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References from Methylmalonic Acid Induces Oxaliplatin Resistance Through Promoting DNA Damage Repair via the ATM/ATR Pathway in Gastric Cancer. Local targets link to admitted publications; unresolved targets remain external evidence.
Global Cancer Statistics 2022: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries
2024 · External reference
Periodic Oxaliplatin Administration in Synergy With PER2‐Mediated PCNA Transcription Repression Promotes Chronochemotherapeutic Efficacy of OSCC
10.1002/advs.201900667 · 2019 · External reference
Deciphering Drug Resistance in Gastric Cancer: Potential Mechanisms and Future Perspectives
10.1016/j.biopha.2024.116310 · 2024 · External reference
METTL3 Promotes Drug Resistance to Oxaliplatin in Gastric Cancer Cells Through DNA Repair Pathway
10.3389/fphar.2023.1257410 · 2023 · External reference
A Metabolomic Approach to Identifying Platinum Resistance in Ovarian Cancer
10.1186/s13048-015-0140-8 · 2015 · External reference
‘Metabolic Reprogramming’ in Ovarian Cancer Cells Resistant to Cisplatin
10.2174/156800911794328501 · 2011 · External reference
Bioenergetic Adaptations in Chemoresistant Ovarian Cancer Cells
10.1038/s41598-017-09206-0 · 2017 · External reference
MACC1 Decreases the Chemosensitivity of Gastric Cancer Cells to Oxaliplatin by Regulating FASN Expression
10.3892/or.2017.5519 · 2017 · External reference
Lysophosphatidylcholine Acyltransferase 2‐Mediated Lipid Droplet Production Supports Colorectal Cancer Chemoresistance
10.1038/s41467-017-02732-5 · 2018 · External reference
Methylmalonic Acidemia. A Disorder Associated With Acidosis, Hyperglycinemia, and Hyperlactatemia
10.1111/j.1651-2227.1968.tb07314.x · 1968 · External reference
Recognition, Isolation, and Characterization of Rat Liver D‐Methylmalonyl Coenzyme A Hydrolase
10.1016/s0021-9258(17)44433-4 · 1983 · External reference
The Complex Machinery of Human Cobalamin Metabolism
10.1002/jimd.12593 · 2023 · External reference
Age‐Induced Accumulation of Methylmalonic Acid Promotes Tumour Progression
10.1038/s41586-020-2630-0 · 2020 · External reference
Population Reference Values for Serum Methylmalonic Acid Concentrations and Its Relationship With Age, Sex, Race‐Ethnicity, Supplement Use, Kidney Function and Serum Vitamin B12 in the Post‐Folic Acid Fortification Period
10.3390/nu10010074 · 2018 · External reference
Elevated Serum Methylmalonic Acid Concentrations Are Common Among Elderly Americans
10.1093/jn/132.9.2799 · 2002 · External reference
Methylmalonic Acid in Aging and Disease
10.1016/j.tem.2023.11.001 · 2024 · External reference
Serum Methylmalonic Acid Concentrations at Breast Cancer Diagnosis Significantly Correlate With Clinical Frailty
10.1007/s11357-023-00908-0 · 2024 · External reference
Methylmalonic Acid Induces Metabolic Abnormalities and Exhaustion in CD8(+) T Cells to Suppress Anti‐Tumor Immunity
10.1038/s41388-024-03191-1 · 2025 · External reference
Tumor‐Produced and Aging‐Associated Oncometabolite Methylmalonic Acid Promotes Cancer‐Associated Fibroblast Activation to Drive Metastatic Progression
10.1038/s41467-022-33862-0 · 2022 · External reference
Sophoridine Inhibits Proliferation and Migration by Targeting PIM1 in Breast Cancer
10.1080/13880209.2025.2537123 · 2025 · External reference
The Emerging Role of Dysregulated Propionate Metabolism and Methylmalonic Acid in Metabolic Disease, Aging, and Cancer
10.1016/j.cmet.2025.01.005 · 2025 · External reference
GammaH2AX and Cancer
10.1038/nrc2523 · 2008 · External reference
ATAD5 Promotes Replication Restart by Regulating RAD51 and PCNA in Response to Replication Stress
10.1038/s41467-019-13667-4 · 2019 · External reference
Methylmalonic Acidemia Controlled With Oral Administration of Vitamin B12
