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References from Exploring the potential mechanism of Xiaoqinglong Decoction in the treatment of acute exacerbations of chronic obstructive pulmonary disease based on network pharmacology and in silico study. Local targets link to admitted publications; unresolved targets remain external evidence.
Chronic obstructive pulmonary disease exacerbation fundamentals: diagnosis, treatment, prevention and disease impact.
10.1111/resp.14041 · 2021 · External reference
Infections and airway inflammation in chronic obstructive pulmonary disease severe exacerbations.
10.1164/rccm.200506-859oc · 2006 · External reference
Cough and sputum production are associated with frequent exacerbations and hospitalizations in COPD subjects.
10.1378/chest.08-2062 · 2009 · External reference
Bufei Yishen granule combined with acupoint sticking improves pulmonary function and morphormetry in chronic obstructive pulmonary disease rats.
10.1186/s12906-015-0787-0 · 2015 · External reference
Xiaoqinglong decoction (a traditional Chinese medicine) combined conventional treatment for acute exacerbation of chronic obstructive pulmonary disease: a systematic review and meta-analysis.
10.1097/md.0000000000019571 · 2020 · External reference
Traditional Chinese medicine classic herbal formula Xiaoqinglong decoction for acute exacerbation of chronic obstructive pulmonary disease: a systematic review protocol.
10.1097/md.0000000000013761 · 2018 · External reference
Xiaoqinglong decoction attenuates chronic obstructive pulmonary disease in rats via inhibition of autophagy.
10.1155/2018/6705871 · 2018 · External reference
Effects of Xiaoqinglong decoction on gene expression profiles in a rat chronic obstructive pulmonary disease model.
10.5582/bst.2012.v6.5.262 · 2012 · External reference
Network pharmacology-based prediction of the active ingredients and potential targets of Mahuang Fuzi Xixin decoction for application to allergic rhinitis.
10.1016/j.jep.2015.10.040 · 2015 · External reference
Network pharmacology: new opportunity for the modernization of traditional Chinese medicine.
2012 · External reference
TCMSP: a database of systems pharmacology for drug discovery from herbal medicines.
10.1186/1758-2946-6-13 · 2014 · External reference
Computation and molecular pharmacology to trace the anti-rheumatoid activity of Angelicae Pubescentis Radix.
10.1186/s12906-022-03769-w · 2022 · External reference
Exploring the pharmacological mechanisms of Xihuang pills against prostate cancer via integrating network pharmacology and experimental validation in vitro and in vivo.
10.3389/fphar.2021.791269 · 2021 · External reference
In silico pharmacology for drug discovery: methods for virtual ligand screening and profiling.
10.1038/sj.bjp.0707305 · 2007 · External reference
PubChem substance and compound databases.
10.1093/nar/gkv951 · 2016 · External reference
SwissADME: a free web tool to evaluate pharmacokinetics, drug-likeness and medicinal chemistry friendliness of small molecules.
10.1038/srep42717 · 2017 · External reference
UniProt: the universal protein knowledgebase in 2023.
10.1093/nar/gkac1052 · 2023 · External reference
GeneCards: a novel functional genomics compendium with automated data mining and query reformulation support.
10.1093/bioinformatics/14.8.656 · 1998 · External reference
Searching online Mendelian inheritance in man (OMIM): a knowledgebase of human genes and genetic phenotypes.
10.1002/cpbi.27 · 2017 · External reference
DrugBank 5.0: a major update to the DrugBank database for 2018.
10.1093/nar/gkx1037 · 2018 · External reference
Therapeutic target database update 2022: facilitating drug discovery with enriched comparative data of targeted agents.
10.1093/nar/gkab953 · 2022 · External reference
STRING v10: protein-protein interaction networks, integrated over the tree of life.
10.1093/nar/gku1003 · 2015 · External reference
Cytoscape: a software environment for integrated models of biomolecular interaction networks.
10.1101/gr.1239303 · 2003 · External reference
cytoHubba: identifying hub objects and sub-networks from complex interactome.
