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References from FIN56-induced ferroptosis suppresses the development of endometriosis by augmenting mitochondrial ROS and lipid peroxidation via the ACACA/ARID5A/NOX4 axis. Local targets link to admitted publications; unresolved targets remain external evidence.
Endometriosis
10.1210/er.2018-00242 · 2019 · External reference
Precise capture of circulating endometrial cells in endometriosis
10.1097/cm9.0000000000002910 · 2024 · External reference
Identification of circular RNAs as a novel biomarker for ovarian endometriosis
10.4103/0366-6999.226070 · 2018 · External reference
Advances in targeting estrogen synthesis and receptors in patients with endometriosis
10.1080/13543784.2022.2152325 · 2022 · External reference
Ferroptosis turns 10: Emerging mechanisms, physiological functions, and therapeutic applications
10.1016/j.cell.2022.06.003 · 2022 · External reference
NOX4 promotes ferroptosis of astrocytes by oxidative stress-induced lipid peroxidation via the impairment of mitochondrial metabolism in Alzheimer’s diseases
10.1016/j.redox.2021.101947 · 2021 · External reference
Systematic analysis of the aberrances and functional implications of ferroptosis in cancer
10.1016/j.isci.2020.101302 · 2020 · External reference
A targetable CoQ-FSP1 axis drives ferroptosis- and radiation-resistance in KEAP1 inactive lung cancers
10.1038/s41467-022-29905-1 · 2022 · External reference
Endometriosis: The role of iron overload and ferroptosis
10.1007/s43032-020-00164-z · 2020 · External reference
AMPK regulates NADPH homeostasis to promote tumor cell survival during energy
10.1038/nature11066 · 2012 · External reference
Acetyl-CoA carboxylase 1-dependent protein acetylation controls breast cancer
10.1016/j.cmet.2017.09.018 · 2017 · External reference
Emerging targets in lipid metabolism for cancer therapy
10.1016/j.tips.2024.04.007 · 2024 · External reference
Ferroptosis at the intersection of lipid metabolism and cellular signaling
10.1016/j.molcel.2022.03.022 · 2022 · External reference
Global survey of cell death mechanisms reveals metabolic regulation of ferroptosis
10.1038/nchembio.2079 · 2016 · External reference
Human haploid cell genetics reveals roles for lipid metabolism genes in nonapoptotic cell Death
10.1021/acschembio.5b00245 · 2015 · External reference
Energy-stress-mediated AMPK activation inhibits ferroptosis
10.1038/s41556-020-0461-8 · 2020 · External reference
LKB1-AMPK axis negatively regulates ferroptosis by inhibiting fatty acid synthesis
10.1038/s41392-020-00297-2 · 2020 · External reference
The role of AMP-activated protein kinase in oxytosis/ferroptosis: Protector or potentiator?
10.1089/ars.2022.0013 · 2022 · External reference
Pharmacological inhibition of NOX4 improves mitochondrial function and survival in human beta-cells
10.3390/biomedicines9121865 · 2021 · External reference
Cooperation between CYB5R3 and NOX4 via coenzyme Q mitigates endothelial inflammation
10.1016/j.redox.2021.102166 · 2021 · External reference
Mitochondria and oxidative stress in ovarian endometriosis
10.1016/j.freeradbiomed.2019.03.027 · 2019 · External reference
Erastin induces ferroptosis via ferroportin-mediated iron accumulation in endometriosis
10.1093/humrep/deaa363 · 2021 · External reference
Silencing of lncRNA MALAT1 facilitates erastin-induced ferroptosis in endometriosis through miR-145-5p/MUC1 signaling
10.1038/s41420-022-00975-w · 2022 · External reference
Macrophages originated IL-33/ST2 inhibits ferroptosis in endometriosis via the ATF3/SLC7A11 axis
10.1038/s41419-023-06182-4 · 2023 · External reference
Isolation, characterization, and comparison of human endometrial and endometriosis cells in vitro
1994 · External reference
ERβ-activated LINC01018 promotes endometriosis development by regulating the CDC25C/CDK1/CyclinB1 pathway
10.1016/j.jgg.2023.12.012 · 2024 · External reference
The Hippo Pathway Effector TAZ Regulates Ferroptosis in Renal Cell Carcinoma
10.1016/j.celrep.2019.07.107 · 2019 · External reference
Endometrial ability to implant in ectopic sites can be prevented by interleukin-12 in a murine model of endometriosis
10.1093/humrep/14.12.2944 · 1999 · External reference
Establishment of endometriotic models: The past and future
10.1097/cm9.0000000000000885 · 2020 · External reference
The interaction between ferroptosis and lipid metabolism in cancer
10.1038/s41392-020-00216-5 · 2020 · External reference
FerrDb V2: Update of the manually curated database of ferroptosis regulators and ferroptosis-disease associations
10.1093/nar/gkac935 · 2023 · External reference
Melatonin, a potentially effective drug for the treatment of infected bone nonunion
10.1111/jpi.12914 · 2024 · External reference
TLR4-induced NF-κB and MAPK signaling regulate the IL-6 mRNA stabilizing protein Arid5a
10.1093/nar/gkx064 · 2017 · External reference
Osteoporotic bone loss from excess iron accumulation is driven by NOX4-triggered ferroptosis in osteoblasts
