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References from Heart Rate Variability as a Tell-Tale Marker of Pain-Related Autonomic Dysfunction in Chronic Pancreatitis. Local targets link to admitted publications; unresolved targets remain external evidence.
Chronic pancreatitis
10.1056/nejmcp1809396 · 2022 · External reference
Diagnosis and management of chronic pancreatitis: a review
10.1001/jama.2019.19411 · 2019 · External reference
Peering into the “Black Box” of the complex chronic pancreatitis syndrome
10.1097/mpa.0000000000000715 · 2016 · External reference
Working group for the International (IAP – APA – JPS – EPC) Consensus Guidelines for Chronic Pancreatitis. Guidelines for the understanding and management of pain in chronic pancreatitis
10.1016/j.pan.2017.07.006 · 2017 · External reference
Pain and chronic pancreatitis: a complex interplay of multiple mechanisms
10.3748/wjg.v19.i42.7282 · 2013 · External reference
Pain in chronic pancreatitis: managing beyond the pancreatic duct
10.3748/wjg.v19.i38.6319 · 2013 · External reference
Neuropancreatology: the nervous system and pain management in pancreatic diseases
10.3390/life14030299 · 2024 · External reference
Neuroimmune regulation in the pancreas
10.1016/j.fmre.2022.08.001 · 2022 · External reference
Relationships between the autonomic nervous system and the pancreas including regulation of regeneration and apoptosis: recent developments
10.1097/00006676-200408000-00019 · 2004 · External reference
Sympathetic innervation during development is necessary for pancreatic islet architecture and functional maturation
10.1016/j.celrep.2013.06.019 · 2013 · External reference
Evidence that the sympathetic nervous system elicits rapid, coordinated, and reciprocal adjustments of insulin secretion and insulin sensitivity during cold exposure
10.2337/db16-1351 · 2017 · External reference
Central control of glucose homeostasis: the brain–endocrine pancreas axis
10.1016/s1262-3636(10)70466-3 · 2010 · External reference
Gastrointestinal pain
10.1038/s41572-019-0135-7 · 2020 · External reference
Nerve growth factor and its high-affinity receptor in chronic pancreatitis
10.1097/00000658-199911000-00002 · 1999 · External reference
Brain-derived neurotrophic factor (BDNF) is upregulated and associated with pain in chronic pancreatitis
10.1023/a:1010684916863 · 2001 · External reference
Visceral pain-peripheral sensitisation
10.1136/gut.47.suppl_4.iv54 · 2000 · External reference
Central sensitization: implications for the diagnosis and treatment of pain
10.1016/j.pain.2010.09.030 · 2011 · External reference
Towards a neurobiological understanding of pain in chronic pancreatitis: mechanisms and implications for treatment
10.1097/pr9.0000000000000625 · 2017 · External reference
A clinically feasible method for the assessment and characterization of pain in patients with chronic pancreatitis
10.1016/j.pan.2019.11.007 · 2020 · External reference
Pain-associated adaptive cortical reorganisation in chronic pancreatitis
10.1159/000321644 · 2010 · External reference
Increased sympathetic activity in chronic pancreatitis patients is associated with hyperalgesia
10.3109/15360288.2010.519762 · 2010 · External reference
Pancreatic neuropathy results in “neural remodeling” and altered pancreatic innervation in chronic pancreatitis and pancreatic cancer
10.1038/ajg.2009.380 · 2009 · External reference
Heart rate variability
10.7326/0003-4819-118-6-199303150-00008 · 1993 · External reference
Heart rate variability in atrial fibrillation: the balance between sympathetic and parasympathetic nervous system
10.1111/eci.13174 · 2019 · External reference
Time- and frequency-domain measures of heart rate variability predict cardiovascular outcome in patients with type 2 diabetes
10.1016/j.diabres.2018.07.001 · 2018 · External reference
Systematic review of autonomic nervous system functioning in pediatric chronic pain
10.1097/ajp.0000000000000915 · 2021 · External reference
Heart rate variability and somatization in adolescents with irritable bowel syndrome
10.5056/jnm22019 · 2023 · External reference
Heart rate variability characteristics of patients with irritable bowel syndrome and associations with symptoms
10.1111/nmo.13320 · 2018 · External reference
Heart rate variability—an index of the efficacy of complementary therapies in irritable bowel syndrome: a systematic review
10.3390/nu14163447 · 2022 · External reference
Heart rate variability as a predictor of disease exacerbation in pediatric inflammatory bowel disease
10.1016/j.jpsychores.2022.110911 · 2022 · External reference
Heart rate variability and inflammatory bowel disease in humans: a systematic review and meta-analysis
10.1097/md.0000000000023430 · 2020 · External reference
Update on the impact, diagnosis and management of cardiovascular autonomic neuropathy in diabetes: what is defined, what is new, and what is unmet
