Research graph
References from m6A-modified circCD2AP suppressed ferroptosis in bladder cancer by upregulating FOXC1 to promote PARK7 transcriptional activity. Local targets link to admitted publications; unresolved targets remain external evidence.
Global Cancer Statistics 2020: GLOBOCAN Estimates of incidence and mortality Worldwide for 36 cancers in 185 Countries
2021 · External reference
Comparison of the survival outcomes between primary and secondary muscle-invasive bladder cancer: A propensity score-matched study
10.1097/cm9.0000000000002512 · 2023 · External reference
Treatment resistance in urothelial carcinoma: An evolutionary perspective
10.1038/s41571-018-0026-y · 2018 · External reference
Novel combination therapies for the treatment of bladder cancer
2020 · External reference
Lymphovascular invasion status at transurethral resection of bladder tumors may predict subsequent poor response of T1 tumors to bacillus Calmette-Guérin
10.1186/s12894-016-0122-1 · 2016 · External reference
The biogenesis, biology and characterization of circular RNAs
10.1038/s41576-019-0158-7 · 2019 · External reference
Regulation of cancer progression by circRNA and functional proteins
10.1002/jcp.30608 · 2022 · External reference
Circular RNA circSLC8A1 acts as a sponge of miR-130b/miR-494 in suppressing bladder cancer progression via regulating PTEN
10.1186/s12943-019-1040-0 · 2019 · External reference
Circular RNA MYLK as a competing endogenous RNA promotes bladder cancer progression through modulating VEGFA/VEGFR2 signaling pathway
10.1016/j.canlet.2017.06.027 · 2017 · External reference
Analysis of ceRNA network identifies prognostic circRNA biomarkers in bladder cancer
10.4149/neo_2019_190107n25 · 2019 · External reference
The emerging role of m6a modification in regulating the immune system and autoimmune diseases
2021 · External reference
N(6)-methyladenosine METTL3 promotes cervical cancer tumorigenesis and Warburg effect through YTHDF1/HK2 modification
10.1038/s41419-020-03071-y · 2020 · External reference
The m(6)A methyltransferase METTL3 promotes bladder cancer progression via AFF4/NF-κB/MYC signaling network
10.1038/s41388-019-0683-z · 2019 · External reference
Reading m(6)A in the transcriptome: m(6)A-binding proteins
10.1016/j.tcb.2017.10.001 · 2018 · External reference
Modulation of circRNA metabolism by m(6)A modification
10.1016/j.celrep.2020.107641 · 2020 · External reference
N(6)-methyladenosine modification of circNSUN2 facilitates cytoplasmic export and stabilizes HMGA2 to promote colorectal liver metastasis
10.1038/s41467-019-12651-2 · 2019 · External reference
Circular RNA-protein interactions: Functions, mechanisms, and identification
10.7150/thno.42174 · 2020 · External reference
IGF2BP3 facilitates cell proliferation and tumorigenesis via modulation of JAK/STAT signalling pathway in human bladder cancer
10.1111/jcmm.16003 · 2020 · External reference
circRARS synergises with IGF2BP3 to regulate RNA methylation recognition to promote tumour progression in renal cell carcinoma
10.1002/ctm2.1512 · 2023 · External reference
m(6)A-modified circFOXK2 targets GLUT1 to accelerate oral squamous cell carcinoma aerobic glycolysis
10.1038/s41417-022-00526-6 · 2023 · External reference
FOXC1, the new player in the cancer sandbox
10.18632/oncotarget.22742 · 2018 · External reference
Overexpression of forkhead box C1 promotes tumor metastasis and indicates poor prognosis in hepatocellular carcinoma
10.1002/hep.26029 · 2013 · External reference
Exosome-mediated mir-4792 transfer promotes bladder cancer cell proliferation via enhanced FOXC1/c-Myc signaling and warburg effect
2022 · External reference
ELAVL1 is transcriptionally activated by FOXC1 and promotes ferroptosis in myocardial ischemia/reperfusion injury by regulating autophagy
10.1186/s10020-021-00271-w · 2021 · External reference
Ferroptosis: An iron-dependent form of nonapoptotic cell death
