Research graph
References from Preclinical and clinical trials for vaccine induction of CD4-binding site neutralizing antibodies. Local targets link to admitted publications; unresolved targets remain external evidence.
Strategies for HIV-1 vaccines that induce broadly neutralizing antibodies
10.1038/s41577-022-00753-w · 2023 · External reference
Prophylactic HIV-1 vaccine trials: past, present, and future
10.1016/s2352-3018(23)00264-3 · 2023 · External reference
Env exceptionalism: why are HIV-1 Env glycoproteins atypical immunogens?
10.1016/j.chom.2020.03.018 · 2020 · External reference
The HIV-1 envelope glycoprotein: structure, function and interactions with neutralizing antibodies
10.1038/s41579-025-01206-6 · 2025 · External reference
Antiviral neutralizing antibodies: from in vitro to in vivo activity
10.1038/s41577-023-00858-w · 2023 · External reference
Passive and active antibody studies in primates to inform HIV vaccines
2018 · External reference
Two randomized trials of neutralizing antibodies to prevent HIV-1 acquisition
10.1056/nejmoa2031738 · 2021 · External reference
Development of broadly neutralizing antibodies in HIV-1 infected elite neutralizers
10.1186/s12977-018-0443-0 · 2018 · External reference
Co-evolution of a broadly neutralizing HIV-1 antibody and founder virus
10.1038/nature12053 · 2013 · External reference
B-cell–lineage immunogen design in vaccine development with HIV-1 as a case study
10.1038/nbt.2197 · 2012 · External reference
Vaccination generates broadly cross-neutralizing antibodies to the HIV Env apex
10.1038/s41586-026-10429-3 · 2026 · External reference
Induction of broadly neutralizing HIV antibodies by a two-step mechanism informs vaccine design
10.1126/science.aec6396 · 2026 · External reference
Identification of common features in prototype broadly neutralizing antibodies to HIV envelope V2 apex to facilitate vaccine design
10.1016/j.immuni.2015.10.014 · 2015 · External reference
Human immunoglobulin repertoire analysis guides design of vaccine priming immunogens targeting HIV V2-apex broadly neutralizing antibody precursors
10.1016/j.immuni.2022.09.001 · 2022 · External reference
Germline-targeting HIV immunogen induces cross-neutralizing antibodies in outbred macaques
10.1016/j.immuni.2026.03.012 · 2026 · External reference
Structural and genetic basis of HIV-1 envelope V2 apex recognition by rhesus broadly neutralizing antibodies
10.1084/jem.20250638 · 2025 · External reference
Deep mining of the human antibody repertoire identifies frequent and genetically diverse CDRH3 topologies targetable by vaccination
10.1073/pnas.2532810123 · 2026 · External reference
Vaccine priming of rare HIV broadly neutralizing antibody precursors in nonhuman primates
10.1126/science.adj8321 · 2024 · External reference
Antibodies in HIV-1 vaccine development and therapy
10.1126/science.1241144 · 2013 · External reference
Identification of a CD4-binding-site antibody to HIV that evolved near-pan neutralization breadth
10.1016/j.immuni.2016.10.027 · 2016 · External reference
Profiling of HIV-1 elite neutralizer cohort reveals a CD4bs bnAb for HIV-1 prevention and therapy
10.1038/s41590-025-02286-5 · 2025 · External reference
Structural basis for broad and potent neutralization of HIV-1 by antibody VRC01
10.1126/science.1192819 · 2010 · External reference
Structural repertoire of HIV-1-neutralizing antibodies targeting the CD4 supersite in 14 donors
10.1016/j.cell.2015.05.007 · 2015 · External reference
Maturation pathway from germline to broad HIV-1 neutralizer of a CD4-mimic antibody
10.1016/j.cell.2016.02.022 · 2016 · External reference
Restriction of HIV-1 escape by a highly broad and potent neutralizing antibody
10.1016/j.cell.2020.01.010 · 2020 · External reference
Progress on priming HIV-1 immunity
10.1126/science.adp3459 · 2024 · External reference
