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References from Causal relationship between metabolites, cerebral volume, and amyotrophic lateral sclerosis. Local targets link to admitted publications; unresolved targets remain external evidence.
Safety, tolerability, and efficacy of fasudil in amyotrophic lateral sclerosis (ROCK-ALS): a phase 2, randomised, double-blind, placebo-controlled trial.
10.1016/s1474-4422(24)00373-9 · 2024 · External reference
Advancements in genetic research and RNA therapy strategies for amyotrophic lateral sclerosis (ALS): current progress and future prospects.
10.1007/s00415-025-12975-8 · 2025 · External reference
Whole-genome sequencing identifies common-to-rare variants associated with human blood metabolites.
10.1038/ng.3809 · 2017 · External reference
Emerging applications of metabolomics in drug discovery and precision medicine.
10.1038/nrd.2016.32 · 2016 · External reference
Plasma metabolites to profile pathways in noncommunicable disease multimorbidity.
10.1038/s41591-021-01266-0 · 2021 · External reference
Heritability estimates for 361 blood metabolites across 40 genome-wide association studies.
10.1038/s41467-019-13770-6 · 2020 · External reference
Mendelian randomization: prospects, potentials, and limitations.
10.1093/ije/dyh132 · 2004 · External reference
Brain white matter shape changes in amyotrophic lateral sclerosis (ALS): a fractal dimension study.
10.1371/journal.pone.0073614 · 2013 · External reference
Classification of amyotrophic lateral sclerosis by brain volume, connectivity, and network dynamics.
10.1002/hbm.25679 · 2022 · External reference
Whole-brain and regional brain atrophy in amyotrophic lateral sclerosis.
2007 · External reference
Genomic atlas of the plasma metabolome prioritizes metabolites implicated in human diseases.
10.1038/s41588-022-01270-1 · 2023 · External reference
Genome-wide association study of cerebellar volume provides insights into heritable mechanisms underlying brain development and mental health.
10.1038/s42003-022-03672-7 · 2022 · External reference
An integrative transcriptome-wide analysis of amyotrophic lateral sclerosis for the identification of potential genetic markers and drug candidates.
10.3390/ijms22063216 · 2021 · External reference
Mendelian randomization.
10.1001/jama.2017.17219 · 2017 · External reference
PLINK: a tool set for whole-genome association and population-based linkage analyses.
10.1086/519795 · 2007 · External reference
Combined effects of host genetics and diet on human gut microbiota and incident disease in a single population cohort.
10.1038/s41588-021-00991-z · 2022 · External reference
Genome-wide association study in 8,956 German individuals identifies influence of ABO histo-blood groups on gut microbiome.
10.1038/s41588-020-00747-1 · 2021 · External reference
Large-scale association analyses identify host factors influencing human gut microbiome composition.
10.1038/s41588-020-00763-1 · 2021 · External reference
Causal relationships among the gut microbiome, short-chain fatty acids and metabolic diseases.
10.1038/s41588-019-0350-x · 2019 · External reference
PhenoScanner: a database of human genotype-phenotype associations.
10.1093/bioinformatics/btw373 · 2016 · External reference
The interaction between smoking, alcohol and the gut microbiome.
10.1016/j.bpg.2017.10.006 · 2017 · External reference
Environmental factors shaping the gut microbiome in a Dutch population.
10.1038/s41586-022-04567-7 · 2022 · External reference
Metabolic abnormalities, dietary risk factors and nutritional management in amyotrophic lateral sclerosis.
10.3390/nu13072273 · 2021 · External reference
Pre-diagnostic plasma lipid levels and the risk of amyotrophic lateral sclerosis.
10.1080/21678421.2020.1822411 · 2021 · External reference
Effect of presymptomatic body mass index and consumption of fat and alcohol on amyotrophic lateral sclerosis.
10.1001/jamaneurol.2015.1584 · 2015 · External reference
Smoking and risk for amyotrophic lateral sclerosis: analysis of the EPIC cohort.
