Research graph
References from Application of hydrogel technologies in the treatment of musculoskeletal disorders. Local targets link to admitted publications; unresolved targets remain external evidence.
Nanoclay reinforced biomaterials for mending musculoskeletal tissue disorders
10.1002/adhm.202100217 · 2021 · External reference
Enhanced tendon healing by a tough hydrogel with an adhesive side and high drug-loading capacity
10.1038/s41551-021-00810-0 · 2022 · External reference
Recent advances in GelMA hydrogel transplantation for musculoskeletal disorders and related disease treatment
10.7150/thno.80615 · 2023 · External reference
Bone regeneration strategies: Engineered scaffolds, bioactive molecules and stem cells current stage and future perspectives
10.1016/j.biomaterials.2018.07.017 · 2018 · External reference
Bone development and regeneration 2.0
10.3390/ijms24108761 · 2023 · External reference
Continuously released Zn(2+) in 3D-printed PLGA/beta-TCP/Zn scaffolds for bone defect repair by improving osteoinductive and anti-inflammatory properties
2023 · External reference
Active magnesium boride/alginate hydrogels rejuvenate senescent cells
10.1021/acsnano.4c07833 · 2024 · External reference
Enriched mesoporous bioactive glass scaffolds as bone substitutes in critical diaphyseal bone defects in rabbits
10.1016/j.actbio.2024.04.005 · 2024 · External reference
Extracellular and intracellular effects of bioactive glass nanoparticles on osteogenic differentiation of bone marrow mesenchymal stem cells and bone regeneration in zebrafish osteoporosis model
10.1016/j.actbio.2023.11.037 · 2024 · External reference
Rejuvenating aged bone repair through multihierarchy reactive oxygen species-regulated hydrogel
2023 · External reference
Peptide-functionalized double network hydrogel with compressible shape memory effect for intervertebral disc regeneration
10.1002/btm2.10447 · 2023 · External reference
Hydrogels and hydrogel nanocomposites: Enhancing healthcare through human and environmental treatment
10.1002/adhm.202101820 · 2022 · External reference
Graphene oxide-doped gellan gum-PEGDA bilayered hydrogel mimicking the mechanical and lubrication properties of articular cartilage
10.1002/adhm.202001434 · 2021 · External reference
Collagen hydrogel viscoelasticity regulates MSC chondrogenesis in a ROCK-dependent manner
10.1126/sciadv.ade9497 · 2023 · External reference
Materials design for bone-tissue engineering
10.1038/s41578-020-0204-2 · 2020 · External reference
The decisive early phase of bone regeneration
10.1038/s41584-022-00887-0 · 2023 · External reference
Guided bone regeneration in long-bone defect with a bilayer mineralized collagen membrane
10.1186/s42825-023-00144-4 · 2023 · External reference
Recent advances in PLGA-based biomaterials for bone tissue regeneration
10.1016/j.actbio.2021.03.067 · 2021 · External reference
Scaffold fabrication technologies and structure/function properties in bone tissue engineering
10.1002/adfm.202010609 · 2021 · External reference
Recent advances in design of functional biocompatible hydrogels for bone tissue engineering
10.1002/adfm.202009432 · 2021 · External reference
3D printing of microenvironment-specific bioinspired and exosome-reinforced hydrogel scaffolds for efficient cartilage and subchondral bone regeneration
2023 · External reference
Double-network DNA macroporous hydrogel enables aptamer-directed cell recruitment to accelerate bone healing
2023 · External reference
Injectable hydrogel with NIR light-responsive, dual-mode PTH release for osteoregeneration in osteoporosis
10.1002/adfm.202105383 · 2021 · External reference
A MnO2 nanosheets doping double crosslinked hydrogel for cartilage defect repair through alleviating inflammation and guiding chondrogenic differentiation
10.1016/j.biomaterials.2024.122875 · 2025 · External reference
Smart responsive in situ hydrogel systems applied in bone tissue engineering
