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References from 4‐Octyl Itaconate Attenuates Age‐Induced Parotid Gland Dysfunction Through the Suppression of Fibrosis and Lipid Deposition by AMPKα/PPARα and the Inhibition of Oxidative Stress via the AMPKα/Nrf2 Signaling Pathway. Local targets link to admitted publications; unresolved targets remain external evidence.
Salivary Flow, Saliva, pH and Buffering Capacity in 70‐Year‐Old Men and Women. Correlation to Dental Health, Dryness in the Mouth, Disease and Drug Treatment
10.1111/j.1365-2842.1984.tb00565.x · 1984 · External reference
Aging and Saliva: A Review of the Literature
10.1111/j.1754-4505.1996.tb00842.x · 1996 · External reference
Salivary Secretion, Taste and Hyposalivation
10.1111/j.1365-2842.2007.01794.x · 2007 · External reference
Meta‐Analysis of Salivary Flow Rates in Young and Older Adults
10.1111/jgs.13652 · 2015 · External reference
Salivary Flow Decreases in Healthy Elderly People Independently of Dental Status and Drug Intake
10.1111/jtxs.12191 · 2016 · External reference
Saliva: An All‐Rounder of Our Body
10.1016/j.ejpb.2019.06.016 · 2019 · External reference
Unresolved reference
2015 · External reference
Aging, Inflammation and the Environment
10.1016/j.exger.2017.12.015 · 2018 · External reference
Metabolic Communication and Healthy Aging: Where Should We Focus Our Energy?
10.1016/j.devcel.2020.06.011 · 2020 · External reference
Role of p53 in the Regulation of Cellular Senescence
10.3390/biom10030420 · 2020 · External reference
Inflamm‐Aging: Autoimmunity, and the Immune‐Risk Phenotype
10.1016/j.autrev.2004.03.004 · 2004 · External reference
Inflamm‐Aging Does Not Simply Reflect Increases in Pro‐Inflammatory Markers
10.1016/j.mad.2014.06.005 · 2014 · External reference
Modulation of Fracture Healing by Senescence‐Associated Secretory Phenotype (SASP): A Narrative Review of the Current Literature
10.1186/s40001-023-01604-7 · 2024 · External reference
Role of Cellular Senescence in Inflammatory Lung Diseases
10.1016/j.cytogfr.2023.02.001 · 2023 · External reference
Cellular Senescence, a Novel Area of Investigation for Metastatic Diseases
10.3390/cells12060860 · 2023 · External reference
Characterization of Cellular Senescence in Aging Skeletal Muscle
10.1038/s43587-022-00250-8 · 2022 · External reference
Naturally Occurring p16Ink4a‐Positive Cells Shorten Healthy Lifespan
10.1038/nature16932 · 2016 · External reference
Salivary Secretion in Health and Disease
10.1111/joor.12664 · 2018 · External reference
Effects of Gender, Age, and Body Mass Index on Fat Contents and Apparent Diffusion Coefficients in Healthy Parotid Glands: An MRI Evaluation
10.1007/s00330-014-3265-z · 2014 · External reference
Advanced Glycation End Products Increase Salivary Gland Hypofunction in d‐Galactose‐Induced Aging Rats and Its Prevention by Physical Exercise
10.3390/cimb43030142 · 2021 · External reference
Mitochondrial Dysfunction and Cell Senescence: Deciphering a Complex Relationship
10.1002/1873-3468.13498 · 2019 · External reference
The Mitochondrial Basis of Aging and Age‐Related Disorders
10.3390/genes8120398 · 2017 · External reference
Ganoderma lucidum Polysaccharides Ameliorates D‐Galactose‐Induced Aging Salivary Secretion Disorders by Upregulating the Rhythm and Aquaporins
10.1016/j.exger.2023.112147 · 2023 · External reference
Immune‐Responsive Gene 1 Protein Links Metabolism to Immunity by Catalyzing Itaconic Acid Production
10.1073/pnas.1218599110 · 2013 · External reference
Itaconate Is an Anti‐Inflammatory Metabolite That Activates Nrf2 via Alkylation of KEAP1
10.1038/nature25986 · 2018 · External reference
Electrophilic Properties of Itaconate and Derivatives Regulate the IκBζ‐ATF3 Inflammatory Axis
10.1038/s41586-018-0052-z · 2018 · External reference
