Research graph
References from Prekallikrein: the catalytic crossroads of inflammation and thrombosis. Local targets link to admitted publications; unresolved targets remain external evidence.
Human plasma kallikrein: roles in coagulation, fibrinolysis, inflammation pathways, and beyond
10.3389/fphys.2023.1188816 · 2023 · External reference
Proteolytic activity of contact factor zymogens
10.1111/jth.15149 · 2021 · External reference
Severe plasma prekallikrein deficiency: clinical characteristics, novel KLKB1 mutations, and estimated prevalence
10.1111/jth.14805 · 2020 · External reference
Biology of factor XI
10.1182/blood.2023020719 · 2024 · External reference
Plasma prekallikrein: its role in hereditary angioedema and health and disease
10.3389/fmed.2018.00003 · 2018 · External reference
Inhibition of prekallikrein for hereditary angioedema
10.1056/nejmoa2109329 · 2022 · External reference
Hereditary angioedema
10.1056/nejmra1808012 · 2020 · External reference
Efficacy and safety of donidalorsen for hereditary angioedema
10.1056/nejmoa2402478 · 2024 · External reference
A comparison of the effects of factor XII deficiency and prekallikrein deficiency on thrombus formation
10.1016/j.thromres.2016.02.020 · 2016 · External reference
Factor XI inhibition for the prevention of catheter-associated thrombosis in patients with cancer undergoing central line placement: a phase 2 clinical trial
10.1161/atvbaha.123.319692 · 2024 · External reference
Abelacimab for prevention of venous thromboembolism
10.1056/nejmoa2105872 · 2021 · External reference
The safety and efficacy of novel agents targeting factors XI and XII in early phase human trials
10.1055/s-0039-1692439 · 2019 · External reference
National trends in ambulatory oral anticoagulant use
10.1016/j.amjmed.2015.05.044 · 2015 · External reference
Rivaroxaban versus warfarin in nonvalvular atrial fibrillation
10.1056/nejmoa1009638 · 2011 · External reference
Challenging clinical scenarios for therapeutic anticoagulation: a practical approach
10.1016/j.thromres.2022.08.015 · 2022 · External reference
Protease activity in single-chain prekallikrein
10.1182/blood.2019002224 · 2020 · External reference
Lack of plasma kallikrein-kinin system cascade in teleosts
10.1371/journal.pone.0081057 · 2013 · External reference
Genes lost during the transition from land to water in cetaceans highlight genomic changes associated with aquatic adaptations
10.1126/sciadv.aaw6671 · 2019 · External reference
The evolution of factor XI and the kallikrein-kinin system
10.1182/bloodadvances.2020002456 · 2020 · External reference
Molecular modeling of the prekallikrein structure provides insights into high-molecular-weight kininogen binding and zymogen activation
10.1111/j.1538-7836.2007.02792.x · 2007 · External reference
Structures of factor XI and prekallikrein bound to domain 6 of high-molecular weight kininogen reveal alternate domain 6 conformations and exosites
10.1016/j.jtha.2023.03.042 · 2023 · External reference
Mapping of the discontinuous H-kininogen binding site of plasma prekallikrein. Evidence for a critical role of apple domain-2
10.1074/jbc.274.36.25777 · 1999 · External reference
The contact activation and kallikrein/kinin systems: pathophysiologic and physiologic activities
10.1111/jth.13194 · 2016 · External reference
Polyphosphate, platelets, and coagulation
10.1111/ijlh.12349 · 2015 · External reference
Kallikrein cvleaves C3 and activates complement
10.1159/000484257 · 2018 · External reference
Effects of factor XI deficiency on ferric chloride-induced vena cava thrombosis in mice
10.1111/j.1538-7836.2006.02093.x · 2006 · External reference
Factor XII structure-function relationships