Accelerating innovation: advancing opportunities in HIV vaccine development
10.2174/011570162x364991250710044947 · 2025 · External reference
Rational HIV immunogen design to target specific germline B cell receptors
10.1126/science.1234150 · 2013 · External reference
Priming a broadly neutralizing antibody response to HIV-1 using a germline-targeting immunogen
10.1126/science.aac5894 · 2015 · External reference
Engineering HIV envelope protein to activate germline B cell receptors of broadly neutralizing anti-CD4 binding site antibodies
10.1084/jem.20122824 · 2013 · External reference
Specifically modified Env immunogens activate B-cell precursors of broadly neutralizing HIV-1 antibodies in transgenic mice
10.1038/ncomms10618 · 2016 · External reference
Self-assembling protein nanoparticles in the design of vaccines
10.1016/j.csbj.2015.11.001 · 2015 · External reference
Innate immune recognition of glycans targets HIV nanoparticle immunogens to germinal centers
10.1126/science.aat9120 · 2019 · External reference
Interplay of diverse adjuvants and nanoparticle presentation of native-like HIV-1 envelope trimers
10.1038/s41541-021-00364-x · 2021 · External reference
Precursor frequency and affinity determine B cell competitive fitness in germinal centers, tested with germline-targeting HIV vaccine immunogens
10.1016/j.immuni.2017.11.023 · 2018 · External reference
Vaccination induces HIV broadly neutralizing antibody precursors in humans
10.1126/science.add6502 · 2022 · External reference
Vaccination with mRNA-encoded nanoparticles drives early maturation of HIV bnAb precursors in humans
10.1126/science.adr8382 · 2025 · External reference
Germline-targeting HIV vaccination induces neutralizing antibodies to the CD4 binding site
10.1126/sciimmunol.adk9550 · 2024 · External reference
Germline-targeting HIV-1 Env vaccination induces VRC01-class antibodies with rare insertions
10.1016/j.xcrm.2023.101003 · 2023 · External reference
Enhancing and shaping the immunogenicity of native-like HIV-1 envelope trimers with a two-component protein nanoparticle
10.1038/s41467-019-12080-1 · 2019 · External reference
Design and crystal structure of a native-like HIV-1 envelope trimer that engages multiple broadly neutralizing antibody precursors in vivo
10.1084/jem.20161160 · 2017 · External reference
Precise targeting of human HIV broadly neutralizing antibody precursors
10.1126/science.adv5572 · 2025 · External reference
Vaccine genetics of IGHV1-2 VRC01-class broadly neutralizing antibody precursor naïve human B cells
10.1038/s41541-021-00376-7 · 2021 · External reference
A naturally arising broad and potent CD4-binding site antibody with low somatic mutation
10.1126/sciadv.abp8155 · 2022 · External reference
Short CDRL1 in intermediate VRC01-like mAbs is not sufficient to overcome key glycan barriers on HIV-1 Env. Simon V, editor
10.1128/jvi.00744-24 · 2024 · External reference
High affinity germinal center B cells are actively selected into the plasma cell compartment
10.1084/jem.20061254 · 2006 · External reference
Affinity of antigen encounter and other early B-cell signals determine B-cell fate
10.1016/j.coi.2007.04.009 · 2007 · External reference
Antibody affinity shapes the choice between memory and germinal center B cell fates
10.1016/j.cell.2020.09.063 · 2020 · External reference
Restricted clonality and limited germinal center reentry characterize memory B cell reactivation by boosting
10.1016/j.cell.2019.11.032 · 2020 · External reference
Germinal centers output clonally diverse plasma cell populations expressing high- and low-affinity antibodies
10.1016/j.cell.2023.10.022 · 2023 · External reference
Affinity alone does not drive long-lived plasma cell differentiation
10.1111/imcb.12770 · 2024 · External reference
Lack of affinity signature for germinal center cells that have initiated plasma cell differentiation
