Research graph
References from Brain gray matter changes across chronic pain trajectories: MRI evidence from 35,000 individuals. Local targets link to admitted publications; unresolved targets remain external evidence.
The mutually reinforcing dynamics between pain and stress: mechanisms, impacts and management strategies
10.3389/fpain.2024.1445280 · 2024 · External reference
Selective decreased grey matter volume of the pain-matrix network in cluster headache
10.1177/0333102411431334 · 2012 · External reference
Image processing and quality control for the first 10,000 brain imaging datasets from UK Biobank
10.1016/j.neuroimage.2017.10.034 · 2018 · External reference
Disruption of default mode network dynamics in acute and chronic pain states
10.1016/j.nicl.2017.10.019 · 2018 · External reference
Human brain mechanisms of pain perception and regulation in health and disease
10.1016/j.ejpain.2004.11.001 · 2005 · External reference
Chronic back pain is associated with decreased prefrontal and thalamic gray matter density
10.1523/jneurosci.2541-04.2004 · 2004 · External reference
Changes in regional gray matter volume in women with chronic pelvic pain: a voxel-based morphometry study
10.1016/j.pain.2012.01.032 · 2012 · External reference
A meta-analytic study of experimental and chronic orofacial pain excluding headache disorders
10.1016/j.nicl.2018.09.018 · 2018 · External reference
Identification of clusters of individuals relevant to temporomandibular disorders and other chronic pain conditions: the OPPERA study: the OPPERA study
10.1097/j.pain.0000000000000518 · 2016 · External reference
Beyond feeling: chronic pain hurts the brain, disrupting the default-mode network dynamics
10.1523/jneurosci.4123-07.2008 · 2008 · External reference
Functional reorganization of the default mode network across chronic pain conditions
10.1371/journal.pone.0106133 · 2014 · External reference
Corticostriatal functional connectivity predicts transition to chronic back pain
10.1038/nn.3153 · 2012 · External reference
Brain morphological signatures for chronic pain
10.1371/journal.pone.0026010 · 2011 · External reference
Increased prefrontal activation during pain perception in major depression
10.1016/j.biopsych.2007.02.011 · 2007 · External reference
The basolateral amygdala-anterior cingulate pathway contributes to depression-like behaviors and comorbidity with chronic pain behaviors in male mice
10.1038/s41467-023-37878-y · 2023 · External reference
Cortical thickness alterations and systemic inflammation define long-COVID patients with cognitive impairment
10.1016/j.bbi.2023.11.028 · 2024 · External reference
Mapping brain structure variability in chronic pain: the role of widespreadness and pain type and its mediating relationship with suicide attempt
10.1016/j.biopsych.2023.07.016 · 2024 · External reference
Longitudinal structural and functional brain network alterations in a mouse model of neuropathic pain
10.1016/j.neuroscience.2018.04.020 · 2018 · External reference
Neuroplasticity of ascending and descending pathways after somatosensory system injury: reviewing knowledge to identify neuropathic pain therapeutic targets
10.1038/sc.2015.225 · 2016 · External reference
Neuroplasticity of supraspinal structures associated with pathological pain
10.1002/ar.23587 · 2017 · External reference
A framework for understanding the relationship between descending pain modulation, motor corticospinal, and neuroplasticity regulation systems in chronic myofascial pain
10.3389/fnhum.2016.00308 · 2016 · External reference
Decreased gray matter volumes in the cingulo-frontal cortex and the amygdala in patients with fibromyalgia
10.1097/psy.0b013e3181a32da0 · 2009 · External reference
Cognitive and emotional control of pain and its disruption in chronic pain
10.1038/nrn3516 · 2013 · External reference
The UK Biobank resource with deep phenotyping and genomic data
10.1038/s41586-018-0579-z · 2018 · External reference