10.4093/dmj.2018.0259 · 2019 · External reference
Adynamic response to cold pain reflects dysautonomia in type 1 diabetes and polyneuropathy
10.1038/s41598-023-37617-9 · 2023 · External reference
Individualized pain treatment in chronic pancreatitis (INPAIN): an international, multicenter, investigator-initiated, prospective, cohort study
10.1097/mpa.0000000000002388 · 2025 · External reference
The M-ANNHEIM classification of chronic pancreatitis: introduction of a unifying classification system based on a review of previous classifications of the disease
10.1007/s00535-006-1945-4 · 2007 · External reference
Electrocardiography assessment of sympatico–vagal balance during resting and pain using the Texas Instruments ADS1299
10.3390/bioengineering10020205 · 2023 · External reference
Deriving the 12-lead electrocardiogram from four (EASI) electrodes
10.1016/0022-0736(88)90090-8 · 1988 · External reference
Improved EASI coefficients: their derivation, values, and performance
10.1054/jelc.2002.37151 · 2002 · External reference
Automatic filtering of outliers in RR intervals before analysis of heart rate variability in Holter recordings: a comparison with carefully edited data
10.1186/1475-925x-11-2 · 2012 · External reference
Long-term microgravity exposure increases ECG repolarization instability manifested by low-frequency oscillations of T-wave vector
10.3389/fphys.2019.01510 · 2019 · External reference
Periodic repolarization dynamics as predictor of risk for sudden cardiac death in chronic heart failure patients
10.1038/s41598-021-99861-1 · 2021 · External reference
Periodic repolarisation dynamics: a natural probe of the ventricular response to sympathetic activation
10.15420/aer.2015:30:2 · 2016 · External reference
Deceleration capacity of heart rate as a predictor of mortality after myocardial infarction: cohort study
10.1016/s0140-6736(06)68735-7 · 2006 · External reference
Effects of sympatho-vagal interaction on ventricular electrophysiology and their modulation during beta-blockade
10.1016/j.yjmcc.2020.01.011 · 2020 · External reference
Cardiac vagus and exercise
10.1152/physiol.00041.2018 · 2019 · External reference
Heart rate variability and pain: associations of two interrelated homeostatic processes
10.1016/j.biopsycho.2007.10.004 · 2008 · External reference
Analysis of heart rate variability and implication of different factors on heart rate variability
10.2174/1573403x16999201231203854 · 2021 · External reference
Roles of heart rate variability in assessing autonomic nervous system in functional gastrointestinal disorders: a systematic review
10.3390/diagnostics13020293 · 2023 · External reference
Recent advancements in the relationship between the autonomic nervous system and the pancreas, encompassing the regulation of regeneration and apoptosis
10.3390/cells14171371 · 2025 · External reference
Exocrine pancreatic insufficiency related fat malabsorption and its association with autonomic neuropathy in Asian Indians with type 2 diabetes mellitus
10.1016/j.dsx.2021.102273 · 2021 · External reference
Meta-analytic evidence for decreased heart rate variability in chronic pain implicating parasympathetic nervous system dysregulation
10.1097/j.pain.0000000000000360 · 2016 · External reference
Prediction of pain using electrocardiographic-derived autonomic measures: a systematic review
10.1002/ejp.2175 · 2024 · External reference
Heart rate variability and experimentally induced pain in healthy adults: a systematic review
10.1002/j.1532-2149.2013.00379.x · 2014 · External reference
Heart rate variability is related to pain severity and predominant bowel pattern in women with irritable bowel syndrome
10.1111/j.1365-2982.2006.00877.x · 2007 · External reference
Heart rate variability, deceleration capacity of heart rate, and death: a veteran twins study
10.1161/jaha.123.032740 · 2024 · External reference
Biomarker periodic repolarization dynamics indicates enhanced risk for arrhythmias and sudden cardiac death in myocardial infarction in pigs
10.1161/jaha.123.032405 · 2024 · External reference
Autonomic dysfunction, diabetes and metabolic syndrome
10.1111/jdi.13691 · 2021 · External reference
Both prediabetes and type 2 diabetes are associated with lower heart rate variability: the Maastricht study
10.2337/dc19-2367 · 2020 · External reference
Heart rate variability in type 2 diabetes mellitus: a systematic review and meta-analysis
10.1371/journal.pone.0195166 · 2018 · External reference
A meta-analysis on heart rate variability biofeedback and depressive symptoms
10.1038/s41598-021-86149-7 · 2021 · External reference
A scoping review
10.3390/bs12100389 · 2022 · External reference
Clinical review: a review and analysis of heart rate variability and the diagnosis and prognosis of infection
10.1186/cc8132 · 2009 · External reference
Pitfalls of assessment of autonomic function by heart rate variability
10.1186/s40101-019-0193-2 · 2019 · External reference