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References from IGF2BP3-Mediated m6A Modification of OLR1 mRNA Promotes Immune Evasion in CRC via the PI3K/AKT/mTOR Pathway. Local targets link to admitted publications; unresolved targets remain external evidence.
Cancer statistics, 2025
2025 · External reference
Global cancer statistics 2022: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries
2024 · External reference
Recent advances and challenges in colorectal cancer: from molecular research to treatment
10.3748/wjg.v31.i21.106964 · 2025 · External reference
Unraveling the complexities of colorectal cancer and its promising therapies: an updated review
10.1016/j.intimp.2024.113325 · 2024 · External reference
Combination therapy with immune checkpoint inhibitors in colorectal cancer: challenges, resistance mechanisms, and the role of microbiota
10.1016/j.biopha.2025.118014 · 2025 · External reference
Advancements in immunotherapy for colorectal cancer treatment: a comprehensive review of strategies, challenges, and future prospective
10.1007/s00384-024-04790-w · 2024 · External reference
Effectiveness and safety of immune checkpoint inhibitors in colorectal cancer: a systematic review of real-world studies
10.1007/s11912-025-01676-0 · 2025 · External reference
Tertiary lymphoid structures in colorectal cancer- organization and immune cell interactions
10.62347/gryy2849 · 2024 · External reference
A bibliometric analysis of immune escape in colorectal cancer: research trends, key contributors, and future directions
10.3389/fimmu.2025.1614613 · 2025 · External reference
Early immune evasion in colorectal cancer: interplay between stem cells and the tumor microenvironment
10.1016/j.trecan.2025.04.016 · 2025 · External reference
LOX-1 in cardiovascular disease: a comprehensive molecular and clinical review
10.3390/ijms25105276 · 2024 · External reference
LOX-1 and cancer: an indissoluble liaison
10.1038/s41417-020-00279-0 · 2021 · External reference
PRRX1-OLR1 axis supports CAFs-mediated lung cancer progression and immune suppression
10.1186/s12935-024-03436-9 · 2024 · External reference
OLR1 is closely related to poor prognosis and immune cell infiltration in gastric cancer
10.1038/s41598-025-25552-w · 2025 · External reference
OLR1 is a prognostic factor and correlates with immune infiltration in breast cancer
10.1016/j.intimp.2021.108275 · 2021 · External reference
A comprehensive analysis of the expression and the prognosis for LOX-1 in multiple cancer types
10.1080/02648725.2023.2199477 · 2024 · External reference
Causal roles and clinical utility of Cardiovascular Proteins in Colorectal Cancer Risk: a multimodal study integrating Mendelian Randomization, Expression Profiling, and survival analysis
10.1186/s12920-024-01909-4 · 2024 · External reference
Knockdown of OLR1 weakens glycolytic metabolism to repress colon cancer cell proliferation and chemoresistance by downregulating SULT2B1 via c-MYC
10.1038/s41419-021-04174-w · 2021 · External reference
N6-methyladenosine (m6A) modification in inflammation: a bibliometric analysis and literature review
10.7717/peerj.18645 · 2024 · External reference
Roles and therapeutic implications of m6A modification in cancer immunotherapy
10.3389/fimmu.2023.1132601 · 2023 · External reference
A comprehensive review of m6A/m6Am RNA methyltransferase structures
10.1093/nar/gkab378 · 2021 · External reference
R-loops’ m6A modification and its roles in cancers
10.1186/s12943-024-02148-y · 2024 · External reference
N6-methyladenosine (m6A) modification in gynecological malignancies
10.1002/jcp.30828 · 2022 · External reference
The role of m6A RNA methylation in cancer metabolism
10.1186/s12943-022-01500-4 · 2022 · External reference
The importance of N6-methyladenosine modification in tumor immunity and immunotherapy
10.1186/s40164-022-00281-2 · 2022 · External reference
Multi-omics analysis of N6-methyladenosine reader IGF2BP3 as a promising biomarker in pan-cancer
10.3389/fimmu.2023.1071675 · 2023 · External reference
Targeting IGF2BP3 in cancer
10.3390/ijms24119423 · 2023 · External reference
The role of insulin-like growth factor 2 mRNA-binding proteins (IGF2BPs) as m(6)A readers in cancer
10.7150/ijbs.70458 · 2022 · External reference
Abnormal expression of N6-methyladenosine RNA methylation regulator IGF2BP3 in colon cancer predicts a poor prognosis
10.1155/2022/5883101 · 2022 · External reference
Lipid-driven OLR1/FOXM1/FGF19 axis orchestrates crosstalk in an epithelial-fibroblast positive feedback promoting progesterone resistance in endometrial cancer
