Research graph
References from The microbiota–proteostasis axis: implications in neurodegenerative diseases. Local targets link to admitted publications; unresolved targets remain external evidence.
Protein misfolding, aggregation, and conformational strains in neurodegenerative diseases
10.1038/s41593-018-0235-9 · 2018 · External reference
Adapting proteostasis for disease intervention
10.1126/science.1141448 · 2008 · External reference
Ageing as a risk factor for neurodegenerative disease
10.1038/s41582-019-0244-7 · 2019 · External reference
The genetic epidemiology of neurodegenerative disease
10.1172/jci24761 · 2005 · External reference
Environmental pollutants as risk factors for neurodegenerative disorders: Alzheimer and Parkinson diseases
10.3389/fncel.2015.00124 · 2015 · External reference
Staging of brain pathology related to sporadic Parkinson's disease
10.1016/s0197-4580(02)00065-9 · 2003 · External reference
Direct evidence of Parkinson pathology spread from the gastrointestinal tract to the brain in rats
10.1007/s00401-014-1343-6 · 2014 · External reference
Transneuronal propagation of pathologic α-synuclein from the gut to the brain models Parkinson's disease
10.1016/j.neuron.2019.05.035 · 2019 · External reference
Oh my gut! is the microbial origin of neurodegenerative diseases real?
10.1128/iai.00437-22 · 2023 · External reference
Metagenomic analysis of the human distal gut microbiome
10.1126/science.1124234 · 2006 · External reference
Current understanding of the human microbiome
10.1038/nm.4517 · 2018 · External reference
From dietary fiber to host physiology: short-chain fatty acids as key bacterial metabolites
10.1016/j.cell.2016.05.041 · 2016 · External reference
Colonization of the Caenorhabditis elegans gut with human enteric bacterial pathogens leads to proteostasis disruption that is rescued by butyrate
10.1371/journal.ppat.1009510 · 2021 · External reference
Protective roles of intestinal microbiota derived short chain fatty acids in Alzheimer's disease-type beta-amyloid neuropathological mechanisms
10.1080/14737175.2018.1400909 · 2018 · External reference
Short-chain fatty acids as modulators of redox signaling in health and disease
10.1016/j.redox.2021.102165 · 2021 · External reference
Short chain fatty acids (SCFAs)-mediated gut epithelial and immune regulation and its relevance for inflammatory bowel diseases
10.3389/fimmu.2019.01486 · 2019 · External reference
Microbial amyloids in neurodegenerative amyloid diseases
10.1111/febs.17023 · 2025 · External reference
Gut microbiota dysbiosis: triggers, consequences, diagnostic and therapeutic options
10.3390/microorganisms10030578 · 2022 · External reference
The human intestinal microbiome in health and disease
10.1056/nejmra1600266 · 2016 · External reference
The multiomics blueprint of the individual with the most extreme lifespan
10.1016/j.xcrm.2025.102368 · 2025 · External reference
Identification of proteotoxic and proteoprotective bacteria that non-specifically affect proteins associated with neurodegenerative diseases
10.1016/j.isci.2024.110828 · 2024 · External reference
Bacteria-derived protein aggregates contribute to the disruption of host proteostasis
10.3390/ijms23094807 · 2022 · External reference
Genetic correlations between Alzheimer's disease and gut microbiome genera
10.1038/s41598-023-31730-5 · 2023 · External reference
Protein folding and misfolding
10.1038/nature02261 · 2003 · External reference
Navigating the landscape of protein folding and proteostasis: from molecular chaperones to therapeutic innovations
10.1038/s41392-025-02439-w · 2025 · External reference
Protein misfolding, functional amyloid, and human disease
10.1146/annurev.biochem.75.101304.123901 · 2006 · External reference
Self-propagation of pathogenic protein aggregates in neurodegenerative diseases
10.1038/nature12481 · 2013 · External reference
Soluble protein oligomers in neurodegeneration: lessons from the Alzheimer's amyloid beta-peptide
10.1038/nrm2101 · 2007 · External reference
