Research graph
References from Molecular biomarker profiling in noninfectious uveitis: a chronological review of discovery. Local targets link to admitted publications; unresolved targets remain external evidence.
Characteristics of uveitis in european tertiary ophthalmology centers: a systematic review and meta-analysis
10.1080/09273948.2026.2658756 · 2026 · External reference
Age-related differences in the etiology and clinical characteristics of uveitis in Japan: a retrospective comparative study
10.1080/09273948.2026.2648128 · 2026 · External reference
Incidence and prevalence of non-infectious uveitis: a systematic review and meta-analysis
10.1097/iae.0000000000004812 · 2026 · External reference
Experimental allergic uveitis. I. Production in the guinea pig and rabbit by immunization with retina in adjuvant
10.4049/jimmunol.101.1.151 · 1968 · External reference
Experimental allergic uveitis: homologous retina as uveitogenic antigen
10.1038/206253a0 · 1965 · External reference
Letter: HL-A5 and Behçet's disease
10.1016/s0140-6736(73)93343-6 · 1973 · External reference
Ankylosing spondylitis and HL-A 27
10.1016/s0140-6736(73)91360-3 · 1973 · External reference
T lymphocyte subsets in uveitis
10.1016/0002-9394(83)90379-3 · 1983 · External reference
TH17 cells contribute to uveitis and scleritis and are expanded by IL-2 and inhibited by IL-27/STAT1
10.1038/nm1585 · 2007 · External reference
Identification of the lymphokines, interferon-gamma and interleukin-2, in inflammatory eye diseases
1988 · External reference
Aqueous humor interleukin-6 levels in uveitis
1990 · External reference
Cytokines in human intraocular inflammation
10.3109/02713689208999531 · 1992 · External reference
The CC chemokines CCL8, CCL13 and CCL20 are local inflammatory biomarkers of HLA-B27-associated uveitis
10.1111/aos.13835 · 2019 · External reference
10.1016/j.xops.2021.100010 · 2021 · Admitted local publication
Intraocular dendritic cells characterize HLA-B27-associated acute anterior uveitis
10.7554/elife.67396 · 2021 · External reference
Revising the diagnosis of idiopathic uveitis by peripheral blood transcriptomics
10.1016/j.ajo.2020.09.012 · 2021 · External reference
Experimental allergic uveitis. Isolation, characterization, and localization of a soluble uveitopathogenic antigen from bovine retina
10.4049/jimmunol.119.6.1949 · 1977 · External reference
Autoimmunity in hereditary retinal degenerations. II. Clinical studies: antiretinal antibodies and fluorescein angiogram findings
10.1136/bjo.69.10.758 · 1985 · External reference
Autoimmunity in hereditary retinal degeneration. I. Basic studies
10.1136/bjo.69.1.19 · 1985 · External reference
Association of antiretinal antibodies and cystoid macular edema in patients with retinitis pigmentosa
10.1016/s0002-9394(98)00446-2 · 1999 · External reference
Ocular infiltrating CD4+ T cells from patients with Vogt–Koyanagi–Harada disease recognize human melanocyte antigens
10.1167/iovs.05-1547 · 2006 · External reference
Extracellular vesicle-based liquid biopsy biomarkers and their application in precision immuno-oncology
10.1186/s40364-023-00540-2 · 2023 · External reference
Exacerbation of cancer-associated retinopathy with antirecoverin antibodies during atezolizumab treatment for extensive-stage small cell lung cancer: a case report
10.1016/j.resinv.2025.08.001 · 2025 · External reference
Serum antirecoverin antibodies is found in elderly patients with retinitis pigmentosa and cancer
10.1111/aos.14373 · 2020 · External reference
Comprehensive profiling of extracellular vesicles in uveitis and scleritis enables biomarker discovery and mechanism exploration
10.1186/s12967-023-04228-x · 2023 · External reference
Biopotency and surrogate assays to validate the immunomodulatory potency of extracellular vesicles derived from mesenchymal stem/stromal cells for the treatment of experimental autoimmune uveitis
10.1002/jev2.12497 · 2024 · External reference
Challenges and opportunities in state-of-the-art proteomics analysis for biomarker development from plasma extracellular vesicles
10.1002/pmic.70036 · 2026 · External reference
CD63/81 small extracellular vesicles in the aqueous humor are retinoblastoma associated
10.1167/iovs.64.10.5 · 2023 · External reference
Phenotypic and functional characterization of aqueous humor derived extracellular vesicles
10.1016/j.exer.2023.109393 · 2023 · External reference
Birdshot retinochoroidopathy associated with HLA-A29 antigen and immune responsiveness to retinal S-antigen
10.1016/0002-9394(82)90069-1 · 1982 · External reference