10.1002/advs.202511943 · 2026 · External reference
Dysregulated lipid metabolism and intervertebral disc degeneration: the important role of ox-LDL/LOX-1 in endplate chondrocyte senescence and calcification
10.1186/s10020-024-00887-8 · 2024 · External reference
A novel lipid prognostic signature of ADCY2, LIPE, and OLR1 in head and neck squamous cell carcinoma
10.3389/fonc.2021.735993 · 2021 · External reference
Oxidized low-density lipoprotein receptor 1: a novel potential therapeutic target for intracerebral hemorrhage
10.4103/1673-5374.332157 · 2022 · External reference
Procyanidin B2 alleviates oxidized low-density lipoprotein-induced cell injury, inflammation, monocyte chemotaxis, and oxidative stress by inhibiting the nuclear factor kappa-B pathway in human umbilical vein endothelial cells
10.1186/s12872-024-03858-3 · 2024 · External reference
Prognostic value and immunotherapy analysis of immune cell-related genes in laryngeal cancer
10.7717/peerj.19239 · 2025 · External reference
Single-cell transcriptome analysis identifies MIF as a novel tumor-associated neutrophil marker for pancreatic ductal adenocarcinoma
10.1038/s41698-025-01085-3 · 2025 · External reference
GEO data mining identifies OLR1 as a potential biomarker in NSCLC immunotherapy
10.3389/fonc.2021.629333 · 2021 · External reference
OLR1 is a pan-cancer prognostic and immunotherapeutic predictor associated with EMT and cuproptosis in HNSCC
10.3390/ijms241612904 · 2023 · External reference
Expression of OLR1 gene on tumor-associated macrophages of head and neck squamous cell carcinoma, and its correlation with clinical outcome
10.1080/2162402x.2023.2203073 · 2023 · External reference
Multiomics and machine learning-driven CD8(+) T-cell heterogeneity score for head and neck squamous cell carcinoma
10.1016/j.omtn.2024.102413 · 2025 · External reference
HSPA12B secreted by tumor-associated endothelial cells might induce M2 polarization of macrophages via activating PI3K/Akt/mTOR signaling
10.2147/ott.s254985 · 2020 · External reference
Lectin-like oxidized low-density lipoprotein receptor-1 facilitates metastasis of gastric cancer through driving epithelial-mesenchymal transition and PI3K/Akt/GSK3beta activation
10.1038/srep45275 · 2017 · External reference
PI3K/AKT/mTOR axis in cancer: from pathogenesis to treatment
10.1002/mco2.70295 · 2025 · External reference
Spermine synthase engages in macrophages M2 polarization to sabotage antitumor immunity in hepatocellular carcinoma
10.1038/s41418-024-01409-z · 2025 · External reference
Breaking epigenetic shackles: targeting ARID1A methylation and the PI3K/AKT/mTOR-PD-L1 axis to overcome immune escape in gastric cancer
10.7717/peerj.20251 · 2025 · External reference
Prevalences of CT-detected calcification in the basal ganglia in idiopathic hypoparathyroidism and pseudohypoparathyroidism
10.1007/bf00342514 · 1985 · External reference
NCKAP1 inhibits the progression of renal carcinoma via modulating immune responses and the PI3K/AKT/mTOR signaling pathway
10.3390/ijms26062813 · 2025 · External reference
IGF2BP3 promotes autophagy-mediated TNBC metastasis via m6A-dependent, cap-independent c-Met translation
10.1186/s12964-025-02316-7 · 2025 · External reference
m6A methylated EphA2 and VEGFA through IGF2BP2/3 regulation promotes vasculogenic mimicry in colorectal cancer via PI3K/AKT and ERK1/2 signaling
10.1038/s41419-022-04950-2 · 2022 · External reference
IGF2BP3 boosts lactate generation to accelerate gastric cancer immune evasion
10.1007/s10495-024-02020-w · 2024 · External reference
m(6)A-modified circRAPGEF1 interaction with IGF2BP3 promotes hepatocellular carcinoma progression via reprogramming aspartate metabolism
10.1002/advs.202503851 · 2025 · External reference
IGF2BP3-EGFR-AKT axis promotes breast cancer MDA-MB-231 cell growth
10.1016/j.bbamcr.2023.119542 · 2023 · External reference
Multi-omics analysis unveils the predictive value of IGF2BP3/SPHK1 signaling in cancer stem cells for prognosis and immunotherapeutic response in muscle-invasive bladder cancer
10.1186/s12967-024-05685-8 · 2024 · External reference
WTAP/IGF2BP3 mediated m6A modification of the EGR1/PTEN axis regulates the malignant phenotypes of endometrial cancer stem cells
10.1186/s13046-024-03120-w · 2024 · External reference
IGF2BP2 promotes lung adenocarcinoma progression by regulating LOX1 and tumor-associated neutrophils
10.1007/s12026-024-09563-9 · 2024 · External reference