The amyloid state and its association with protein misfolding diseases
10.1038/nrm3810 · 2014 · External reference
Proteostasis and the aging proteome in health and disease
10.1093/gerona/glu049 · 2014 · External reference
Protein aggregation and neurodegenerative disease
10.1038/nm1066 · 2004 · External reference
Brucella induces an unfolded protein response via TcpB that supports intracellular replication in macrophages
10.1371/journal.ppat.1003785 · 2013 · External reference
Inhibition of heat shock protein expression by Helicobacter pylori
10.1016/j.micpath.2009.08.002 · 2009 · External reference
Modulation of host proteostasis by Prevotella corporis via induction of the heat shock response
10.1016/j.cstres.2026.100150 · 2026 · External reference
The role of microbial amyloid in neurodegeneration
10.1371/journal.ppat.1006654 · 2017 · External reference
A protein–protein interaction map reveals that the Coxiella burnetii effector CirB inhibits host proteasome activity
10.1371/journal.ppat.1010660 · 2022 · External reference
Shigella effector IpaH4.5 targets 19S regulatory particle subunit RPN13 in the 26S proteasome to dampen cytotoxic T lymphocyte activation
10.1111/cmi.12974 · 2019 · External reference
Secreted bacterial effectors that inhibit host protein synthesis are critical for induction of the innate immune response to virulent Legionella pneumophila
10.1371/journal.ppat.1001289 · 2011 · External reference
Role of neuroinflammation in neurodegeneration development
10.1038/s41392-023-01486-5 · 2023 · External reference
Gut symbionts alleviate MASH through a secondary bile acid biosynthetic pathway
10.1016/j.cell.2024.03.034 · 2024 · External reference
The influence of Akkermansia muciniphila on intestinal barrier function
10.1186/s13099-024-00635-7 · 2024 · External reference
Role of E-cadherin in epithelial barrier dysfunction: implications for bacterial infection, inflammation, and disease pathogenesis
10.3389/fcimb.2025.1506636 · 2025 · External reference
Bacteroides fragilis toxin stimulates intestinal epithelial cell shedding and gamma-secretase-dependent E-cadherin cleavage
10.1242/jcs.03455 · 2007 · External reference
Bacteroides fragilis in the gut microbiomes of Alzheimer's disease activates microglia and triggers pathogenesis in neuronal C/EBPβ transgenic mice
10.1038/s41467-023-41283-w · 2023 · External reference
Association of human gut microbiota with Alzheimer's disease pathogenesis: an exploratory clinical study
10.3390/brainsci16020242 · 2026 · External reference
Hydrogen sulfide produced by gut bacteria may induce Parkinson's disease
10.3390/cells11060978 · 2022 · External reference
Alterations in the gut microbiota contribute to cognitive impairment induced by the ketogenic diet and hypoxia
10.1016/j.chom.2021.07.004 · 2021 · External reference
Sensing of bacterial type IV secretion via the unfolded protein response
10.1128/mbio.00418-12 · 2013 · External reference
Brucella modulates secretory trafficking via multiple type IV secretion effector proteins
10.1371/journal.ppat.1003556 · 2013 · External reference
Unusual presentation of neurobrucellosis presenting with the features of parkinsonism: two case reports and a review of the literature
10.3389/fnins.2026.1804126 · 2026 · External reference
Neurobrucellosis manifesting as secondary hemiparkinsonism in a veterinary technician: a case report and evidence-based review
10.1016/j.idcr.2025.e02376 · 2025 · External reference
Identification of Chlamydia pneumoniae and NLRP3 inflammasome activation in Alzheimer's disease retina
10.1038/s41467-026-68580-4 · 2026 · External reference
The molecular mechanism of induction of unfolded protein response by Chlamydia
10.1016/j.bbrc.2018.11.034 · 2019 · External reference
Desulfovibrio bacteria enhance alpha-synuclein aggregation in a Caenorhabditis elegans model of Parkinson's disease
10.3389/fcimb.2023.1181315 · 2023 · External reference
Genome-wide screen identifies curli amyloid fibril as a bacterial component promoting host neurodegeneration
10.1073/pnas.2106504118 · 2021 · External reference