Plastic reorganization of hippocampal and neocortical circuitry in experimental traumatic brain injury in the immature rat
10.1089/neu.2005.22.989 · 2005 · External reference
Prefrontal cortex and mediodorsal thalamus reduced connectivity is associated with spatial working memory impairment in rats with inflammatory pain
10.1016/j.pain.2013.07.020 · 2013 · External reference
Chronic musculoskeletal pain rarely presents in a single body site: results from a UK population study
10.1093/rheumatology/kem118 · 2007 · External reference
Traumatic brain injury alters long-term hippocampal neuron morphology in juvenile, but not immature, rats
10.1007/s00381-014-2446-z · 2014 · External reference
Gray matter alterations in chronic pain: a network-oriented meta-analytic approach
10.1016/j.nicl.2014.04.007 · 2014 · External reference
Fibromyalgia interacts with age to change the brain
10.1016/j.nicl.2013.08.015 · 2013 · External reference
Altered primary motor cortex structure, organization, and function in chronic pain: a systematic review and meta-analysis
10.1016/j.jpain.2017.10.007 · 2018 · External reference
A fresh look at propriospinal interneurons plasticity and intraspinal circuits remodeling after spinal cord injury
10.1016/j.ibneur.2023.04.001 · 2023 · External reference
Mechanisms and treatments of chronic pain after traumatic brain injury
10.1016/j.neuint.2023.105630 · 2023 · External reference
A crash course in good and bad controls
10.1177/00491241221099552 · 2024 · External reference
Hemispheric lateralization of somatosensory processing
10.1152/jn.2001.85.6.2602 · 2001 · External reference
Thickening in the somatosensory cortex of patients with migraine
10.1212/01.wnl.0000291618.32247.2d · 2007 · External reference
Central mechanisms of pain revealed through functional and structural MRI
10.1007/s11481-012-9386-8 · 2013 · External reference
Cerebellar contributions to major depression
10.3389/fpsyt.2018.00634 · 2018 · External reference
Automatic parcellation of human cortical gyri and sulci using standard anatomical nomenclature
10.1016/j.neuroimage.2010.06.010 · 2010 · External reference
Changes in the structural complexity of the aged brain
10.1111/j.1474-9726.2007.00289.x · 2007 · External reference
From chronic pain to depression: neurogenesis-driven microglial remodeling in the hippocampal dentate gyrus
10.1126/science.aee6177 · 2026 · External reference
The role of psychosocial processes in the development and maintenance of chronic pain
10.1016/j.jpain.2016.01.001 · 2016 · External reference
Pain sensitivity is inversely related to regional grey matter density in the brain
10.1016/j.pain.2013.12.004 · 2014 · External reference
Rapid treatment-induced brain changes in pediatric CRPS
10.1007/s00429-014-0957-8 · 2016 · External reference
Functional connectivity across dorsal and ventral attention networks in response to task difficulty and experimental pain
10.1016/j.neulet.2022.136967 · 2023 · External reference
Genetic basis to structural grey matter associations with chronic pain
10.1093/brain/awab334 · 2021 · External reference
A shared genetic signature for common chronic pain conditions and its impact on biopsychosocial traits
10.1016/j.jpain.2022.10.005 · 2023 · External reference
Differences in neuroplasticity after spinal cord injury in varying animal models and humans
10.4103/1673-5374.243694 · 2019 · External reference
Structural and functional reorganization of propriospinal connections promotes functional recovery after spinal cord injury
10.4103/1673-5374.155425 · 2015 · External reference
Whole brain segmentation
10.1016/s0896-6273(02)00569-x · 2002 · External reference
Reduced cortical thickness of brain areas involved in pain processing in patients with chronic pancreatitis
10.1016/j.cgh.2011.11.024 · 2012 · External reference
A pain-induced tonic hypodopaminergic state augments phasic dopamine release in the nucleus accumbens
10.1097/j.pain.0000000000001925 · 2020 · External reference
Pain perception: multiple matrices or one?