10.1186/1752-0509-8-s4-s11 · 2014 · External reference
CytoNCA: a Cytoscape plugin for centrality analysis and evaluation of protein interaction networks.
10.1016/j.biosystems.2014.11.005 · 2015 · External reference
Cytoscape automation: empowering workflow-based network analysis.
10.1186/s13059-019-1758-4 · 2019 · External reference
DAVID: a web server for functional enrichment analysis and functional annotation of gene lists (2021 update).
10.1093/nar/gkac194 · 2022 · External reference
SRplot: a free online platform for data visualization and graphing.
10.1371/journal.pone.0294236 · 2023 · External reference
The Protein Data Bank.
10.1093/nar/28.1.235 · 2000 · External reference
Virtual screening with AutoDock: theory and practice.
10.1517/17460441.2010.484460 · 2010 · External reference
Using AutoDock for ligand-receptor docking.
2008 · External reference
Scalable constant pH molecular dynamics in GROMACS.
10.1021/acs.jctc.2c00516 · 2022 · External reference
GROMACS: fast, flexible, and free.
10.1002/jcc.20291 · 2005 · External reference
Deciphering the pharmacological mechanisms of Scutellaria baicalensis Georgi on oral leukoplakia by combining network pharmacology, molecular docking and experimental evaluations.
10.1016/j.phymed.2022.154195 · 2022 · External reference
Definition, causes, pathogenesis, and consequences of chronic obstructive pulmonary disease exacerbations.
10.1016/j.ccm.2020.06.007 · 2020 · External reference
Global burden of COPD.
10.1111/resp.12660 · 2016 · External reference
COPD 2020: changes and challenges.
10.1152/ajplung.00429.2020 · 2020 · External reference
COPD in the elderly patient.
10.1055/s-0030-1265900 · 2010 · External reference
Biological targets for therapeutic interventions in COPD: clinical potential.
2006 · External reference
Associations of Chinese herbal medicine use with the risks of acute exacerbation and mortality in patients with chronic obstructive pulmonary disease: a nationwide retrospective cohort study.
10.1089/jicm.2021.0103 · 2022 · External reference
Xiaoqinglong decoction protects the lungs of AECOPD mice through the AMPK/mTOR signaling pathway.
10.1155/2020/9865290 · 2020 · External reference
Correlations of silent information regulator of transcription 1 (SIRT1) expression, inflammatory factors, and oxidative stress with pulmonary function in patients with acute exacerbation of chronic obstructive pulmonary disease (AECOPD).
10.12659/msm.929046 · 2021 · External reference
PM2.5 increases susceptibility to acute exacerbation of COPD via NOX4/Nrf2 redox imbalance-mediated mitophagy.
10.1016/j.redox.2022.102587 · 2023 · External reference
Quercetin and derivatives: useful tools in inflammation and pain management.
10.4155/fmc-2016-0186 · 2017 · External reference
Quercetin: its antioxidant mechanism, antibacterial properties and potential application in prevention and control of toxipathy.
10.3390/molecules27196545 · 2022 · External reference
Antimicrobial activity of quercetin: an approach to its mechanistic principle.
10.3390/molecules27082494 · 2022 · External reference
Quercetin and its derivates as antiviral potentials: a comprehensive review.
10.1002/ptr.7309 · 2022 · External reference
Quercetin alleviates ferroptosis accompanied by reducing M1 macrophage polarization during neutrophilic airway inflammation.
10.1016/j.ejphar.2022.175407 · 2023 · External reference
Quercetin and metabolic syndrome: a review.
10.1002/ptr.7144 · 2021 · External reference
Senescence-mediated anticancer effects of quercetin.
10.1016/j.nutres.2022.04.007 · 2022 · External reference
Quercetin: a potential candidate for the treatment of arthritis.
10.2174/1566524021666210315125330 · 2022 · External reference
Anticancer effect and apoptosis induction by quercetin in the human lung cancer cell line A-549.
2012 · External reference
Quercetin improves epithelial regeneration from airway basal cells of COPD patients.
