Research graph
References from Advancements and future directions in transforming therapies of prostate cancer. Local targets link to admitted publications; unresolved targets remain external evidence.
Abiraterone and increased survival in metastatic prostate cancer
10.1056/nejmoa1014618 · 2011 · External reference
Increased survival with enzalutamide in prostate cancer after chemotherapy
10.1056/nejmoa1207506 · 2012 · External reference
Apalutamide treatment and metastasis-free survival in prostate cancer
10.1056/nejmoa1715546 · 2018 · External reference
Darolutamide in nonmetastatic, castration-resistant prostate cancer
10.1056/nejmoa1815671 · 2019 · External reference
Rezvilutamide versus bicalutamide in combination with androgen-deprivation therapy in patients with high-volume, metastatic, hormone-sensitive prostate cancer (CHART): A randomised, open-label, phase 3 trial
10.1016/s1470-2045(22)00507-1 · 2022 · External reference
Olaparib for metastatic castration-resistant prostate cancer
10.1056/nejmoa1911440 · 2020 · External reference
Niraparib plus abiraterone acetate with prednisone in patients with metastatic castration-resistant prostate cancer and homologous recombination repair gene alterations: Second interim analysis of the randomized phase III MAGNITUDE trial
10.1016/j.annonc.2023.06.009 · 2023 · External reference
Talazoparib plus enzalutamide in men with first-line metastatic castration-resistant prostate cancer (TALAPRO-2): A randomised, placebo-controlled, phase 3 trial
10.1016/s0140-6736(23)01055-3 · 2023 · External reference
Rucaparib or physician’s choice in metastatic prostate cancer
10.1056/nejmoa2214676 · 2023 · External reference
CONTACT-2: Phase 3 study of cabozantinib (C) plus atezolizumab (A) vs second novel hormonal therapy (NHT) in patients (pts) with metastatic castration-resistant prostate cancer (mCRPC)
10.1200/jco.2024.42.4_suppl.18 · 2024 · External reference
PARP and CDK4/6 inhibitor combination therapy induces apoptosis and suppresses neuroendocrine differentiation in prostate cancer
10.1158/1535-7163.mct-20-0848 · 2021 · External reference
Pan-AKT inhibitor capivasertib with docetaxel and prednisolone in metastatic castration-resistant prostate cancer: A randomized, placebo-controlled phase II trial (ProCAID)
10.1200/jco.20.01576 · 2021 · External reference
Ipatasertib plus abiraterone and prednisolone in metastatic castration-resistant prostate cancer (IPATential150): A multicentre, randomised, double-blind, phase 3 trial
10.1016/s0140-6736(21)00580-8 · 2021 · External reference
An operational definition of epigenetics
10.1101/gad.1787609 · 2009 · External reference
LBA69 Prostate cancer efficacy results from a randomised phase III evaluation of transdermal oestradiol (tE2) versus luteinising hormone releasing hormone agonists (LHRHa) for androgen suppression in non-metastatic (M0) prostate cancer
10.1016/j.annonc.2024.08.2312 · 2024 · External reference
Treatment of mCRPC in the AR-axis-targeted therapy-resistant state
10.1093/annonc/mdv267 · 2015 · External reference
The role of CYP17A1 in prostate cancer development: Structure, function, mechanism of action, genetic variations and its inhibition
10.4149/gpb_2017024 · 2017 · External reference
The role of ketoconazole in current prostate cancer care
10.1038/s41585-018-0077-y · 2018 · External reference
Phase III, randomized, double-blind, multicenter trial comparing orteronel (TAK-700) plus prednisone with placebo plus prednisone in patients with metastatic castration-resistant prostate cancer that has progressed during or after docetaxel-based therapy: ELM-PC 5
10.1200/jco.2014.56.5119 · 2015 · External reference
Abiraterone acetate for treatment of metastatic castration-resistant prostate cancer: Final overall survival analysis of the COU-AA-301 randomised, double-blind, placebo-controlled phase 3 study
10.1016/s1470-2045(12)70379-0 · 2012 · External reference
Abiraterone in metastatic prostate cancer without previous chemotherapy
10.1056/nejmoa1209096 · 2013 · External reference