Microbiome or infections: amyloid-containing biofilms as a trigger for complex human diseases
10.3389/fimmu.2021.638867 · 2021 · External reference
A gut bacterial amyloid promotes α-synuclein aggregation and motor impairment in mice
10.7554/elife.53111 · 2020 · External reference
Exposure to the functional bacterial amyloid protein curli enhances alpha-synuclein aggregation in aged Fischer 344 rats and Caenorhabditis elegans
10.1038/srep34477 · 2016 · External reference
Gut microbiota produces biofilm-associated amyloids with potential for neurodegeneration
10.1038/s41467-024-48309-x · 2024 · External reference
The deubiquitinase ElaD is present in the majority of Escherichia coli strains
10.3389/fmicb.2025.1681308 · 2025 · External reference
A noncanonical polyamine from bacteria antagonizes host mitochondrial function
10.1038/s41467-025-66499-w · 2025 · External reference
The periodontal pathogen Fusobacterium nucleatum exacerbates Alzheimer's pathogenesis via specific pathways
10.3389/fnagi.2022.912709 · 2022 · External reference
Fusobacterium nucleatum secretes outer membrane vesicles and promotes intestinal inflammation
10.1128/mbio.02706-20 · 2021 · External reference
Causal associations between Helicobacter pylori infection and the risk and symptoms of Parkinson's disease: a Mendelian randomization study
10.3389/fimmu.2024.1412157 · 2024 · External reference
Helicobacter pylori eradication improves motor fluctuations in advanced Parkinson's disease patients: a prospective cohort study (HP-PD trial)
10.1371/journal.pone.0251042 · 2021 · External reference
Alzheimer's disease and Helicobacter pylori infection: inflammation from stomach to brain?
10.3233/jad-190496 · 2020 · External reference
Exosomes as nanocarriers for systemic delivery of the Helicobacter pylori virulence factor
10.1038/srep18346 · 2016 · External reference
An enteric bacterial infection triggers neuroinflammation and neurobehavioral impairment in 3xTg-AD transgenic mice
10.1093/infdis/jiae165 · 2024 · External reference
Legionella suppresses the host unfolded protein response via multiple mechanisms
10.1038/ncomms8887 · 2015 · External reference
Legionella pneumophila glucosyltransferase inhibits host elongation factor 1A
10.1073/pnas.0601562103 · 2006 · External reference
Activation of the unfolded protein response by Listeria monocytogenes
10.1111/j.1462-5822.2012.01769.x · 2012 · External reference
Listeria monocytogenes transiently alters mitochondrial dynamics during infection
10.1073/pnas.1100126108 · 2011 · External reference
Endoplasmic reticulum stress response is involved in Mycobacterium tuberculosis protein ESAT-6-mediated apoptosis
10.1016/j.febslet.2010.04.050 · 2010 · External reference
Mycobacterial HBHA induces endoplasmic reticulum stress-mediated apoptosis through the generation of reactive oxygen species and cytosolic Ca2+ in murine macrophage RAW 264.7 cells
10.1038/cddis.2013.489 · 2013 · External reference
Porphyromonas gingivalis in Alzheimer's disease brains: evidence for disease causation and treatment with small-molecule inhibitors
10.1126/sciadv.aau3333 · 2019 · External reference
Bacterial DNA promotes tau aggregation
10.1038/s41598-020-59364-x · 2020 · External reference
Porphyromonas gingivalis and Alzheimer disease: recent findings and potential therapies
10.1002/jper.20-0104 · 2020 · External reference
Porphyromonas gingivalis infection induces amyloid-β accumulation in monocytes/macrophages
10.3233/jad-190298 · 2019 · External reference
Porphyromonas gingivalis-induced periodontitis could contribute to cognitive impairment in Sprague-Dawley rats via the P38 MAPK signaling pathway
10.3389/fncel.2023.1141339 · 2023 · External reference
P. mirabilis-derived pore-forming haemolysin, HpmA drives intestinal alpha-synuclein aggregation in a mouse model of neurodegeneration
10.1016/j.ebiom.2023.104887 · 2023 · External reference
Accelerated amyloid beta pathogenesis by bacterial amyloid FapC
10.1002/advs.202070100 · 2020 · External reference