10.1001/jamaneurol.2016.0757 · 2016 · External reference
The brain in chronic CRPS pain: abnormal gray-white matter interactions in emotional and autonomic regions
10.1016/j.neuron.2008.08.022 · 2008 · External reference
Anatomical alterations of the visual motion processing network in migraine with and without aura
10.1371/journal.pmed.0030402 · 2006 · External reference
The genetic architecture of the human cerebral cortex
10.1126/science.aay6690 · 2020 · External reference
When pain hurts: nociceptive stimulation induces a state of maladaptive plasticity and impairs recovery after spinal cord injury
10.1089/neu.2016.4626 · 2017 · External reference
Dissecting the neural circuitry for pain modulation and chronic pain: insights from optogenetics
10.1007/s12264-022-00835-8 · 2022 · External reference
The innate immunity of the central nervous system in chronic pain: the role of toll-like receptors
10.1007/s00018-007-6494-3 · 2007 · External reference
Different pain, different brain: thalamic anatomy in neuropathic and non-neuropathic chronic pain syndromes
10.1523/jneurosci.5980-10.2011 · 2011 · External reference
Thalamic atrophy associated with painful osteoarthritis of the hip is reversible after arthroplasty: a longitudinal voxel-based morphometric study
10.1002/art.27585 · 2010 · External reference
Shape shifting pain: chronification of back pain shifts brain representation from nociceptive to emotional circuits
10.1093/brain/awt211 · 2013 · External reference
Structural imaging studies of patients with chronic pain: an anatomical likelihood estimate meta-analysis
10.1097/j.pain.0000000000002681 · 2023 · External reference
Neuroplasticity related to chronic pain and its modulation by microglia
10.1186/s41232-022-00199-6 · 2022 · External reference
Behavioral, metabolic and functional brain changes in a rat model of chronic neuropathic pain: a longitudinal MRI study
10.1016/j.neuroimage.2014.12.024 · 2015 · External reference
Deciphering nociplastic pain: clinical features, risk factors and potential mechanisms
10.1038/s41582-024-00966-8 · 2024 · External reference
Altered structure and function in the hippocampus and medial prefrontal cortex in patients with burning mouth syndrome
10.1016/j.pain.2014.04.022 · 2014 · External reference
Thickening of the somatosensory cortex in migraine without aura
10.1177/0333102414531155 · 2014 · External reference
Regional grey matter changes in patients with migraine: a voxel-based morphometry study
10.1111/j.1468-2982.2008.01550.x · 2008 · External reference
Cortical astrocytes rewire somatosensory cortical circuits for peripheral neuropathic pain
10.1172/jci82859 · 2016 · External reference
Functional and structural plasticity in the primary somatosensory cortex associated with chronic pain
10.1111/jnc.14012 · 2017 · External reference
Neuromodulation for chronic pain
10.1016/s0140-6736(21)00794-7 · 2021 · External reference
S1 is associated with chronic low back pain: a functional and structural MRI study
10.1186/1744-8069-9-43 · 2013 · External reference
Prediction and action in cortical pain processing
10.1093/cercor/bhac102 · 2023 · External reference
Chronic nociplastic pain affecting the musculoskeletal system: clinical criteria and grading system
10.1097/j.pain.0000000000002324 · 2021 · External reference
Accelerated brain gray matter loss in fibromyalgia patients: premature aging of the brain?
10.1523/jneurosci.0098-07.2007 · 2007 · External reference
Cellular circuits in the brain and their modulation in acute and chronic pain
10.1152/physrev.00040.2019 · 2021 · External reference
Compensatory plasticity: time matters
10.3389/fnhum.2014.00340 · 2014 · External reference
Normal age-related brain morphometric changes: nonuniformity across cortical thickness, surface area and gray matter volume?
10.1016/j.neurobiolaging.2010.07.013 · 2012 · External reference
Brain gray matter alterations in Chinese patients with chronic knee osteoarthritis pain based on voxel-based morphometry
10.1097/md.0000000000010145 · 2018 · External reference
Chronic pain produces hypervigilance to predator odor in mice
10.1016/j.cub.2020.06.025 · 2020 · External reference
Hippocampal volume, FKBP5 genetic risk alleles, and childhood trauma interact to increase vulnerability to chronic multisite musculoskeletal pain
10.1038/s41598-022-10411-9 · 2022 · External reference
“Neuroinflammation”: does it have a role in chronic pain? Evidence from human imaging
10.1097/j.pain.0000000000003342 · 2024 · External reference
Default mode network connectivity encodes clinical pain: an arterial spin labeling study
10.1016/j.pain.2012.07.029 · 2013 · External reference
Changes in gray matter volume after microsurgical lumbar discectomy: a longitudinal analysis