Abiraterone acetate plus prednisone versus placebo plus prednisone in chemotherapy-naive men with metastatic castration-resistant prostate cancer (COU-AA-302): Final overall survival analysis of a randomised, double-blind, placebo-controlled phase 3 study
10.1016/s1470-2045(14)71205-7 · 2015 · External reference
Abiraterone for prostate cancer not previously treated with hormone therapy
10.1056/nejmoa1702900 · 2017 · External reference
Abiraterone acetate plus prednisone in patients with newly diagnosed high-risk metastatic castration-sensitive prostate cancer (LATITUDE): Final overall survival analysis of a randomised, double-blind, phase 3 trial
10.1016/s1470-2045(19)30082-8 · 2019 · External reference
Abiraterone plus prednisone added to androgen deprivation therapy and docetaxel in de novo metastatic castration-sensitive prostate cancer (PEACE-1): A multicentre, open-label, randomised, phase 3 study with a 2 × 2 factorial design
10.1016/s0140-6736(22)00367-1 · 2022 · External reference
Enzalutamide in metastatic prostate cancer before chemotherapy
10.1056/nejmoa1405095 · 2014 · External reference
Enzalutamide in men with nonmetastatic, castration-resistant prostate cancer
10.1056/nejmoa1800536 · 2018 · External reference
Enzalutamide and survival in nonmetastatic, castration-resistant prostate cancer
10.1056/nejmoa2003892 · 2020 · External reference
ARCHES: A randomized, phase III study of androgen deprivation therapy with enzalutamide or placebo in men with metastatic hormone-sensitive prostate cancer
10.1200/jco.19.00799 · 2019 · External reference
LBA25 Final overall survival (OS) analysis from ARCHES: A phase III, randomized, double-blind, placebo (PBO)-controlled study of enzalutamide (ENZA)+ androgen deprivation therapy (ADT) in men with metastatic hormone-sensitive prostate cancer (mHSPC)
10.1016/j.annonc.2021.08.2101 · 2021 · External reference
Enzalutamide with standard first-line therapy in metastatic prostate cancer
10.1056/nejmoa1903835 · 2019 · External reference
Updated overall survival outcomes in ENZAMET (ANZUP 1304), an international, cooperative group trial of enzalutamide in metastatic hormone-sensitive prostate cancer (mHSPC)
10.1200/jco.2022.40.17_suppl.lba5004 · 2022 · External reference
Improved outcomes with enzalutamide in biochemically recurrent prostate cancer
10.1056/nejmoa2303974 · 2023 · External reference
Effect of apalutamide on health-related quality of life in patients with non-metastatic castration-resistant prostate cancer: An analysis of the SPARTAN randomised, placebo-controlled, phase 3 trial
10.1016/s1470-2045(18)30456-x · 2018 · External reference
Apalutamide for metastatic, castration-sensitive prostate cancer
10.1056/nejmoa1903307 · 2019 · External reference
Apalutamide in patients with metastatic castration-sensitive prostate cancer: Final survival analysis of the randomized, double-blind, phase III TITAN study
10.1200/jco.20.03488 · 2021 · External reference
Nonmetastatic, castration-resistant prostate cancer and survival with darolutamide
10.1056/nejmoa2001342 · 2020 · External reference
Darolutamide and survival in metastatic, hormone-sensitive prostate cancer
10.1056/nejmoa2119115 · 2022 · External reference
Darolutamide plus androgen-deprivation therapy and docetaxel in metastatic hormone-sensitive prostate cancer by disease volume and risk subgroups in the phase III ARASENS trial
10.1200/jco.23.00041 · 2023 · External reference
LBA68 Efficacy and safety of darolutamide plus androgen-deprivation therapy (ADT) in patients with metastatic hormone-sensitive prostate cancer (mHSPC) from the phase III ARANOTE trial
10.1016/j.annonc.2024.08.2311 · 2024 · External reference
Major adverse cardiovascular events of enzalutamide versus abiraterone in prostate cancer: A retrospective cohort study
10.1038/s41391-023-00757-0 · 2023 · External reference
Highly potent and selective nonsteroidal dual inhibitors of CYP17/CYP11B2 for the treatment of prostate cancer to reduce risks of cardiovascular diseases
10.1021/jm400484p · 2013 · External reference
599P A phase I dose-escalation study of LAE001/prednisone plus afuresertib in patients with metastatic castration-resistant prostate cancer (mCRPC) following standard of care (SOC) treatment
