Research graph
References from Baicalein Ameliorates Postmenopausal Osteoporosis With Iron Accumulation by Inhibiting Osteoclastogenesis via Nrf2 Activation. Local targets link to admitted publications; unresolved targets remain external evidence.
Postmenopausal Osteoporosis
10.1056/nejmcp2307353 · 2023 · External reference
Long‐Term and Sequential Treatment for Osteoporosis
10.1038/s41574-023-00866-9 · 2023 · External reference
The Effect of Abnormal Iron Metabolism on Osteoporosis
10.1007/s12011-019-01867-4 · 2020 · External reference
Ovaries of Estrogen Receptor 1‐Deficient Mice Show Iron Overload and Signs of Aging
10.3389/fendo.2024.1325386 · 2024 · External reference
Fundamentals of Redox Regulation in Biology
10.1038/s41580-024-00730-2 · 2024 · External reference
Prussian Blue Nanoparticles Prevent RANKL‐Induced Osteoclastogenesis by Scavenging ROS and Inactivating NF‐κB/MAPK Signaling Pathways
10.1096/fj.202402646r · 2025 · External reference
Serum Ferritin Levels Are Positively Associated With Bone Mineral Density in Elderly Korean Men: The 2008‐2010 Korea National Health and Nutrition Examination Surveys
10.1007/s00774-013-0540-z · 2014 · External reference
Higher Serum Ferritin Level and Lower Femur Neck Strength in Women at the Stage of Bone Loss (>/= 45 Years of Age): The Fourth Korea National Health and Nutrition Examination Survey (KNHANES IV)
10.3109/07435800.2016.1155600 · 2016 · External reference
A Clinical‐Stage Nrf2 Activator Suppresses Osteoclast Differentiation via the Iron‐Ornithine Axis
10.1016/j.cmet.2024.03.005 · 2024 · External reference
Nrf2 Signaling Pathway: Focus on Oxidative Stress in Osteoporosis
10.1007/s00198-025-07592-0 · 2025 · External reference
NRF2 Is Essential for Iron‐Overload Stimulated Osteoclast Differentiation Through Regulation of Redox and Iron Homeostasis
10.1007/s10565-023-09834-5 · 2023 · External reference
The Novel Nrf2 Agonist Neobavaisoflavone Attenuates Periodontitis by Inhibiting Osteoclastogenesis Through Iron Homeostasis Regulation and Senescence Suppression
10.1016/j.freeradbiomed.2025.12.058 · 2026 · External reference
Epimedin B Attenuates Ovariectomy‐Induced Bone Loss by Suppressing Osteoclastogenesis Through Decreasing ROS Production and Targeting ESR1
10.1016/j.freeradbiomed.2025.08.033 · 2025 · External reference
Baicalein Attenuates Brain Iron Accumulation Through Protecting Aconitase 1 From Oxidative Stress in Rotenone‐Induced Parkinson's Disease in Rats
10.3390/antiox12010012 · 2023 · External reference
Baicalein Alleviates Iron Overload‐Induced Ferroptosis and Osteogenic Blockade in Osteoblasts by Activating the Nrf2/GPX4 Pathway
10.34133/bmef.0230 · 2026 · External reference
Iron‐Binding and Anti‐Fenton Properties of Baicalein and Baicalin
10.1016/j.jinorgbio.2008.11.003 · 2009 · External reference
Lysosome‐Iron‐Mitochondria Axis in Osteoclasts: Iron as a Central Player
2025 · External reference
Fighting Age‐Related Orthopedic Diseases: Focusing on Ferroptosis
10.1038/s41413-023-00247-y · 2023 · External reference
Baicalein Protects Against Iron Overload Induced Liver Dysfunction in Thalassemic Mice
10.1166/jbn.2023.3642 · 2023 · External reference
Inhibition of Microsomal Lipid Peroxidation by Baicalein: A Possible Formation of an Iron‐Baicalein Complex
1996 · External reference
Effects of Dietary Baicalin Supplementation on Iron Overload‐Induced Mouse Liver Oxidative Injury
10.1016/j.ejphar.2004.11.060 · 2005 · External reference
Dietary Supplementation of Baicalin and Quercetin Attenuates Iron Overload Induced Mouse Liver Injury
10.1016/j.ejphar.2006.01.067 · 2006 · External reference
Protective Effects of Baicalin and Quercetin on an Iron‐Overloaded Mouse: Comparison of Liver, Kidney and Heart Tissues
10.1080/14786419.2010.495070 · 2011 · External reference
Baicalein (5,6,7‐Trihydroxyflavone) Reduces Oxidative Stress‐Induced DNA Damage by Upregulating the DNA Repair System
10.1007/s10565-012-9233-y · 2012 · External reference
Protective Effects of Baicalein Against Cell Damage by Reactive Oxygen Species
10.1248/cpb.46.1383 · 1998 · External reference
Role of Mitochondrial Reactive Oxygen Species in Osteoclast Differentiation
10.1111/j.1749-6632.2009.05377.x · 2010 · External reference
The Keap1/Nrf2 Protein Axis Plays a Role in Osteoclast Differentiation by Regulating Intracellular Reactive Oxygen Species Signaling *
10.1074/jbc.m113.478545 · 2013 · External reference
Nrf2 Knockout Dysregulates Iron Metabolism and Increases the Hemolysis Through ROS in Aging Mice
10.1016/j.lfs.2020.117838 · 2020 · External reference
Role of Iron Accumulation in Osteoporosis and the Underlying Mechanisms
10.1007/s11596-023-2764-z · 2023 · External reference
Influence of Iron on Bone Homeostasis
10.3390/ph11040107 · 2018 · External reference
Shaping the Bone Through Iron and Iron‐Related Proteins
10.1053/j.seminhematol.2021.06.002 · 2021 · External reference
Deferoxamine, Deferasirox, and Deferiprone Triple Iron Chelator Combination Therapy for Transfusion‐Dependent β‐Thalassaemia With Very High Iron Overload: A Randomised Clinical Trial
10.1016/j.lansea.2024.100495 · 2024 · External reference
Safety, Tolerability, and Pharmacokinetics of Oral Baicalein Tablets in Healthy Chinese Subjects: A Single‐Center, Randomized, Double‐Blind, Placebo‐Controlled Multiple‐Ascending‐Dose Study
10.1111/cts.13063 · 2021 · External reference
Multiple‐Ascending‐Dose Pharmacokinetics and Safety Evaluation of Baicalein Chewable Tablets in Healthy Chinese Volunteers
10.1007/s40261-016-0418-7 · 2016 · External reference