10.3389/fbioe.2024.1389733 · 2024 · External reference
Silk-fabric reinforced silk for artificial bones
10.1002/adma.202308748 · 2024 · External reference
Hydrogels for ameliorating osteoarthritis: Mechanical modulation, anti-inflammation, and regeneration
10.1002/bmm2.12078 · 2024 · External reference
Bone repair biomaterials: A perspective from immunomodulation
10.1002/adfm.202208639 · 2022 · External reference
Rational design of multifunctional CuS nanoparticle-PEG composite soft hydrogel-coated 3D hard polycaprolactone scaffolds for efficient bone regeneration
10.1002/adfm.202202470 · 2022 · External reference
In situ deposition of drug and gene nanoparticles on a patterned supramolecular hydrogel to construct a directionally osteochondral plug
10.1007/s40820-023-01228-w · 2023 · External reference
Homogeneous “hard-soft” biphasic bone adhesives promote comminuted fracture healing through interfacial adaptation and mechanical property maintenance
10.1002/adma.202502598 · 2025 · External reference
Injectable and biodegradable piezoelectric hydrogel for osteoarthritis treatment
10.1038/s41467-023-41594-y · 2023 · External reference
Injectable bottlebrush hydrogels with tissue-mimetic mechanical properties
10.1126/sciadv.abm2469 · 2022 · External reference
Simultaneous nano- and microscale structural control of injectable hydrogels via the assembly of nanofibrous protein microparticles for tissue regeneration
10.1016/j.biomaterials.2019.119458 · 2019 · External reference
A natural polymer-based hydrogel with shape controllability and high toughness and its application to efficient osteochondral regeneration
10.1039/d3mh00544e · 2023 · External reference
Nanoclay gels attenuate BMP2-associated inflammation and promote chondrogenesis to enhance BMP2-spinal fusion
2025 · External reference
Engineering large-scale self-mineralizing bone organoids with bone matrix-inspired hydroxyapatite hybrid bioinks
2024 · External reference
Thermosensitive hydrogel based on PEO–PPO–PEO poloxamers for a controlled in situ release of recombinant adeno-associated viral vectors for effective gene therapy of cartilage defects
2019 · External reference
High-strength, biomimetic functional chitosan-based hydrogels for full-thickness osteochondral defect repair
10.1021/acsbiomaterials.2c00187 · 2022 · External reference
Full-thickness osteochondral defect repair using a biodegradable bilayered scaffold of porous zinc and chondroitin sulfate hydrogel
2024 · External reference
Ultra-durable cell-free bioactive hydrogel with fast shape memory and on-demand drug release for cartilage regeneration
10.1038/s41467-023-43334-8 · 2023 · External reference
Osteoarthritis
10.1016/s0140-6736(14)60802-3 · 2015 · External reference
Osteoarthritis
10.1016/s0140-6736(19)30417-9 · 2019 · External reference
Microenvironment in subchondral bone: Predominant regulator for the treatment of osteoarthritis
10.1136/annrheumdis-2020-218089 · 2021 · External reference
Molecular co-assembled strategy tuning protein conformation for cartilage regeneration
10.1038/s41467-024-45703-3 · 2024 · External reference
Injectable hydrogels for cartilage and bone tissue engineering
10.1038/boneres.2017.14 · 2017 · External reference
Biodegradable piezoelectric-conductive integrated hydrogel scaffold for repair of osteochondral defects
2024 · External reference
3D bioprinting of heterogeneous constructs providing tissue-specific microenvironment based on host–guest modulated dynamic hydrogel bioink for osteochondral regeneration
10.1002/adfm.202200710 · 2022 · External reference
Adhesive hydrogels in osteoarthritis: From design to application
2023 · External reference
Injectable nanocomposite hydrogels with enhanced lubrication and antioxidant properties for the treatment of osteoarthritis
2024 · External reference
Advanced application of stimuli-responsive drug delivery system for inflammatory arthritis treatment
2022 · External reference