10.1016/j.annonc.2021.08.1112 · 2021 · External reference
1817P A phase I/II efficacy and safety study of LAE001/prednisone and afuresertib in patients with metastatic castration-resistant prostate cancer (mCRPC) following 1-3 lines of standard of care
10.1016/j.annonc.2023.09.2765 · 2023 · External reference
First-in-class small molecule to inhibit CYP11A1 and steroid hormone biosynthesis
10.1158/1535-7163.mct-22-0115 · 2022 · External reference
Phase 1 results of the ODM-208 first-in-human phase 1-2 trial in patients with metastatic castration-resistant prostate cancer (CYPIDES)
10.1200/jco.2022.40.6_suppl.018 · 2022 · External reference
1364MO Preliminary phase II results of the CYPIDES study of ODM-208 in metastatic castration-resistant prostate (mCRPC) cancer patients
10.1016/j.annonc.2022.07.1496 · 2022 · External reference
1605P Opevesostat (MK-5684/ODM-208), an oral CYP11A1 inhibitor, in metastatic castration-resistant prostate cancer (mCRPC): Updated CYPIDES phase II results
10.1016/j.annonc.2024.08.1686 · 2024 · External reference
Targeted inhibition of CYP11A1 in castration-resistant prostate cancer
2024 · External reference
MK-5684 (ODM-208), a CYP11A1 inhibitor, in patients with metastatic castration-resistant prostate cancer (mCRPC) with and without AR-LBD mutations: CYPIDES phase 2 results
10.1200/jco.2024.42.4_suppl.159 · 2024 · External reference
ODM-204, a novel dual inhibitor of CYP17A1 and androgen receptor: Early results from phase I dose escalation in men with castration-resistant prostate cancer
10.1016/j.euf.2018.08.022 · 2020 · External reference
Novel dual inhibitors of AR/AR variants and AKR1C3: Preclinical activities for advanced prostate cancer therapy
2024 · External reference
Targeting the N-terminal domain of the androgen receptor: A new approach for the treatment of advanced prostate cancer
10.1634/theoncologist.2016-0161 · 2016 · External reference
Intrinsic disorder in the androgen receptor: Identification, characterisation and drugability
10.1039/c1mb05249g · 2012 · External reference
EPI-001, A compound active against castration-resistant prostate cancer, targets transactivation unit 5 of the androgen receptor
10.1021/acschembio.6b00182 · 2016 · External reference
EPI-7386 is a novel N-terminal domain androgen receptor inhibitor for the treatment of prostate cancer
10.1093/annonc/mdz244.065 · 2019 · External reference
Comprehensive in vitro characterization of the mechanism of action of EPI-7386, an androgen receptor N-terminal domain inhibitor
10.1158/1538-7445.am2021-1209 · 2021 · External reference
Phase 1/2 study of EPI-7386 in combination with enzalutamide (enz) compared with enz alone in subjects with metastatic castration-resistant prostate cancer (mCRPC)
10.1200/jco.2023.41.6_suppl.179 · 2023 · External reference
1813P Phase I/II trial of oral EPI-7386 in combination with enzalutamide (enz) compared to enz alone in metastatic castration-resistant prostate cancer (mCRPC) subjects: Current phase I (PI) results
10.1016/j.annonc.2023.09.2761 · 2023 · External reference
Treatment of prostate cancers and kennedy’s disease by PROTAC-androgen receptor degradation
10.1021/acsmedchemlett.9b00115 · 2019 · External reference
Phase 1/2 study of ARV-110, an androgen receptor (AR) PROTAC degrader, in metastatic castration-resistant prostate cancer (mCRPC)
2022 · External reference
First-in-human phase 1 study of CC-94676, a first-in-class androgen receptor (AR) ligand-directed degrader (LDD), in patients (pts) with metastatic castration-resistant prostate cancer (mCRPC)
10.1200/jco.2024.42.4_suppl.134 · 2024 · External reference
ARV-766, a proteolysis targeting chimera (PROTAC) androgen receptor (AR) degrader, in metastatic castration-resistant prostate cancer (mCRPC): Initial results of a phase 1/2 study
10.1200/jco.2024.42.16_suppl.5011 · 2024 · External reference
Safety and clinical activity of BMS-986365 (CC-94676), a dual androgen receptor ligand-directed degrader and antagonist, in heavily pretreated patients with metastatic castration-resistant prostate cancer
10.1016/j.annonc.2024.09.005 · 2024 · External reference