Structural basis of Pseudomonas biofilm-forming functional amyloid FapC formation
10.1126/sciadv.adx7829 · 2025 · External reference
Stealth and mimicry by deadly bacterial toxins
10.1016/j.tibs.2005.12.007 · 2006 · External reference
Pseudomonas aeruginosa in chronic lung disease: untangling the dysregulated host immune response
10.3389/fimmu.2024.1405376 · 2024 · External reference
The Salmonella type III secretion effector, Salmonella leucine-rich repeat protein (SlrP), targets the human chaperone ERdj3
10.1074/jbc.m110.100669 · 2010 · External reference
The Salmonella effector protein SopA modulates innate immune responses by targeting TRIM E3 ligase family members
10.1371/journal.ppat.1005552 · 2016 · External reference
The Salmonella deubiquitinase SseL inhibits selective autophagy of cytosolic aggregates
10.1371/journal.ppat.1002743 · 2012 · External reference
The Salmonella kinase SteC targets the MAP kinase MEK to regulate the host actin cytoskeleton
10.1016/j.chom.2012.09.011 · 2012 · External reference
Shiga toxin B-subunit binds to the chaperone BiP and the nucleolar protein B23
10.1042/bc20050001 · 2006 · External reference
Functional amyloid formation by Streptococcus mutans
10.1099/mic.0.060855-0 · 2012 · External reference
Amyloid aggregation of Streptococcus mutans Cnm influences its collagen-binding activity
10.1128/aem.01149-21 · 2021 · External reference
Gut microbial production of imidazole propionate drives Parkinson's pathologies
10.1038/s41467-025-63473-4 · 2025 · External reference
Treponema denticola induces neuronal apoptosis by promoting amyloid-β accumulation in mice
10.3390/pathogens11101150 · 2022 · External reference
Molecular and immunological evidence of oral Treponema in the human brain and their association with Alzheimer's disease
10.1046/j.0902-0055.2001.00100.x · 2002 · External reference
Alzheimer's disease – a neurospirochetosis. Analysis of the evidence following Koch's and Hill's criteria
10.1186/1742-2094-8-90 · 2011 · External reference
Treponema denticola has the potential to cause neurodegeneration in the midbrain via the periodontal route of infection-narrative review
10.3390/ijerph20116049 · 2023 · External reference
Role of dentilisin in Treponema denticola epithelial cell layer penetration
10.1016/j.resmic.2003.08.001 · 2003 · External reference
Treponema denticola induces Alzheimer-like tau hyperphosphorylation by activating hippocampal neuroinflammation in mice
10.1177/00220345221076772 · 2022 · External reference
BiP-dependent export of cholera toxin from endoplasmic reticulum-derived microsomes
10.1016/s0014-5793(03)01217-1 · 2003 · External reference
Cholera toxin up-regulates endoplasmic reticulum proteins that correlate with sensitivity to the toxin
10.3181/0705-rm-132 · 2008 · External reference
Genetics of Alzheimer disease
10.1177/0891988710383571 · 2010 · External reference
Epidemiology of Parkinson's disease
10.1016/s1474-4422(06)70471-9 · 2006 · External reference
Longitudinal analysis of a dominantly inherited Alzheimer disease mutation carrier protected from dementia
10.1038/s41591-025-03494-0 · 2025 · External reference
Genome-wide association study identifies variants at CLU and CR1 associated with Alzheimer's disease
10.1038/ng.439 · 2009 · External reference
Apolipoprotein E alleles as risk factors in Alzheimer's disease
10.1146/annurev.med.47.1.387 · 1996 · External reference
APOE ε4 carriers share immune-related proteomic changes across neurodegenerative diseases
10.1038/s41591-025-03835-z · 2025 · External reference
Peripheral proteinopathy in neurodegenerative diseases
10.1186/s40035-024-00461-6 · 2025 · External reference
Mind-altering microorganisms: the impact of the gut microbiota on brain and behaviour
10.1038/nrn3346 · 2012 · External reference
Microbiota-gut-brain axis and the central nervous system
10.18632/oncotarget.17754 · 2017 · External reference
Vagal neuron expression of the microbiota-derived metabolite receptor, free fatty acid receptor (FFAR3), is necessary for normal feeding behavior
