Research graph
References from Hepatic Sialylation Defects Increase Susceptibility to Obesity and Steatosis in Mice. Local targets link to admitted publications; unresolved targets remain external evidence.
Associations Between Energy Balance‐Related Behaviours and Childhood Obesity Among Vulnerable Populations in Greece: Implications for Public Health Policy and Intervention Development
10.3390/nu17213486 · 2025 · External reference
Obesity Is a Disease: A Consensus Report by the Alliance to Fight Obesity in Greece
10.53590/japt.02.1049 · 2023 · External reference
Early Roots of Childhood Obesity: Risk Factors, Mechanisms, and Prevention Strategies
10.3390/ijms26157388 · 2025 · External reference
Obesity, Diabetes, and Inflammation: Pathophysiology and Clinical Implications
10.1016/j.immuni.2025.09.011 · 2025 · External reference
Cross‐Tissue Omics Analysis Discovers Ten Adipose Genes Encoding Secreted Proteins in Obesity‐Related Non‐Alcoholic Fatty Liver Disease
10.1016/j.ebiom.2023.104620 · 2023 · External reference
Sialic Acid Metabolism and Sialyltransferases: Natural Functions and Applications
10.1007/s00253-012-4040-1 · 2012 · External reference
Dietary Sialic Acids: Distribution, Structure, and Functions
10.1080/10408398.2023.2202254 · 2024 · External reference
Aptamer‐CRISPR/Cas12a‐Based Lateral Flow Technique for Visualized Rapid Detection of Endogenous Damage Factor Neu5Gc in Red Meat
10.3390/foods14162879 · 2025 · External reference
A Cellular Coupling Strategy Leveraging Pathway Modularization and Cofactor Regeneration for the Biosynthesis of 3′‐Sialyllactose
10.1021/acs.jafc.5c04764 · 2025 · External reference
Sialic Acid Metabolism as a Potential Therapeutic Target of Atherosclerosis
10.1186/s12944-019-1113-5 · 2019 · External reference
Sialylation Is Dispensable for Early Murine Embryonic Development in Vitro
10.1002/cbic.201700083 · 2017 · External reference
Identification, Expression and Tissue Distribution of Cytidine 5′‐Monophosphate N‐Acetylneuraminic Acid Synthetase Activity in the Rat
10.1023/a:1006940927639 · 1998 · External reference
Unresolved reference
2023 · External reference
Sialylation Inhibition Impairs Migration and Promotes Adhesion of GBM Cells
10.3390/ijms262110708 · 2025 · External reference
Inhibition of Hypersialylation in Human Intervertebral Disc Degeneration Modulates Inflammation and Metabolism
2025 · External reference
Hepatic Sialic Acid Synthesis Modulates Glucose Homeostasis in Both Liver and Skeletal Muscle
10.1016/j.molmet.2023.101812 · 2023 · External reference
Structural Diversity, Composition Variation and Neurodevelopmental‐Promoting Effects of Human Milk Oligosaccharides: A Systematic Review
10.1016/j.carbpol.2025.124229 · 2025 · External reference
Human Milk Composition Is Associated With Maternal Overweight/Obesity and Low Milk Supply, With Implications for Infant Weight Outcomes: A Cross‐Sectional Study
10.1016/j.ajcnut.2025.10.015 · 2025 · External reference
Comprehensive Characterization of Atypical Serum Albumin N‐Glycosylation Reveals Hepatocellular Carcinoma Diagnostic Biomarkers
10.1021/acs.analchem.5c04997 · 2025 · External reference
Hexosamine Biosynthesis Dysfunction‐Induced LIFR N‐Glycosylation Deficiency Exacerbates Steatotic Liver Ischemia/Reperfusion Injury
10.1016/j.metabol.2025.156258 · 2025 · External reference
Modulation of Hepatocyte Sialylation Drives Spontaneous Fatty Liver Disease and Inflammation
10.1093/glycob/cwz096 · 2020 · External reference
ST6GAL1 Inhibits Metastasis of Hepatocellular Carcinoma via Modulating Sialylation of MCAM on Cell Surface
10.1038/s41388-022-02571-9 · 2023 · External reference
Cardiac Disruption of SDHAF4‐Mediated Mitochondrial Complex II Assembly Promotes Dilated Cardiomyopathy
10.1038/s41467-022-31548-1 · 2022 · External reference
The Human Milk Oligosaccharide 3'sialyllactose Reduces Low‐Grade Inflammation and Atherosclerosis Development in Mice
10.1172/jci.insight.181329 · 2024 · External reference
Cre‐Mediated Gene Deletion in the Mammary Gland
10.1093/nar/25.21.4323 · 1997 · External reference
Synthesis of N‐Glycolylneuraminic Acid (Neu5Gc) and Its Glycosides
10.3389/fimmu.2019.02004 · 2019 · External reference
Large‐Scale Glycoproteome Analysis Reveals Inverted Distribution of Neu5Gc and Neu5Ac in Mouse Liver Tissues and Cell Lines
10.1016/j.carbpol.2025.123910 · 2025 · External reference
Identification of Fibrosis‐Associated Biomarkers in Heart Failure and Human Cancers