Living and injectable porous hydrogel microsphere with paracrine activity for cartilage regeneration
2023 · External reference
Dome-arrayed chitosan/PVA hydrogel-based solar evaporator for steam generation
10.1038/s41598-022-08589-z · 2022 · External reference
Hydrogel composite mimics biological tissues
10.1039/d2sm00505k · 2022 · External reference
Small extracellular vesicles in combination with sleep-related circRNA3503: A targeted therapeutic agent with injectable thermosensitive hydrogel to prevent osteoarthritis
2021 · External reference
Polyphosphazene-based biomaterials for biomedical applications
10.3390/ijms232415993 · 2022 · External reference
Precise cell type electrical stimulation therapy via force-electric hydrogel microspheres for cartilage healing
2024 · External reference
Nanoarchitectonics of cartilage-targeting hydrogel microspheres with reactive oxygen species responsiveness for the repair of osteoarthritis
10.1021/acsami.2c12703 · 2022 · External reference
Dual-functional injectable hydrogel for osteoarthritis treatments
10.1002/adhm.202302551 · 2024 · External reference
Transporting hydrogel via Chinese acupuncture needles for lesion positioning therapy
10.1002/advs.202200079 · 2022 · External reference
A microneedle platform Co-encapsulating chondral organoids and PpIX for spatiotemporally orchestrated tumor ablation and osteochondral regeneration
2026 · External reference
Intervertebral disc transplantation in the treatment of degenerative spine disease: A preliminary study
10.1016/s0140-6736(07)60496-6 · 2007 · External reference
Fusion surgery for lumbar degenerative disc disease: Still more questions than answers
10.1016/j.spinee.2014.11.004 · 2015 · External reference
Polyphenol-mediated adhesive and anti-inflammatory double-network hydrogels for repairing postoperative intervertebral disc defects
10.1021/acsami.4c11901 · 2024 · External reference
Cutting-edge biomaterials in intervertebral disc degeneration tissue engineering
10.3390/pharmaceutics16080979 · 2024 · External reference
In vitro characterization and in vivo behavior of human nucleus pulposus and annulus fibrosus cells in clinical-grade fibrin and collagen-enriched fibrin gels
10.1089/ten.tea.2014.0279 · 2015 · External reference
Enhancing cell seeding and osteogenesis of MSCs on 3D printed scaffolds through injectable BMP2 immobilized ECM-mimetic gel
10.1016/j.dental.2019.04.004 · 2019 · External reference
Synthesis, properties, and biomedical applications of gelatin methacryloyl (GelMA) hydrogels
10.1016/j.biomaterials.2015.08.045 · 2015 · External reference
Investigating the morphological, mechanical and degradation properties of scaffolds comprising collagen, gelatin and elastin for use in soft tissue engineering
10.1016/j.jmbbm.2012.02.028 · 2012 · External reference
Fibronectin promotes elastin deposition, elasticity and mechanical strength in cellularised collagen-based scaffolds
10.1016/j.biomaterials.2018.07.013 · 2018 · External reference
Development of GelMA/PCL and dECM/PCL resins for 3D printing of acellular in vitro tissue scaffolds by stereolithography
10.1016/j.msec.2020.110958 · 2020 · External reference
Mitochondria-engine with self-regulation to restore degenerated intervertebral disc cells via bioenergetic robust hydrogel design
2024 · External reference
Self-healing hydrogels loaded with Spatholobi Caulis alleviate disc degeneration by promoting autophagy in nucelus pulposus
2024 · External reference
Repair of degenerative nucleus pulposus by polyphenol nanosphere-encapsulated hydrogel gene delivery system
10.1016/j.biomaterials.2023.122132 · 2023 · External reference
Enzymatically bioactive nucleus pulposus matrix hydrogel microspheres for exogenous stem cells therapy and endogenous repair strategy to achieve disc regeneration
10.1002/advs.202304761 · 2024 · External reference
Cartilage endplate-targeted engineered exosome releasing and acid neutralizing hydrogel reverses intervertebral disc degeneration
