Research graph
References from Monitoring and dose adjustment of regional citrate anticoagulation for continuous renal replacement therapy. Local targets link to admitted publications; unresolved targets remain external evidence.
Effect of regional citrate anticoagulation vs systemic heparin anticoagulation during continuous kidney replacement therapy on dialysis filter life span and mortality among critically ill patients with acute kidney injury: a randomized clinical trial
10.1001/jama.2020.18618 · External reference
Citrate versus heparin anticoagulation for continuous renal replacement therapy: an updated meta-analysis of RCTs
10.1007/s00134-015-4099-0 · 2015 · External reference
Anticoagulation strategies in continuous renal replacement therapy
10.1111/sdi.12959 · 2021 · External reference
Section 5: dialysis interventions for treatment of AKI
10.1038/kisup.2011.35 · 2012 · External reference
A randomized controlled trial of regional citrate versus regional heparin anticoagulation for continuous renal replacement therapy in critically ill adults
10.1097/ccm.0000000000001004 · 2015 · External reference
Citrate anticoagulation versus systemic heparinisation in continuous venovenous hemofiltration in critically ill patients with acute kidney injury: a multicenter randomized clinical trial
10.1186/s13054-014-0472-6 · 2014 · External reference
Citrate anticoagulation for continuous venovenous hemofiltration
10.1097/ccm.0b013e3181953c5e · 2009 · External reference
Heparin versus citrate anticoagulation for continuous renal replacement therapy in intensive care: the RRAM observational study
10.3310/zxhi9396 · 2022 · External reference
Troubleshooting ionized hypocalcemia in patients on continuous KRT with regional citrate anticoagulation
10.34067/kid.0000001053 · 2026 · External reference
Citrate: how to get started and what, when, and how to monitor?
10.2478/jtim-2018-0026 · 2018 · External reference
Regional citrate anticoagulation protocol for patients with presumed absent citrate metabolism
10.34067/kid.0005342020 · 2021 · External reference
A practical citrate anticoagulation continuous venovenous hemodiafiltration protocol for metabolic control and high solute clearance
10.2215/cjn.00040505 · 2006 · External reference
Regional citrate anticoagulation “nonshock” protocol with precalculated flow settings for patients with at least 6 L/hour liver citrate clearance
10.1186/s12882-021-02443-6 · 2021 · External reference
Management of dysnatremias with continuous renal replacement therapy
10.1111/sdi.12983 · 2021 · External reference
Clinical review: Patency of the circuit in continuous renal replacement therapy
10.1186/cc5937 · 2007 · External reference
Ionized hypocalcemia prior to continuous veno-venous hemodialysis initiation: prevalence and consequences
10.1186/s12871-026-03894-w · 2026 · External reference
Increased total to ionized calcium ratio during continuous venovenous hemodialysis with regional citrate anticoagulation
10.1097/00003246-200104000-00010 · 2001 · External reference
Total-to-ionized calcium ratio predicts mortality in continuous renal replacement therapy with citrate anticoagulation in critically ill patients
10.1186/cc11363 · 2012 · External reference
Incidence and outcome of metabolic disarrangements consistent with citrate accumulation in critically ill patients undergoing continuous venovenous hemodialysis with regional citrate anticoagulation
10.1016/j.jcrc.2013.10.015 · 2014 · External reference
Albumin-corrected calcium ratios for citrate accumulation increase detection and improve mortality prediction in continuous kidney replacement therapy
10.1186/s13054-026-05933-x · 2026 · External reference
Citrate accumulation during CRRT: the impact of diagnostic criteria
10.1186/s13054-026-05932-y · 2026 · External reference
Albumin-corrected total/ionized calcium ratio is not superior to total/ionized calcium ratio as an indicator of citrate accumulation
10.5301/ijao.5000621 · 2017 · External reference
Determinants of total/ionized calcium in patients undergoing citrate CVVH: a retrospective observational study
10.1016/j.jcrc.2020.05.005 · 2020 · External reference
Complications of regional citrate anticoagulation: accumulation or overload?