10.1186/s12967-024-05759-7 · 2024 · External reference
CMP‐Neu5Ac Hydroxylase Null Mice as a Model for Studying Metabolic Disorders Caused by the Evolutionary Loss of Neu5Gc in Humans
2015 · External reference
Mammalian cytidine 5’‐monophosphate N‐acetylneuraminic acid synthetase: a nuclear protein with evolutionarily conserved structural motifs
10.1073/pnas.95.16.9140 · 1998 · External reference
Cytidine Monophosphate N‐Acetylneuraminic Acid Synthetase Enhances Invasion of Human Triple‐Negative Breast Cancer Cells
10.2147/ott.s177639 · 2018 · External reference
CMP‐N‐Acetylneuraminic Acid Synthetase Interacts With Fragile X Related Protein 1
10.3892/mmr.2016.5438 · 2016 · External reference
Disruption of Sialic Acid Metabolism Drives Tumor Growth by Augmenting CD8(+) T Cell Apoptosis
10.1002/ijc.32084 · 2019 · External reference
Developmental Origins of Health and Disease: Current Knowledge and Potential Mechanisms
10.1093/nutrit/nux053 · 2017 · External reference
Recent Progress on Health Effects and Biosynthesis of Two Key Sialylated Human Milk Oligosaccharides, 3′‐Sialyllactose and 6′‐Sialyllactose
10.1016/j.biotechadv.2022.108058 · 2023 · External reference
Rapid, Quantitative Analysis of 3′‐and 6′‐Sialyllactose in Milk by Flow‐Injection Analysis‐Mass Spectrometry: Screening of Milks for Naturally Elevated Sialyllactose Concentration
10.3168/jds.2013-6972 · 2013 · External reference
Exercise‐Induced 3′‐Sialyllactose in Breast Milk Is a Critical Mediator to Improve Metabolic Health and Cardiac Function in Mouse Offspring
10.1038/s42255-020-0223-8 · 2020 · External reference
High‐Fat Diet‐Induced Obesity in Animal Models
10.1017/s0954422410000168 · 2010 · External reference
An Overview of Murine High Fat Diet as a Model for Type 2 Diabetes Mellitus
10.1155/2016/2902351 · 2016 · External reference
Sappanone A, a Potential Natural Inhibitor of PI3K, Alleviates Metabolic Dysfunction‐Associated Steatohepatitis in Experimental Models
10.1016/j.bcp.2025.117305 · 2025 · External reference
Efficacy of GLP‐1‐Based Therapies on Metabolic Dysfunction‐Associated Steatotic Liver Disease and Metabolic Dysfunction‐Associated Steatohepatitis: A Systematic Review and Meta‐Analysis
10.1210/clinem/dgaf336 · 2025 · External reference
Maternal High‐Fat Diet During Lactation Reduces Sialylated Milk Oligosaccharides and Shapes Early‐Life Microbiota in Rat Offspring
10.1039/d5fo00559k · 2025 · External reference
Early Developmental Conditioning of Later Health and Disease: Physiology or Pathophysiology?
10.1152/physrev.00029.2013 · 2014 · External reference
Desialylation of O‐Glycans on Glycoprotein Ibα Drives Receptor Signaling and Platelet Clearance
10.3324/haematol.2019.240440 · 2021 · External reference
Focal‐Adhesion Kinase Regulates the Sialylation of N‐Glycans via the PI4KIIα‐PI4P Pathway
10.1016/j.jbc.2023.105051 · 2023 · External reference
Non‐Alcoholic Fatty Liver Disease
10.1016/s0140-6736(20)32511-3 · 2021 · External reference
Glucose‐Mediated N‐Glycosylation of SCAP Is Essential for SREBP‐1 Activation and Tumor Growth
10.1016/j.ccell.2015.09.021 · 2015 · External reference
Key Events in Cancer: Dysregulation of SREBPs
10.3389/fphar.2023.1130747 · 2023 · External reference
Molecular Mechanisms of Mitochondrial Dynamics
10.1038/s41580-024-00785-1 · 2025 · External reference
Mitochondrial Alterations in Fatty Liver Diseases
10.1016/j.jhep.2022.09.020 · 2023 · External reference
α‐Ketoglutarate Prevents Hyperlipidemia‐Induced Fatty Liver Mitochondrial Dysfunction and Oxidative Stress by Activating the AMPK‐Pgc‐1α/Nrf2 Pathway
10.1016/j.redox.2024.103230 · 2024 · External reference
Herba Houttuyniae Extract Benefits Hyperlipidemic Mice via Activation of the AMPK/PGC‐1α/Nrf2 Cascade
10.3390/nu12010164 · 2020 · External reference
Altered Granulopoietic Profile and Exaggerated Acute Neutrophilic Inflammation in Mice With Targeted Deficiency in the Sialyltransferase ST6Gal I
10.1182/blood-2006-04-014779 · 2006 · External reference
Loss of Sialic Acid Side‐Chain O‐Acetylation Exacerbates Colitis
10.1073/pnas.2505249122 · 2025 · External reference
Human Species‐Specific Loss of CMP‐N‐Acetylneuraminic Acid Hydroxylase Enhances Atherosclerosis via Intrinsic and Extrinsic Mechanisms
10.1073/pnas.1902902116 · 2019 · External reference
Sialic Acid Is a Critical Fetal Defense Against Maternal Complement Attack
10.1172/jci99945 · 2019 · External reference