2024 · External reference
M2 macrophage-derived small extracellular vesicles ameliorate pyroptosis and intervertebral disc degeneration
10.34133/bmr.0047 · 2024 · External reference
A nucleobase-driven self-gelled hyaluronic acid-based injectable adhesive hydrogel enhances intervertebral disc repair
2024 · External reference
An anti-senescence hydrogel with pH-responsive drug release for mitigating intervertebral disc degeneration and low back pain
2024 · External reference
Oxygen-controllable injectable hydrogel alleviates intervertebral disc degeneration by balancing extracellular matrix metabolism
2024 · External reference
A one-stone-two-birds strategy for intervertebral disc repair: Constructing a reductive chelation hydrogel to mitigate oxidative stress and promote disc matrix reconstruction
2024 · External reference
Magnetically attracting hydrogel reshapes iron metabolism for tissue repair
2024 · External reference
Paravertebrally-injected multifunctional hydrogel for sustained anti-inflammation and pain relief in lumbar disc herniation
10.1002/adhm.202401227 · 2024 · External reference
Hydrogel augmentation of the lumbar intervertebral disc: An early feasibility study of a treatment for discogenic low back pain
10.1016/j.jvir.2023.09.018 · 2024 · External reference
Influence of cuff muscle fatty degeneration on anatomic and functional outcomes after simple suture of full-thickness tears
10.1016/s1058-2746(03)00211-8 · 2003 · External reference
Biomimetic glycosaminoglycan-based scaffolds improve skeletal muscle regeneration in a murine volumetric muscle loss model
2021 · External reference
Sandwich biomimetic scaffold based tendon stem/progenitor cell alignment in a 3D microenvironment for functional tendon regeneration
10.1021/acsami.2c16584 · 2023 · External reference
Engineering tendon assembloids to probe cellular crosstalk in disease and repair
10.3791/65987 · 2024 · External reference
High-strength fiber-reinforced composite hydrogel scaffolds as biosynthetic tendon graft material
10.1021/acsbiomaterials.9b01716 · 2020 · External reference
Biocompatibility of a marine collagen-based scaffold in vitro and in vivo
10.3390/md18080420 · 2020 · External reference
Augmentation of tendon and ligament repair with fiber-reinforced hydrogel composites
10.1002/adhm.202400668 · 2024 · External reference
Tough and tunable scaffold-hydrogel composite biomaterial for soft-to-hard musculoskeletal tissue interfaces
10.1126/sciadv.abb6763 · 2020 · External reference
Motion lubrication suppressed mechanical activation via hydrated fibrous gene patch for tendon healing
10.1126/sciadv.adc9375 · 2023 · External reference
Bioactive fiber-reinforced hydrogel to tailor cell microenvironment for structural and functional regeneration of myotendinous junction
10.1126/sciadv.adm7164 · 2024 · External reference
Instantaneous self-healing and strongly adhesive self-adaptive hyaluronic acid-based hydrogel for controlled drug release to promote tendon wound healing
2023 · External reference
Programmable DNA hydrogel provides suitable microenvironment for enhancing TSPCS therapy in healing of tendinopathy
10.1002/smll.202207231 · 2023 · External reference
Thermosensitive chitosan-gelatin-glycerol phosphate hydrogels as collagenase carrier for tendon-bone healing in a rabbit model
10.3390/polym12020436 · 2020 · External reference
Evaluating the efficacy of a thermoresponsive hydrogel for delivering anti-collagen antibodies to reduce posttraumatic scarring in orthopedic tissues
10.3390/gels9120971 · 2023 · External reference
Thermosensitive hydrogel harboring cd146/igf-1 nanoparticles for skeletal-muscle regeneration
10.1021/acsabm.1c00688 · 2021 · External reference
Cocktail-like gradient gelatin/hyaluronic acid bioimplant for enhancing tendon-bone healing in fatty-infiltrated rotator cuff injury models
10.1016/j.ijbiomac.2023.125421 · 2023 · External reference