Itaconate Links Inhibition of Succinate Dehydrogenase With Macrophage Metabolic Remodeling and Regulation of Inflammation
10.1016/j.cmet.2016.06.004 · 2016 · External reference
Injured Myocardium‐Targeted Theranostic Nanoplatform for Multi‐Dimensional Immune‐Inflammation Regulation in Acute Myocardial Infarction
10.1002/advs.202414740 · 2025 · External reference
Dimethyl Itaconate Attenuates Palmitate‐Induced Insulin Resistance in Skeletal Muscle Cells Through the AMPK/FGF21/PPARδ‐Mediated Suppression of Inflammation
10.1016/j.lfs.2021.120129 · 2021 · External reference
4‐Octyl Itaconate Attenuates Cell Proliferation by Cellular Senescence via Glutathione Metabolism Disorders and Mitochondrial Dysfunction in Melanoma
10.1089/ars.2024.0629 · 2025 · External reference
Itaconate Alleviates Anesthesia/Surgery‐Induced Cognitive Impairment by Activating a Nrf2‐Dependent Anti‐Neuroinflammation and Neurogenesis via Gut‐Brain Axis
10.1186/s12974-024-03103-w · 2024 · External reference
Aging Relevant Metabolite Itaconate Inhibits Inflammatory Bone Loss
10.3389/fendo.2022.885879 · 2022 · External reference
Extracellular Vesicles Derived From Salivary Gland Stem Cells Cultured on Microwell Scaffolds Loaded With WNT3A Promote the Recovery of Salivary Gland Function Damaged by Radiation via the YWHAZ‐PI3K‐AKT Pathway
10.1016/j.bioactmat.2025.06.024 · 2025 · External reference
Metabolic Landscape in Cardiac Aging: Insights Into Molecular Biology and Therapeutic Implications
10.1038/s41392-023-01378-8 · 2023 · External reference
Mitochondrial STAT3 Exacerbates LPS‐Induced Sepsis by Driving CPT1a‐Mediated Fatty Acid Oxidation
10.7150/thno.63751 · 2022 · External reference
Loss‐ or Gain‐Of‐Function Mutations in ACOX1 Cause Axonal Loss via Different Mechanisms
10.1016/j.neuron.2020.02.021 · 2020 · External reference
Rutin Exhibits Hepatoprotective Effects in a Mouse Model of Non‐Alcoholic Fatty Liver Disease by Reducing Hepatic Lipid Levels and Mitigating Lipid‐Induced Oxidative Injuries
10.1016/j.intimp.2017.05.026 · 2017 · External reference
AdipoRon Ameliorates the Progression of Heart Failure With Preserved Ejection Fraction via Mitigating Lipid Accumulation and Fibrosis
10.1016/j.jare.2024.02.015 · 2025 · External reference
Negative Regulation of Pro‐Apoptotic AMPK/JNK Pathway by Itaconate in Mice With Fulminant Liver Injury
10.1038/s41419-023-06001-w · 2023 · External reference
γ‐Mangostin Ameliorates Free Fatty Acid‐Induced Lipid Accumulation via the SIRT1/LKB1/AMPK Pathway in HepG2 and L02 Cells
10.1021/acs.jafc.9b05632 · 2019 · External reference
The Role of Mammalian Sirtuins in the Regulation of Metabolism, Aging, and Longevity
10.1007/978-3-642-21631-2_7 · 2011 · External reference
SIRT1 and Aging Related Signaling Pathways
10.1016/j.mad.2020.111215 · 2020 · External reference
Delphinidin Attenuates Cognitive Deficits and Pathology of Alzheimer's Disease by Preventing Microglial Senescence via AMPK/SIRT1 Pathway
10.1186/s13195-025-01783-x · 2025 · External reference
Eotaxin‐1/CCL11 Promotes Cellular Senescence in Human‐Derived Fibroblasts Through Pro‐Oxidant and Pro‐Inflammatory Pathways
10.3389/fimmu.2023.1243537 · 2023 · External reference
Circulating Mitochondrial DAMPs Cause Inflammatory Responses to Injury
10.1038/nature08780 · 2010 · External reference
Clearance of p16Ink4a‐Positive Senescent Cells Delays Ageing‐Associated Disorders
10.1038/nature10600 · 2011 · External reference
Chronic Inflammation (Inflammaging) and Its Potential Contribution to Age‐Associated Diseases
10.1093/gerona/glu057 · 2014 · External reference
The Itaconate Family of Immunomodulators Grows
10.1038/s42255-022-00578-w · 2022 · External reference
Protective Effects of IRG1/Itaconate on Acute Colitis Through the Inhibition of Gasdermins‐Mediated Pyroptosis and Inflammation Response
