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References from Summary Report of the Fifth International Pancreas and Islet Transplant Association Summit on Stem Cell–derived Islets. Local targets link to admitted publications; unresolved targets remain external evidence.
Embryonic stem cell lines derived from human blastocysts.
10.1126/science.282.5391.1145 · 1998 · External reference
Induction of pluripotent stem cells from adult human fibroblasts by defined factors.
10.1016/j.cell.2007.11.019 · 2007 · External reference
Induced pluripotent stem cell lines derived from human somatic cells.
10.1126/science.1151526 · 2007 · External reference
Implanted pluripotent stem-cell-derived pancreatic endoderm cells secrete glucose-responsive C-peptide in patients with type 1 diabetes.
10.1016/j.stem.2021.10.003 · 2021 · External reference
Stem cell-derived, fully differentiated islets for type 1 diabetes.
10.1056/nejmoa2506549 · 2025 · External reference
Transplantation of chemically induced pluripotent stem-cell-derived islets under abdominal anterior rectus sheath in a type 1 diabetes patient.
10.1016/j.cell.2024.09.004 · 2024 · External reference
Treating a type 2 diabetic patient with impaired pancreatic islet function by personalized endoderm stem cell-derived islet tissue.
10.1038/s41421-024-00662-3 · 2024 · External reference
Autologous induced stem-cell-derived retinal cells for macular degeneration.
10.1056/nejmoa1608368 · 2017 · External reference
Personalized iPSC-derived dopamine progenitor cells for parkinson’s disease.
10.1056/nejmoa1915872 · 2020 · External reference
iPLAT1: the first-in-human clinical trial of iPSC-derived platelets as a phase 1 autologous transfusion study.
10.1182/blood.2022017296 · 2022 · External reference
Human pluripotent stem cell-based cardiac repair: lessons learned and challenges ahead.
10.1016/j.addr.2025.115594 · 2025 · External reference
Improvement in glycaemic control and elimination of exogenous insulin use in patients with type 1 diabetes infused with fully differentiated islet cells (VX-880).
2024 · External reference
Mapping histological and functional maturation of human endocrine pancreas across early postnatal periods.
2024 · External reference
Understanding islet dysfunction in type 2 diabetes through multidimensional pancreatic phenotyping: the human pancreas analysis program.
10.1016/j.cmet.2022.09.013 · 2022 · External reference
Alpha cell dysfunction in islets from nondiabetic, glutamic acid decarboxylase autoantibody-positive individuals.
10.1172/jci156243 · 2022 · External reference
Diabetes as a pancreatic microvascular disease-A pericytic perspective.
10.1369/00221554241236535 · 2024 · External reference
The pericyte of the pancreatic islet regulates capillary diameter and local blood flow.
10.1016/j.cmet.2018.02.016 · 2018 · External reference
Pericyte control of blood flow in intraocular islet grafts impacts glucose homeostasis in mice.
10.2337/db21-1104 · 2022 · External reference
Pericyte dysfunction and impaired vasomotion are hallmarks of islets during the pathogenesis of type 1 diabetes.
10.1016/j.celrep.2023.112913 · 2023 · External reference
Parallel genome-scale CRISPR-Cas9 screens uncouple human pluripotent stem cell identity versus fitness.
10.1038/s41467-024-53284-4 · 2024 · External reference
CRISPR screening uncovers a central requirement for HHEX in pancreatic lineage commitment and plasticity restriction.
10.1038/s41556-022-00946-4 · 2022 · External reference
CRISPR screening uncovers a long-range enhancer for ONECUT1 in pancreatic differentiation and links a diabetes risk variant.
10.1016/j.celrep.2024.114640 · 2024 · External reference
QSER1 protects DNA methylation valleys from de novo methylation.
10.1126/science.abd0875 · 2021 · External reference
Dynamic network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer gene regulatory activity during cell state transitions.
10.1038/s41588-023-01450-7 · 2023 · External reference
Engineering synthetic suppressor T cells that execute locally targeted immunoprotective programs.
10.1126/science.adl4793 · 2024 · External reference
Targeting the cytoskeleton to direct pancreatic differentiation of human pluripotent stem cells.
10.1038/s41587-020-0430-6 · 2020 · External reference
Depolymerizing F-actin accelerates the exit from pluripotency to enhance stem cell-derived islet differentiation.