Bipolar androgen therapy (BAT): A patient’s guide
10.1002/pros.24328 · 2022 · External reference
Bipolar androgen therapy: When excess fuel extinguishes the fire
10.3390/biomedicines11072084 · 2023 · External reference
Bipolar androgen therapy sensitizes castration-resistant prostate cancer to subsequent androgen receptor ablative therapy
10.1016/j.ejca.2020.11.043 · 2021 · External reference
A multicohort open-label phase II trial of bipolar androgen therapy in men with metastatic castration-resistant prostate cancer (RESTORE): A comparison of post-abiraterone versus post-enzalutamide cohorts
10.1016/j.eururo.2020.06.042 · 2021 · External reference
TRANSFORMER: A randomized phase II study comparing bipolar androgen therapy versus enzalutamide in asymptomatic men with castration-resistant metastatic prostate cancer
10.1200/jco.20.02759 · 2021 · External reference
Efficacy and safety of bipolar androgen therapy in castration-resistant prostate cancer following abiraterone or enzalutamide resistance: A systematic review
2022 · External reference
Optimal sequencing of enzalutamide and abiraterone acetate plus prednisone in metastatic castration-resistant prostate cancer: A multicentre, randomised, open-label, phase 2, crossover trial
10.1016/s1470-2045(19)30688-6 · 2019 · External reference
Efficacy of enzalutamide following abiraterone acetate in chemotherapy-naive metastatic castration-resistant prostate cancer patients
10.1016/j.eururo.2014.06.045 · 2015 · External reference
DNA damage and transcription stress
10.1016/j.molcel.2023.11.014 · 2024 · External reference
The multifaceted roles of PARP1 in DNA repair and chromatin remodelling
10.1038/nrm.2017.53 · 2017 · External reference
The long tail of oncogenic drivers in prostate cancer
10.1038/s41588-018-0078-z · 2018 · External reference
Integrative clinical genomics of advanced prostate cancer
10.1016/j.cell.2015.05.001 · 2015 · External reference
Survival with olaparib in metastatic castration-resistant prostate cancer
10.1056/nejmoa2022485 · 2020 · External reference
First-line combination treatment with PARP and androgen receptor-signaling inhibitors in HRR-deficient mCRPC: Applying clinical study findings to clinical practice in the United States
10.1016/j.ctrv.2024.102726 · 2024 · External reference
Androgen receptor inhibitor-induced “BRCAness” and PARP inhibition are synthetically lethal for castration-resistant prostate cancer
10.1126/scisignal.aam7479 · 2017 · External reference
Olaparib plus abiraterone versus placebo plus abiraterone in metastatic castration-resistant prostate cancer (PROpel): Final prespecified overall survival results of a randomised, double-blind, phase 3 trial
10.1016/s1470-2045(23)00382-0 · 2023 · External reference
1601P First results from ZZFIRST: A randomized phase II trial of enzalutamide (EZ) with or without talazoparib (TALA) in metastatic hormone-naïve prostate cancer (mHNPC)
10.1016/j.annonc.2024.08.1682 · 2024 · External reference
BRCAness revisited
10.1038/nrc.2015.21 · 2016 · External reference
DNA-repair defects and olaparib in metastatic prostate cancer
10.1056/nejmoa1506859 · 2015 · External reference
Talazoparib monotherapy in metastatic castration-resistant prostate cancer with DNA repair alterations (TALAPRO-1): An open-label, phase 2 trial
10.1016/s1470-2045(21)00376-4 · 2021 · External reference
Microenvironmentally responsive chemotherapeutic prodrugs and CHEK2 inhibitors self-assembled micelles: Protecting fertility and enhancing chemotherapy
2023 · External reference
ATM-inhibitor AZD1390 is a radiosensitizer for breast cancer CNS metastasis
10.1158/1078-0432.ccr-23-0290 · 2023 · External reference
Effect of cisplatin and gemcitabine with or without berzosertib in patients with advanced urothelial carcinoma: A phase 2 randomized clinical trial
10.1001/jamaoncol.2021.3441 · 2021 · External reference
Combination platinum-based and DNA damage response-targeting cancer therapy: Evolution and future directions
10.2174/0929867323666161214114948 · 2017 · External reference
PARP inhibitors combined with radiotherapy: Are we ready?
