Research graph
References from Causal effects of circulating cathepsins on cholecystitis, cholelithiasis, primary biliary cholangitis, primary sclerosing cholangitis, acute pancreatitis, and chronic pancreatitis. Local targets link to admitted publications; unresolved targets remain external evidence.
Age-period-cohort analysis of gallbladder and biliary diseases epidemiological trends from 1990 to 2021 and forecasts for 2035: a systematic analysis from the global burden of disease study 2021.
10.1186/s12876-025-03592-w · 2025 · External reference
Global incidence and mortality of pancreatic diseases: a systematic review, meta-analysis, and meta-regression of population-based cohort studies.
10.1016/s2468-1253(16)30004-8 · 2016 · External reference
The pathogenesis, models and therapeutic advances of primary biliary cholangitis.
10.1016/j.biopha.2021.111754 · 2021 · External reference
Cysteine cathepsins: from structure, function and regulation to new frontiers.
10.1016/j.bbapap.2011.10.002 · 2012 · External reference
The ins and outs of cathepsins: physiological function and role in disease management.
10.3390/cells9071679 · 2020 · External reference
Cathepsins and compartmentalization in antigen presentation.
10.1016/s0952-7915(99)00058-8 · 2000 · External reference
Cysteine cathepsins and extracellular matrix degradation.
10.1016/j.bbagen.2014.03.017 · 2014 · External reference
Cathepsin B links oxidative stress to the activation of NLRP3 inflammasome.
10.1016/j.yexcr.2017.11.015 · 2018 · External reference
Molecular cloning of human cathepsin O, a novel endoproteinase and homologue of rabbit OC2.
10.1016/0014-5793(94)01349-6 · 1995 · External reference
Prognostic significance of cathepsin V (CTSV/CTSL2) in breast ductal carcinoma in situ.
10.1136/jclinpath-2019-205939 · 2020 · External reference
Cathepsin H functions as an aminopeptidase in secretory vesicles for production of enkephalin and galanin peptide neurotransmitters.
10.1111/j.1471-4159.2012.07788.x · 2012 · External reference
Reading Mendelian randomisation studies: a guide, glossary, and checklist for clinicians.
10.1136/bmj.k601 · 2018 · External reference
Mendelian randomization: genetic anchors for causal inference in epidemiological studies.
10.1093/hmg/ddu328 · 2014 · External reference
Mendelian randomization: causal inference leveraging genetic data.
10.1017/s0033291724000321 · 2024 · External reference
Sensitivity analyses for robust causal inference from Mendelian randomization analyses with multiple genetic variants.
10.1097/ede.0000000000000559 · 2017 · External reference
The causal relationship between cathepsins and digestive system tumors: a Mendelian randomization study.
10.3389/fonc.2024.1365138 · 2024 · External reference
Bidirectional two-sample Mendelian randomization analysis investigates causal associations between cathepsins and inflammatory bowel disease.
10.3389/fgene.2024.1436407 · 2024 · External reference
A cross-population atlas of genetic associations for 220 human phenotypes.
10.1038/s41588-021-00931-x · 2021 · External reference
Common genetic associations between age-related diseases.
10.1038/s43587-021-00051-5 · 2021 · External reference
International genome-wide meta-analysis identifies new primary biliary cirrhosis risk loci and targetable pathogenic pathways.
10.1038/ncomms9019 · 2015 · External reference
Genome-wide association study of primary sclerosing cholangitis identifies new risk loci and quantifies the genetic relationship with inflammatory bowel disease.
10.1038/ng.3745 · 2017 · External reference
Assessing the suitability of summary data for two-sample Mendelian randomization analyses using MR-Egger regression: the role of the I2 statistic.
2016 · External reference
Consistent estimation in mendelian randomization with some invalid instruments using a weighted median estimator.
10.1002/gepi.21965 · 2016 · External reference
Mendelian randomization with invalid instruments: effect estimation and bias detection through Egger regression.
10.1093/ije/dyv080 · 2015 · External reference
Detection of widespread horizontal pleiotropy in causal relationships inferred from Mendelian randomization between complex traits and diseases.
10.1038/s41588-018-0099-7 · 2018 · External reference
The epidemiology of pancreatitis and pancreatic cancer.
10.1053/j.gastro.2013.01.068 · 2013 · External reference
Cathepsin B deficiency ameliorates liver lipid deposition, inflammatory cell infiltration, and fibrosis after diet-induced nonalcoholic steatohepatitis.
10.1016/j.trsl.2020.04.011 · 2020 · External reference
Role of cathepsin B in intracellular trypsinogen activation and the onset of acute pancreatitis.
10.1172/jci9411 · 2000 · External reference
Active cathepsins B, L, and S in murine and human pancreatitis.
10.1152/ajpgi.00073.2012 · 2012 · External reference
The multifaceted role of cathepsins in liver disease.
