Research graph
References from Genetic evidence for CTSH as a potential therapeutic target in sepsis. Local targets link to admitted publications; unresolved targets remain external evidence.
Distinct functional neutrophil phenotypes in sepsis patients correlate with disease severity.
10.3389/fimmu.2024.1341752 · 2024 · External reference
The third international consensus definitions for sepsis and septic shock (Sepsis-3).
10.1001/jama.2016.0287 · 2016 · External reference
Global, regional, and national sepsis incidence and mortality, 1990–2021: a systematic analysis.
10.1016/s2214-109x(25)00356-0 · 2025 · External reference
National incidence and mortality of hospitalized sepsis in China.
10.1186/s13054-023-04385-x · 2023 · External reference
The prevalence, risk factors, and outcomes of sepsis in critically ill patients in China: a multicenter prospective cohort study.
10.3389/fmed.2020.593808 · 2020 · External reference
The burden and contemporary epidemiology of sepsis in children.
10.1016/s2352-4642(24)00140-8 · 2024 · External reference
Clinical prognostic models in children with sepsis in low- and middle-income countries: a systematic review and meta-analysis.
10.3389/fped.2024.1463986 · 2024 · External reference
Therapeutic targets for sepsis: multicenter proteome-wide analyses and experimental validation.
10.1021/acs.jproteome.5c00148 · 2025 · External reference
Enhancing sepsis biomarker development: key considerations from public and private perspectives.
10.1186/s13054-024-05032-9 · 2024 · External reference
Molecular biomarkers and more efficient therapies for sepsis.
10.3390/biomedicines13020468 · 2025 · External reference
Multi-omic studies on the pathogenesis of sepsis.
10.1186/s12967-025-06366-w · 2025 · External reference
GSTP1 as a novel protective target in sepsis: evidence from proteome-wide Mendelian randomization and multi-omics analyses.
10.1186/s12879-026-12748-2 · 2026 · External reference
Mendelian randomization as a tool to inform drug development using human genetics.
10.1017/pcm.2023.5 · 2023 · External reference
Drug-target Mendelian randomisation applied to metabolic dysfunction-associated steatotic liver disease: opportunities and challenges.
10.1136/egastro-2024-100114 · 2024 · External reference
A robust cis-Mendelian randomization method with application to drug target discovery.
10.1038/s41467-024-50385-y · 2024 · External reference
Genetic drug target validation using Mendelian randomisation.
10.1038/s41467-020-16969-0 · 2020 · External reference
Proteome-wide Mendelian randomization analysis identified potential drug targets for atrial fibrillation.
10.1161/jaha.122.029003 · 2023 · External reference
Proteome-wide Mendelian randomization in global biobank meta-analysis reveals multi-ancestry drug targets for common diseases.
10.1016/j.xgen.2022.100195 · 2022 · External reference
Multi-ancestry Mendelian randomization of omics traits revealing drug targets of COVID-19 severity.
10.1016/j.ebiom.2022.104112 · 2022 · External reference
Potential drug targets for multiple sclerosis identified through Mendelian randomization analysis.
10.1093/brain/awad070 · 2023 · External reference
Shared genetic association between inflammatory bowel disease and acute myeloid leukemia: insights from Mendelian randomization and transcriptomic analyses.
10.1007/s00011-025-02038-z · 2025 · External reference
Mendelian randomization and transcriptome data analysis reveal bidirectional causal relationships and mechanisms between type 2 diabetes and gastric cancer.
10.2174/0109298673348645241226091059 · 2025 · External reference
Spatial localization of cathepsins: implications in immune activation and resolution during infections.
10.3389/fimmu.2022.955407 · 2022 · External reference
Autophagy and autophagic cell death in sepsis: friend or foe?
10.1186/s40560-024-00754-y · 2024 · External reference
Variant-specific priors clarify colocalisation analysis.
10.1371/journal.pgen.1011697 · 2025 · External reference
Cysteine cathepsins and drug discovery: knowns and unknowns.
10.1134/s0006297925602205 · 2025 · External reference
Cathepsin H: molecular characteristics and clues to function and mechanism.
10.1016/j.bcp.2023.115585 · 2023 · External reference
The third international consensus definitions for sepsis and septic shock (Sepsis-3).