10.1016/j.freeradbiomed.2023.01.026 · 2023 · External reference
Fin56-induced ferroptosis is supported by autophagy-mediated GPX4 degradation and functions synergistically with mTOR inhibition to kill bladder cancer cells
10.1038/s41419-021-04306-2 · 2021 · External reference
Endometriosis and adenomyosis: Shared pathophysiology
10.1016/j.fertnstert.2023.03.006 · 2023 · External reference
Intercellular interaction dictates cancer cell ferroptosis via NF2-YAP signalling
10.1038/s41586-019-1426-6 · 2019 · External reference
Adverse effects of ferroptotic therapy: Mechanisms and management
10.1016/j.trecan.2024.01.002 · 2024 · External reference
Ferroptosis in cancer therapy: A novel approach to reversing drug resistance
10.1186/s12943-022-01530-y · 2022 · External reference
Double-edged roles of ferroptosis in endometriosis and endometriosis-related infertility
10.1038/s41420-023-01606-8 · 2023 · External reference
The role of iron in the pathogenesis of endometriosis: A systematic review
10.1093/hropen/hoad033 · 2023 · External reference
Endometrial stromal cell autophagy-dependent ferroptosis caused by iron overload in ovarian endometriosis is inhibited by the ATF4-xCT pathway
10.1093/molehr/gaad046 · 2023 · External reference
Upregulated fibulin-1 increased endometrial stromal cell viability and migration by repressing EFEMP1-dependent ferroptosis in endometriosis
10.1155/2022/4809415 · 2022 · External reference
Long noncoding RNA ADAMTS9-AS1 represses ferroptosis of endometrial stromal cells by regulating the miR-6516-5p/GPX4 axis in endometriosis
10.1038/s41598-022-04963-z · 2022 · External reference
Deferoxamine mitigates ferroptosis and inflammation in hippocampal neurons after subarachnoid hemorrhage by activating the Nrf2/TXNRD1 axis
10.1007/s12035-023-03525-2 · 2023 · External reference
Acetyl-CoA metabolism in cancer
10.1038/s41568-022-00543-5 · 2023 · External reference
Inhibition of acetyl-CoA carboxylase by phosphorylation or the inhibitor ND-654
10.1016/j.cmet.2018.08.020 · 2019 · External reference
Association between endometriosis and cancer: A comprehensive review and a critical analysis of clinical and epidemiological evidence
10.1016/j.ygyno.2005.11.033 · 2006 · External reference
Ferroptosis: An iron-dependent form of nonapoptotic cell death
10.1016/j.cell.2012.03.042 · 2012 · External reference
The NOX family of ROS-generating NADPH oxidases: Physiology and pathophysiology
10.1152/physrev.00044.2005 · 2007 · External reference
The double-edged roles of ROS in cancer prevention and therapy
10.7150/thno.56747 · 2021 · External reference
NADPH-oxidases as potential pharmacological targets for thrombosis and depression comorbidity
10.1016/j.redox.2024.103060 · 2024 · External reference
NADPH oxidases in neurodegenerative disorders: Mechanisms and therapeutic opportunities
10.1089/ars.2023.0002 · 2024 · External reference
Targeting oxidative stress involved in endometriosis and its pain
10.3390/biom12081055 · 2022 · External reference
Increased genomic instability and reshaping of tissue microenvironment underlie oncogenic properties of Arid1a mutations
10.1126/sciadv.adh4435 · 2024 · External reference
ARID1A mutations in lung cancer: Biology, prognostic role, and therapeutic implications
10.1016/j.molmed.2023.04.005 · 2023 · External reference
Cancer-associated mutations in endometriosis without cancer
10.1056/nejmoa1614814 · 2017 · External reference
Single-cell transcriptomic analysis of endometriosis
10.1038/s41588-022-01254-1 · 2023 · External reference
Recent advances in the role of Arid5a in immune diseases and cancer
2021 · External reference
Arid5a, an RNA-binding protein in immune regulation: RNA stability, inflammation, and autoimmunity
10.1016/j.it.2020.01.004 · 2020 · External reference
Arid5a promotes immune evasion by augmenting tryptophan metabolism and chemokine expression
10.1158/2326-6066.cir-21-0014 · 2021 · External reference
Reprogramming of tumor-associated macrophages by targeting β-catenin/FOSL2/ARID5A signaling: A potential treatment of lung cancer
10.1126/sciadv.aaz6105 · 2020 · External reference
Expression and prognostic values of ARID family members in breast cancer
10.18632/aging.202489 · 2021 · External reference
Feedback regulation of Arid5a and Ppar-γ2 maintains adipose tissue homeostasis
10.1073/pnas.1906712116 · 2019 · External reference
Iron storage is significantly increased in peritoneal macrophages of endometriosis patients and correlates with iron overload in peritoneal fluid
10.1016/j.fertnstert.2008.02.103 · 2009 · External reference
Lysophosphatidyl choline, a chemotactic factor for monocytes/T-lymphocytes is elevated in endometriosis
10.1210/jcem.83.6.4823 · 1998 · External reference
Ferroptosis resistance mechanisms in endometriosis for diagnostic model establishment
10.1016/j.rbmo.2021.04.002 · 2021 · External reference
Endometrial stromal cell ferroptosis promotes angiogenesis in endometriosis
10.1038/s41420-022-00821-z · 2022 · External reference