10.3389/fnhum.2015.00012 · 2015 · External reference
Cortical thickness alterations in chronic pain disorder: an exploratory MRI study
10.1097/psy.0000000000000605 · 2018 · External reference
Decreased activation of cingulo-frontal-parietal cognitive/attention network during an attention-demanding task in patients with chronic low back pain
10.1007/s00234-014-1391-6 · 2014 · External reference
Publisher correction: reproducible brain-wide association studies require thousands of individuals
10.1038/s41586-022-04692-3 · 2022 · External reference
Pain induces adaptations in ventral tegmental area dopamine neurons to drive anhedonia-like behavior
10.1038/s41593-021-00924-3 · 2021 · External reference
Pain-induced negative affect is mediated via recruitment of the nucleus accumbens kappa opioid system
10.1016/j.neuron.2019.02.029 · 2019 · External reference
Chronic pain may change the structure of the brain
10.1016/j.pain.2008.02.034 · 2008 · External reference
Pain pathways and nervous system plasticity: learning and memory in pain
10.1093/pm/pnz017 · 2019 · External reference
Functional and structural alterations in the migraine cerebellum
10.1177/0271678x17722109 · 2019 · External reference
Morphological and functional reorganization of rat medial prefrontal cortex in neuropathic pain
10.1073/pnas.0809897106 · 2009 · External reference
Neuroimaging evidence of motor control and pain processing in the human midcingulate cortex
10.1093/cercor/bhu001 · 2015 · External reference
Contribution of chronic pain and neuroticism to abnormal forebrain gray matter in patients with temporomandibular disorder
10.1016/j.neuroimage.2010.12.013 · 2011 · External reference
Abnormal gray matter aging in chronic pain patients
10.1016/j.brainres.2012.03.040 · 2012 · External reference
Gray matter adaptations to chronic pain in people with whiplash-associated disorders are partially reversed after treatment: a voxel-based morphometry study
10.1016/j.jpain.2024.01.336 · 2024 · External reference
Trigeminal neuroplasticity underlies allodynia in a preclinical model of mild closed head traumatic brain injury (cTBI)
10.1016/j.neuropharm.2016.03.016 · 2016 · External reference
Apparent thinning of human visual cortex during childhood is associated with myelination
10.1073/pnas.1904931116 · 2019 · External reference
Reward and motivation in pain and pain relief
10.1038/nn.3811 · 2014 · External reference
Cortical thickness of Broca's area and right homologue is related to grammar learning aptitude and pitch discrimination proficiency
10.1016/j.bandl.2018.12.002 · 2019 · External reference
Gray matter volume reduction reflects chronic pain in trigeminal neuralgia
10.1016/j.neuroimage.2013.02.029 · 2013 · External reference
Peripheral nerve injuries, pain, and neuroplasticity
10.1016/j.jht.2018.01.011 · 2018 · External reference
Distinct genetic influences on cortical surface area and cortical thickness
10.1093/cercor/bhp026 · 2009 · External reference
Morphological alterations in the congenital blind based on the analysis of cortical thickness and surface area
10.1016/j.neuroimage.2009.03.076 · 2009 · External reference
Altered resting-state functional connectivity within corticostriatal and subcortical-striatal circuits in chronic pain
10.1038/s41598-022-16835-7 · 2022 · External reference
A new vision of the role of the cerebellum in pain processing
10.1007/s00702-024-02872-1 · 2025 · External reference
Bayesian model selection in social research
10.2307/271063 · 1995 · External reference
Specification of cerebral cortical areas
10.1126/science.3291116 · 1988 · External reference
Gray matter volumes of pain-related brain areas are decreased in fibromyalgia syndrome
10.1016/j.jpain.2010.10.003 · 2011 · External reference
Brain gray matter changes in migraine patients with T2-visible lesions: a 3-T MRI study
10.1161/01.str.0000226589.00599.4d · 2006 · External reference
Brain gray matter decrease in chronic pain is the consequence and not the cause of pain
10.1523/jneurosci.3687-09.2009 · 2009 · External reference
Structural brain changes in chronic pain reflect probably neither damage nor atrophy
10.1371/journal.pone.0054475 · 2013 · External reference
Asymmetric lateralization during pain processing
10.3390/sym13122416 · 2021 · External reference
Altered regional brain morphology in patients with chronic facial pain
10.1111/j.1526-4610.2010.01637.x · 2010 · External reference
Affective components and intensity of pain correlate with structural differences in gray matter in chronic back pain patients
10.1016/j.pain.2006.05.004 · 2006 · External reference
Gray matter decrease in patients with chronic tension type headache