10.1002/ana.21653 · 2009 · External reference
Improving the visualization, interpretation and analysis of two-sample summary data Mendelian randomization via the Radial plot and Radial regression.
10.1093/ije/dyy101 · 2018 · External reference
Sample size and power calculations in Mendelian randomization with a single instrumental variable and a binary outcome.
10.1093/ije/dyu005 · 2014 · External reference
STEPHEN BURGESS, SIMON G. THOMPSON. Mendelian Randomization: Methods for Using Genetic Variants in Causal Estimation. CRC Press.
10.1111/biom.12674 · 2017 · External reference
Mendelian randomization analysis with multiple genetic variants using summarized data.
10.1002/gepi.21758 · 2013 · External reference
Consistent estimation in mendelian randomization with some invalid instruments using a weighted median estimator.
10.1002/gepi.21965 · 2016 · External reference
Robust inference in summary data Mendelian randomization via the zero modal pleiotropy assumption.
10.1093/ije/dyx102 · 2017 · External reference
Mendelian randomization with invalid instruments: effect estimation and bias detection through Egger regression.
10.1093/ije/dyv080 · 2015 · External reference
Mediation analysis: a practitioner’s guide.
10.1146/annurev-publhealth-032315-021402 · 2016 · External reference
Understanding the consequences of education inequality on cardiovascular disease: mendelian randomisation study.
10.1136/bmj.l1855 · 2019 · External reference
N1-acetylspermidine is a determinant of hair follicle stem cell fate.
10.1242/jcs.252767 · 2021 · External reference
Recent advances in understanding amyotrophic lateral sclerosis and emerging therapies.
10.12703/b/9-12 · 2020 · External reference
The small heat shock protein B8 (HspB8) promotes autophagic removal of misfolded proteins involved in amyotrophic lateral sclerosis (ALS).
10.1093/hmg/ddq257 · 2010 · External reference
Action of spermidine, N1-acetylspermidine, and N8-acetylspermidine at apurinic sites in DNA.
10.1016/0014-5793(90)81200-8 · 1990 · External reference
Implications of trimethylamine N-oxide (TMAO) and betaine in human health: beyond being osmoprotective compounds.
10.3389/fmolb.2022.964624 · 2022 · External reference
Betaine reduces β-amyloid-induced paralysis through activation of cystathionine-β-synthase in an Alzheimer model of Caenorhabditis elegans.
10.1186/s12263-018-0611-9 · 2018 · External reference
Betaine regulates the gut-liver axis: a therapeutic approach for chronic liver diseases.
10.3389/fnut.2025.1478542 · 2025 · External reference
Amyotrophic lateral sclerosis: a neurodegenerative disorder poised for successful therapeutic translation.
10.1038/s41573-022-00612-2 · 2023 · External reference
Genetically predicted plasma metabolome mediates the causal link between immune cells and risk of gout.
10.1111/1756-185x.70094 · 2025 · External reference
Exploring the impact of metabolites function on heart failure and coronary heart disease: insights from a Mendelian randomization (MR) study.
10.62347/oqxz7740 · 2024 · External reference
Current knowledge and recent insights into the genetic basis of amyotrophic lateral sclerosis.
2018 · External reference
Genetics of amyotrophic lateral sclerosis.
10.1101/cshperspect.a024125 · 2018 · External reference
Distinct responses of neurons and astrocytes to TDP-43 proteinopathy in amyotrophic lateral sclerosis.
10.1093/brain/awz419 · 2020 · External reference
Oxidative stress and inflammation in the pathogenesis of neurological disorders: mechanisms and implications.
10.1016/j.apsb.2024.10.004 · 2025 · External reference
Inflammatory signature in amyotrophic lateral sclerosis predicting disease progression.
10.1038/s41598-024-67165-9 · 2024 · External reference
Targeting gene C9orf72 pathogenesis for amyotrophic lateral sclerosis.
