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References from Cannabinoid actions in a nonsurgical mouse model of sensitized dural nociceptors. Local targets link to admitted publications; unresolved targets remain external evidence.
Cannabinoids mediate analgesia largely via peripheral type 1 cannabinoid receptors in nociceptors
10.1038/nn1916 · 2007 · External reference
Cannabinoid (CB1) receptor activation inhibits trigeminovascular neurons
10.1124/jpet.106.106971 · 2007 · External reference
Anandamide is able to inhibit trigeminal neurons using an in vivo model of trigeminovascular-mediated nociception
10.1124/jpet.103.059808 · 2004 · External reference
CB(2): therapeutic target-in-waiting
10.1016/j.pnpbp.2011.12.001 · 2012 · External reference
Comprehensive review of medicinal Marijuana, cannabinoids, and therapeutic implications in medicine and headache: what a long strange trip it's been
10.1111/head.12570 · 2015 · External reference
Dural stimulation in rats causes brain-derived neurotrophic factor-dependent priming to subthreshold stimuli including a migraine trigger
10.1097/j.pain.0000000000000692 · 2016 · External reference
Non-invasive dural stimulation in mice: a novel preclinical model of migraine
10.1177/0333102418779557 · 2019 · External reference
Cannabinoid CB(2) receptor orthologues; in vitro function and perspectives for preclinical to clinical translation
10.1111/bph.16172 · 2024 · External reference
Quantitative assessment of tactile allodynia in the rat paw
10.1016/0165-0270(94)90144-9 · 1994 · External reference
A highly potent, orally bioavailable pyrazole-derived cannabinoid CB2 Receptor- selective full agonist for in vivo studies
10.1021/acsptsci.4c00269 · 2024 · External reference
Acid-sensing ion channels and nociception in the peripheral and central nervous systems
10.1016/j.neuropharm.2015.02.009 · 2015 · External reference
CB2 cannabinoid receptors as a therapeutic target-what does the future hold?
10.1124/mol.114.094649 · 2014 · External reference
Ca2+/calcineurin-dependent inactivation of neuronal L-type Ca2+ channels requires priming by AKAP-anchored protein kinase A
10.1016/j.celrep.2014.04.039 · 2014 · External reference
Efficient analysis of experimental observations
10.1146/annurev.pa.20.040180.002301 · 1980 · External reference
ASICs as therapeutic targets for migraine
10.1016/j.neuropharm.2014.12.015 · 2015 · External reference
Smoked medicinal cannabis for neuropathic pain in HIV: a randomized, crossover clinical trial
10.1038/npp.2008.120 · 2009 · External reference
Cannabinoids, the endocannabinoid system, and pain: a review of preclinical studies
10.1097/j.pain.0000000000002268 · 2021 · External reference
Design and synthesis of cannabinoid receptor 1 antagonists for peripheral selectivity
10.1021/jm201731z · 2012 · External reference
Cannabinoid CB2 receptors are upregulated via bivalent histone modifications and control primary afferent input to the spinal cord in neuropathic pain
10.1016/j.jbc.2022.101999 · 2022 · External reference
Modulation of TTX-R INa by PKC and PKA and their role in PGE2-induced sensitization of rat sensory neurons in vitro
10.1523/jneurosci.18-24-10345.1998 · 1998 · External reference
Cannabinoid CB(2) receptor-mediated analgesia: mechanism-based insights and therapeutic potential
10.1111/bph.70116 · 2025 · External reference
Cannabinoid CB(2) receptors in primary sensory neurons are implicated in CB(2) agonist-mediated suppression of paclitaxel-induced neuropathic nociception and sexually-dimorphic sparing of morphine tolerance
10.1016/j.biopha.2024.116879 · 2024 · External reference
Conditional deletion of CB2 cannabinoid receptors from peripheral sensory neurons eliminates CB2-mediated antinociceptive efficacy in a mouse model of carrageenan-induced inflammatory pain
10.1016/j.neuropharm.2023.109601 · 2023 · External reference
Protein kinase Cδ as a neuronal mechanism for headache in a chronic intermittent nitroglycerin model of migraine in mice
10.1097/j.pain.0000000000002353 · 2021 · External reference
Cannabinoid receptors undergo axonal flow in sensory nerves
10.1016/s0306-4522(99)00220-1 · 1999 · External reference
Cannabinoid inhibition of adenylate cyclase. Pharmacology of the response in neuroblastoma cell membranes
10.1016/s0026-895x(25)15066-9 · 1984 · External reference
Expression of the transient receptor potential channels TRPV1, TRPA1 and TRPM8 in mouse trigeminal primary afferent neurons innervating the dura
10.1186/1744-8069-8-66 · 2012 · External reference
Cyclic AMP-dependent phosphorylation of neuronal nitric oxide synthase mediates penile erection
10.1073/pnas.1213790109 · 2012 · External reference
A-kinase anchoring protein mediates TRPV1 thermal hyperalgesia through PKA phosphorylation of TRPV1