1976 · External reference
Plasma L‐Aspartic Acid Predicts the Risk of Gastric Cancer and Modifies the Primary Prevention Effect: A Multistage Metabolomic Profiling and Mendelian Randomization Study
2025 · External reference
Gut Microbial Metabolite 4‐Hydroxybenzeneacetic Acid Drives Colorectal Cancer Progression via Accumulation of Immunosuppressive PMN‐MDSCs
10.1172/jci199353 · 2025 · External reference
NBS1 Lactylation Is Required for Efficient DNA Repair and Chemotherapy Resistance
10.1038/s41586-024-07620-9 · 2024 · External reference
Glutamine Metabolism Controls Amphiregulin‐Facilitated Chemoresistance to Cisplatin in Human Chondrosarcoma
10.7150/ijbs.86116 · 2023 · External reference
N(6)‐Methyladenosine‐Mediated LDHA Induction Potentiates Chemoresistance of Colorectal Cancer Cells Through Metabolic Reprogramming
10.7150/thno.73746 · 2022 · External reference
Serum Vitamin Levels and Their Relationships With Other Biomarkers in Korean Breast Cancer Patients
10.3390/nu12092831 · 2020 · External reference
Altered Propionate Metabolism Contributes to Tumour Progression and Aggressiveness
10.1038/s42255-022-00553-5 · 2022 · External reference
Methylmalonic Acid at the Serum Level in the Elderly Contributes to Cell Growth via Mitochondrial Dysfunction in Colorectal Cancer Cell Spheroids
10.1016/j.bbrep.2024.101909 · 2025 · External reference
Methylmalonic Acid Promotes Colorectal Cancer Progression via Activation of Wnt/β‐Catenin Pathway Mediated Epithelial‐Mesenchymal Transition
10.1186/s12935-023-02973-z · 2023 · External reference
Concordant and Opposite Roles of DNA‐PK and the ‘Facilitator of Chromatin Transcription’ (FACT) in DNA Repair, Apoptosis and Necrosis After Cisplatin
10.1186/1476-4598-10-74 · 2011 · External reference
The Ubiquitin E3/E4 Ligase UBE4A Adjusts Protein Ubiquitylation and Accumulation at Sites of DNA Damage, Facilitating Double‐Strand Break Repair
10.1016/j.molcel.2018.02.002 · 2018 · External reference
DNA Strand Breaks and Apoptosis Induced by Oxaliplatin in Cancer Cells
10.1016/s0006-2952(03)00260-0 · 2003 · External reference
L3MBTL2 Regulates Chromatin Remodeling During Spermatogenesis
10.1038/s41418-019-0283-z · 2019 · External reference
HJURP Promotes Malignant Progression and Mediates Sensitivity to Cisplatin and WEE1‐Inhibitor in Serous Ovarian Cancer
10.7150/ijbs.65589 · 2022 · External reference
Kinome Screen of Ferroptosis Reveals a Novel Role of ATM in Regulating Iron Metabolism
10.1038/s41418-019-0393-7 · 2020 · External reference
Participation of the ATR/CHK1 Pathway in Replicative Stress Targeted Therapy of High‐Grade Ovarian Cancer
10.1186/s13045-020-00874-6 · 2020 · External reference
Extracellular Signal‐Regulated Kinases Modulate DNA Damage Response—A Contributing Factor to Using MEK Inhibitors in Cancer Therapy
10.2174/092986711798194388 · 2011 · External reference
ARID1A Deficiency Impairs the DNA Damage Checkpoint and Sensitizes Cells to PARP Inhibitors
10.1158/2159-8290.cd-14-0849 · 2015 · External reference
The Cell Cycle Checkpoint Inhibitors in the Treatment of Leukemias
10.1186/s13045-017-0443-x · 2017 · External reference
ATAD5 Deficiency Alters DNA Damage Metabolism and Sensitizes Cells to PARP Inhibition
10.1093/nar/gkaa255 · 2020 · External reference
ATAD5‐BAZ1B Interaction Modulates PCNA Ubiquitination During DNA Repair
10.1038/s41467-024-55005-3 · 2024 · External reference
Serum Vitamin B12 and Folate Status Among Patients With Chemotherapy Treatment for Advanced Colorectal Cancer
10.1080/03009730903027172 · 2009 · External reference
Prevalence and Aetiology of Anaemia in Lymphoid Malignancies
2013 · External reference
Antitumor Activity of Sitagliptin and Vitamin B12 on Ehrlich Ascites Carcinoma Solid Tumor in Mice
10.1002/jbt.22645 · 2021 · External reference