10.3389/fphar.2023.1234973 · 2023 · External reference
Inhibitors of immune checkpoints-PD-1, PD-L1, CTLA-4-new opportunities for cancer patients and a new challenge for internists and general practitioners
10.1007/s10555-021-09976-0 · 2021 · External reference
Randomized, double-blind, phase III trial of ipilimumab versus placebo in asymptomatic or minimally symptomatic patients with metastatic chemotherapy-naive castration-resistant prostate cancer
10.1200/jco.2016.69.1584 · 2017 · External reference
Ipilimumab versus placebo after radiotherapy in patients with metastatic castration-resistant prostate cancer that had progressed after docetaxel chemotherapy (CA184-043): A multicentre, randomised, double-blind, phase 3 trial
10.1016/s1470-2045(14)70189-5 · 2014 · External reference
Long-term complete remission with Ipilimumab in metastatic castrate-resistant prostate cancer: Case report of two patients
10.1186/s40425-017-0232-7 · 2017 · External reference
Final analysis of the Ipilimumab versus placebo following radiotherapy phase III trial in postdocetaxel metastatic castration-resistant prostate cancer identifies an excess of long-term survivors
10.1016/j.eururo.2020.07.032 · 2020 · External reference
Pembrolizumab for advanced prostate adenocarcinoma: Findings of the KEYNOTE-028 study
10.1093/annonc/mdy232 · 2018 · External reference
Pembrolizumab for treatment-refractory metastatic castration-resistant prostate cancer: Multicohort, open-label phase II KEYNOTE-199 study
10.1200/jco.19.01638 · 2020 · External reference
KEYNOTE-199 cohorts (C) 4 and 5: Phase II study of pembrolizumab (pembro) plus enzalutamide (enza) for enza-resistant metastatic castration-resistant prostate cancer (mCRPC)
10.1200/jco.2020.38.15_suppl.5543 · 2020 · External reference
Pembrolizumab plus olaparib for patients with previously treated and biomarker-unselected metastatic castration-resistant prostate cancer: The randomized, open-label, phase III KEYLYNK-010 trial
10.1200/jco.23.00233 · 2023 · External reference
1771MO Pembrolizumab (pembro) plus enzalutamide (enza) for patients (pts) with metastatic castration-resistant prostate cancer (mCRPC): Randomized double-blind phase III KEYNOTE-641 study
10.1016/j.annonc.2023.09.2721 · 2023 · External reference
Pembrolizumab plus docetaxel for patients with metastatic castration-resistant prostate cancer (mCRPC): Randomized, double-blind, phase 3 KEYNOTE-921 study
2023 · External reference
690TiP a phase III, randomized, double-blind trial of nivolumab or placebo combined with docetaxel for metastatic castration-resistant prostate cancer (mCRPC; CheckMate 7DX)
10.1016/j.annonc.2020.08.2084 · 2020 · External reference
Nivolumab plus docetaxel in patients with chemotherapy-naïve metastatic castration-resistant prostate cancer: Results from the phase II CheckMate 9KD trial
10.1016/j.ejca.2021.09.043 · 2022 · External reference
Atezolizumab with enzalutamide versus enzalutamide alone in metastatic castration-resistant prostate cancer: A randomized phase 3 trial
10.1038/s41591-021-01600-6 · 2022 · External reference
LBA67 Cabozantinib (C) plus atezolizumab (A) versus 2nd novel hormonal therapy (NHT) in patients (Pts) with metastatic castration-resistant prostate cancer (mCRPC): Final overall survival (OS) results of the phase III, randomized, CONTACT-02 study
10.1016/j.annonc.2024.08.2310 · 2024 · External reference
CCTG IND 232: A phase II study of durvalumab with or without tremelimumab in patients with metastatic castration resistant prostate cancer (mCRPC)
10.1093/annonc/mdz394.044 · 2019 · External reference
Combined CTLA-4 and PD-L1 blockade in patients with chemotherapy-naïve metastatic castration-resistant prostate cancer is associated with increased myeloid and neutrophil immune subsets in the bone microenvironment