10.1016/j.jhep.2021.06.031 · 2021 · External reference
Cysteine cathepsins and their extracellular roles: shaping the microenvironment.
10.3390/cells8030264 · 2019 · External reference
Cysteine cathepsin proteases: regulators of cancer progression and therapeutic response.
10.1038/nrc4027 · 2015 · External reference
Lysosomal membrane permeabilization in cell death: concepts and challenges.
10.1016/j.mito.2014.06.006 · 2014 · External reference
Macrophage-derived cathepsin s remodels the extracellular matrix to promote liver fibrogenesis.
10.1053/j.gastro.2023.05.039 · 2023 · External reference
Cathepsin B aggravates acute pancreatitis by activating the NLRP3 inflammasome and promoting the caspase-1-induced pyroptosis.
10.1016/j.intimp.2021.107496 · 2021 · External reference
Lysosomes in cell death.
10.1038/sj.onc.1207512 · 2004 · External reference
Cathepsin L and B as potential markers for liver fibrosis: insights from patients and experimental models.
10.1038/ctg.2017.25 · 2017 · External reference
Tsisteinovye katepsiny: stroenie, fiziologicheskie funktsii i rol’ v kantserogeneze (Cysteine cathepsins: structure, physiological functions and their role in carcinogenesis).
10.18097/pbmc20216706453 · 2021 · External reference
Association between hereditary spherocytosis and gallstone disease: pathophysiology, diagnosis, and management.
10.4240/wjgs.v17.i7.105033 · 2025 · External reference
Human cathepsin V functional expression, tissue distribution, electrostatic surface potential, enzymatic characterization, and chromosomal localization.
10.1021/bi982175f · 1999 · External reference
Specialized roles for cysteine cathepsins in health and disease.
10.1172/jci42918 · 2010 · External reference
Cathepsin V: molecular characteristics and significance in health and disease.
10.1016/j.mam.2022.101086 · 2022 · External reference
Cathepsin L inactivates human trypsinogen, whereas cathepsin L-deletion reduces the severity of pancreatitis in mice.
10.1053/j.gastro.2009.10.048 · 2010 · External reference
Models of acute and chronic pancreatitis.
10.1053/j.gastro.2012.12.043 · 2013 · External reference
Cathepsin H: molecular characteristics and clues to function and mechanism.
10.1016/j.bcp.2023.115585 · 2023 · External reference
Consistent estimation in mendelian randomization with some invalid instruments using a weighted median estimator.
10.1002/gepi.21965 · ExternalCitation · doi-reference
Molecular cloning of human cathepsin O, a novel endoproteinase and homologue of rabbit OC2.
10.1016/0014-5793(94)01349-6 · ExternalCitation · doi-reference
Cysteine cathepsins and extracellular matrix degradation.
10.1016/j.bbagen.2014.03.017 · ExternalCitation · doi-reference
Cysteine cathepsins: from structure, function and regulation to new frontiers.
10.1016/j.bbapap.2011.10.002 · ExternalCitation · doi-reference
Cathepsin H: molecular characteristics and clues to function and mechanism.
10.1016/j.bcp.2023.115585 · ExternalCitation · doi-reference
The pathogenesis, models and therapeutic advances of primary biliary cholangitis.
10.1016/j.biopha.2021.111754 · ExternalCitation · doi-reference
Cathepsin B aggravates acute pancreatitis by activating the NLRP3 inflammasome and promoting the caspase-1-induced pyroptosis.
10.1016/j.intimp.2021.107496 · ExternalCitation · doi-reference
The multifaceted role of cathepsins in liver disease.
10.1016/j.jhep.2021.06.031 · ExternalCitation · doi-reference
Cathepsin V: molecular characteristics and significance in health and disease.
10.1016/j.mam.2022.101086 · ExternalCitation · doi-reference
Lysosomal membrane permeabilization in cell death: concepts and challenges.
10.1016/j.mito.2014.06.006 · ExternalCitation · doi-reference
Cathepsin B deficiency ameliorates liver lipid deposition, inflammatory cell infiltration, and fibrosis after diet-induced nonalcoholic steatohepatitis.
10.1016/j.trsl.2020.04.011 · ExternalCitation · doi-reference
Cathepsin B links oxidative stress to the activation of NLRP3 inflammasome.
10.1016/j.yexcr.2017.11.015 · ExternalCitation · doi-reference
Cathepsins and compartmentalization in antigen presentation.
10.1016/s0952-7915(99)00058-8 · ExternalCitation · doi-reference
Global incidence and mortality of pancreatic diseases: a systematic review, meta-analysis, and meta-regression of population-based cohort studies.
10.1016/s2468-1253(16)30004-8 · ExternalCitation · doi-reference
Mendelian randomization: causal inference leveraging genetic data.