10.1016/j.gendis.2022.05.039 · 2023 · External reference
Alleviating Pyroptosis of Intestinal Epithelial Cells to Restore Mucosal Integrity in Ulcerative Colitis by Targeting Delivery of 4‐Octyl‐Itaconate
10.1021/acsnano.4c01520 · 2024 · External reference
Immune‐Responsive Gene 1/Itaconate Activates Nuclear Factor Erythroid 2‐Related Factor 2 in Hepatocytes to Protect Against Liver Ischemia‐Reperfusion Injury
10.1002/hep.31147 · 2020 · External reference
The Cell Autonomous and Non‐Autonomous Roles of Itaconate in Immune Response
10.1016/j.cellin.2024.100224 · 2025 · External reference
The Immunometabolite Itaconate Stimulates OXGR1 to Promote Mucociliary Clearance During the Pulmonary Innate Immune Response
10.1172/jci160463 · 2023 · External reference
Protective Effects of 4‐Octyl Itaconate Against Inflammatory Response in Angiotensin II‐Induced Oxidative Stress in Human Primary Retinal Pigment Epithelium
10.1016/j.bbrc.2021.03.113 · 2021 · External reference
Is Modulation of Oxidative Stress an Answer? The State of the Art of Redox Therapeutic Actions in Neurodegenerative Diseases
10.1155/2016/7909380 · 2016 · External reference
Electrophilic Nrf2 Activators and Itaconate Inhibit Inflammation at Low Dose and Promote IL‐1β Production and Inflammatory Apoptosis at High Dose
10.1016/j.redox.2020.101647 · 2020 · External reference
Overexpression of Thioredoxin Prevents Acute Hepatitis Caused by Thioacetamide or Lipopolysaccharide in Mice
10.1053/jhep.2003.50203 · 2003 · External reference
NF‐κB Signaling Pathways in Neurological Inflammation: A Mini Review
2015 · External reference
NF‐κB in Aging and Disease
2011 · External reference
Role of AMPK Mediated Pathways in Autophagy and Aging
10.1016/j.biochi.2021.11.008 · 2022 · External reference
The Role of Sirtuins in Cellular Homeostasis
10.1007/s13105-016-0492-6 · 2016 · External reference
It Takes Two to Tango: NAD+ and Sirtuins in Aging/Longevity Control
10.1038/npjamd.2016.17 · 2016 · External reference
NAD+ Metabolism and Its Roles in Cellular Processes During Ageing
10.1038/s41580-020-00313-x · 2021 · External reference
Declining NAD+ Induces a Pseudohypoxic State Disrupting Nuclear‐Mitochondrial Communication During Aging
10.1016/j.cell.2013.11.037 · 2013 · External reference
Minireview: The PGC‐1 Coactivator Networks: Chromatin‐Remodeling and Mitochondrial Energy Metabolism
10.1210/me.2008-0344 · 2009 · External reference
Itaconate Restrains Acute Proinflammatory Activation of Microglia After Traumatic Brain Injury in Mice
10.1126/scitranslmed.adn2635 · 2025 · External reference
Itaconic Acid Underpins Hepatocyte Lipid Metabolism in Non‐Alcoholic Fatty Liver Disease in Male Mice
10.1038/s42255-023-00801-2 · 2023 · External reference
Acod1/Itaconate Activates Nrf2 in Pulmonary Microvascular Endothelial Cells to Protect Against the Obesity‐Induced Pulmonary Microvascular Endotheliopathy
10.1186/s12931-024-02827-w · 2024 · External reference
Immune Response Gene 1 Deficiency Aggravates High Fat Diet‐Induced Nonalcoholic Fatty Liver Disease via Promotion of Redox‐Sensitive AKT Suppression
10.1016/j.bbadis.2023.166656 · 2023 · External reference
Molecular Mechanism of PPARα Action and Its Impact on Lipid Metabolism, Inflammation and Fibrosis in Non‐Alcoholic Fatty Liver Disease
10.1016/j.jhep.2014.10.039 · 2015 · External reference
PPAR α as a Metabolic Modulator of the Liver: Role in the Pathogenesis of Nonalcoholic Steatohepatitis (NASH)
10.3390/biology11050792 · 2022 · External reference
Mitochondrial CPT1A: Insights Into Structure, Function, and Basis for Drug Development
10.3389/fphar.2023.1160440 · 2023 · External reference
Diosgenin Ameliorates Palmitic Acid‐Induced Lipid Accumulation via AMPK/ACC/CPT‐1A and SREBP‐1c/FAS Signaling Pathways in LO2 Cells
10.1186/s12906-019-2671-9 · 2019 · External reference