10.1055/s-0043-1769509 · 2024 · External reference
Model for surface-dependent factor XII activation: the roles of factor XII heavy chain domains
10.1182/bloodadvances.2021005976 · 2022 · External reference
Reduced thrombosis in Klkb1-/- mice is mediated by increased Mas receptor, prostacyclin, Sirt1, and KLF4 and decreased tissue factor
10.1182/blood-2014-01-550285 · 2015 · External reference
Selective depletion of plasma prekallikrein or coagulation factor XII inhibits thrombosis in mice without increased risk of bleeding
10.1182/blood-2011-05-355248 · 2011 · External reference
Prekallikrein deficiency in man
10.1084/jem.138.6.1345 · 1973 · External reference
Severe prekallikrein deficiency associated with low level of factor XII: A case report
10.30699/ijp.2021.131638.2463 · 2021 · External reference
Oral sebetralstat for on-demand treatment of hereditary angioedema attacks
10.1056/nejmoa2314192 · 2024 · External reference
Oral plasma kallikrein inhibitor for prophylaxis in hereditary angioedema
10.1056/nejmoa1716995 · 2018 · External reference
Inhibiting plasma kallikrein for hereditary angioedema prophylaxis
10.1056/nejmoa1605767 · 2017 · External reference
Effect of lanadelumab compared with placebo on prevention of hereditary angioedema attacks: A randomized clinical trial
10.1001/jama.2018.16773 · 2018 · External reference
Real-world effectiveness of lanadelumab in hereditary angioedema: multicountry INTEGRATED Observational Study
10.1016/j.jaip.2024.12.008 · 2025 · External reference
Antisense inhibition of prekallikrein to control hereditary angioedema
10.1056/nejmoa1915035 · 2020 · External reference
Effects of plasma kallikrein deficiency on haemostasis and thrombosis in mice: murine ortholog of the Fletcher trait
10.1160/th11-10-0682 · 2012 · External reference
Effect of lanadelumab compared with placebo on prevention of hereditary angioedema attacks: A randomized clinical trial
10.1001/jama.2018.16773 · ExternalCitation · doi-reference
National trends in ambulatory oral anticoagulant use
10.1016/j.amjmed.2015.05.044 · ExternalCitation · doi-reference
Real-world effectiveness of lanadelumab in hereditary angioedema: multicountry INTEGRATED Observational Study
10.1016/j.jaip.2024.12.008 · ExternalCitation · doi-reference
Structures of factor XI and prekallikrein bound to domain 6 of high-molecular weight kininogen reveal alternate domain 6 conformations and exosites
10.1016/j.jtha.2023.03.042 · ExternalCitation · doi-reference
A comparison of the effects of factor XII deficiency and prekallikrein deficiency on thrombus formation
10.1016/j.thromres.2016.02.020 · ExternalCitation · doi-reference
Challenging clinical scenarios for therapeutic anticoagulation: a practical approach
10.1016/j.thromres.2022.08.015 · ExternalCitation · doi-reference
The safety and efficacy of novel agents targeting factors XI and XII in early phase human trials
10.1055/s-0039-1692439 · ExternalCitation · doi-reference
Factor XII structure-function relationships
10.1055/s-0043-1769509 · ExternalCitation · doi-reference
Rivaroxaban versus warfarin in nonvalvular atrial fibrillation
10.1056/nejmoa1009638 · ExternalCitation · doi-reference
Inhibiting plasma kallikrein for hereditary angioedema prophylaxis
10.1056/nejmoa1605767 · ExternalCitation · doi-reference
Oral plasma kallikrein inhibitor for prophylaxis in hereditary angioedema
10.1056/nejmoa1716995 · ExternalCitation · doi-reference
Antisense inhibition of prekallikrein to control hereditary angioedema
10.1056/nejmoa1915035 · ExternalCitation · doi-reference
Abelacimab for prevention of venous thromboembolism
10.1056/nejmoa2105872 · ExternalCitation · doi-reference
