 · 2019 · External reference
Benzo(a)pyrene Induces Cardiac Hypertrophy via the Aryl Hydrocarbon Receptor‐Mediated DNA Damage
10.1016/j.scitotenv.2025.181061 · 2025 · External reference