10.1186/s12931-024-02742-0 · 2024 · External reference
Quercetin attenuates airway inflammation and mucus production induced by cigarette smoke in rats.
10.1016/j.intimp.2012.03.006 · 2012 · External reference
Quercetin prevents rhinovirus-induced progression of lung disease in mice with COPD phenotype.
10.1371/journal.pone.0199612 · 2018 · External reference
Immunopharmacological activities of luteolin in chronic diseases.
10.3390/ijms24032136 · 2023 · External reference
Luteolin as a modulator of skin aging and inflammation.
10.1002/biof.1699 · 2021 · External reference
Luteolin suppresses inflammation and oxidative stress in chronic obstructive pulmonary disease through inhibition of the NOX4-mediated NF-κB signaling pathway.
10.1002/iid3.820 · 2023 · External reference
Functional study on the relaxation of isolated smooth muscle in rats by Schisandra chinensis lignans.
2021 · External reference
Research progress on the pharmacological effects, metabolic pathways, and metabolites of Schisandra chinensis lignans.
2021 · External reference
Kaempferol as a dietary anti-inflammatory agent: current therapeutic standing.
10.3390/molecules25184073 · 2020 · External reference
Protective effect of kaempferol glucoside against lipopolysaccharide-caused acute lung injury via targeting Nrf2/NF-κB/NLRP3/GSDMD: integrating experimental and computational studies.
10.1016/j.jsps.2024.102073 · 2024 · External reference
The role of nuclear factor kappa B in the pathogenesis of pulmonary diseases: implications for therapy.
10.1007/bf03256650 · 2003 · External reference
Signal transducer and activator of transcription (STAT) signalling and T-cell lymphomas.
10.1111/j.1365-2567.2005.02091.x · 2005 · External reference
Candidate genes for COPD in two large data sets.
10.1183/09031936.00091709 · 2011 · External reference
mTOR signalling: jack-of-all-trades 1.
10.1139/bcb-2018-0004 · 2019 · External reference
Nitric oxide-enhanced caspase-3 and acidic sphingomyelinase interaction: a novel mechanism by which airway epithelial cells escape ceramide-induced apoptosis.
10.1016/j.yexcr.2006.12.001 · 2007 · External reference
Caspase-3/Gasdermin E-mediated pyroptosis contributes to Ricin toxin-induced inflammation.
10.1016/j.toxlet.2024.04.007 · 2024 · External reference
Hydrogen coadministration slows the development of COPD-like lung disease in a cigarette smoke-induced rat model.
10.2147/copd.s124547 · 2017 · External reference
The BCL2L1 and PGAM5 axis defines hypoxia-induced receptor-mediated mitophagy.
10.4161/auto.29568 · 2014 · External reference
Contribution of the mitochondria to locomotor muscle dysfunction in patients with COPD.
10.1016/j.chest.2015.11.021 · 2016 · External reference
The many roles of c-Myc in apoptosis.
10.1146/annurev.physiol.60.1.575 · 1998 · External reference
The C-Jun oncoprotein.
1993 · External reference
Research on the effect of Bufei Tang on COPD apoptosis based on the IL-17A/JNK/c-Jun pathway.
2023 · External reference
Regulation of lung epithelial cell senescence in smoking-induced COPD/emphysema by microR-125a-5p via Sp1 mediation of SIRT1/HIF-1a.
10.7150/ijbs.65861 · 2022 · External reference
Signal transduction by tumor necrosis factor and its relatives.
10.1016/s0962-8924(01)02064-5 · 2001 · External reference
Verproside inhibits TNF-α-induced MUC5AC expression through suppression of the TNF-α/NF-κB pathway in human airway epithelial cells.
10.1016/j.cyto.2015.08.262 · 2016 · External reference
A Chinese herbal formula ameliorates COPD by inhibiting the inflammatory response via downregulation of p65, JNK, and p38.
10.1016/j.phymed.2021.153475 · 2021 · External reference
Cortex Mori Radicis[Morus Alba L. (Moraceae)] extract alleviates senescence via PI3K/Akt signaling in COPD fibroblasts.