10.3390/ijms26094276 · 2025 · External reference
Causal relationship between human blood metabolites and risk of ischemic stroke: a Mendelian randomization study.
10.3389/fgene.2024.1333454 · 2024 · External reference
Chronic exercise improves hepatic acylcarnitine handling.
10.1016/j.isci.2024.109083 · 2024 · External reference
Metabolomics identifies shared lipid pathways in independent amyotrophic lateral sclerosis cohorts.
10.1093/brain/awac025 · 2022 · External reference
Longitudinal metabolomics in amyotrophic lateral sclerosis implicates impaired lipid metabolism.
10.1002/ana.27208 · 2025 · External reference
Exploring advancements in the treatment of amyotrophic lateral sclerosis: a comprehensive review of current modalities and future prospects.
2023 · External reference
Retrospective observational study on the use of acetyl-L-carnitine in ALS.
10.1007/s00415-023-11844-6 · 2023 · External reference
Mild cognitive impairment in amyotrophic lateral sclerosis: current view.
10.1007/s00702-024-02850-7 · 2025 · External reference
Longitudinal clinical and neuroanatomical correlates of memory impairment in motor neuron disease.
10.1016/j.nicl.2020.102545 · 2021 · External reference
Neuroimaging correlates of domain-specific cognitive deficits in amyotrophic lateral sclerosis.
10.1016/j.nicl.2025.103749 · 2025 · External reference
Pathophysiology, clinical heterogeneity, and therapeutic advances in amyotrophic lateral sclerosis: a comprehensive review of molecular mechanisms, diagnostic challenges, and multidisciplinary management strategies.
2025 · External reference
Progression of cognitive and behavioural impairment in early amyotrophic lateral sclerosis.
10.1136/jnnp-2020-322992 · 2020 · External reference
Gene therapy breakthroughs in ALS: a beacon of hope for 20% of ALS patients.
10.1186/s40035-025-00477-6 · 2025 · External reference
The BCAT1 CXXC motif provides protection against ROS in acute myeloid leukaemia cells.
10.3390/antiox11040683 · 2022 · External reference
Multiple roles of branched-chain amino acid metabolism in tumour progression.
10.1186/s12929-025-01132-y · 2025 · External reference
High concentration of branched-chain amino acids promotes oxidative stress, inflammation and migration of human peripheral blood mononuclear cells via mTORC1 activation.
10.1016/j.freeradbiomed.2017.01.009 · 2017 · External reference
Pancreatic cancer: branched-chain amino acids as putative key metabolic regulators?
10.1007/s10555-021-10016-0 · 2021 · External reference
Tryptophan metabolism in health and disease.
10.1016/j.cmet.2023.06.004 · 2023 · External reference
Cannabinoids modulate the microbiota-gut-brain axis in HIV/SIV infection by reducing neuroinflammation and dysbiosis while concurrently elevating endocannabinoid and indole-3-propionate levels.
10.1186/s12974-023-02729-6 · 2023 · External reference
Gut microbiota-derived indole derivatives alleviate neurodegeneration in aging through activating GPR30/AMPK/SIRT1 Pathway.
10.1002/mnfr.202200739 · 2023 · External reference
Involvement of the microbiota-gut-brain axis in chronic restraint stress: disturbances of the kynurenine metabolic pathway in both the gut and brain.
10.1080/19490976.2020.1869501 · 2021 · External reference
Chaperone mediated autophagy degrades TDP-43 protein and is affected by TDP-43 aggregation.
10.3389/fnmol.2020.00019 · 2020 · External reference
HSC70 expression is reduced in lymphomonocytes of sporadic ALS patients and contributes to TDP-43 accumulation.
10.1080/21678421.2019.1672749 · 2020 · External reference
Metabolism and mis-metabolism of the neuropathological signature protein TDP-43.
2014 · External reference
Mendelian randomization.