10.1016/j.cell.2012.03.042 · 2012 · External reference
Ferroptosis: Process and function
10.1038/cdd.2015.158 · 2016 · External reference
DJ-1 suppresses ferroptosis through preserving the activity of S-adenosyl homocysteine hydrolase
10.1038/s41467-020-15109-y · 2020 · External reference
Correction to virus bioresistor (VBR) for the detection of the bladder cancer marker DJ-1 in urine at 10 pM in one minute
2020 · External reference
The role of m6A RNA methylation in cancer metabolism
10.1186/s12943-022-01500-4 · 2022 · External reference
Cysteine dioxygenase 1 mediates erastin-induced ferroptosis in human gastric cancer cells
10.1016/j.neo.2017.10.005 · 2017 · External reference
Bladder cancer
10.1100/2011/251920 · 2011 · External reference
Bladder cancer: Current challenges and future directions
10.3390/medicina57080749 · 2021 · External reference
Circular RNAs: Characterization, cellular roles, and applications
10.1016/j.cell.2022.04.021 · 2022 · External reference
The emerging roles of circRNAs in cancer and oncology
10.1038/s41571-021-00585-y · 2022 · External reference
Ferroptosis: Bug or feature
10.1111/imr.12533 · 2017 · External reference
Ferroptosis in cancer progression: Role of noncoding RNAs
10.7150/ijbs.66917 · 2022 · External reference
CircIL4R facilitates the tumorigenesis and inhibits ferroptosis in hepatocellular carcinoma by regulating the miR-541-3p/GPX4 axis
10.1002/cbin.11444 · 2020 · External reference
CircRNA-ST6GALNAC6 increases the sensitivity of bladder cancer cells to erastin-induced ferroptosis by regulating the HSPB1/P38 axis
10.1038/s41374-022-00826-3 · 2022 · External reference
A METTL3-METTL14 complex mediates mammalian nuclear RNA N6-adenosine methylation
10.1038/nchembio.1432 · 2014 · External reference
N(6)-methyladenosine modification regulates ferroptosis through autophagy signaling pathway in hepatic stellate cells
10.1016/j.redox.2021.102151 · 2021 · External reference
METTL14 promotes doxorubicin-induced cardiomyocyte ferroptosis by regulating the KCNQ1OT1-miR-7-5p-TFRC axis
10.1007/s10565-021-09660-7 · 2023 · External reference
METTL3 promote tumor proliferation of bladder cancer by accelerating pri-miR221/222 maturation in m6A-dependent manner
10.1186/s12943-019-1036-9 · 2019 · External reference
Exosomal miR-4443 promotes cisplatin resistance in non-small cell lung carcinoma by regulating FSP1 m6A modification-mediated ferroptosis
10.1016/j.lfs.2021.119399 · 2021 · External reference
METTL3 promotes lung adenocarcinoma tumor growth and inhibits ferroptosis by stabilizing SLC7A11 m(6)A modification
10.1186/s12935-021-02433-6 · 2022 · External reference
YTHDC1 mediates nuclear export of N(6)-methyladenosine methylated mRNAs
10.7554/elife.31311 · 2017 · External reference
CircMET promotes tumor proliferation by enhancing CDKN2A mRNA decay and upregulating SMAD3
10.1186/s12943-022-01497-w · 2022 · External reference
Recognition of RNA N(6)-methyladenosine by IGF2BP proteins enhances mRNA stability and translation
10.1038/s41556-018-0045-z · 2018 · External reference
The interaction of circRNAs and RNA binding proteins: An important part of circRNA maintenance and function
10.1002/jnr.24356 · 2020 · External reference
FOXC1 promotes HCC proliferation and metastasis by upregulating DNMT3B to induce DNA hypermethylation of CTH promoter
10.1186/s13046-021-01829-6 · 2021 · External reference
Overexpression of FOXC1 promotes tumor metastasis by activating the Wnt/β-catenin signaling pathway in gastric cancer
10.1007/s10620-021-07226-5 · 2022 · External reference
Serum DJ-1 as a diagnostic marker and prognostic factor for pancreatic cancer
10.1111/j.1751-2980.2011.00488.x · 2011 · External reference
DJ-1 upregulates the Nrf2/GPX4 signal pathway to inhibit trophoblast ferroptosis in the pathogenesis of preeclampsia
10.1038/s41598-022-07065-y · 2022 · External reference