10.1001/jama.2016.0287 · ExternalCitation · doi-reference
Shared genetic association between inflammatory bowel disease and acute myeloid leukemia: insights from Mendelian randomization and transcriptomic analyses.
10.1007/s00011-025-02038-z · ExternalCitation · doi-reference
Cathepsin H: molecular characteristics and clues to function and mechanism.
10.1016/j.bcp.2023.115585 · ExternalCitation · doi-reference
Multi-ancestry Mendelian randomization of omics traits revealing drug targets of COVID-19 severity.
10.1016/j.ebiom.2022.104112 · ExternalCitation · doi-reference
Proteome-wide Mendelian randomization in global biobank meta-analysis reveals multi-ancestry drug targets for common diseases.
10.1016/j.xgen.2022.100195 · ExternalCitation · doi-reference
Global, regional, and national sepsis incidence and mortality, 1990–2021: a systematic analysis.
10.1016/s2214-109x(25)00356-0 · ExternalCitation · doi-reference
The burden and contemporary epidemiology of sepsis in children.
10.1016/s2352-4642(24)00140-8 · ExternalCitation · doi-reference
Mendelian randomization as a tool to inform drug development using human genetics.
10.1017/pcm.2023.5 · ExternalCitation · doi-reference
Therapeutic targets for sepsis: multicenter proteome-wide analyses and experimental validation.
10.1021/acs.jproteome.5c00148 · ExternalCitation · doi-reference
Genetic drug target validation using Mendelian randomisation.
10.1038/s41467-020-16969-0 · ExternalCitation · doi-reference
A robust cis-Mendelian randomization method with application to drug target discovery.
10.1038/s41467-024-50385-y · ExternalCitation · doi-reference
Potential drug targets for multiple sclerosis identified through Mendelian randomization analysis.
10.1093/brain/awad070 · ExternalCitation · doi-reference
Cysteine cathepsins and drug discovery: knowns and unknowns.
10.1134/s0006297925602205 · ExternalCitation · doi-reference
Drug-target Mendelian randomisation applied to metabolic dysfunction-associated steatotic liver disease: opportunities and challenges.
10.1136/egastro-2024-100114 · ExternalCitation · doi-reference
Proteome-wide Mendelian randomization analysis identified potential drug targets for atrial fibrillation.
10.1161/jaha.122.029003 · ExternalCitation · doi-reference
GSTP1 as a novel protective target in sepsis: evidence from proteome-wide Mendelian randomization and multi-omics analyses.
10.1186/s12879-026-12748-2 · ExternalCitation · doi-reference
Multi-omic studies on the pathogenesis of sepsis.
10.1186/s12967-025-06366-w · ExternalCitation · doi-reference
National incidence and mortality of hospitalized sepsis in China.
10.1186/s13054-023-04385-x · ExternalCitation · doi-reference
Enhancing sepsis biomarker development: key considerations from public and private perspectives.
10.1186/s13054-024-05032-9 · ExternalCitation · doi-reference
Autophagy and autophagic cell death in sepsis: friend or foe?
10.1186/s40560-024-00754-y · ExternalCitation · doi-reference
Variant-specific priors clarify colocalisation analysis.
10.1371/journal.pgen.1011697 · ExternalCitation · doi-reference
Mendelian randomization and transcriptome data analysis reveal bidirectional causal relationships and mechanisms between type 2 diabetes and gastric cancer.
10.2174/0109298673348645241226091059 · ExternalCitation · doi-reference
Spatial localization of cathepsins: implications in immune activation and resolution during infections.
10.3389/fimmu.2022.955407 · ExternalCitation · doi-reference
Distinct functional neutrophil phenotypes in sepsis patients correlate with disease severity.
10.3389/fimmu.2024.1341752 · ExternalCitation · doi-reference
The prevalence, risk factors, and outcomes of sepsis in critically ill patients in China: a multicenter prospective cohort study.
10.3389/fmed.2020.593808 · ExternalCitation · doi-reference
Clinical prognostic models in children with sepsis in low- and middle-income countries: a systematic review and meta-analysis.
10.3389/fped.2024.1463986 · ExternalCitation · doi-reference
Molecular biomarkers and more efficient therapies for sepsis.
10.3390/biomedicines13020468 · ExternalCitation · doi-reference