10.1136/jitc-2021-002919 · 2021 · External reference
Nivolumab plus ipilimumab, with or without enzalutamide, in AR-V7-expressing metastatic castration-resistant prostate cancer: A phase-2 nonrandomized clinical trial
10.1002/pros.24110 · 2021 · External reference
Nivolumab plus ipilimumab for metastatic castration-resistant prostate cancer: preliminary analysis of patients in the CheckMate 650 trial
10.1016/j.ccell.2020.08.007 · 2020 · External reference
Nivolumab plus ipilimumab for the treatment of post-chemotherapy metastatic castration-resistant prostate cancer (mCRPC): Additional results from the randomized phase 2 CheckMate 650 trial
10.1200/jco.2023.41.6_suppl.22 · 2023 · External reference
Correlation of B7-H3 with androgen receptor, immune pathways and poor outcome in prostate cancer: An expression-based analysis
10.1038/pcan.2016.49 · 2017 · External reference
B7 score and T cell infiltration stratify immune status in prostate cancer
10.1136/jitc-2021-002455 · 2021 · External reference
Neoadjuvant enoblituzumab in localized prostate cancer: A single-arm, phase 2 trial
10.1038/s41591-023-02284-w · 2023 · External reference
A novel anti-B7-H3 × anti-CD3 bispecific antibody with potent antitumor activity
2022 · External reference
Targeting B7-H3 in prostate cancer: Preclinical proof of concept with MGC018, an investigational anti-B7-H3 antibody-drug conjugate
10.1158/1538-7445.am2022-330 · 2022 · External reference
1842TiP Phase II randomized trial of two dose levels of vobramitamab duocarmazine in participants with metastatic castration resistant prostate cancer (mCRPC; TAMARACK)
10.1016/j.annonc.2023.09.2790 · 2023 · External reference
B7-H3 specific CAR-T cells exhibit potent activity against prostate cancer
10.1038/s41420-023-01453-7 · 2023 · External reference
Rovalpituzumab tesirine, a DLL3-targeted antibody-drug conjugate, in recurrent small-cell lung cancer: A first-in-human, first-in-class, open-label, phase 1 study
10.1016/s1470-2045(16)30565-4 · 2017 · External reference
Delta-like protein 3 expression and therapeutic targeting in neuroendocrine prostate cancer
10.1126/scitranslmed.aav0891 · 2019 · External reference
Phase 1b study of tarlatamab, a half-life extended bispecific T-cell engager (HLE BiTE immune therapy) targeting DLL3, in de novo or treatment emergent neuroendocrine prostate cancer (NEPC)
2022 · External reference
PSMA-targeting TGFβ-insensitive armored CAR T cells in metastatic castration-resistant prostate cancer: A phase 1 trial
10.1038/s41591-022-01726-1 · 2022 · External reference
PSCA-CAR T cell therapy in metastatic castration-resistant prostate cancer: A phase 1 trial
10.1038/s41591-024-02979-8 · 2024 · External reference
EpCAM-targeting CAR-T cell immunotherapy is safe and efficacious for epithelial tumors
10.1126/sciadv.adg9721 · 2023 · External reference
Prospect of prostate cancer treatment: Armed CAR-T or combination therapy
10.3390/cancers14040967 · 2022 · External reference
Sipuleucel-T immunotherapy for castration-resistant prostate cancer
10.1056/nejmoa1001294 · 2010 · External reference
A phase 3 trial of GVAX immunotherapy for prostate cancer vs. docetaxel plus prednisone in asymptomatic, castration-resistant prostate cancer (CRPC)
2009 · External reference
Efficacy and safety of autologous dendritic cell-based immunotherapy, docetaxel, and prednisone vs placebo in patients with metastatic castration-resistant prostate cancer: The VIABLE phase 3 randomized clinical trial
10.1001/jamaoncol.2021.7298 · 2022 · External reference
Phase III trial of PROSTVAC in asymptomatic or minimally symptomatic metastatic castration-resistant prostate cancer
10.1200/jco.18.02031 · 2019 · External reference
A randomized phase III trial of personalized peptide vaccination for castration‑resistant prostate cancer progressing after docetaxel