Genome-wide association study of anterior uveitis
10.1136/bjo-2024-326037 · 2025 · External reference
HLA typing in uveitis: use and misuse
10.1016/j.ajo.2009.09.018 · 2010 · External reference
Secukinumab in refractory noninfectious anterior uveitis
10.3389/fopht.2025.1491981 · 2025 · External reference
The role of IL-17A in axial spondyloarthritis and psoriatic arthritis: recent advances and controversies
10.1136/annrheumdis-2019-215356 · 2019 · External reference
The use of non-TNF targeted biologics in Behçet's disease: real-life data from the International AIDA Network Behçet's Disease Registry
10.1093/rheumatology/keag086 · 2026 · External reference
Secukinumab in the treatment of noninfectious uveitis: results of three randomized, controlled clinical trials
10.1016/j.ophtha.2012.09.040 · 2013 · External reference
Incidence of uveitis in patients with axial spondylarthritis treated with biologics or targeted synthetics: a systematic review and network meta-analysis
10.1002/art.42788 · 2024 · External reference
Functionally distinct ERAP1 and ERAP2 are a hallmark of HLA-A29-(birdshot) uveitis
2018 · External reference
Genetics and the axial spondyloarthritis spectrum
10.1093/rheumatology/keaa464 · 2020 · External reference
A pathogenic CD4 T cell phenotype in experimental uveitis shares common features with other immune mediated inflammatory diseases
10.1093/discim/kyaf019 · 2026 · External reference
In vivo engineering of immunosuppressive T cells to treat ocular autoimmune diseases
10.1016/j.exer.2026.111041 · 2026 · External reference
Clinical remission of sight-threatening non-infectious uveitis is characterized by an upregulation of peripheral T-regulatory cell polarized towards T-bet and TIGIT
10.3389/fimmu.2018.00907 · 2018 · External reference
Immunopathogenic role of the HLA-B*51:01-specific immunopeptidome in Behçet's disease
10.1016/j.jaut.2026.103523 · 2026 · External reference
Transcriptome network analysis implicates CX3CR1-positive type 3 dendritic cells in noninfectious uveitis
10.7554/elife.74913 · 2023 · External reference
Immune mediators in birdshot chorioretinopathy: a systematic review
10.1080/09273948.2026.2655441 · 2026 · External reference
Type 3 innate lymphoid cells producing IL-17 and IL-22 are expanded in the gut, in the peripheral blood, synovial fluid and bone marrow of patients with ankylosing spondylitis
10.1136/annrheumdis-2014-206323 · 2015 · External reference
Single-cell profiling reveals CCL5Hi GZMAHi effector memory CD8 T cell association to oligoarticular juvenile idiopathic arthritis
10.1093/rheumatology/keag211 · 2026 · External reference
Tissue resident memory T cells populate the human uveal tract
2026 · External reference
Autoimmunity-associated T cell receptors recognize HLA-B*27-bound peptides
10.1038/s41586-022-05501-7 · 2022 · External reference
High-dose humanized anti-IL-2 receptor alpha antibody (daclizumab) for the treatment of active, noninfectious uveitis
10.1016/j.jaut.2008.05.001 · 2008 · External reference
Humanized antiinterleukin-2 (IL-2) receptor alpha therapy: long-term results in uveitis patients and preliminary safety and activity data for establishing parameters for subcutaneous administration
10.1016/s0896-8411(03)00113-6 · 2003 · External reference
Cutting edge: in vivo blockade of human IL-2 receptor induces expansion of CD56(bright) regulatory NK cells in patients with active uveitis
10.4049/jimmunol.174.9.5187 · 2005 · External reference
A cell atlas foundation model for scalable search of similar human cells
10.1038/s41586-024-08411-y · 2025 · External reference
AB0899 serum levels of calprotectin in active non infectious endogenous uveitis. Comparison with healthy controls
10.1136/annrheumdis-2016-eular.3731 · 2016 · External reference
Usefulness of combined measurement of serum soluble IL-2R and angiotensin-converting enzyme in the detection of uveitis associated with Japanese sarcoidosis
10.2147/opth.s264595 · 2020 · External reference
Diagnostic value of serum-soluble interleukin 2 receptor levels vs angiotensin-converting enzyme in patients with sarcoidosis-associated uveitis
10.1001/jamaophthalmol.2017.4771 · 2017 · External reference
Multiple cytokine analysis of aqueous humor in uveitis with or without secondary glaucoma
10.1186/s12886-024-03691-4 · 2024 · External reference
Multiplex bead immunoassay analysis of aqueous humor reveals distinct cytokine profiles in uveitis
10.1167/iovs.05-0444 · 2005 · External reference
Cytokines, chemokines and soluble adhesion molecules in aqueous humor of children with uveitis
