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References from The Genetic and Epigenetic Mechanisms of <scp>mtDNA</scp> in Regulation of Inflammation and Metabolism. Local targets link to admitted publications; unresolved targets remain external evidence.
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Tetracyclines Cause Cell Stress‐Dependent ATF4 Activation and mTOR Inhibition
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Mitochondrial Retrograde Signaling at the Crossroads of Tumor Bioenergetics, Genetics and Epigenetics
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Global DNA Methylation Levels Are Modulated by Mitochondrial DNA Variants
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Short Single‐Stranded DNA Degradation Products Augment the Activation of Toll‐Like Receptor 9
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Toll‐Like Receptor 9 Contains Two DNA Binding Sites That Function Cooperatively to Promote Receptor Dimerization and Activation
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Mitochondrial DNA in Inflammation and Immunity
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Selective Packaging of Mitochondrial Proteins Into Extracellular Vesicles Prevents the Release of Mitochondrial DAMPs
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Packaging and Transfer of Mitochondrial DNA via Exosomes Regulate Escape From Dormancy in Hormonal Therapy‐Resistant Breast Cancer
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Circulating Mitochondrial DAMPs Cause Inflammatory Responses to Injury
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Mitochondrial DNA Is Released by Shock and Activates Neutrophils via P38 Map Kinase
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Mitochondrial Transcription Factor A Serves as a Danger Signal by Augmenting Plasmacytoid Dendritic Cell Responses to DNA
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Mitochondrial DNA and TLR9 Drive Muscle Inflammation Upon Opa1 Deficiency
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PINK1 Attenuates mtDNA Release in Alveolar Epithelial Cells and TLR9 Mediated Profibrotic Responses
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Mitochondrial DNA That Escapes From Autophagy Causes Inflammation and Heart Failure
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Significance of Serum mtDNA Concentration in Lung Injury Induced by Hip Fracture
10.1097/shk.0000000000000366 · 2015 · External reference
New Mitochondrial DNA Synthesis Enables NLRP3 Inflammasome Activation
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DAMP‐Sensing Receptors in Sterile Inflammation and Inflammatory Diseases
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Autophagy Proteins Regulate Innate Immune Responses by Inhibiting the Release of Mitochondrial DNA Mediated by the NALP3 Inflammasome
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Oxidized Mitochondrial DNA Released After Inflammasome Activation Is a Disease Biomarker for Myelodysplastic Syndromes
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Metformin Inhibition of Mitochondrial ATP and DNA Synthesis Abrogates NLRP3 Inflammasome Activation and Pulmonary Inflammation
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Mechanisms of Mitochondrial DNA Escape and Its Relationship With Different Metabolic Diseases
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VDAC Oligomers Form Mitochondrial Pores to Release mtDNA Fragments and Promote Lupus‐Like Disease
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Oxidized DNA Fragments Exit Mitochondria via mPTP‐ and VDAC‐Dependent Channels to Activate NLRP3 Inflammasome and Interferon Signaling
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Cytosolic Nucleic Acid Sensors in Inflammatory and Autoimmune Disorders
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ATM Inhibition Enhances Cancer Immunotherapy by Promoting mtDNA Leakage and cGAS/STING Activation
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Mitochondrial DNA Replication Stress Triggers a Pro‐Inflammatory Endosomal Pathway of Nucleoid Disposal
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Mitochondrial DNA Release via the Mitochondrial Permeability Transition Pore Activates the cGAS‐STING Pathway, Exacerbating Inflammation in Acute Kawasaki Disease
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Activation of the cGAS‐STING Innate Immune Response in Cells With Deficient Mitochondrial Topoisomerase TOP1MT
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Cellular Pyrimidine Imbalance Triggers Mitochondrial DNA–Dependent Innate Immunity
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Loss of Mitochondrial Protease CLPP Activates Type I IFN Responses Through the Mitochondrial DNA–cGAS–STING Signaling Axis
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MRE11‐Dependent Instability in Mitochondrial DNA Fork Protection Activates a cGAS Immune Signaling Pathway
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Enhanced cGAS‐STING–Dependent Interferon Signaling Associated With Mutations in ATAD3A