10.3892/or.2020.7847 · 2021 · External reference
PD-1 or PD-L1 blockade restores antitumor efficacy following SSX2 epitope-modified DNA vaccine immunization
10.1158/2326-6066.cir-14-0206 · 2015 · External reference
Phase 2 trial of T-cell activation using MVI-816 and pembrolizumab in patients with metastatic, castration-resistant prostate cancer (mCRPC)
10.1136/jitc-2021-004198 · 2022 · External reference
High and low mutational burden tumors versus immunologically hot and cold tumors and response to immune checkpoint inhibitors
10.1186/s40425-018-0479-7 · 2018 · External reference
Cancer-associated fibroblast heterogeneity, activation and function: Implications for prostate cancer
10.3390/biom13010067 · 2022 · External reference
Myeloid-derived suppressor cells as key players and promising therapy targets in prostate cancer
10.3389/fonc.2022.862416 · 2022 · External reference
Decrease in CD8+ lymphocyte number and altered cytokine profile in human prostate cancer
2011 · External reference
Dysfunction of PSA-specific CD8+ T cells in prostate cancer patients correlates with CD38 and Tim-3 expression
10.1007/s00262-015-1752-y · 2015 · External reference
Taxane-induced blockade to nuclear accumulation of the androgen receptor predicts clinical responses in metastatic prostate cancer
10.1158/0008-5472.can-11-1417 · 2011 · External reference
Docetaxel down-regulates the expression of androgen receptor and prostate-specific antigen but not prostate-specific membrane antigen in prostate cancer cell lines: Implications for PSA surrogacy
10.1002/pros.21004 · 2009 · External reference
Distinct response to platinum-based chemotherapy among patients with metastatic castration-resistant prostate cancer harboring alterations in genes involved in homologous recombination
10.1097/ju.0000000000001819 · 2021 · External reference
Platinum-based chemotherapy in metastatic prostate cancer with DNA repair gene alterations
10.1200/po.19.00346 · 2020 · External reference
Palbociclib and letrozole in advanced breast cancer
10.1056/nejmoa1607303 · 2016 · External reference
AR, the cell cycle, and prostate cancer
10.1621/nrs.06001 · 2008 · External reference
The strange case of CDK4/6 inhibitors: mechanisms, resistance, and combination strategies
10.1016/j.trecan.2016.11.006 · 2017 · External reference
A randomized phase II study of androgen deprivation therapy with or without palbociclib in RB-positive metastatic hormone-sensitive prostate cancer
10.1158/1078-0432.ccr-21-0024 · 2021 · External reference
Pharmacodynamics effects of CDK4/6 inhibitor LEE011 (ribociclib) in high-risk, localised prostate cancer: A study protocol for a randomised controlled phase II trial (LEEP study: LEE011 in high-risk, localised Prostate cancer)
10.1136/bmjopen-2019-033667 · 2020 · External reference
A phase Ib/II study of the CDK4/6 inhibitor ribociclib in combination with docetaxel plus prednisone in metastatic castration-resistant prostate cancer
10.1158/1078-0432.ccr-21-4302 · 2022 · External reference
Cyclin-dependent kinase 4/6 inhibitor palbociclib in combination with ralaniten analogs for the treatment of androgen receptor-positive prostate and breast cancers
10.1158/1535-7163.mct-21-0411 · 2022 · External reference
Optimal targeting of PI3K-AKT and mTOR in advanced oestrogen receptor-positive breast cancer
10.1016/s1470-2045(23)00676-9 · 2024 · External reference
PI3K/AKT/mTOR signaling transduction pathway and targeted therapies in cancer
10.1186/s12943-023-01827-6 · 2023 · External reference
Recent advances in targeted strategies for triple-negative breast cancer
10.1186/s13045-023-01497-3 · 2023 · External reference
Capivasertib combines with docetaxel to enhance anti-tumour activity through inhibition of AKT-mediated survival mechanisms in prostate cancer
