Research graph
References from Single-cell transcriptomics combined with Mendelian randomization reveals the pivotal role of WDR83OS in clear cell renal cell carcinoma. Local targets link to admitted publications; unresolved targets remain external evidence.
Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries.
2021 · External reference
Renal cell carcinoma.
10.1038/nrdp.2017.9 · 2017 · External reference
Systemic therapy for metastatic renal-cell carcinoma.
10.1056/nejmra1601333 · 2017 · External reference
Recent advances in the management of clear cell renal cell carcinoma: novel biomarkers and targeted therapies.
10.3390/cancers15123207 · 2023 · External reference
The genetic basis of kidney cancer: a metabolic disease.
10.1038/nrurol.2010.47 · 2010 · External reference
Intratumor heterogeneity and branched evolution revealed by multiregion sequencing.
10.1056/nejmoa1113205 · 2012 · External reference
Mutations of the VHL tumour suppressor gene in renal carcinoma.
10.1038/ng0594-85 · 1994 · External reference
Systematic sequencing of renal carcinoma reveals inactivation of histone modifying genes.
10.1038/nature08672 · 2010 · External reference
Frequent mutations of genes encoding ubiquitin-mediated proteolysis pathway components in clear cell renal cell carcinoma.
10.1038/ng.1014 · 2011 · External reference
Exome sequencing identifies frequent mutation of the SWI/SNF complex gene PBRM1 in renal carcinoma.
10.1038/nature09639 · 2011 · External reference
Immune-based and novel therapies in variant histology renal cell carcinomas.
10.3390/cancers17020326 · 2025 · External reference
Metanephric adenoma with BRAF V600K mutation and a doubtful radiological imaging: pitfalls in the diagnostic process.
10.1007/s00795-020-00269-z · 2021 · External reference
First-line ICIs in renal cell carcinoma.
10.1080/21645515.2023.2225386 · 2023 · External reference
Cabozantinib versus sunitinib as initial targeted therapy for patients with metastatic renal cell carcinoma of poor or intermediate risk: the alliance A031203 CABOSUN trial.
10.1200/jco.2016.70.7398 · 2017 · External reference
Lenvatinib plus pembrolizumab versus sunitinib for first-line treatment of patients with advanced renal cell carcinoma (CLEAR): extended follow-up from the phase 3, randomised, open-label trial.
2022 · External reference
Nivolumab plus cabozantinib versus sunitinib for advanced renal-cell carcinoma.
10.1056/nejmoa2026982 · 2021 · External reference
Applications of single-cell sequencing in cancer research: progress and perspectives.
10.1186/s13045-021-01105-2 · 2021 · External reference
Single-cell RNA sequencing in multiple pathologic types of renal cell carcinoma revealed novel potential tumor-specific markers.
10.3389/fonc.2021.719564 · 2021 · External reference
Single-cell sequencing links multiregional immune landscapes and tissue-resident T cells in ccRCC to tumor topology and therapy efficacy.
10.1016/j.ccell.2021.03.007 · 2021 · External reference
Trans-ethnic Mendelian-randomization study reveals causal relationships between cardiometabolic factors and chronic kidney disease.
10.1093/ije/dyab203 · 2022 · External reference
Causal effects of gut microbiota on renal tumor: a Mendelian randomization study.
10.1097/js9.0000000000001041 · 2024 · External reference
AutoDock4 and AutoDockTools4: automated docking with selective receptor flexibility.
10.1002/jcc.21256 · 2009 · External reference
AutoDock Vina: improving the speed and accuracy of docking with a new scoring function, efficient optimization, and multithreading.
10.1002/jcc.21334 · 2010 · External reference
AutoDock Vina 1.2.0: new docking methods, expanded force field, and python bindings.
10.1021/acs.jcim.1c00203 · 2021 · External reference
Tumor microenvironment dynamics in clear-cell renal cell carcinoma.
10.1158/2159-8290.cd-19-0499 · 2019 · External reference
Integrated single-cell transcriptomic atlas of human kidney endothelial cells.
10.1681/asn.0000000000000320 · 2024 · External reference
Single-cell transcriptional profiling of clear cell renal cell carcinoma reveals a tumor-associated endothelial tip cell phenotype.
10.1038/s42003-024-06478-x · 2024 · External reference
Recent advances in the management of clear cell renal cell carcinoma: novel biomarkers and targeted therapies.
10.3390/cancers15123207 · 2023 · External reference
Patterns of ribosomal protein expression specify normal and malignant human cells.
10.1186/s13059-016-1104-z · 2016 · External reference
Identification of novel loci for pediatric cholestatic liver disease defined by KIF12, PPM1F, USP53, LSR, and WDR83OS pathogenic variants.
10.1038/s41436-018-0288-x · 2019 · External reference
Homozygous variants in WDR83OS lead to a neurodevelopmental disorder with hypercholanemia.
10.1016/j.ajhg.2024.10.002 · 2024 · External reference
TMSB10 acts as a biomarker and promotes progression of clear cell renal cell carcinoma.
2020 · External reference
Integrated analysis of the roles of oxidative stress related genes and prognostic value in clear cell renal cell carcinoma.