10.1001/jama.2017.17219 · ExternalCitation · doi-reference
Effect of presymptomatic body mass index and consumption of fat and alcohol on amyotrophic lateral sclerosis.
10.1001/jamaneurol.2015.1584 · ExternalCitation · doi-reference
Smoking and risk for amyotrophic lateral sclerosis: analysis of the EPIC cohort.
10.1002/ana.21653 · ExternalCitation · doi-reference
Longitudinal metabolomics in amyotrophic lateral sclerosis implicates impaired lipid metabolism.
10.1002/ana.27208 · ExternalCitation · doi-reference
Mendelian randomization analysis with multiple genetic variants using summarized data.
10.1002/gepi.21758 · ExternalCitation · doi-reference
Consistent estimation in mendelian randomization with some invalid instruments using a weighted median estimator.
10.1002/gepi.21965 · ExternalCitation · doi-reference
Classification of amyotrophic lateral sclerosis by brain volume, connectivity, and network dynamics.
10.1002/hbm.25679 · ExternalCitation · doi-reference
Gut microbiota-derived indole derivatives alleviate neurodegeneration in aging through activating GPR30/AMPK/SIRT1 Pathway.
10.1002/mnfr.202200739 · ExternalCitation · doi-reference
Retrospective observational study on the use of acetyl-L-carnitine in ALS.
10.1007/s00415-023-11844-6 · ExternalCitation · doi-reference
Advancements in genetic research and RNA therapy strategies for amyotrophic lateral sclerosis (ALS): current progress and future prospects.
10.1007/s00415-025-12975-8 · ExternalCitation · doi-reference
Mild cognitive impairment in amyotrophic lateral sclerosis: current view.
10.1007/s00702-024-02850-7 · ExternalCitation · doi-reference
Pancreatic cancer: branched-chain amino acids as putative key metabolic regulators?
10.1007/s10555-021-10016-0 · ExternalCitation · doi-reference
Action of spermidine, N1-acetylspermidine, and N8-acetylspermidine at apurinic sites in DNA.
10.1016/0014-5793(90)81200-8 · ExternalCitation · doi-reference
Oxidative stress and inflammation in the pathogenesis of neurological disorders: mechanisms and implications.
10.1016/j.apsb.2024.10.004 · ExternalCitation · doi-reference
The interaction between smoking, alcohol and the gut microbiome.
10.1016/j.bpg.2017.10.006 · ExternalCitation · doi-reference
Tryptophan metabolism in health and disease.
10.1016/j.cmet.2023.06.004 · ExternalCitation · doi-reference
High concentration of branched-chain amino acids promotes oxidative stress, inflammation and migration of human peripheral blood mononuclear cells via mTORC1 activation.
10.1016/j.freeradbiomed.2017.01.009 · ExternalCitation · doi-reference
Chronic exercise improves hepatic acylcarnitine handling.
10.1016/j.isci.2024.109083 · ExternalCitation · doi-reference
Longitudinal clinical and neuroanatomical correlates of memory impairment in motor neuron disease.
10.1016/j.nicl.2020.102545 · ExternalCitation · doi-reference
Neuroimaging correlates of domain-specific cognitive deficits in amyotrophic lateral sclerosis.
10.1016/j.nicl.2025.103749 · ExternalCitation · doi-reference
Safety, tolerability, and efficacy of fasudil in amyotrophic lateral sclerosis (ROCK-ALS): a phase 2, randomised, double-blind, placebo-controlled trial.
10.1016/s1474-4422(24)00373-9 · ExternalCitation · doi-reference
Whole-genome sequencing identifies common-to-rare variants associated with human blood metabolites.
10.1038/ng.3809 · ExternalCitation · doi-reference
Emerging applications of metabolomics in drug discovery and precision medicine.
10.1038/nrd.2016.32 · ExternalCitation · doi-reference
Heritability estimates for 361 blood metabolites across 40 genome-wide association studies.