10.1016/j.phymed.2024.156004 · 2024 · External reference
Luteolin as a modulator of skin aging and inflammation.
10.1002/biof.1699 · ExternalCitation · doi-reference
Searching online Mendelian inheritance in man (OMIM): a knowledgebase of human genes and genetic phenotypes.
10.1002/cpbi.27 · ExternalCitation · doi-reference
Luteolin suppresses inflammation and oxidative stress in chronic obstructive pulmonary disease through inhibition of the NOX4-mediated NF-κB signaling pathway.
10.1002/iid3.820 · ExternalCitation · doi-reference
GROMACS: fast, flexible, and free.
10.1002/jcc.20291 · ExternalCitation · doi-reference
Quercetin and metabolic syndrome: a review.
10.1002/ptr.7144 · ExternalCitation · doi-reference
Quercetin and its derivates as antiviral potentials: a comprehensive review.
10.1002/ptr.7309 · ExternalCitation · doi-reference
The role of nuclear factor kappa B in the pathogenesis of pulmonary diseases: implications for therapy.
10.1007/bf03256650 · ExternalCitation · doi-reference
CytoNCA: a Cytoscape plugin for centrality analysis and evaluation of protein interaction networks.
10.1016/j.biosystems.2014.11.005 · ExternalCitation · doi-reference
Definition, causes, pathogenesis, and consequences of chronic obstructive pulmonary disease exacerbations.
10.1016/j.ccm.2020.06.007 · ExternalCitation · doi-reference
Contribution of the mitochondria to locomotor muscle dysfunction in patients with COPD.
10.1016/j.chest.2015.11.021 · ExternalCitation · doi-reference
Verproside inhibits TNF-α-induced MUC5AC expression through suppression of the TNF-α/NF-κB pathway in human airway epithelial cells.
10.1016/j.cyto.2015.08.262 · ExternalCitation · doi-reference
Quercetin alleviates ferroptosis accompanied by reducing M1 macrophage polarization during neutrophilic airway inflammation.
10.1016/j.ejphar.2022.175407 · ExternalCitation · doi-reference
Quercetin attenuates airway inflammation and mucus production induced by cigarette smoke in rats.
10.1016/j.intimp.2012.03.006 · ExternalCitation · doi-reference
Network pharmacology-based prediction of the active ingredients and potential targets of Mahuang Fuzi Xixin decoction for application to allergic rhinitis.
10.1016/j.jep.2015.10.040 · ExternalCitation · doi-reference
Protective effect of kaempferol glucoside against lipopolysaccharide-caused acute lung injury via targeting Nrf2/NF-κB/NLRP3/GSDMD: integrating experimental and computational studies.
10.1016/j.jsps.2024.102073 · ExternalCitation · doi-reference
Senescence-mediated anticancer effects of quercetin.
10.1016/j.nutres.2022.04.007 · ExternalCitation · doi-reference
A Chinese herbal formula ameliorates COPD by inhibiting the inflammatory response via downregulation of p65, JNK, and p38.
10.1016/j.phymed.2021.153475 · ExternalCitation · doi-reference
Deciphering the pharmacological mechanisms of Scutellaria baicalensis Georgi on oral leukoplakia by combining network pharmacology, molecular docking and experimental evaluations.
10.1016/j.phymed.2022.154195 · ExternalCitation · doi-reference
Cortex Mori Radicis[Morus Alba L. (Moraceae)] extract alleviates senescence via PI3K/Akt signaling in COPD fibroblasts.
10.1016/j.phymed.2024.156004 · ExternalCitation · doi-reference
PM2.5 increases susceptibility to acute exacerbation of COPD via NOX4/Nrf2 redox imbalance-mediated mitophagy.
10.1016/j.redox.2022.102587 · ExternalCitation · doi-reference
Caspase-3/Gasdermin E-mediated pyroptosis contributes to Ricin toxin-induced inflammation.
10.1016/j.toxlet.2024.04.007 · ExternalCitation · doi-reference
Nitric oxide-enhanced caspase-3 and acidic sphingomyelinase interaction: a novel mechanism by which airway epithelial cells escape ceramide-induced apoptosis.
