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References from MLL1 downregulation drives hair cell ferroptosis via mitochondrial and endoplasmic reticulum stress mechanisms through PERK–eIF2α–ATF4–Chop and PI3K/Akt–Lrp1 signaling pathway. Local targets link to admitted publications; unresolved targets remain external evidence.
Molecular mechanisms of sensorineural hearing loss and development of inner ear therapeutics
10.3390/ijms22115647 · 2021 · External reference
New treatment options for hearing loss
10.1038/nrd4533 · 2015 · External reference
A human induced pluripotent stem cell-based modular platform to challenge sensorineural hearing loss
10.1002/stem.3346 · 2021 · External reference
Oxidative stress-induced apoptosis of cochlear sensory cells: Otoprotective strategies
10.1016/s0736-5748(99)00094-5 · 2000 · External reference
Necroptosis and apoptosis contribute to cisplatin and aminoglycoside ototoxicity
10.1523/jneurosci.1384-18.2019 · 2019 · External reference
Autophagy protects auditory hair cells against neomycin-induced damage
10.1080/15548627.2017.1359449 · 2017 · External reference
Induction of mitophagy in the HEI-OC1 auditory cell line and activation of the Atg12/LC3 pathway in the organ of Corti
10.1016/j.heares.2018.01.003 · 2018 · External reference
Regulated necrosis: The expanding network of non-apoptotic cell death pathways
10.1038/nrm3737 · 2014 · External reference
Ferroptosis: An iron-dependent form of nonapoptotic cell death
10.1016/j.cell.2012.03.042 · 2012 · External reference
Ferroptosis: A regulated cell death nexus linking metabolism, redox biology, and disease
10.1016/j.cell.2017.09.021 · 2017 · External reference
Regulation of ferroptotic cancer cell death by GPX4
10.1016/j.cell.2013.12.010 · 2014 · External reference
NRF2 plays a critical role in mitigating lipid peroxidation and ferroptosis
10.1016/j.redox.2019.101107 · 2019 · External reference
Ferroptosis and its role in diverse brain diseases
10.1007/s12035-018-1403-3 · 2019 · External reference
Ischemia-induced ACSL4 activation contributes to ferroptosis-mediated tissue injury in intestinal ischemia/reperfusion
10.1038/s41418-019-0299-4 · 2019 · External reference
Molecular mechanisms of ferroptosis and its role in cancer therapy
10.1111/jcmm.14511 · 2019 · External reference
Inhibition of ferroptosis protects house ear institute-organ of Corti 1 cells and cochlear hair cells from cisplatin-induced ototoxicity
10.1111/jcmm.15839 · 2020 · External reference
Ferrostatin-1 protects auditory hair cells from cisplatin-induced ototoxicity in vitro and in vivo
10.1016/j.bbrc.2020.10.019 · 2020 · External reference
Autophagy-dependent ferroptosis contributes to cisplatin-induced hearing loss
10.1016/j.toxlet.2021.07.010 · 2021 · External reference
Liproxstatin-1 protects hair cell-like HEI-OC1 cells and cochlear hair cells against neomycin ototoxicity
10.1155/2020/1782659 · 2020 · External reference
Relieving ferroptosis may partially reverse neurodegeneration of the auditory cortex
10.1111/febs.15266 · 2020 · External reference
The COMPASS family of histone H3K4 methylases: Mechanisms of regulation in development and disease pathogenesis
10.1146/annurev-biochem-051710-134100 · 2012 · External reference
COMPASS: A complex of proteins associated with a trithorax-related SET domain protein
10.1073/pnas.231473398 · 2001 · External reference
Inhibition of KDM5A attenuates cisplatin-induced hearing loss via regulation of the MAPK/AKT pathway
10.1007/s00018-022-04565-y · 2022 · External reference
Carbonic anhydrase 9 confers resistance to ferroptosis/apoptosis in malignant mesothelioma under hypoxia
10.1016/j.redox.2019.101297 · 2019 · External reference
ACSL4 deficiency confers protection against ferroptosis-mediated acute kidney injury
10.1016/j.redox.2022.102262 · 2022 · External reference
Ferroptosis promotes cyst growth in autosomal dominant polycystic kidney disease mouse models
10.1681/asn.2021040460 · 2021 · External reference
HMGB1 regulates ferroptosis through Nrf2 pathway in mesangial cells in response to high glucose
10.1042/bsr20202924 · 2021 · External reference
HSPB1 as a novel regulator of ferroptotic cancer cell death
10.1038/onc.2015.32 · 2015 · External reference
Molecular mechanisms of cell death: Recommendations of the Nomenclature Committee on Cell Death 2018
10.1038/s41418-017-0012-4 · 2018 · External reference
Inhibiting DNA methylation alleviates cisplatin-induced hearing loss by decreasing oxidative stress-induced mitochondria-dependent apoptosis via the LRP1-PI3K/AKT pathway
10.1016/j.apsb.2021.11.002 · 2022 · External reference
LRP1 expression in microglia is protective during CNS autoimmunity
10.1186/s40478-016-0343-2 · 2016 · External reference
hSETD1A regulates Wnt target genes and controls tumor growth of colorectal cancer cells
10.1158/0008-5472.can-13-1400 · 2014 · External reference
Epigenetic balance of gene expression by Polycomb and COMPASS families
10.1126/science.aad9780 · 2016 · External reference
The MLL1-H3K4me3 axis-mediated PD-L1 expression and pancreatic cancer immune evasion
10.1093/jnci/djw283 · 2017 · External reference
Structural and functional features and significance of the physical linkage between ER and mitochondria
10.1083/jcb.200604016 · 2006 · External reference
ER tubules mark sites of mitochondrial division
10.1126/science.1207385 · 2011 · External reference