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ATAD3 Controls Mitochondrial Cristae Structure in Mouse Muscle, Influencing mtDNA Replication and Cholesterol Levels
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Human Mitochondrial DNA‐Protein Complexes Attach to a Cholesterol‐Rich Membrane Structure
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Apoptotic Caspases Prevent the Induction of Type I Interferons by Mitochondrial DNA
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Apoptotic Caspases Suppress mtDNA‐Induced STING‐Mediated Type I IFN Production
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Mitochondrial Integrity Regulated by Lipid Metabolism Is a Cell‐Intrinsic Checkpoint for Treg Suppressive Function
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Phospholipase D3 Degrades Mitochondrial DNA to Regulate Nucleotide Signaling and APP Metabolism
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TGR5 Supresses cGAS/STING Pathway by Inhibiting GRP75‐Mediated Endoplasmic Reticulum‐Mitochondrial Coupling in Diabetic Retinopathy
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Eribulin Activates the cGAS‐STING Pathway via the Cytoplasmic Accumulation of Mitochondrial DNA
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Nuclear cGAS: Sequestration and Beyond
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N(6)‐Deoxyadenosine Methylation in Mammalian Mitochondrial DNA
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Targeting N(6)‐Methyladenine of Tubular Mitochondrial DNA Against Hypertensive CKD
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N6‐Deoxyadenosine Methylation in Mammalian Mitochondrial DNA
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Mitochondrial Non‐Coding RNAs Are Potential Mediators of Mitochondrial Homeostasis
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Mitochondria‐Associated microRNAs in Rat Hippocampus Following Traumatic Brain Injury
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A Novel Chimeric Mitochondrial RNA Localized in the Nucleus of Mouse Sperm
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Unique Features of Long Non‐Coding RNA Biogenesis and Function
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On the Origin of Cancer Cells
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Forced Cytochrome B Gene Mutation Expression Induces Mitochondrial Proliferation and Prevents Apoptosis in Human Uroepithelial SV‐HUC‐1 Cells
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Positive Contribution of Pathogenic Mutations in the Mitochondrial Genome to the Promotion of Cancer by Prevention From Apoptosis
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Mitochondrial DNA Mutations Drive Aerobic Glycolysis to Enhance Checkpoint Blockade Response in Melanoma
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Origins and Functional Consequences of Somatic Mitochondrial DNA Mutations in Human Cancer
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Heteroplasmic Shifts in Tumor Mitochondrial Genomes Reveal Tissue‐Specific Signals of Relaxed and Positive Selection
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Mitochondrial Mutations Drive Prostate Cancer Aggression
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Mitochondrial Genome Variation and Prostate Cancer: A Review of the Mutational Landscape and Application to Clinical Management
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Mutational Load of the Mitochondrial Genome Predicts Pathological Features and Biochemical Recurrence in Prostate Cancer
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Mitochondrial OXPHOS Biogenesis: Co‐Regulation of Protein Synthesis, Import, and Assembly Pathways
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OxPhos Defects Cause Hypermetabolism and Reduce Lifespan in Cells and in Patients With Mitochondrial Diseases
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Biological and Translational Attributes of Mitochondrial DNA Copy Number: Laboratory Perspective to Clinical Relevance
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The TFAM‐To‐mtDNA Ratio Defines Inner‐Cellular Nucleoid Populations With Distinct Activity Levels
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Plausible Role of Mitochondrial DNA Copy Number in Neurodegeneration‐a Need for Therapeutic Approach in Parkinson's Disease (PD)
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Multi‐Tissue Metabolomics Reveal mtDNA‐ and Diet‐Specific Metabolite Profiles in a Mouse Model of Cardiometabolic Disease
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Mitochondrial Mutations in Cancer
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Mitochondrial DNA Quantity Increases With Histopathologic Grade in Premalignant and Malignant Head and Neck Lesions
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The Role of Mitochondrial DNA Alterations in Esophageal Squamous Cell Carcinomas
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Mitoepigenetics and Gliomas: Epigenetic Alterations to Mitochondrial DNA and Nuclear DNA Alter mtDNA Expression and Contribute to Glioma Pathogenicity
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Let‐7a Induces Metabolic Reprogramming in Breast Cancer Cells via Targeting Mitochondrial Encoded ND4