10.1016/j.yexcr.2006.12.001 · ExternalCitation · doi-reference
Signal transduction by tumor necrosis factor and its relatives.
10.1016/s0962-8924(01)02064-5 · ExternalCitation · doi-reference
Scalable constant pH molecular dynamics in GROMACS.
10.1021/acs.jctc.2c00516 · ExternalCitation · doi-reference
In silico pharmacology for drug discovery: methods for virtual ligand screening and profiling.
10.1038/sj.bjp.0707305 · ExternalCitation · doi-reference
SwissADME: a free web tool to evaluate pharmacokinetics, drug-likeness and medicinal chemistry friendliness of small molecules.
10.1038/srep42717 · ExternalCitation · doi-reference
COPD in the elderly patient.
10.1055/s-0030-1265900 · ExternalCitation · doi-reference
Associations of Chinese herbal medicine use with the risks of acute exacerbation and mortality in patients with chronic obstructive pulmonary disease: a nationwide retrospective cohort study.
10.1089/jicm.2021.0103 · ExternalCitation · doi-reference
GeneCards: a novel functional genomics compendium with automated data mining and query reformulation support.
10.1093/bioinformatics/14.8.656 · ExternalCitation · doi-reference
The Protein Data Bank.
10.1093/nar/28.1.235 · ExternalCitation · doi-reference
Therapeutic target database update 2022: facilitating drug discovery with enriched comparative data of targeted agents.
10.1093/nar/gkab953 · ExternalCitation · doi-reference
UniProt: the universal protein knowledgebase in 2023.
10.1093/nar/gkac1052 · ExternalCitation · doi-reference
DAVID: a web server for functional enrichment analysis and functional annotation of gene lists (2021 update).
10.1093/nar/gkac194 · ExternalCitation · doi-reference
STRING v10: protein-protein interaction networks, integrated over the tree of life.
10.1093/nar/gku1003 · ExternalCitation · doi-reference
PubChem substance and compound databases.
10.1093/nar/gkv951 · ExternalCitation · doi-reference
DrugBank 5.0: a major update to the DrugBank database for 2018.
10.1093/nar/gkx1037 · ExternalCitation · doi-reference
Traditional Chinese medicine classic herbal formula Xiaoqinglong decoction for acute exacerbation of chronic obstructive pulmonary disease: a systematic review protocol.
10.1097/md.0000000000013761 · ExternalCitation · doi-reference
Xiaoqinglong decoction (a traditional Chinese medicine) combined conventional treatment for acute exacerbation of chronic obstructive pulmonary disease: a systematic review and meta-analysis.
10.1097/md.0000000000019571 · ExternalCitation · doi-reference
Cytoscape: a software environment for integrated models of biomolecular interaction networks.
10.1101/gr.1239303 · ExternalCitation · doi-reference
Signal transducer and activator of transcription (STAT) signalling and T-cell lymphomas.
10.1111/j.1365-2567.2005.02091.x · ExternalCitation · doi-reference
Global burden of COPD.
10.1111/resp.12660 · ExternalCitation · doi-reference
Chronic obstructive pulmonary disease exacerbation fundamentals: diagnosis, treatment, prevention and disease impact.
10.1111/resp.14041 · ExternalCitation · doi-reference
mTOR signalling: jack-of-all-trades 1.
10.1139/bcb-2018-0004 · ExternalCitation · doi-reference
The many roles of c-Myc in apoptosis.
10.1146/annurev.physiol.60.1.575 · ExternalCitation · doi-reference
COPD 2020: changes and challenges.
10.1152/ajplung.00429.2020 · ExternalCitation · doi-reference
Xiaoqinglong decoction attenuates chronic obstructive pulmonary disease in rats via inhibition of autophagy.
10.1155/2018/6705871 · ExternalCitation · doi-reference
Xiaoqinglong decoction protects the lungs of AECOPD mice through the AMPK/mTOR signaling pathway.