10.1016/j.molmet.2021.101350 · 2021 · External reference
Enteroendocrine cells sense bacterial tryptophan catabolites to activate enteric and vagal neuronal pathways
10.1016/j.chom.2020.11.011 · 2021 · External reference
Ingestion of Lactobacillus strain regulates emotional behavior and central GABA receptor expression in a mouse via the vagus nerve
10.1073/pnas.1102999108 · 2011 · External reference
Interaction of the vagus nerve and serotonin in the gut-brain axis
10.3390/ijms26031160 · 2025 · External reference
A gut-brain neural circuit for nutrient sensory transduction
10.1126/science.aat5236 · 2018 · External reference
Enteroendocrine cells: the gatekeepers of microbiome-gut-brain communication
10.1038/s41522-025-00810-x · 2025 · External reference
The enteric nervous system and neurogastroenterology
10.1038/nrgastro.2012.32 · 2012 · External reference
The microbiota-gut-brain axis
10.1152/physrev.00018.2018 · 2019 · External reference
Interactions between the microbiota and enteric nervous system during gut-brain disorders
10.1016/j.neuropharm.2021.108721 · 2021 · External reference
The bowel and beyond: the enteric nervous system in neurological disorders
10.1038/nrgastro.2016.107 · 2016 · External reference
The enteric nervous system
10.1152/physrev.00018.2022 · 2023 · External reference
The vagus nerve at the interface of the microbiota-gut-brain axis
10.3389/fnins.2018.00049 · 2018 · External reference
Vagotomy and Parkinson disease: a Swedish register-based matched-cohort study
10.1212/wnl.0000000000003961 · 2017 · External reference
Vagotomy and subsequent risk of Parkinson's disease
10.1002/ana.24448 · 2015 · External reference
Role of the microbiota in immunity and inflammation
10.1016/j.cell.2014.03.011 · 2014 · External reference
Aging, frailty, and the microbiome-how dysbiosis influences human aging and disease
10.1053/j.gastro.2020.09.060 · 2021 · External reference
Gut microbiota, metabolites and host immunity
10.1038/nri.2016.42 · 2016 · External reference
Host microbiota constantly control maturation and function of microglia in the CNS
10.1038/nn.4030 · 2015 · External reference
Inflammation and immune dysfunction in Parkinson disease
10.1038/s41577-022-00684-6 · 2022 · External reference
The blood-brain barrier in neuroimmunology: tales of separation and assimilation
10.1016/j.bbi.2014.08.007 · 2015 · External reference
The role of short-chain fatty acids in microbiota–gut–brain communication
10.1038/s41575-019-0157-3 · 2019 · External reference
Microbiota-derived indoles alleviate intestinal inflammation and modulate microbiome by microbial cross-feeding
10.1186/s40168-024-01750-y · 2024 · External reference
Microbiome-derived indole-3-lactic acid reduces amyloidopathy through aryl-hydrocarbon receptor activation
10.1016/j.bbi.2024.08.051 · 2024 · External reference
Association between the relative abundance of butyrate-producing and mucin-degrading taxa and Parkinson's disease
10.1016/j.neuroscience.2025.04.050 · 2025 · External reference
Intestinal macrophages modulate synucleinopathy along the gut–brain axis
10.1038/s41586-025-09984-y · 2026 · External reference
Indigenous bacteria from the gut microbiota regulate host serotonin biosynthesis
10.1016/j.cell.2015.02.047 · 2015 · External reference
Postnatal microbial colonization programs the hypothalamic-pituitary-adrenal system for stress response in mice
10.1113/jphysiol.2004.063388 · 2004 · External reference
Towards a systems view of IBS
10.1038/nrgastro.2015.121 · 2015 · External reference
Redefining a new genomic blueprint of the human gut microbiota
10.1099/acmi.ac2019.po0041 · 2019 · External reference
Mechanisms and implications of the gut microbial modulation of intestinal metabolic processes
10.1038/s44324-025-00066-1 · 2025 · External reference
Functions of gut microbiota metabolites, current status and future perspectives
10.14336/ad.2022.0104 · 2022 · External reference
Pathological tau propagation from the brain to the colon via the vagal efferent pathway in Alzheimer's disease
10.1136/gutjnl-2024-334571 · 2026 · External reference