10.1016/j.pain.2008.02.022 · 2008 · External reference
Receptor mechanisms mediating the anti-neuroinflammatory effects of endocannabinoid system modulation in a rat model of migraine
10.1111/ejn.14897 · 2022 · External reference
cAMP-dependent protein kinase phosphorylation of the acid-sensing ion channel-1 regulates its binding to the protein interacting with C-kinase-1
10.1073/pnas.252782799 · 2003 · External reference
Changes of trigeminal ganglion neurons innervating the temporomandibular joint in chronic pain rat model
10.1155/2024/7015382 · 2024 · External reference
Cannabinoids inhibit acid-sensing ion channel currents in rat dorsal root ganglion neurons
10.1371/journal.pone.0045531 · 2012 · External reference
Two types of neurotransmitter release patterns in isolectin B4-positive and negative trigeminal ganglion neurons
10.1016/j.neuroscience.2006.09.053 · 2007 · External reference
Sensitization of TRPA1 by protein kinase A
10.1371/journal.pone.0170097 · 2017 · External reference
Correction: Significant Determinants of Mouse Pain Behaviour
10.1371/journal.pone.0245813 · 2021 · External reference
Evaluation of protective effects of non-selective cannabinoid receptor agonist WIN 55,212-2 against the nitroglycerine-induced acute and chronic animal models of migraine: a mechanistic study
10.1016/j.lfs.2019.116670 · 2019 · External reference
Adenosine A2A and histamine H3 receptors interact at the cAMP/PKA pathway to modulate depolarization-evoked [(3)H]-GABA release from rat striato-pallidal terminals
10.1007/s11302-018-9638-z · 2019 · External reference
Synthetic peripherally-restricted cannabinoid suppresses chemotherapy-induced peripheral neuropathy pain symptoms by CB1 receptor activation
10.1016/j.neuropharm.2018.07.002 · 2018 · External reference
AKAP-anchored PKA maintains neuronal L-type calcium channel activity and NFAT transcriptional signaling
10.1016/j.celrep.2014.04.027 · 2014 · External reference
Sativex successfully treats neuropathic pain characterised by allodynia: a randomised, double-blind, placebo-controlled clinical trial
10.1016/j.pain.2007.08.028 · 2007 · External reference
The cannabinoid receptor agonist, WIN 55, 212-2, attenuates tumor-evoked hyperalgesia through peripheral mechanisms
10.1016/j.brainres.2008.03.063 · 2008 · External reference
The neuronal distribution of cannabinoid receptor type 1 in the trigeminal ganglion of the rat
10.1016/s0306-4522(03)00333-6 · 2003 · External reference
A cryptic pocket in CB1 drives peripheral and functional selectivity
10.1038/s41586-025-08618-7 · 2025 · External reference
Peripherally selective cannabinoid 1 receptor (CB1R) agonists for the treatment of neuropathic pain
10.1021/acs.jmedchem.6b00516 · 2016 · External reference
Efficacy and safety of medical Marijuana in migraine headache: a systematic review
2022 · External reference
Cannabinoids in chronic pain: therapeutic potential through microglia modulation
10.3389/fncir.2021.816747 · 2022 · External reference
PKCepsilon regulates behavioral sensitivity, binding and tolerance to the CB1 receptor agonist WIN55,212-2
10.1038/npp.2008.230 · 2009 · External reference
Involvement of PKA-dependent upregulation of nNOS-CGRP in adrenomedullin-initiated mechanistic pathway underlying CFA-induced response in rats
10.1016/j.expneurol.2012.10.006 · 2013 · External reference
Sensitization of ASIC3 by proteinase-activated receptor 2 signaling contributes to acidosis-induced nociception
10.1186/s12974-017-0916-4 · 2017 · External reference
Microglial cannabinoid CB(2) receptors in pain modulation
10.3390/ijms24032348 · 2023 · External reference
Selective targeting of peripheral cannabinoid receptors prevents behavioral symptoms and sensitization of trigeminal neurons in mouse models of migraine and medication overuse headache
10.1097/j.pain.0000000000002214 · 2021 · External reference
Ion channels and migraine
10.1111/head.12323 · 2014 · External reference
Dural afferents express acid-sensing ion channels: a role for decreased meningeal pH in migraine headache
10.1016/j.pain.2010.09.036 · 2011 · External reference
pH-evoked dural afferent signaling is mediated by ASIC3 and is sensitized by mast cell mediators
10.1111/head.12152 · 2013 · External reference
Peripherally restricted cannabinoid 1 receptor agonist as a novel analgesic in cancer-induced bone pain
10.1097/j.pain.0000000000001278 · 2018 · External reference
Induction of CB2 receptor expression in the rat spinal cord of neuropathic but not inflammatory chronic pain models
10.1046/j.1460-9568.2003.02704.x · 2003 · External reference
Combined effects of cannabidiol and Δ9-tetrahydrocannabinol alleviate migraine-like symptoms in mice
10.1177/03331024251314487 · 2025 · External reference