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Nuclear‐Encoded lncRNA MALAT1 Epigenetically Controls Metabolic Reprogramming in HCC Cells Through the Mitophagy Pathway
10.1016/j.omtn.2020.09.040 · 2021 · External reference
Modulation of Mitochondrial DNA Copy Number in a Model of Glioblastoma Induces Changes to DNA Methylation and Gene Expression of the Nuclear Genome in Tumours
10.1186/s13072-018-0223-z · 2018 · External reference
Global DNA Methylation Synergistically Regulates the Nuclear and Mitochondrial Genomes in Glioblastoma Cells
10.1093/nar/gky339 · 2018 · External reference
DNA sensor cGAS‐mediated immune recognition
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New Insights on Anti‐Tumor Immunity of CD8(+) T Cells: Cancer Stem Cells, Tumor Immune Microenvironment and Immunotherapy
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STING Signaling Promotes NK Cell Antitumor Immunity and Maintains a Reservoir of TCF‐1(+) NK Cells
10.1016/j.celrep.2023.113108 · 2023 · External reference
Specific Activation of cGAS‐STING Pathway by Nanotherapeutics‐Mediated Ferroptosis Evoked Endogenous Signaling for Boosting Systemic Tumor Immunotherapy
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Growing Tumors Induce a Local STING Dependent Type I IFN Response in Dendritic Cells
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SENP3 Senses Oxidative Stress to Facilitate STING‐Dependent Dendritic Cell Antitumor Function
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Discordance in STING‐Induced Activation and Cell Death Between Mouse and Human Dendritic Cell Populations
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Metabolic Regulation of cGAS‐STING Signaling in the Tumor Microenvironment: Dual Immune Roles and Therapeutic Implications
10.1016/j.cytogfr.2025.06.002 · 2025 · External reference
An Immunometabolic Route for Activating cGAS/STING to Drive Anticancer Immunity
10.1158/0008-5472.can-24-1624 · 2024 · External reference
Mitochondrial DNA Released by Senescent Tumor Cells Enhances PMN‐MDSC‐Driven Immunosuppression Through the cGAS‐STING Pathway
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The cGAS‐STING Pathway: A Dual Regulator of Immune Response in Cancer and Therapeutic Implications
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OMA1 Competitively Binds to HSPA9 to Promote Mitophagy and Activate the cGAS‐STING Pathway to Mediate GBM Immune Escape
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mtDNA Mutations Increase Tumorigenicity in Prostate Cancer
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Defining the Hallmarks of Metastasis
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Hypoxia Induced HMGB1 and Mitochondrial DNA Interactions Mediate Tumor Growth in Hepatocellular Carcinoma Through Toll‐Like Receptor 9
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Mitochondrial DNA Mutation Stimulates Prostate Cancer Growth in Bone Stromal Environment
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The Roles of the mtDNA‐cGAS‐STING Axis in Tumor Immunity: From Immune Activation to Immune Evasion
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Neutrophil Extracellular Traps in Hepatocellular Carcinoma Are Enriched in Oxidized Mitochondrial DNA Which Is Highly Pro‐Inflammatory and Pro‐Metastatic
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BRCA1 Deficiency Impairs Mitophagy and Promotes Inflammasome Activation and Mammary Tumor Metastasis
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New Hallmarks of Ageing: A 2022 Copenhagen Ageing Meeting Summary
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An mtDNA Mutation Accelerates Liver Aging by Interfering With the ROS Response and Mitochondrial Life Cycle
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Two‐Stage Association Study and Meta‐Analysis of Mitochondrial DNA Variants in Parkinson Disease
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Germline Mitochondrial DNA Mutations Aggravate Ageing and Can Impair Brain Development
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Mitochondrial DNA Copy Number in Peripheral Blood Cells Declines With Age and Is Associated With General Health Among Elderly
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Mitochondrial DNA Deletions in Human Brain: Regional Variability and Increase With Advanced Age
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Alzheimer's Brains Harbor Somatic mtDNA Control‐Region Mutations That Suppress Mitochondrial Transcription and Replication
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Blood‐Derived Mitochondrial DNA Copy Number Is Associated With Alzheimer Disease, Alzheimer‐Related Biomarkers and Serum Metabolites
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Lower Mitochondrial DNA Content but Not Increased Mutagenesis Associates With Decreased Base Excision Repair Activity in Brains of AD Subjects
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Investigating the Genetic Association of Mitochondrial DNA Copy Number With Neurodegenerative Diseases
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