10.1038/s41467-019-13770-6 · ExternalCitation · doi-reference
Amyotrophic lateral sclerosis: a neurodegenerative disorder poised for successful therapeutic translation.
10.1038/s41573-022-00612-2 · ExternalCitation · doi-reference
Environmental factors shaping the gut microbiome in a Dutch population.
10.1038/s41586-022-04567-7 · ExternalCitation · doi-reference
Causal relationships among the gut microbiome, short-chain fatty acids and metabolic diseases.
10.1038/s41588-019-0350-x · ExternalCitation · doi-reference
Genome-wide association study in 8,956 German individuals identifies influence of ABO histo-blood groups on gut microbiome.
10.1038/s41588-020-00747-1 · ExternalCitation · doi-reference
Large-scale association analyses identify host factors influencing human gut microbiome composition.
10.1038/s41588-020-00763-1 · ExternalCitation · doi-reference
Combined effects of host genetics and diet on human gut microbiota and incident disease in a single population cohort.
10.1038/s41588-021-00991-z · ExternalCitation · doi-reference
Genomic atlas of the plasma metabolome prioritizes metabolites implicated in human diseases.
10.1038/s41588-022-01270-1 · ExternalCitation · doi-reference
Plasma metabolites to profile pathways in noncommunicable disease multimorbidity.
10.1038/s41591-021-01266-0 · ExternalCitation · doi-reference
Inflammatory signature in amyotrophic lateral sclerosis predicting disease progression.
10.1038/s41598-024-67165-9 · ExternalCitation · doi-reference
Genome-wide association study of cerebellar volume provides insights into heritable mechanisms underlying brain development and mental health.
10.1038/s42003-022-03672-7 · ExternalCitation · doi-reference
Involvement of the microbiota-gut-brain axis in chronic restraint stress: disturbances of the kynurenine metabolic pathway in both the gut and brain.
10.1080/19490976.2020.1869501 · ExternalCitation · doi-reference
HSC70 expression is reduced in lymphomonocytes of sporadic ALS patients and contributes to TDP-43 accumulation.
10.1080/21678421.2019.1672749 · ExternalCitation · doi-reference
Pre-diagnostic plasma lipid levels and the risk of amyotrophic lateral sclerosis.
10.1080/21678421.2020.1822411 · ExternalCitation · doi-reference
PLINK: a tool set for whole-genome association and population-based linkage analyses.
10.1086/519795 · ExternalCitation · doi-reference
PhenoScanner: a database of human genotype-phenotype associations.
10.1093/bioinformatics/btw373 · ExternalCitation · doi-reference
Metabolomics identifies shared lipid pathways in independent amyotrophic lateral sclerosis cohorts.
10.1093/brain/awac025 · ExternalCitation · doi-reference
Distinct responses of neurons and astrocytes to TDP-43 proteinopathy in amyotrophic lateral sclerosis.
10.1093/brain/awz419 · ExternalCitation · doi-reference
The small heat shock protein B8 (HspB8) promotes autophagic removal of misfolded proteins involved in amyotrophic lateral sclerosis (ALS).
10.1093/hmg/ddq257 · ExternalCitation · doi-reference
Mendelian randomization: prospects, potentials, and limitations.
10.1093/ije/dyh132 · ExternalCitation · doi-reference
Sample size and power calculations in Mendelian randomization with a single instrumental variable and a binary outcome.
10.1093/ije/dyu005 · ExternalCitation · doi-reference
Mendelian randomization with invalid instruments: effect estimation and bias detection through Egger regression.
10.1093/ije/dyv080 · ExternalCitation · doi-reference
Robust inference in summary data Mendelian randomization via the zero modal pleiotropy assumption.
10.1093/ije/dyx102 · ExternalCitation · doi-reference
Improving the visualization, interpretation and analysis of two-sample summary data Mendelian randomization via the Radial plot and Radial regression.