Intrastriatal injection of Parkinson's disease intestine and vagus lysates initiates α-synucleinopathy in rat brain
10.1038/s41419-022-05531-z · 2023 · External reference
Gut-seeded α-synuclein fibrils promote gut dysfunction and brain pathology specifically in aged mice
10.1038/s41593-020-0589-7 · 2020 · External reference
Gut-to-brain α-synuclein transmission in Parkinson's disease: evidence for prion-like mechanisms
10.3390/ijms24087205 · 2023 · External reference
Inoculation of α-synuclein preformed fibrils into the mouse gastrointestinal tract induces Lewy body-like aggregates in the brainstem via the vagus nerve
10.1186/s13024-018-0257-5 · 2018 · External reference
Gut inflammation triggers C/EBPβ/δ-secretase-dependent gut-to-brain propagation of aβ and tau fibrils in Alzheimer's disease
10.15252/embj.2020106320 · 2021 · External reference
Gut microbiota regulate motor deficits and neuroinflammation in a model of Parkinson's disease
10.1016/j.cell.2016.11.018 · 2016 · External reference
Gut microbiome alterations in Alzheimer's disease
10.1038/s41598-017-13601-y · 2017 · External reference
Potential roles of gut microbiome and metabolites in modulating ALS in mice
10.1038/s41586-019-1443-5 · 2019 · External reference
Functional implications of microbial and viral gut metagenome changes in early stage L-DOPA-naïve Parkinson's disease patients
10.1186/s13073-017-0428-y · 2017 · External reference
The nasal and gut microbiome in Parkinson's disease and idiopathic rapid eye movement sleep behavior disorder
10.1002/mds.27105 · 2018 · External reference
Proteomics analysis of the gut-brain axis in a gut microbiota-dysbiosis model of depression
10.1038/s41398-021-01689-w · 2021 · External reference
Modelling the gastrointestinal carriage of Klebsiella pneumoniae infections
10.1128/mbio.03121-22 · 2023 · External reference
A high burden of asymptomatic gastrointestinal infections in traditional communities in Papua New Guinea
10.4269/ajtmh.17-0282 · 2017 · External reference
High prevalence of Shigella or enteroinvasive Escherichia coli carriage among residents of an internally displaced persons camp in South Sudan
10.4269/ajtmh.17-0339 · 2018 · External reference
Faecal carriage of Pseudomonas aeruginosa in healthy humans: antimicrobial susceptibility and global genetic lineages
10.1111/1574-6941.12301 · 2014 · External reference
The epidemiology of fecal carriage of nontyphoidal Salmonella among healthy children and adults in three sites in Kenya
10.1371/journal.pntd.0011716 · 2023 · External reference
The evolution of functional amyloids and their impact on host-microbe interactions
10.1002/advs.202510109 · 2025 · External reference
Profiling of bacterial flora in gastric biopsies from patients with Helicobacter pylori-associated gastritis and histologically normal control individuals by temperature gradient gel electrophoresis and 16S rDNA sequence analysis
10.1099/0022-1317-49-9-817 · 2000 · External reference
Biofilm-associated amyloid proteins linked with the progression of neurodegenerative diseases
10.3390/ijms26062695 · 2025 · External reference
Sequestration of cellular interacting partners by protein aggregates: implication in a loss-of-function pathology
10.1111/febs.13722 · 2016 · External reference
Suppression of aggregate and amyloid formation by a novel intrinsically disordered region in metazoan Hsp110 chaperones
10.1016/j.jbc.2021.100567 · 2021 · External reference
Chaperone-dependent amyloid assembly protects cells from prion toxicity
10.1073/pnas.0802593105 · 2008 · External reference
Modulation of amyloid states by molecular chaperones
10.1101/cshperspect.a033969 · 2019 · External reference
Host manipulation by bacterial type III and type IV secretion system effector proteases
10.1111/cmi.13384 · 2021 · External reference
Local and systemic mechanisms linking periodontal disease and inflammatory comorbidities
10.1038/s41577-020-00488-6 · 2021 · External reference
