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References from SAP ‐Derived Exosomes Promote Intestinal Barrier Injury Through FKBP5‐Mediated Suppression of RIPK 3/ MLKL Signaling. Local targets link to admitted publications; unresolved targets remain external evidence.
Diagnosis and Management of Acute Pancreatitis
10.1053/j.gastro.2024.02.052 · 2024 · External reference
Acute Pancreatitis Is Characterized by Generalized Intestinal Barrier Dysfunction in Early Stage
10.1016/j.pan.2022.11.011 · 2023 · External reference
Gut Microbiota Predicts Severity and Reveals Novel Metabolic Signatures in Acute Pancreatitis
10.1136/gutjnl-2023-330987 · 2024 · External reference
The Biology, Function, and Biomedical Applications of Exosomes
10.1126/science.aau6977 · 2020 · External reference
Activated T Cells Recruit Exosomes Secreted by Dendritic Cells via LFA‐1
10.1182/blood-2008-08-174094 · 2009 · External reference
HucMSC‐Exosome Mediated‐Wnt4 Signaling Is Required for Cutaneous Wound Healing
10.1002/stem.1771 · 2015 · External reference
Exosome Reporter Mice Reveal the Involvement of Exosomes in Mediating Neuron to Astroglia Communication in the CNS
10.1038/s41467-019-11534-w · 2019 · External reference
Cardiac Fibroblast‐Derived microRNA Passenger Strand‐Enriched Exosomes Mediate Cardiomyocyte Hypertrophy
10.1172/jci70577 · 2014 · External reference
Exosomes in the Pathology of Neurodegenerative Diseases
10.1074/jbc.r116.757955 · 2016 · External reference
Exosomes and Their Role in Cancer Progression
10.33160/yam.2019.06.002 · 2019 · External reference
Exosome‐Inflammasome Crosstalk and Their Roles in Inflammatory Responses
10.7150/thno.54004 · 2021 · External reference
Inflammatory Capacity of Exosomes Released in the Early Stages of Acute Pancreatitis Predicts the Severity of the Disease
10.1002/path.5811 · 2022 · External reference
Emodin Ameliorates Severe Acute Pancreatitis‐Associated Acute Lung Injury in Rats by Modulating Exosome‐Specific miRNA Expression Profiles
10.2147/ijn.s428924 · 2023 · External reference
Exosomes Are Involved in Total Body Irradiation‐Induced Intestinal Injury in Mice
10.1038/s41401-021-00615-6 · 2021 · External reference
Cell Death in the Gut Epithelium and Implications for Chronic Inflammation
10.1038/s41575-020-0326-4 · 2020 · External reference
Cell Death
10.1016/j.cell.2023.11.044 · 2024 · External reference
The Mechanism of Lung and Intestinal Injury in Acute Pancreatitis: A Review
10.3389/fmed.2022.904078 · 2022 · External reference
Octreotide Attenuates Experimental Severe Acute Pancreatitis Through Inhibiting Pyroptosis and Modulating Intestinal Homeostasis
10.1016/j.ejphar.2025.177314 · 2025 · External reference
Necroptosis in Immunity, Tissue Homeostasis, and Cancer
10.1016/j.coi.2024.102455 · 2024 · External reference
Protein Shapeshifting in Necroptotic Cell Death Signaling
10.1016/j.tibs.2024.11.006 · 2025 · External reference
MLKL: Functions Beyond Serving as the Executioner of Necroptosis
10.7150/thno.54072 · 2021 · External reference
Necroptosis Mediators RIPK3 and MLKL Suppress Intracellular Listeria Replication Independently of Host Cell Killing
10.1083/jcb.201810014 · 2019 · External reference
Mixed Lineage Kinase Domain‐Like Protein MLKL Breaks Down Myelin Following Nerve Injury
10.1016/j.molcel.2018.09.011 · 2018 · External reference
An Immunohistochemical Atlas of Necroptotic Pathway Expression
10.1038/s44321-024-00074-6 · 2024 · External reference
A Better Model of Acute Pancreatitis for Evaluating Therapy
10.1097/00000658-199201000-00007 · 1992 · External reference
Intestinal Mucosal Lesion in Low‐Flow States. I. A Morphological, Hemodynamic, and Metabolic Reappraisal
10.1001/archsurg.1970.01340280030009 · 1970 · External reference
FKBP12 Mediates Necroptosis by Initiating RIPK1‐RIPK3‐MLKL Signal Transduction in Response to TNF Receptor 1 Ligation
10.1242/jcs.227777 · 2019 · External reference
Exosome‐Based Therapies for Inflammatory Disorders: A Review of Recent Advances
10.1186/s13287-024-04107-2 · 2024 · External reference
Exosome‐Mediated Effects and Applications in Inflammatory Bowel Disease
10.1111/brv.12608 · 2020 · External reference
Suxiao Jiuxin Pill Promotes Exosome Secretion From Mouse Cardiac Mesenchymal Stem Cells In Vitro
10.1038/aps.2018.19 · 2018 · External reference
Exosomes From Activated Hepatic Stellate Cells Contain GLUT1 and PKM2: A Role for Exosomes in Metabolic Switch of Liver Nonparenchymal Cells
10.1096/fj.201802675r · 2019 · External reference
Intestinal Barrier Dysfunction, LPS Translocation, and Disease Development
10.1210/jendso/bvz039 · 2020 · External reference
Lipopolysaccharide Directly Affects Pancreatic Acinar Cells: Implications on Acute Pancreatitis Pathophysiology
10.1023/a:1005521007609 · 2000 · External reference
Gene‐Stress‐Epigenetic Regulation of FKBP5: Clinical and Translational Implications
10.1038/npp.2015.235 · 2016 · External reference
FK506 Binding Proteins and Inflammation Related Signalling Pathways; Basic Biology, Current Status and Future Prospects for Pharmacological Intervention
10.1016/j.pharmthera.2020.107623 · 2020 · External reference
Roles of RIPK3 in Necroptosis, Cell Signaling, and Disease
10.1038/s12276-022-00868-z · 2022 · External reference
The Necroptosis Adaptor RIPK3 Promotes Injury‐Induced Cytokine Expression and Tissue Repair
10.1016/j.immuni.2014.09.016 · 2014 · External reference
Understanding Necroptosis in Pancreatic Diseases
10.3390/biom12060828 · 2022 · External reference
Cre/loxP System for Generating Tissue‐Specific Knockout Mouse Models
2004 · External reference
Pancreas‐Specific CHRM3 Activation Causes Pancreatitis in Mice
10.1172/jci.insight.132585 · 2021 · External reference
Mesalazine and Thymoquinone Attenuate Intestinal Tumour Development in Msh2(loxP/loxP) Villin‐Cre Mice
10.1136/gutjnl-2014-307663 · 2015 · External reference
MiR155 Disrupts the Intestinal Barrier by Inducing Intestinal Inflammation and Altering the Intestinal Microecology in Severe Acute Pancreatitis
10.1007/s10620-021-07022-1 · 2022 · External reference
Emerging Role of lncRNAs in the Normal and Diseased Intestinal Barrier
10.1007/s00011-018-1170-7 · 2018 · External reference
Exosome and Exosomal microRNA: Trafficking, Sorting, and Function
10.1016/j.gpb.2015.02.001 · 2015 · External reference