Endoplasmic reticulum-associated degradation regulates mitochondrial dynamics in brown adipocytes
10.1126/science.aay2494 · 2020 · External reference
Apoptosis and apoptotic body: Disease message and therapeutic target potentials
10.1042/bsr20180992 · 2019 · External reference
Crosstalk between apoptosis, necrosis and autophagy
10.1016/j.bbamcr.2013.06.001 · 2013 · External reference
Ferroptosis: Molecular mechanisms and health implications
10.1038/s41422-020-00441-1 · 2021 · External reference
Ferroptosis: Mechanisms, biology and role in disease
10.1038/s41580-020-00324-8 · 2021 · External reference
Molecular mechanisms and physiological functions of mitophagy
10.15252/embj.2020104705 · 2021 · External reference
Dynamin-related protein Drp1 is required for mitochondrial division in mammalian cells
10.1091/mbc.12.8.2245 · 2001 · External reference
Endogenous Drp1 mediates mitochondrial autophagy and protects the heart against energy stress
10.1161/circresaha.116.303356 · 2015 · External reference
Ferroptosis involves in intestinal epithelial cell death in ulcerative colitis
10.1038/s41419-020-2299-1 · 2020 · External reference
Ferroptosis-induced endoplasmic reticulum stress: Cross-talk between ferroptosis and apoptosis
10.1158/1541-7786.mcr-18-0055 · 2018 · External reference
Endoplasmic reticulum stress: Its role in disease and novel prospects for therapy
2012 · External reference
Amino acid deprivation induces CREBZF/Zhangfei expression via an AARE-like element in the promoter
10.1016/j.bbrc.2009.12.059 · 2010 · External reference
Nrf2- and ATF4-dependent upregulation of xCT modulates the sensitivity of T24 bladder carcinoma cells to proteasome inhibition
10.1128/mcb.00221-14 · 2014 · External reference
Pharmacological inhibition of cystine-glutamate exchange induces endoplasmic reticulum stress and ferroptosis
10.7554/elife.02523 · 2014 · External reference
Both transcriptional regulation and translational control of ATF4 are central to the integrated stress response
10.1074/jbc.m110.167213 · 2010 · External reference
Roles of CHOP/GADD153 in endoplasmic reticulum stress
10.1038/sj.cdd.4401373 · 2004 · External reference
Endoplasmic reticulum stress-mediated autophagy activation is involved in cadmium-induced ferroptosis of renal tubular epithelial cells
10.1016/j.freeradbiomed.2021.09.008 · 2021 · External reference
Cadmium induces liver dysfunction and ferroptosis through the endoplasmic stress-ferritinophagy axis
10.1016/j.ecoenv.2022.114123 · 2022 · External reference
ATF4 promotes angiogenesis and neuronal cell death and confers ferroptosis in a xCT-dependent manner
10.1038/onc.2017.146 · 2017 · External reference
Loss of cysteinyl-tRNA synthetase (CARS) induces the transsulfuration pathway and inhibits ferroptosis induced by cystine deprivation
10.1038/cdd.2015.93 · 2016 · External reference
Heme oxygenase-1 mediates BAY 11-7085 induced ferroptosis
10.1016/j.canlet.2017.12.025 · 2018 · External reference
Deregulation of the Akt pathway in human cancer
10.2174/156800908783497140 · 2008 · External reference
The PI 3-kinase/Akt signaling pathway delivers an anti-apoptotic signal
10.1101/gad.11.6.701 · 1997 · External reference
Role of PI 3-kinase, Akt and Bcl-2-related proteins in sustaining the survival of neurotrophic factor-independent adult sympathetic neurons
10.1083/jcb.200101068 · 2001 · External reference
AKT signaling mediates IGF-I survival actions on otic neural progenitors
10.1371/journal.pone.0030790 · 2012 · External reference
All Akt isoforms (Akt1, Akt2, Akt3) are involved in normal hearing, but only Akt2 and Akt3 are involved in auditory hair cell survival in the mammalian inner ear
10.1371/journal.pone.0121599 · 2015 · External reference
Akt and c-Jun N-terminal kinase are regulated in response to moderate noise exposure in the cochlea of guinea pigs
10.1159/000103871 · 2007 · External reference
A PI3K pathway mediates hair cell survival and opposes gentamicin toxicity in neonatal rat organ of Corti
10.1007/s10162-006-0050-y · 2006 · External reference
Inhibition of histone methyltransferase PRMT5 attenuates cisplatin-induced hearing loss through the PI3K/Akt-mediated mitochondrial apoptotic pathway
10.1016/j.jpha.2023.04.014 · 2023 · External reference
Prevention of noise-induced hearing loss by calpain inhibitor MDL-28170 is associated with upregulation of PI3K/Akt survival signaling pathway
10.3389/fncel.2023.1199656 · 2023 · External reference
Identification of the low density lipoprotein (LDL) receptor-related protein-1 interactome in central nervous system myelin suggests a role in the clearance of necrotic cell debris
10.1074/jbc.m112.384693 · 2013 · External reference
Cell-surface calreticulin initiates clearance of viable or apoptotic cells through trans-activation of LRP on the phagocyte
10.1016/j.cell.2005.08.032 · 2005 · External reference
The low-density lipoprotein receptor-related protein is a pro-survival receptor in Schwann cells: Possible implications in peripheral nerve injury
10.1523/jneurosci.2709-06.2006 · 2006 · External reference
Gamma-secretase limits the inflammatory response through the processing of LRP1
10.1126/scisignal.1164263 · 2008 · External reference
Astrocytic LRP1 enables mitochondria transfer to neurons and mitigates brain ischemic stroke by suppressing ARF1 lactylation
10.1016/j.cmet.2024.05.016 · 2024 · External reference