10.1007/s00432-023-04983-w · 2023 · External reference
Inflammatory networks in renal cell carcinoma.
10.3390/cancers15082212 · 2023 · External reference
AutoDock4 and AutoDockTools4: automated docking with selective receptor flexibility.
10.1002/jcc.21256 · ExternalCitation · doi-reference
AutoDock Vina: improving the speed and accuracy of docking with a new scoring function, efficient optimization, and multithreading.
10.1002/jcc.21334 · ExternalCitation · doi-reference
Integrated analysis of the roles of oxidative stress related genes and prognostic value in clear cell renal cell carcinoma.
10.1007/s00432-023-04983-w · ExternalCitation · doi-reference
Metanephric adenoma with BRAF V600K mutation and a doubtful radiological imaging: pitfalls in the diagnostic process.
10.1007/s00795-020-00269-z · ExternalCitation · doi-reference
Homozygous variants in WDR83OS lead to a neurodevelopmental disorder with hypercholanemia.
10.1016/j.ajhg.2024.10.002 · ExternalCitation · doi-reference
Single-cell sequencing links multiregional immune landscapes and tissue-resident T cells in ccRCC to tumor topology and therapy efficacy.
10.1016/j.ccell.2021.03.007 · ExternalCitation · doi-reference
AutoDock Vina 1.2.0: new docking methods, expanded force field, and python bindings.
10.1021/acs.jcim.1c00203 · ExternalCitation · doi-reference
Systematic sequencing of renal carcinoma reveals inactivation of histone modifying genes.
10.1038/nature08672 · ExternalCitation · doi-reference
Exome sequencing identifies frequent mutation of the SWI/SNF complex gene PBRM1 in renal carcinoma.
10.1038/nature09639 · ExternalCitation · doi-reference
Frequent mutations of genes encoding ubiquitin-mediated proteolysis pathway components in clear cell renal cell carcinoma.
10.1038/ng.1014 · ExternalCitation · doi-reference
Mutations of the VHL tumour suppressor gene in renal carcinoma.
10.1038/ng0594-85 · ExternalCitation · doi-reference
Renal cell carcinoma.
10.1038/nrdp.2017.9 · ExternalCitation · doi-reference
The genetic basis of kidney cancer: a metabolic disease.
10.1038/nrurol.2010.47 · ExternalCitation · doi-reference
Identification of novel loci for pediatric cholestatic liver disease defined by KIF12, PPM1F, USP53, LSR, and WDR83OS pathogenic variants.
10.1038/s41436-018-0288-x · ExternalCitation · doi-reference
Single-cell transcriptional profiling of clear cell renal cell carcinoma reveals a tumor-associated endothelial tip cell phenotype.
10.1038/s42003-024-06478-x · ExternalCitation · doi-reference
Intratumor heterogeneity and branched evolution revealed by multiregion sequencing.
10.1056/nejmoa1113205 · ExternalCitation · doi-reference
Nivolumab plus cabozantinib versus sunitinib for advanced renal-cell carcinoma.
10.1056/nejmoa2026982 · ExternalCitation · doi-reference
Systemic therapy for metastatic renal-cell carcinoma.
10.1056/nejmra1601333 · ExternalCitation · doi-reference
First-line ICIs in renal cell carcinoma.
10.1080/21645515.2023.2225386 · ExternalCitation · doi-reference
Trans-ethnic Mendelian-randomization study reveals causal relationships between cardiometabolic factors and chronic kidney disease.
10.1093/ije/dyab203 · ExternalCitation · doi-reference
Causal effects of gut microbiota on renal tumor: a Mendelian randomization study.
10.1097/js9.0000000000001041 · ExternalCitation · doi-reference
Tumor microenvironment dynamics in clear-cell renal cell carcinoma.
10.1158/2159-8290.cd-19-0499 · ExternalCitation · doi-reference
Applications of single-cell sequencing in cancer research: progress and perspectives.
10.1186/s13045-021-01105-2 · ExternalCitation · doi-reference
Patterns of ribosomal protein expression specify normal and malignant human cells.
10.1186/s13059-016-1104-z · ExternalCitation · doi-reference
Cabozantinib versus sunitinib as initial targeted therapy for patients with metastatic renal cell carcinoma of poor or intermediate risk: the alliance A031203 CABOSUN trial.
10.1200/jco.2016.70.7398 · ExternalCitation · doi-reference
Integrated single-cell transcriptomic atlas of human kidney endothelial cells.
10.1681/asn.0000000000000320 · ExternalCitation · doi-reference
Single-cell RNA sequencing in multiple pathologic types of renal cell carcinoma revealed novel potential tumor-specific markers.
10.3389/fonc.2021.719564 · ExternalCitation · doi-reference
Inflammatory networks in renal cell carcinoma.
10.3390/cancers15082212 · ExternalCitation · doi-reference
Recent advances in the management of clear cell renal cell carcinoma: novel biomarkers and targeted therapies.
10.3390/cancers15123207 · ExternalCitation · doi-reference
Immune-based and novel therapies in variant histology renal cell carcinomas.
10.3390/cancers17020326 · ExternalCitation · doi-reference