10.1093/ije/dyy101 · ExternalCitation · doi-reference
Genetics of amyotrophic lateral sclerosis.
10.1101/cshperspect.a024125 · ExternalCitation · doi-reference
Genetically predicted plasma metabolome mediates the causal link between immune cells and risk of gout.
10.1111/1756-185x.70094 · ExternalCitation · doi-reference
STEPHEN BURGESS, SIMON G. THOMPSON. Mendelian Randomization: Methods for Using Genetic Variants in Causal Estimation. CRC Press.
10.1111/biom.12674 · ExternalCitation · doi-reference
Understanding the consequences of education inequality on cardiovascular disease: mendelian randomisation study.
10.1136/bmj.l1855 · ExternalCitation · doi-reference
Progression of cognitive and behavioural impairment in early amyotrophic lateral sclerosis.
10.1136/jnnp-2020-322992 · ExternalCitation · doi-reference
Mediation analysis: a practitioner’s guide.
10.1146/annurev-publhealth-032315-021402 · ExternalCitation · doi-reference
Betaine reduces β-amyloid-induced paralysis through activation of cystathionine-β-synthase in an Alzheimer model of Caenorhabditis elegans.
10.1186/s12263-018-0611-9 · ExternalCitation · doi-reference
Multiple roles of branched-chain amino acid metabolism in tumour progression.
10.1186/s12929-025-01132-y · ExternalCitation · doi-reference
Cannabinoids modulate the microbiota-gut-brain axis in HIV/SIV infection by reducing neuroinflammation and dysbiosis while concurrently elevating endocannabinoid and indole-3-propionate levels.
10.1186/s12974-023-02729-6 · ExternalCitation · doi-reference
Gene therapy breakthroughs in ALS: a beacon of hope for 20% of ALS patients.
10.1186/s40035-025-00477-6 · ExternalCitation · doi-reference
N1-acetylspermidine is a determinant of hair follicle stem cell fate.
10.1242/jcs.252767 · ExternalCitation · doi-reference
Recent advances in understanding amyotrophic lateral sclerosis and emerging therapies.
10.12703/b/9-12 · ExternalCitation · doi-reference
Brain white matter shape changes in amyotrophic lateral sclerosis (ALS): a fractal dimension study.
10.1371/journal.pone.0073614 · ExternalCitation · doi-reference
Causal relationship between human blood metabolites and risk of ischemic stroke: a Mendelian randomization study.
10.3389/fgene.2024.1333454 · ExternalCitation · doi-reference
Implications of trimethylamine N-oxide (TMAO) and betaine in human health: beyond being osmoprotective compounds.
10.3389/fmolb.2022.964624 · ExternalCitation · doi-reference
Chaperone mediated autophagy degrades TDP-43 protein and is affected by TDP-43 aggregation.
10.3389/fnmol.2020.00019 · ExternalCitation · doi-reference
Betaine regulates the gut-liver axis: a therapeutic approach for chronic liver diseases.
10.3389/fnut.2025.1478542 · ExternalCitation · doi-reference
The BCAT1 CXXC motif provides protection against ROS in acute myeloid leukaemia cells.
10.3390/antiox11040683 · ExternalCitation · doi-reference
An integrative transcriptome-wide analysis of amyotrophic lateral sclerosis for the identification of potential genetic markers and drug candidates.
10.3390/ijms22063216 · ExternalCitation · doi-reference
Targeting gene C9orf72 pathogenesis for amyotrophic lateral sclerosis.
10.3390/ijms26094276 · ExternalCitation · doi-reference
Metabolic abnormalities, dietary risk factors and nutritional management in amyotrophic lateral sclerosis.
10.3390/nu13072273 · ExternalCitation · doi-reference
Exploring the impact of metabolites function on heart failure and coronary heart disease: insights from a Mendelian randomization (MR) study.
10.62347/oqxz7740 · ExternalCitation · doi-reference