10.1186/s13054-017-1880-1 · 2017 · External reference
Incidence, severity, and predictors of citrate accumulation during continuous kidney replacement therapy in the critically ill
10.1186/s13054-025-05691-2 · 2025 · External reference
Hyperlactatemia, lactate kinetics and prediction of citrate accumulation in critically ill patients undergoing continuous renal replacement therapy with regional citrate anticoagulation
10.1097/ccm.0000000000002501 · 2017 · External reference
Hyperlactatemia predicts citrate intolerance with regional citrate anticoagulation during continuous renal replacement therapy
10.1177/0885066617701068 · 2019 · External reference
Lactate as a predictor of citrate accumulation in patients undergoing continuous renal replacement therapy? A systematic review
10.1111/aas.70060 · 2025 · External reference
Metabolic complications of citrate anticoagulation in continuous renal replacement therapy (crrt): a delphi consensus on indications, monitoring and management
10.1186/s13054-026-06066-x · 2026 · External reference
Continuous renal replacement therapy: cause and treatment of electrolyte complications
10.1111/j.1525-139x.2010.00790.x · 2010 · External reference
Clinical review: anticoagulation for continuous renal replacement therapy – heparin or citrate?
10.1186/cc9358 · 2011 · External reference
Prevention of hypomagnesemia in critically ill patients with acute kidney injury on continuous kidney replacement therapy: the role of early supplementation and close monitoring
10.1007/s40620-020-00864-4 · 2021 · External reference
Vascular access, membranes and circuit for CRRT
10.1111/sdi.12977 · 2021 · External reference
Citrate pharmacokinetics and metabolism in cirrhotic and noncirrhotic critically ill patients
10.1097/01.ccm.0000084871.76568.e6 · 2003 · External reference
Safety and efficacy of regional citrate anticoagulation in continuous venovenous hemodialysis in the presence of liver failure: the Liver Citrate Anticoagulation Threshold (L-CAT) observational study
10.1186/s13054-015-1066-7 · 2015 · External reference
Clinical and biological profiles associated with the time of occurrence of citrate accumulation in patients receiving continuous renal replacement therapy
10.1186/s13054-025-05648-5 · External reference
Multidisciplinary guidelines on renal replacement therapy in intensive care medicine
10.1186/s13054-025-05817-6 · 2026 · External reference
Effect of regional citrate anticoagulation vs systemic heparin anticoagulation during continuous kidney replacement therapy on dialysis filter life span and mortality among critically ill patients with acute kidney injury: a randomized clinical trial
10.1001/jama.2020.18618 · ExternalCitation · doi-reference
Citrate versus heparin anticoagulation for continuous renal replacement therapy: an updated meta-analysis of RCTs
10.1007/s00134-015-4099-0 · ExternalCitation · doi-reference
Prevention of hypomagnesemia in critically ill patients with acute kidney injury on continuous kidney replacement therapy: the role of early supplementation and close monitoring
10.1007/s40620-020-00864-4 · ExternalCitation · doi-reference
Incidence and outcome of metabolic disarrangements consistent with citrate accumulation in critically ill patients undergoing continuous venovenous hemodialysis with regional citrate anticoagulation
10.1016/j.jcrc.2013.10.015 · ExternalCitation · doi-reference
Determinants of total/ionized calcium in patients undergoing citrate CVVH: a retrospective observational study
10.1016/j.jcrc.2020.05.005 · ExternalCitation · doi-reference
Section 5: dialysis interventions for treatment of AKI
10.1038/kisup.2011.35 · ExternalCitation · doi-reference
Increased total to ionized calcium ratio during continuous venovenous hemodialysis with regional citrate anticoagulation
10.1097/00003246-200104000-00010 · ExternalCitation · doi-reference
Citrate pharmacokinetics and metabolism in cirrhotic and noncirrhotic critically ill patients
10.1097/01.ccm.0000084871.76568.e6 · ExternalCitation · doi-reference
A randomized controlled trial of regional citrate versus regional heparin anticoagulation for continuous renal replacement therapy in critically ill adults
10.1097/ccm.0000000000001004 · ExternalCitation · doi-reference
Hyperlactatemia, lactate kinetics and prediction of citrate accumulation in critically ill patients undergoing continuous renal replacement therapy with regional citrate anticoagulation
10.1097/ccm.0000000000002501 · ExternalCitation · doi-reference
Citrate anticoagulation for continuous venovenous hemofiltration
10.1097/ccm.0b013e3181953c5e · ExternalCitation · doi-reference
Lactate as a predictor of citrate accumulation in patients undergoing continuous renal replacement therapy? A systematic review
10.1111/aas.70060 · ExternalCitation · doi-reference
Continuous renal replacement therapy: cause and treatment of electrolyte complications
10.1111/j.1525-139x.2010.00790.x · ExternalCitation · doi-reference
Anticoagulation strategies in continuous renal replacement therapy
10.1111/sdi.12959 · ExternalCitation · doi-reference
Vascular access, membranes and circuit for CRRT
10.1111/sdi.12977 · ExternalCitation · doi-reference
Management of dysnatremias with continuous renal replacement therapy
10.1111/sdi.12983 · ExternalCitation · doi-reference
Hyperlactatemia predicts citrate intolerance with regional citrate anticoagulation during continuous renal replacement therapy
10.1177/0885066617701068 · ExternalCitation · doi-reference
Total-to-ionized calcium ratio predicts mortality in continuous renal replacement therapy with citrate anticoagulation in critically ill patients
10.1186/cc11363 · ExternalCitation · doi-reference
Clinical review: Patency of the circuit in continuous renal replacement therapy
10.1186/cc5937 · ExternalCitation · doi-reference
Clinical review: anticoagulation for continuous renal replacement therapy – heparin or citrate?