10.1155/2020/9865290 · ExternalCitation · doi-reference
Infections and airway inflammation in chronic obstructive pulmonary disease severe exacerbations.
10.1164/rccm.200506-859oc · ExternalCitation · doi-reference
Candidate genes for COPD in two large data sets.
10.1183/09031936.00091709 · ExternalCitation · doi-reference
cytoHubba: identifying hub objects and sub-networks from complex interactome.
10.1186/1752-0509-8-s4-s11 · ExternalCitation · doi-reference
TCMSP: a database of systems pharmacology for drug discovery from herbal medicines.
10.1186/1758-2946-6-13 · ExternalCitation · doi-reference
Bufei Yishen granule combined with acupoint sticking improves pulmonary function and morphormetry in chronic obstructive pulmonary disease rats.
10.1186/s12906-015-0787-0 · ExternalCitation · doi-reference
Computation and molecular pharmacology to trace the anti-rheumatoid activity of Angelicae Pubescentis Radix.
10.1186/s12906-022-03769-w · ExternalCitation · doi-reference
Quercetin improves epithelial regeneration from airway basal cells of COPD patients.
10.1186/s12931-024-02742-0 · ExternalCitation · doi-reference
Cytoscape automation: empowering workflow-based network analysis.
10.1186/s13059-019-1758-4 · ExternalCitation · doi-reference
Correlations of silent information regulator of transcription 1 (SIRT1) expression, inflammatory factors, and oxidative stress with pulmonary function in patients with acute exacerbation of chronic obstructive pulmonary disease (AECOPD).
10.12659/msm.929046 · ExternalCitation · doi-reference
Quercetin prevents rhinovirus-induced progression of lung disease in mice with COPD phenotype.
10.1371/journal.pone.0199612 · ExternalCitation · doi-reference
SRplot: a free online platform for data visualization and graphing.
10.1371/journal.pone.0294236 · ExternalCitation · doi-reference
Cough and sputum production are associated with frequent exacerbations and hospitalizations in COPD subjects.
10.1378/chest.08-2062 · ExternalCitation · doi-reference
Virtual screening with AutoDock: theory and practice.
10.1517/17460441.2010.484460 · ExternalCitation · doi-reference
Hydrogen coadministration slows the development of COPD-like lung disease in a cigarette smoke-induced rat model.
10.2147/copd.s124547 · ExternalCitation · doi-reference
Quercetin: a potential candidate for the treatment of arthritis.
10.2174/1566524021666210315125330 · ExternalCitation · doi-reference
Exploring the pharmacological mechanisms of Xihuang pills against prostate cancer via integrating network pharmacology and experimental validation in vitro and in vivo.
10.3389/fphar.2021.791269 · ExternalCitation · doi-reference
Immunopharmacological activities of luteolin in chronic diseases.
10.3390/ijms24032136 · ExternalCitation · doi-reference
Kaempferol as a dietary anti-inflammatory agent: current therapeutic standing.
10.3390/molecules25184073 · ExternalCitation · doi-reference
Antimicrobial activity of quercetin: an approach to its mechanistic principle.
10.3390/molecules27082494 · ExternalCitation · doi-reference
Quercetin: its antioxidant mechanism, antibacterial properties and potential application in prevention and control of toxipathy.
10.3390/molecules27196545 · ExternalCitation · doi-reference
Quercetin and derivatives: useful tools in inflammation and pain management.
10.4155/fmc-2016-0186 · ExternalCitation · doi-reference
The BCL2L1 and PGAM5 axis defines hypoxia-induced receptor-mediated mitophagy.
10.4161/auto.29568 · ExternalCitation · doi-reference
Effects of Xiaoqinglong decoction on gene expression profiles in a rat chronic obstructive pulmonary disease model.
10.5582/bst.2012.v6.5.262 · ExternalCitation · doi-reference
Regulation of lung epithelial cell senescence in smoking-induced COPD/emphysema by microR-125a-5p via Sp1 mediation of SIRT1/HIF-1a.
10.7150/ijbs.65861 · ExternalCitation · doi-reference