Localization of outer membrane proteins in Treponema denticola by quantitative proteome analyses of outer membrane vesicles and cellular fractions
10.1021/acs.jproteome.8b00860 · 2019 · External reference
Bacterial membrane vesicles: the missing link between bacterial infection and Alzheimer disease
10.1093/infdis/jiae228 · 2024 · External reference
Subtilase cytotoxin cleaves newly synthesized BiP and blocks antibody secretion in B lymphocytes
10.1084/jem.20090782 · 2009 · External reference
Helicobacter pylori infection and Parkinson's disease: etiology, pathogenesis and levodopa bioavailability
10.1186/s12979-023-00404-1 · 2024 · External reference
Helicobacter pylori CagA protein is a potent and broad-spectrum amyloid inhibitor
10.1126/sciadv.ads7525 · 2025 · External reference
TRIM proteins in autophagy: selective sensors in cell damage and innate immune responses
10.1038/s41418-020-0495-2 · 2020 · External reference
Tau is necessary for Pseudomonas aeruginosa-induced blood-brain barrier dysfunction
10.1038/s42003-026-09703-x · 2026 · External reference
A subset of type 4 secretion system effectors of Brucella spp. associates to outer membrane vesicles
10.1093/femsml/uqaf046 · 2026 · External reference
Vacuolating cytotoxin A (VacA) and extracellular vesicles in Helicobacter pylori: two key arms in disease development
10.30699/ijp.2024.2031417.3312 · 2025 · External reference
Shiga toxin uptake and sequestration in extracellular vesicles is mediated by its B-subunit
10.3390/toxins12070449 · 2020 · External reference
Listeria monocytogenes virulence factors, including listeriolysin O, are secreted in biologically active extracellular vesicles
10.1074/jbc.ra118.006472 · 2019 · External reference
Association of cholera toxin with Vibrio cholerae outer membrane vesicles which are internalized by human intestinal epithelial cells
10.1016/j.febslet.2011.04.017 · 2011 · External reference
Intestinal infection triggers mitochondria-mediated α-synuclein pathology: relevance to Parkinson's disease
10.1007/s00018-023-04819-3 · 2023 · External reference
Butyrate, neuroepigenetics and the gut microbiome: can a high fiber diet improve brain health?
10.1016/j.neulet.2016.02.009 · 2016 · External reference
Sodium butyrate causes α-synuclein degradation by an Atg5-dependent and PI3K/Akt/mTOR-related autophagy pathway
10.1016/j.yexcr.2019.111772 · 2020 · External reference
Integrated multi-cohort analysis of the Parkinson's disease gut metagenome
10.1002/mds.29300 · 2023 · External reference
Metagenomics of Parkinson's disease implicates the gut microbiome in multiple disease mechanisms
10.1038/s41467-022-34667-x · 2022 · External reference
Sodium butyrate improves memory function in an Alzheimer's disease mouse model when administered at an advanced stage of disease progression
10.3233/jad-2011-110080 · 2011 · External reference
Target intestinal microbiota to alleviate disease progression in amyotrophic lateral sclerosis
10.1016/j.clinthera.2016.12.014 · 2017 · External reference
Changes of colonic bacterial composition in Parkinson's disease and other neurodegenerative diseases
10.3390/nu10060708 · 2018 · External reference
Microbiome profiling reveals gut dysbiosis in a transgenic mouse model of Huntington's disease
10.1016/j.nbd.2018.09.001 · 2020 · External reference
The role of the gut microbiome in the progression of Parkinson's disease: a systematic review of patient cohorts
10.1007/s00415-025-13545-8 · 2026 · External reference
N-butyrate increases heat shock protein 70 through heat shock factor 1 and AMP-activated protein kinase pathways in human intestinal Caco-2 cells
10.1016/j.abb.2023.109525 · 2023 · External reference
Proteome analysis of butyrate-treated human colon cancer cells (HT-29)
10.1002/ijc.10236 · 2002 · External reference
Treatment with sodium butyrate induces autophagy resulting in therapeutic benefits for spinocerebellar ataxia type 3
10.1096/fj.202300963rr · 2024 · External reference
Effects of histone deacetylase inhibitors on transcriptional regulation of the hsp70 gene in Drosophila
10.1038/sj.cr.7310074 · 2006 · External reference