10.1016/j.immuni.2023.12.010 · 2024 · External reference
Germinal center B cells govern their own fate via antibody feedback
10.1084/jem.20120150 · 2013 · External reference
Different B cell populations mediate early and late memory during an endogenous immune response
10.1126/science.1201730 · 2011 · External reference
Antibodies from primary humoral responses modulate the recruitment of naive B cells during secondary responses
10.1016/j.immuni.2022.07.020 · 2022 · External reference
Local antibody feedback enforces a checkpoint on affinity maturation in the germinal center and promotes epitope spreading
10.1016/j.immuni.2026.01.011 · 2026 · External reference
Follicular dendritic cells: dynamic antigen libraries
10.1038/nri3689 · 2014 · External reference
Affinity dependence of the B cell response to antigen: a threshold, a ceiling, and the importance of off-rate
10.1016/s1074-7613(00)80580-4 · 1998 · External reference
Human B cell lineages associated with germinal centers following influenza vaccination are measurably evolving
10.7554/elife.70873 · 2021 · External reference
Recall of B cell memory depends on relative locations of prime and boost immunization
10.1126/sciimmunol.abn5311 · 2022 · External reference
Antigen affinity and site of immunization dictate B cell recall responses
10.1016/j.celrep.2024.115221 · 2025 · External reference
Slow delivery immunization enhances HIV neutralizing antibody and germinal center responses via modulation of immunodominance
10.1016/j.cell.2019.04.012 · 2019 · External reference
Increased B cell selection stringency in germinal centers can explain improved COVID-19 vaccine efficacies with low dose prime or delayed boost
10.3389/fimmu.2021.776933 · 2021 · External reference
Long-primed germinal centres with enduring affinity maturation and clonal migration
10.1038/s41586-022-05216-9 · 2022 · External reference
Clonal expansion and diversification of germinal center and memory B cell responses to booster immunization in primates
10.1016/j.celrep.2025.116142 · 2025 · External reference
Heterologous prime-boost vaccination drives early maturation of HIV broadly neutralizing antibody precursors in humanized mice
10.1126/scitranslmed.adn0223 · 2024 · External reference
Cooperation of B cell lineages in induction of HIV-1-broadly neutralizing antibodies
10.1016/j.cell.2014.06.022 · 2014 · External reference
Initiation of HIV neutralizing B cell lineages with sequential envelope immunizations
10.1038/s41467-017-01336-3 · 2017 · External reference
Safety and immunogenicity of an HIV envelope trimer immunogen that elicits CD4 binding site neutralizing antibody precursors (HVTN 300)
2026 · External reference
Induction of multiple HIV-1 neutralizing B cell precursors in humans
2026 · External reference
Targeted selection of HIV-specific antibody mutations by engineering B cell maturation
10.1126/science.aay7199 · 2019 · External reference
Vaccine induction of CD4-mimicking HIV-1 broadly neutralizing antibody precursors in macaques
10.1016/j.cell.2023.12.002 · 2024 · External reference
Progress with induction of HIV broadly neutralizing antibodies in the Duke Consortia for HIV/AIDS Vaccine Development
10.1097/coh.0000000000000820 · 2023 · External reference
Structural and immunogenetic signatures guide CD4-mimetic HIV vaccine development
10.1016/j.celrep.2026.117180 · 2026 · External reference
Emerging concepts in the science of vaccine adjuvants
10.1038/s41573-021-00163-y · 2021 · External reference
Modulation of antigen delivery and lymph node activation in nonhuman primates by saponin adjuvant saponin/monophosphoryl lipid A nanoparticle
10.1093/pnasnexus/pgae529 · 2024 · External reference
How vaccinating people living with HIV may guide bNAb-based vaccines
10.1002/jia2.70119 · 2026 · External reference