10.1186/cc9358 · ExternalCitation · doi-reference
Ionized hypocalcemia prior to continuous veno-venous hemodialysis initiation: prevalence and consequences
10.1186/s12871-026-03894-w · ExternalCitation · doi-reference
Regional citrate anticoagulation “nonshock” protocol with precalculated flow settings for patients with at least 6 L/hour liver citrate clearance
10.1186/s12882-021-02443-6 · ExternalCitation · doi-reference
Citrate anticoagulation versus systemic heparinisation in continuous venovenous hemofiltration in critically ill patients with acute kidney injury: a multicenter randomized clinical trial
10.1186/s13054-014-0472-6 · ExternalCitation · doi-reference
Safety and efficacy of regional citrate anticoagulation in continuous venovenous hemodialysis in the presence of liver failure: the Liver Citrate Anticoagulation Threshold (L-CAT) observational study
10.1186/s13054-015-1066-7 · ExternalCitation · doi-reference
Complications of regional citrate anticoagulation: accumulation or overload?
10.1186/s13054-017-1880-1 · ExternalCitation · doi-reference
Clinical and biological profiles associated with the time of occurrence of citrate accumulation in patients receiving continuous renal replacement therapy
10.1186/s13054-025-05648-5 · ExternalCitation · doi-reference
Incidence, severity, and predictors of citrate accumulation during continuous kidney replacement therapy in the critically ill
10.1186/s13054-025-05691-2 · ExternalCitation · doi-reference
Multidisciplinary guidelines on renal replacement therapy in intensive care medicine
10.1186/s13054-025-05817-6 · ExternalCitation · doi-reference
Citrate accumulation during CRRT: the impact of diagnostic criteria
10.1186/s13054-026-05932-y · ExternalCitation · doi-reference
Albumin-corrected calcium ratios for citrate accumulation increase detection and improve mortality prediction in continuous kidney replacement therapy
10.1186/s13054-026-05933-x · ExternalCitation · doi-reference
Metabolic complications of citrate anticoagulation in continuous renal replacement therapy (crrt): a delphi consensus on indications, monitoring and management
10.1186/s13054-026-06066-x · ExternalCitation · doi-reference
A practical citrate anticoagulation continuous venovenous hemodiafiltration protocol for metabolic control and high solute clearance
10.2215/cjn.00040505 · ExternalCitation · doi-reference
Citrate: how to get started and what, when, and how to monitor?
10.2478/jtim-2018-0026 · ExternalCitation · doi-reference
Heparin versus citrate anticoagulation for continuous renal replacement therapy in intensive care: the RRAM observational study
10.3310/zxhi9396 · ExternalCitation · doi-reference
Troubleshooting ionized hypocalcemia in patients on continuous KRT with regional citrate anticoagulation
10.34067/kid.0000001053 · ExternalCitation · doi-reference
Regional citrate anticoagulation protocol for patients with presumed absent citrate metabolism
10.34067/kid.0005342020 · ExternalCitation · doi-reference
Albumin-corrected total/ionized calcium ratio is not superior to total/ionized calcium ratio as an indicator of citrate accumulation
10.5301/ijao.5000621 · ExternalCitation · doi-reference