10.1038/s41416-024-02614-w · 2024 · External reference
Randomized phase II study evaluating Akt blockade with ipatasertib, in combination with abiraterone, in patients with metastatic prostate cancer with and without PTEN loss
10.1158/1078-0432.ccr-18-0981 · 2019 · External reference
Integrated Akt/PKB signaling in immunomodulation and its potential role in cancer immunotherapy
10.1093/jnci/djv171 · 2015 · External reference
Cancer epigenetics: From mechanism to therapy
10.1016/j.cell.2012.06.013 · 2012 · External reference
Prostate cancer reactivates developmental epigenomic programs during metastatic progression
10.1038/s41588-020-0664-8 · 2020 · External reference
Global levels of histone modifications predict prostate cancer recurrence
10.1002/pros.21038 · 2010 · External reference
Histone modifications and chromatin organization in prostate cancer
10.2217/epi.10.31 · 2010 · External reference
The polycomb group protein EZH2 is involved in progression of prostate cancer
10.1038/nature01075 · 2002 · External reference
N-Myc induces an EZH2-mediated transcriptional program driving neuroendocrine prostate cancer
10.1016/j.ccell.2016.09.005 · 2016 · External reference
LSD1 demethylates repressive histone marks to promote androgen-receptor-dependent transcription
10.1038/nature04020 · 2005 · External reference
Selective inhibition of tumor oncogenes by disruption of super-enhancers
10.1016/j.cell.2013.03.036 · 2013 · External reference
Super-enhancers in the control of cell identity and disease
10.1016/j.cell.2013.09.053 · 2013 · External reference
Targeting the p300/CBP axis in lethal prostate cancer
10.1158/2159-8290.cd-20-0751 · 2021 · External reference
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Phase 1/2 multiple ascending dose trial of the prostate-specific membrane antigen-targeted antibody drug conjugate MLN2704 in metastatic castration-resistant prostate cancer
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EPI-001, A compound active against castration-resistant prostate cancer, targets transactivation unit 5 of the androgen receptor
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Capivasertib combines with docetaxel to enhance anti-tumour activity through inhibition of AKT-mediated survival mechanisms in prostate cancer
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Distinct response to platinum-based chemotherapy among patients with metastatic castration-resistant prostate cancer harboring alterations in genes involved in homologous recombination
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Delta-like protein 3 expression and therapeutic targeting in neuroendocrine prostate cancer
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B7 score and T cell infiltration stratify immune status in prostate cancer
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Phase 2 trial of T-cell activation using MVI-816 and pembrolizumab in patients with metastatic, castration-resistant prostate cancer (mCRPC)
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Taxane-induced blockade to nuclear accumulation of the androgen receptor predicts clinical responses in metastatic prostate cancer
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Notch pathway inhibition using PF-03084014, a γ-secretase inhibitor (GSI), enhances the antitumor effect of docetaxel in prostate cancer
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PARP and CDK4/6 inhibitor combination therapy induces apoptosis and suppresses neuroendocrine differentiation in prostate cancer
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Phase I study of DSTP3086S, an antibody-drug conjugate targeting six-transmembrane epithelial antigen of prostate 1, in metastatic castration-resistant prostate cancer
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