Research graph
References from Succinate Ameliorates Sepsis‐Associated Acute Kidney Injury by Mediating Inflammation via GPR91. Local targets link to admitted publications; unresolved targets remain external evidence.
Acute Kidney Injury
10.7326/aitc201711070 · 2017 · External reference
Unresolved reference
2016 · External reference
Increased Risk of Death and de Novo Chronic Kidney Disease Following Reversible Acute Kidney Injury
10.1038/ki.2011.405 · 2012 · External reference
Failed Tubule Recovery, AKI‐CKD Transition, and Kidney Disease Progression
10.1681/asn.2015010006 · 2015 · External reference
Autophagy Is Activated to Protect Against Endotoxic Acute Kidney Injury
2016 · External reference
Sepsis‐Associated AKI: Epithelial Cell Dysfunction
10.1016/j.semnephrol.2015.01.009 · 2015 · External reference
Sepsis: Evolving Concepts and Challenges
10.1590/1414-431x20198595 · 2019 · External reference
Epidemiology of Acute Kidney Injury in Critically Ill Patients: The Multinational AKI‐EPI Study
10.1007/s00134-015-3934-7 · 2015 · External reference
Lipopolysaccharide endotoxins
10.1146/annurev.biochem.71.110601.135414 · 2002 · External reference
Increased TLR4 Expression Aggravates Sepsis by Promoting IFN‐ Expression in CD38−/− Mice
2019 · External reference
Succinate, an Intermediate in Metabolism, Signal Transduction, ROS, Hypoxia, and Tumorigenesis
10.1016/j.bbabio.2016.03.012 · 2016 · External reference
Extracellular Succinate Derived From Ectopic Milieu Drives Adhesion and Implantation Growth of Ectopic Endometrial Stromal Cells via the SUCNR1 Signal in Endometriosis
10.1186/s12964-023-01415-7 · 2024 · External reference
miR‐369‐3p Ameliorates Diabetes‐Associated Atherosclerosis by Regulating Macrophage Succinate‐GPR91 Signalling
10.1093/cvr/cvae102 · 2024 · External reference
Protective Effects of the Succinate/SUCNR1 Axis on Damaged Hepatocytes in NAFLD
10.1016/j.metabol.2023.155630 · 2023 · External reference
Citric Acid Cycle Intermediates as Ligands for Orphan G‐Protein‐Coupled Receptors
10.1038/nature02488 · 2004 · External reference
Succinate Receptor GPR91 Provides a Direct Link Between High Glucose Bevels and Renin Release in Murine and Rabbit Kidney
2008 · External reference
Cinnamaldehyde Suppresses NLRP3 Derived IL‐1β via Activating Succinate/HIF‐1 in Rheumatoid Arthritis Rats
2020 · External reference
SUCNR1 Deficiency Alleviates Liver Ischemia‐Reperfusion Injury by Regulating Kupffer Cell Activation and Polarization Through the ERK/NF‐κB Pathway in Mice
10.1007/s10753-025-02290-9 · 2025 · External reference
KDIGO Clinical Practice Guidelines for Acute Kidney Injury
10.1159/000339789 · 2012 · External reference
Succinate Promotes Pulmonary Fibrosis Through GPR91 and Predicts Death in Idiopathic Pulmonary Fibrosis
2024 · External reference
Immunodesign of Experimental Sepsis by Cecal Ligation and Puncture
10.1038/nprot.2008.214 · 2009 · External reference
Pulmonary Succinate Receptor 1 Elevation in High‐Fat Diet Mice Exacerbates Lipopolysaccharides‐Induced Acute Lung Injury via Sensing Succinate
2024 · External reference
SUCNR1‐Mediated Chemotaxis of Macrophages Aggravates Obesity‐Induced Inflammation and Diabetes
10.1007/s00125-017-4261-z · 2017 · External reference
Succinate Uptake by T Cells Suppresses Their Effector Function via Inhibition of Mitochondrial Glucose Oxidation
10.1016/j.celrep.2022.111193 · 2022 · External reference
SLC13 Family of Na+‐Coupled di‐ and Tri‐Carboxylate/Sulfate Transporters
10.1016/j.mam.2012.12.001 · 2013 · External reference
Succinate Is an Inflammatory Signal That Induces IL‐1β Through HIF‐1α
10.1038/nature11986 · 2013 · External reference
Succinate Dehydrogenase Supports Metabolic Repurposing of Mitochondria to Drive Inflammatory Macrophages
10.1016/j.cell.2016.08.064 · 2016 · External reference
SUCNR1 Controls an Anti‐Inflammatory Program in Macrophages to Regulate the Metabolic Response to Obesity
10.1038/s41590-019-0372-7 · 2019 · External reference
Extracellular Succinate Hyperpolarizes M2 Macrophages Through SUCNR1/GPR91‐Mediated Gq Signaling
10.1016/j.celrep.2021.109246 · 2021 · External reference
Macrophage‐Derived Extracellular Succinate Licenses Neural Stem Cells to Suppress Chronic Neuroinflammation
10.1016/j.stem.2018.01.020 · 2018 · External reference
GPR91 Deficiency Exacerbates Allergic Contact Dermatitis While Reducing Arthritic Disease in Mice
10.1111/all.13005 · 2017 · External reference
The Essential Role of Phosphoinositide 3‐Kinases (PI3Ks) in Regulating Pro‐Inflammatory Responses and the Progression of Cancer
2005 · External reference
The PI3K/Akt Pathway in Meta‐Inflammation
10.3390/ijms232315330 · 2022 · External reference
ShK‐Modified UCMSCs Inhibit M1‐Like Macrophage Polarization and Alleviate Osteoarthritis Progression via PI3K/Akt Axis
2025 · External reference
GOLPH3 Promotes Endotoxemia‐Induced Liver and Kidney Injury Through Golgi Stress‐Mediated Apoptosis and Inflammatory Response
10.1038/s41419-023-05975-x · 2023 · External reference
UCHL1 Promoted Polarization of M1 Macrophages by Regulating the PI3K/AKT Signaling Pathway
10.2147/jir.s343487 · 2022 · External reference
Alternative Activation of Macrophages: Mechanism and Functions
10.1016/j.immuni.2010.05.007 · 2010 · External reference