10.1017/s0033291724000321 · ExternalCitation · doi-reference
Human cathepsin V functional expression, tissue distribution, electrostatic surface potential, enzymatic characterization, and chromosomal localization.
10.1021/bi982175f · ExternalCitation · doi-reference
Cathepsin L and B as potential markers for liver fibrosis: insights from patients and experimental models.
10.1038/ctg.2017.25 · ExternalCitation · doi-reference
International genome-wide meta-analysis identifies new primary biliary cirrhosis risk loci and targetable pathogenic pathways.
10.1038/ncomms9019 · ExternalCitation · doi-reference
Genome-wide association study of primary sclerosing cholangitis identifies new risk loci and quantifies the genetic relationship with inflammatory bowel disease.
10.1038/ng.3745 · ExternalCitation · doi-reference
Cysteine cathepsin proteases: regulators of cancer progression and therapeutic response.
10.1038/nrc4027 · ExternalCitation · doi-reference
Detection of widespread horizontal pleiotropy in causal relationships inferred from Mendelian randomization between complex traits and diseases.
10.1038/s41588-018-0099-7 · ExternalCitation · doi-reference
A cross-population atlas of genetic associations for 220 human phenotypes.
10.1038/s41588-021-00931-x · ExternalCitation · doi-reference
Common genetic associations between age-related diseases.
10.1038/s43587-021-00051-5 · ExternalCitation · doi-reference
Lysosomes in cell death.
10.1038/sj.onc.1207512 · ExternalCitation · doi-reference
Cathepsin L inactivates human trypsinogen, whereas cathepsin L-deletion reduces the severity of pancreatitis in mice.
10.1053/j.gastro.2009.10.048 · ExternalCitation · doi-reference
Models of acute and chronic pancreatitis.
10.1053/j.gastro.2012.12.043 · ExternalCitation · doi-reference
The epidemiology of pancreatitis and pancreatic cancer.
10.1053/j.gastro.2013.01.068 · ExternalCitation · doi-reference
Macrophage-derived cathepsin s remodels the extracellular matrix to promote liver fibrogenesis.
10.1053/j.gastro.2023.05.039 · ExternalCitation · doi-reference
Mendelian randomization: genetic anchors for causal inference in epidemiological studies.
10.1093/hmg/ddu328 · ExternalCitation · doi-reference
Mendelian randomization with invalid instruments: effect estimation and bias detection through Egger regression.
10.1093/ije/dyv080 · ExternalCitation · doi-reference
Sensitivity analyses for robust causal inference from Mendelian randomization analyses with multiple genetic variants.
10.1097/ede.0000000000000559 · ExternalCitation · doi-reference
Cathepsin H functions as an aminopeptidase in secretory vesicles for production of enkephalin and galanin peptide neurotransmitters.
10.1111/j.1471-4159.2012.07788.x · ExternalCitation · doi-reference
Reading Mendelian randomisation studies: a guide, glossary, and checklist for clinicians.
10.1136/bmj.k601 · ExternalCitation · doi-reference
Prognostic significance of cathepsin V (CTSV/CTSL2) in breast ductal carcinoma in situ.
10.1136/jclinpath-2019-205939 · ExternalCitation · doi-reference
Active cathepsins B, L, and S in murine and human pancreatitis.
10.1152/ajpgi.00073.2012 · ExternalCitation · doi-reference
Specialized roles for cysteine cathepsins in health and disease.
10.1172/jci42918 · ExternalCitation · doi-reference
Role of cathepsin B in intracellular trypsinogen activation and the onset of acute pancreatitis.
10.1172/jci9411 · ExternalCitation · doi-reference
Age-period-cohort analysis of gallbladder and biliary diseases epidemiological trends from 1990 to 2021 and forecasts for 2035: a systematic analysis from the global burden of disease study 2021.
10.1186/s12876-025-03592-w · ExternalCitation · doi-reference
Tsisteinovye katepsiny: stroenie, fiziologicheskie funktsii i rol’ v kantserogeneze (Cysteine cathepsins: structure, physiological functions and their role in carcinogenesis).
10.18097/pbmc20216706453 · ExternalCitation · doi-reference
Bidirectional two-sample Mendelian randomization analysis investigates causal associations between cathepsins and inflammatory bowel disease.
10.3389/fgene.2024.1436407 · ExternalCitation · doi-reference
The causal relationship between cathepsins and digestive system tumors: a Mendelian randomization study.
10.3389/fonc.2024.1365138 · ExternalCitation · doi-reference
Cysteine cathepsins and their extracellular roles: shaping the microenvironment.
10.3390/cells8030264 · ExternalCitation · doi-reference
The ins and outs of cathepsins: physiological function and role in disease management.
10.3390/cells9071679 · ExternalCitation · doi-reference
Association between hereditary spherocytosis and gallstone disease: pathophysiology, diagnosis, and management.
10.4240/wjgs.v17.i7.105033 · ExternalCitation · doi-reference