Inhibition of prekallikrein for hereditary angioedema
10.1056/nejmoa2109329 · ExternalCitation · doi-reference
Oral sebetralstat for on-demand treatment of hereditary angioedema attacks
10.1056/nejmoa2314192 · ExternalCitation · doi-reference
Efficacy and safety of donidalorsen for hereditary angioedema
10.1056/nejmoa2402478 · ExternalCitation · doi-reference
Hereditary angioedema
10.1056/nejmra1808012 · ExternalCitation · doi-reference
Mapping of the discontinuous H-kininogen binding site of plasma prekallikrein. Evidence for a critical role of apple domain-2
10.1074/jbc.274.36.25777 · ExternalCitation · doi-reference
Prekallikrein deficiency in man
10.1084/jem.138.6.1345 · ExternalCitation · doi-reference
Polyphosphate, platelets, and coagulation
10.1111/ijlh.12349 · ExternalCitation · doi-reference
Effects of factor XI deficiency on ferric chloride-induced vena cava thrombosis in mice
10.1111/j.1538-7836.2006.02093.x · ExternalCitation · doi-reference
Molecular modeling of the prekallikrein structure provides insights into high-molecular-weight kininogen binding and zymogen activation
10.1111/j.1538-7836.2007.02792.x · ExternalCitation · doi-reference
The contact activation and kallikrein/kinin systems: pathophysiologic and physiologic activities
10.1111/jth.13194 · ExternalCitation · doi-reference
Severe plasma prekallikrein deficiency: clinical characteristics, novel KLKB1 mutations, and estimated prevalence
10.1111/jth.14805 · ExternalCitation · doi-reference
Proteolytic activity of contact factor zymogens
10.1111/jth.15149 · ExternalCitation · doi-reference
Genes lost during the transition from land to water in cetaceans highlight genomic changes associated with aquatic adaptations
10.1126/sciadv.aaw6671 · ExternalCitation · doi-reference
Kallikrein cvleaves C3 and activates complement
10.1159/000484257 · ExternalCitation · doi-reference
Effects of plasma kallikrein deficiency on haemostasis and thrombosis in mice: murine ortholog of the Fletcher trait
10.1160/th11-10-0682 · ExternalCitation · doi-reference
Factor XI inhibition for the prevention of catheter-associated thrombosis in patients with cancer undergoing central line placement: a phase 2 clinical trial
10.1161/atvbaha.123.319692 · ExternalCitation · doi-reference
Selective depletion of plasma prekallikrein or coagulation factor XII inhibits thrombosis in mice without increased risk of bleeding
10.1182/blood-2011-05-355248 · ExternalCitation · doi-reference
Reduced thrombosis in Klkb1-/- mice is mediated by increased Mas receptor, prostacyclin, Sirt1, and KLF4 and decreased tissue factor
10.1182/blood-2014-01-550285 · ExternalCitation · doi-reference
Protease activity in single-chain prekallikrein
10.1182/blood.2019002224 · ExternalCitation · doi-reference
Biology of factor XI
10.1182/blood.2023020719 · ExternalCitation · doi-reference
The evolution of factor XI and the kallikrein-kinin system
10.1182/bloodadvances.2020002456 · ExternalCitation · doi-reference
Model for surface-dependent factor XII activation: the roles of factor XII heavy chain domains
10.1182/bloodadvances.2021005976 · ExternalCitation · doi-reference
Lack of plasma kallikrein-kinin system cascade in teleosts
10.1371/journal.pone.0081057 · ExternalCitation · doi-reference
Severe prekallikrein deficiency associated with low level of factor XII: A case report
10.30699/ijp.2021.131638.2463 · ExternalCitation · doi-reference
Plasma prekallikrein: its role in hereditary angioedema and health and disease
10.3389/fmed.2018.00003 · ExternalCitation · doi-reference
Human plasma kallikrein: roles in coagulation, fibrinolysis, inflammation pathways, and beyond
10.3389/fphys.2023.1188816 · ExternalCitation · doi-reference