2025 · External reference
Functional, metabolic and transcriptional maturation of human pancreatic islets derived from stem cells.
10.1038/s41587-022-01219-z · 2022 · External reference
Aberrant metabolite trafficking and fuel sensitivity in human pluripotent stem cell-derived islets.
10.1016/j.celrep.2023.112970 · 2023 · External reference
Stem-cell-derived beta cells mature metabolically upon murine engraftment.
10.1007/s00125-025-06474-8 · 2025 · External reference
Scalable generation of 3D pancreatic islet organoids from human pluripotent stem cells in suspension bioreactors.
10.1016/j.xpro.2023.102580 · 2023 · External reference
Circadian entrainment triggers maturation of human in vitro islets.
10.1016/j.stem.2019.11.011 · 2020 · External reference
Genetic protection from type 1 diabetes resulting from accelerated insulin mRNA decay.
10.1016/j.cell.2025.02.018 · 2025 · External reference
Type 1 diabetes mellitus as a disease of the β-cell (do not blame the immune system?).
10.1038/s41574-020-00443-4 · 2021 · External reference
Autoantibody and T cell responses to oxidative post-translationally modified insulin neoantigenic peptides in type 1 diabetes.
10.1007/s00125-022-05812-4 · 2023 · External reference
The role of β cell stress and neo-epitopes in the immunopathology of type 1 diabetes.
10.3389/fendo.2020.624590 · 2020 · External reference
Human islet T cells are highly reactive to preproinsulin in type 1 diabetes.
10.1073/pnas.2107208118 · 2021 · External reference
Modeling human T1D-associated autoimmune processes.
10.1016/j.molmet.2021.101417 · 2022 · External reference
Baricitinib and β-cell function in patients with new-onset type 1 diabetes.
10.1056/nejmoa2306691 · 2023 · External reference
Teplizumab: a disease-modifying therapy for type 1 diabetes that preserves β-cell function.
10.2337/dc23-0675 · 2023 · External reference
Teplizumab and β-cell function in newly diagnosed type 1 diabetes.
10.1056/nejmoa2308743 · 2023 · External reference
Islet allografts expressing a PD-L1 and IDO fusion protein evade immune rejection and reverse preexisting diabetes in immunocompetent mice without systemic immunosuppression.
10.1111/ajt.17162 · 2022 · External reference
Hypoimmune islets achieve insulin independence after allogeneic transplantation in a fully immunocompetent non-human primate.
10.1016/j.stem.2024.02.001 · 2024 · External reference
Hypoimmune induced pluripotent stem cells survive long term in fully immunocompetent, allogeneic rhesus macaques.
10.1038/s41587-023-01784-x · 2024 · External reference
Human hypoimmune primary pancreatic islets avoid rejection and autoimmunity and alleviate diabetes in allogeneic humanized mice.
10.1126/scitranslmed.adg5794 · 2023 · External reference
Hypoimmune CD19 CAR T cells evade allorejection in patients with cancer and autoimmune disease.
10.1016/j.stem.2025.07.009 · 2025 · External reference
Survival of transplanted allogeneic beta cells with no immunosuppression.
10.1056/nejmoa2503822 · 2025 · External reference
Selective deletion of human leukocyte antigens protects stem cell-derived islets from immune rejection.
10.1016/j.celrep.2021.109538 · 2021 · External reference
Combinatorial genetic engineering strategy for immune protection of stem cell-derived beta cells by chimeric antigen receptor regulatory T cells.
10.1016/j.celrep.2024.114994 · 2024 · External reference
Phase 3 trial of transplantation of human islets in type 1 diabetes complicated by severe hypoglycemia.
10.2337/dc15-1988 · 2016 · External reference
Phase 3 trial of human islet-after-kidney transplantation in type 1 diabetes.
10.1111/ajt.16174 · 2021 · External reference
Long-term outcomes with islet-alone and islet-after-kidney transplantation for type 1 diabetes in the clinical islet transplantation consortium: the CIT-08 study.
10.2337/dc21-2688 · 2022 · External reference
Islet transplantation in type 1 diabetics using an immunosuppressive protocol based on the anti-LFA-1 antibody efalizumab.
10.1111/j.1600-6143.2010.03073.x · 2010 · External reference
Immunosuppressive PLGA TGF-β1 microparticles induce polyclonal and antigen-specific regulatory T cells for local immunomodulation of allogeneic islet transplants.