A multi-functional SiO(3)(2-)-releasing hydrogel with bioinspired mechanical properties and biodegradability for vascularized skeletal muscle regeneration
10.1039/d2tb00388k · 2022 · External reference
Contactless magnetically responsive injectable hydrogel for aligned tissue regeneration
2024 · External reference
A mesoporous silica-loaded multi-functional hydrogel enhanced tendon healing via immunomodulatory and pro-regenerative effects
2024 · External reference
Injectable tissue prosthesis for instantaneous closed-loop rehabilitation
10.1038/s41586-023-06628-x · 2023 · External reference
Wet tissue adhesive polymeric powder hydrogels for skeletal muscle regeneration
2024 · External reference
Dual-targeted metal ion network hydrogel scaffold for promoting the integrated repair of tendon-bone interfaces
10.1021/acsami.3c16544 · 2024 · External reference
Risk factors for readmission with cerebrospinal fluid leakage within 30 days of vestibular schwannoma surgery
10.1093/neuros/nyx197 · 2018 · External reference
Full endoscopic treatment of dural tears in lumbar spine surgery
10.1007/s00586-017-5105-8 · 2017 · External reference
Repair of dural defects with electrospun bacterial cellulose membranes in a rabbit experimental model
10.1016/j.msec.2020.111246 · 2020 · External reference
Polymeric tissue adhesives
10.1021/acs.chemrev.0c00798 · 2021 · External reference
From adhesion to detachment: Strategies to design tissue-adhesive hydrogels
2023 · External reference
A Janus hydrogel sealant with instant wet adhesion and anti-swelling behavior for gastric perforation repair
10.1016/j.nantod.2023.102105 · 2024 · External reference
Recent advances in wet adhesives: Adhesion mechanism, design principle and applications
10.1016/j.progpolymsci.2021.101388 · 2021 · External reference
Controlled tough bioadhesion mediated by ultrasound
10.1126/science.abn8699 · 2022 · External reference
A nonswelling hydrogel with regenerable high wet tissue adhesion for bioelectronics
10.1002/adma.202212302 · 2023 · External reference
Designing nanohesives for rapid, universal, and robust hydrogel adhesion
10.1038/s41467-023-40753-5 · 2023 · External reference
Tough adhesion enhancing strategies for injectable hydrogel adhesives in biomedical applications
10.1016/j.cis.2023.102982 · 2023 · External reference
Injectable, antioxidative, and tissue-adhesive nanocomposite hydrogel as a potential treatment for inner retina injuries
2024 · External reference
A low-swelling hydrogel as a multirole sealant for efficient dural defect sealing and prevention of postoperative adhesion
10.1093/nsr/nwae160 · 2024 · External reference
An injectable rapid-adhesion and anti-swelling adhesive hydrogel for hemostasis and wound sealing
2022 · External reference
High efficacy of tetra-PEG hydrogel sealants for sutureless dural closure
2022 · External reference
A mechanically resilient and tissue-conformable hydrogel with hemostatic and antibacterial capabilities for wound care
10.1002/advs.202303651 · 2023 · External reference
Dry double-sided tape for adhesion of wet tissues and devices
10.1038/s41586-019-1710-5 · 2019 · External reference
An ultrasoft self-fused supramolecular polymer hydrogel for completely preventing postoperative tissue adhesion
10.1002/adma.202008395 · 2021 · External reference
A tough bioadhesive hydrogel supports sutureless sealing of the dural membrane in porcine and ex vivo human tissue
10.1126/scitranslmed.adj0616 · 2024 · External reference
A hydrogel spinal dural patch with potential anti-inflammatory, pain relieving and antibacterial effects
2022 · External reference
A dynamically adaptive wet-adhesive Janus hydrogel patch for sutureless repair of spinal dural defects
2026 · External reference
A pivotal randomized clinical trial evaluating the safety and effectiveness of a novel hydrogel dural sealant as an adjunct to dural repair
10.1093/ons/opw004 · 2017 · External reference