10.1016/j.exer.2007.06.011 · 2007 · External reference
Evidence for tocilizumab as a treatment option in refractory uveitis associated with juvenile idiopathic arthritis
10.3899/jrheum.160231 · 2016 · External reference
Anti-IL6-receptor tocilizumab in refractory and noninfectious uveitic cystoid macular edema: multicenter study of 25 patients
10.1016/j.ajo.2018.12.019 · 2019 · External reference
Tocilizumab employment in the treatment of resistant juvenile idiopathic arthritis associated uveitis
10.1080/09273948.2020.1817501 · 2021 · External reference
Primary (month-6) outcomes of the STOP-uveitis study: evaluating the safety, tolerability, and efficacy of tocilizumab in patients with noninfectious uveitis
10.1016/j.ajo.2017.08.019 · 2017 · External reference
Efficacy and safety of sarilumab for the treatment of posterior segment noninfectious uveitis (SARIL-NIU): the Phase 2 SATURN Study
10.1016/j.ophtha.2018.09.044 · 2019 · External reference
Intraocular interleukin-17 and proinflammatory cytokines in HLA-A29-associated birdshot chorioretinopathy
10.1016/j.ajo.2011.01.031 · 2011 · External reference
Adalimumab in patients with active noninfectious uveitis
10.1056/nejmoa1509852 · 2016 · External reference
Comparative efficacy and safety of tofacitinib versus adalimumab in patients with Behçet's uveitis: a real-world retrospective study
10.1007/s00417-026-07293-2 · 2026 · External reference
Adalimumab reprograms M1 macrophages to attenuate Th1/Th17 responses in Behçet's uveitis and Vogt–Koyanagi–Harada syndrome
10.1167/iovs.67.6.4 · 2026 · External reference
Targeting interleukin-23 in the treatment of noninfectious uveitis
10.1016/j.ophtha.2018.05.014 · 2018 · External reference
Upregulated IL-23 and IL-17 in Behçet patients with active uveitis
10.1167/iovs.07-1390 · 2008 · External reference
Interventions for the treatment of uveitic macular edema: a systematic review and meta-analysis
10.2147/opth.s40268 · 2013 · External reference
Intravitreal therapy for uveitic macular edema-ranibizumab versus methotrexate versus the dexamethasone implant: the MERIT Trial Results
10.1016/j.ophtha.2023.04.011 · 2023 · External reference
Macular edema ranibizumab versus intravitreal anti-inflammatory therapy trial: 24-week outcomes of uveitic macular edema re-treatment
10.1016/j.ophtha.2024.11.021 · 2025 · External reference
Calprotectin as a biomarker for diagnosis and severity of acute noninfectious anterior uveitis in Egyptian patients
10.2147/opth.s389780 · 2022 · External reference
Calprotectin (S100A8/S100A9) detects inflammatory activity in rheumatoid arthritis patients receiving tocilizumab therapy
10.1186/s13075-022-02887-7 · 2022 · External reference
Multiplex cytokine analysis of aqueous humor in juvenile idiopathic arthritis-associated anterior uveitis with or without secondary glaucoma
10.3389/fimmu.2018.00708 · 2018 · External reference
Orchestrating the orchestrators: chemokines in control of T cell traffic
10.1038/ni.f.213 · 2008 · External reference
Aqueous macrophages contribute to conserved CCL2 and CXCL10 gradients in uveitis
10.1016/j.xops.2023.100453 · 2024 · External reference
Chemokines in acute anterior uveitis
10.1076/ceyr.16.12.1202.5034 · 1997 · External reference
Chemokines and gelatinases in the aqueous humor of patients with active uveitis
10.1016/j.ajo.2004.04.046 · 2004 · External reference
Chemokine receptor antagonists: overcoming developmental hurdles
10.1038/nrd2734 · 2009 · External reference
Chemokine receptor antagonists
10.1021/jm300682j · 2012 · External reference
Quantitative urinary proteome analysis reveals potential biomarkers for disease activity of Behcet's disease uveitis
10.1186/s12886-024-03557-9 · 2024 · External reference
Comprehensive proteomic profiling of aqueous humor in idiopathic uveitis and Vogt–Koyanagi–Harada syndrome
10.1021/acsomega.3c10257 · 2024 · External reference
Shared and distinct gut microbiota in spondyloarthritis, acute anterior uveitis, and Crohn's disease
10.1002/art.42658 · 2024 · External reference
10.1186/s12014-025-09564-2
10.1186/s12014-025-09564-2 · 2025 · External reference
Metabolomics of ocular immune diseases
10.1007/s11306-025-02273-9 · 2025 · External reference
Metabolomic alterations associated with Behçet's disease
10.1186/s13075-018-1712-y · 2018 · External reference
Low-dose interleukin-2 fosters a dose-dependent regulatory T cell tuned milieu in T1D patients
10.1016/j.jaut.2015.01.001 · 2015 · External reference
Developments in anticomplement therapy; from disease to clinical trial
10.1016/j.molimm.2018.06.008 · 2018 · External reference