10.1212/01.wnl.0000183067.94400.80 · 2005 · External reference
Striatal grey matter increase in patients suffering from fibromyalgia—a voxel-based morphometry study
10.1016/j.pain.2007.05.010 · 2007 · External reference
Increased gray matter density in young women with chronic vulvar pain
10.1016/j.pain.2008.09.014 · 2008 · External reference
Effective treatment of chronic low back pain in humans reverses abnormal brain anatomy and function
10.1523/jneurosci.5280-10.2011 · 2011 · External reference
Post-injury pain and behaviour: a control theory perspective
10.1038/s41583-023-00699-5 · 2023 · External reference
Visual network alterations in brain functional connectivity in chronic low back pain: a resting state functional connectivity and machine learning study
10.1016/j.nicl.2019.101775 · 2019 · External reference
Gray matter abnormalities associated with fibromyalgia: a meta-analysis of voxel-based morphometric studies
10.1016/j.semarthrit.2016.06.002 · 2016 · External reference
Unraveling the role of CGRP receptor-expressing neurons in the central amygdala: insights into neuropathic pain mechanisms and behavioral responses
10.1016/j.jpain.2024.01.111 · 2024 · External reference
Overlap of five chronic pain conditions: temporomandibular disorders, headache, back pain, irritable bowel syndrome, and fibromyalgia
10.11607/ofph.2581 · 2020 · External reference
Structural brain anomalies and chronic pain: a quantitative meta-analysis of gray matter volume
10.1016/j.jpain.2013.03.001 · 2013 · External reference
An expanded set of genome-wide association studies of brain imaging phenotypes in UK Biobank
10.1038/s41593-021-00826-4 · 2021 · External reference
Differential longitudinal changes in cortical thickness, surface area and volume across the adult life span: regions of accelerating and decelerating change
10.1523/jneurosci.0391-14.2014 · 2014 · External reference
Right-lateralized pain processing in the human cortex: an FMRI study
10.1152/jn.01162.2005 · 2006 · External reference
A prognostic risk score for development and spread of chronic pain
10.1038/s41591-023-02430-4 · 2023 · External reference
Changes in brain gray matter due to repetitive painful stimulation
10.1016/j.neuroimage.2008.05.044 · 2008 · External reference
BDNF-dependent plasticity induced by peripheral inflammation in the primary sensory and the cingulate cortex triggers cold allodynia and reveals a major role for endogenous BDNF as a tuner of the affective aspect of pain
10.1523/jneurosci.0860-14.2014 · 2014 · External reference
Multivariate classification of structural MRI data detects chronic low back pain
10.1093/cercor/bhs378 · 2014 · External reference
Corticolimbic anatomical characteristics predetermine risk for chronic pain
10.1093/brain/aww100 · 2016 · External reference
Cortical reorganization in primary somatosensory cortex in patients with unilateral chronic pain
10.1016/j.jpain.2009.02.006 · 2009 · External reference
Role of primary somatosensory cortex in the coding of pain
10.1016/j.pain.2012.10.021 · 2013 · External reference
An fMRI-based neurologic signature of physical pain
10.1056/nejmoa1204471 · 2013 · External reference
Evaluating the consistency and specificity of neuroimaging data using meta-analysis
10.1016/j.neuroimage.2008.10.061 · 2009 · External reference
Neuromodulation for pain management
10.1007/978-981-13-2050-7_8 · 2019 · External reference
Cortical thickness or grey matter volume? The importance of selecting the phenotype for imaging genetics studies
10.1016/j.neuroimage.2009.12.028 · 2010 · External reference
Cortical thickness and functional connectivity abnormality in chronic headache and low back pain patients
10.1002/hbm.23484 · 2017 · External reference
Chronic myofascial temporomandibular pain is associated with neural abnormalities in the trigeminal and limbic systems
10.1016/j.pain.2010.01.006 · 2010 · External reference
Plasticity in gray and white: neuroimaging changes in brain structure during learning
10.1038/nn.3045 · 2012 · External reference
The enhanced connectivity between the frontoparietal, somatomotor network and thalamus as the most significant network changes of chronic low back pain
10.1016/j.neuroimage.2024.120558 · 2024 · External reference
Descending facilitation: from basic science to the treatment of chronic pain
10.1177/1744806917699212 · 2017 · External reference
Long-term potentiation in the anterior cingulate cortex and chronic pain
10.1098/rstb.2013.0146 · 2014 · External reference
Genetic risk shared across 24 chronic pain conditions: identification and characterization with genomic structural equation modeling
10.1097/j.pain.0000000000002922 · 2023 · External reference