10.3389/fimmu.2021.653088 · 2021 · External reference
The impact of locally-delivered tacrolimus-releasing microspheres and polyethylene glycol-based islet surface modification on xenogeneic islet survival.
10.1016/j.jconrel.2021.06.020 · 2021 · External reference
Local immunomodulatory strategies to prevent allo-rejection in transplantation of insulin-producing cells.
2021 · External reference
Neovascularized implantable cell homing encapsulation platform with tunable local immunosuppressant delivery for allogeneic cell transplantation.
10.1016/j.biomaterials.2020.120232 · 2020 · External reference
Harnessing cellular therapeutics for type 1 diabetes mellitus: progress, challenges, and the road ahead.
10.1038/s41574-024-01029-0 · 2025 · External reference
Modeling of a bioengineered immunomodulating microenvironment for cell therapy.
10.1002/adhm.202304003 · 2025 · External reference
Localization of drug biodistribution in a 3D-bioengineered subcutaneous neovascularized microenvironment.
10.1016/j.mtbio.2022.100390 · 2022 · External reference
Immune engineered extracellular vesicles to modulate T cell activation in the context of type 1 diabetes.
10.1126/sciadv.adg1082 · 2023 · External reference
The EV antibody database: an interactive database of curated antibodies for extracellular vesicle and nanoparticle research.
10.1016/j.vesic.2024.100040 · 2024 · External reference
Long-term survival and function of intrahepatic islet allografts in rhesus monkeys treated with humanized anti-CD154.
10.1073/pnas.96.14.8132 · 1999 · External reference
Long-term survival and function of intrahepatic islet allografts in baboons treated with humanized anti-CD154.
10.2337/diabetes.48.7.1473 · 1999 · External reference
The anti-CD40L monoclonal antibody AT-1501 promotes islet and kidney allograft survival and function in nonhuman primates.
10.1126/scitranslmed.adf6376 · 2023 · External reference
Humanized mouse models for immuno-oncology research.
10.1038/s41571-022-00721-2 · 2023 · External reference
Enhanced development of functional human NK cells in NOD-scid-IL2rg(null) mice expressing human IL15.
10.1096/fj.202200045r · 2022 · External reference
Pancreatic islet cryopreservation by vitrification achieves high viability, function, recovery and clinical scalability for transplantation.
10.1038/s41591-022-01718-1 · 2022 · External reference
Designing a retrievable and scalable cell encapsulation device for potential treatment of type 1 diabetes.
10.1073/pnas.1708806115 · 2018 · External reference
A bioinspired scaffold for rapid oxygenation of cell encapsulation systems.
10.1038/s41467-021-26126-w · 2021 · External reference
An inverse-breathing encapsulation system for cell delivery.
10.4028/b-doxv17 · 2021 · External reference
A nanofibrous encapsulation device for safe delivery of insulin-producing cells to treat type 1 diabetes.
10.1126/scitranslmed.abb4601 · 2021 · External reference
Engineering 3D micro-compartments for highly efficient and scale-independent expansion of human pluripotent stem cells in bioreactors.
10.1016/j.biomaterials.2023.122033 · 2023 · External reference
Bioreactor-produced iPSCs-derived dopaminergic neuron-containing neural microtissues innervate and normalize rotational bias in a dose-dependent manner in a Parkinson rat model.
10.1016/j.neurot.2024.e00436 · 2024 · External reference
Developments in stem cell-derived islet replacement therapy for treating type 1 diabetes.
10.1016/j.stem.2023.04.002 · 2023 · External reference
Identifying and optimizing critical process parameters for large-scale manufacturing of iPSC derived insulin-producing β-cells.
10.1186/s13287-024-03973-0 · 2024 · External reference
Regulatory approval of islet transplantation for treatment of type 1 diabetes: Implications and what is on the horizon.
10.1016/j.ymthe.2023.10.011 · 2023 · External reference
Stem cell-derived islets: next steps for histologic and functional assessment during development as a cellular therapy for the treatment of diabetes.
10.2337/dbi18-0054 · 2019 · External reference
Future directions and clinical trial considerations for novel islet β-cell replacement therapies for type 1 diabetes.
10.2337/dbi24-0037 · 2025 · External reference