Butyrate ameliorates intraocular bacterial infection by promoting autophagy and attenuating the inflammatory response
10.1128/iai.00252-22 · 2023 · External reference
Sodium butyrate-induced autophagy in colorectal cancer unveils the Ca²⁺/CaMKKβ signaling pathway as a potential therapeutic target
10.1038/s41598-025-29618-7 · 2025 · External reference
Butyrate extends health and lifespan in mice with mitochondrial deficiency
10.1038/s41467-026-70547-4 · 2026 · External reference
Sodium butyrate reverses lipopolysaccharide-induced mitochondrial dysfunction in lymphoblasts
10.1111/jcmm.17342 · 2022 · External reference
Inhibition of inflammatory microglia by dietary fiber and short-chain fatty acids
10.1038/s41598-022-27086-x · 2023 · External reference
Age-associated temporal decline in butyrate-producing bacteria plays a key pathogenic role in the onset and progression of neuropathology and memory deficits in 3×Tg-AD mice
10.1080/19490976.2024.2389319 · 2024 · External reference
Role of microbiota-derived short-chain fatty acids in nervous system disorders
10.1016/j.biopha.2021.111661 · 2021 · External reference
Butyrate's role in human health and the current progress towards its clinical application to treat gastrointestinal disease
10.1016/j.clnu.2022.10.024 · 2023 · External reference
Intestinal barrier dysfunction: an evolutionarily conserved hallmark of aging
10.1242/dmm.049969 · 2023 · External reference
Bile acids as modulators of gut microbiota composition and function
10.1080/19490976.2023.2172671 · 2023 · External reference
Bile acid signaling in neurodegenerative and neurological disorders
10.3390/ijms21175982 · 2020 · External reference
The pathological effects of circulating hydrophobic bile acids in Alzheimer's disease
10.3233/adr-220071 · 2023 · External reference
Bile acids induce alterations in mitochondrial function in skeletal muscle fibers
10.3390/antiox11091706 · 2022 · External reference
Microbial transformation of secondary bile acids: roles in gut ecology and autoimmune diseases
10.3389/fimmu.2026.1769792 · 2026 · External reference
Spermidine – an old molecule with a new age-defying immune function
10.1016/j.tcb.2023.08.002 · 2024 · External reference
Lactobacillus reuteri ZJ617 attenuates metabolic syndrome via microbiota-derived spermidine
10.1038/s41467-025-56105-4 · 2025 · External reference
Probiotic and microbial modulation of polyamine production: an emerging avenue for neuroprotection in neurodegenerative disorders
10.1007/s00726-026-03505-5 · 2026 · External reference
Spermine modulation of Alzheimer's Tau and Parkinson's α-synuclein: implications for biomolecular condensation and neurodegeneration
10.1038/s41467-025-65426-3 · 2025 · External reference
Polyamine metabolism dysregulation contributes to muscle fiber vulnerability in ALS
10.1016/j.celrep.2024.115123 · 2025 · External reference
Polyamines mediate glutamine-dependent induction of the intestinal epithelial heat shock response
10.1152/ajpgi.00054.2011 · 2011 · External reference
Regulation of polyamine interconversion enzymes affects α-synuclein levels and toxicity in a Drosophila model of Parkinson's disease
10.1038/s41531-025-01087-9 · 2025 · External reference
Hydrogen sulfide in physiology and diseases of the digestive tract
10.3390/microorganisms3040866 · 2015 · External reference
Hydrogen sulfide is neuroprotective in Alzheimer's disease by sulfhydrating GSK3β and inhibiting tau hyperphosphorylation
10.1073/pnas.2017225118 · 2021 · External reference
Hydrogen sulfide inhibits amyloid formation
10.1021/jp508471v · 2015 · External reference
H(2)S remodels mitochondrial ultrastructure and destabilizes respiratory supercomplexes
10.1016/j.jbc.2025.108433 · 2025 · External reference
Bilophila wadsworthia aggravates high fat diet induced metabolic dysfunctions in mice
10.1038/s41467-018-05249-7 · 2018 · External reference
Role of glutathione metabolism of Treponema denticola in bacterial growth and virulence expression
10.1128/iai.70.3.1113-1120.2002 · 2002 · External reference
Hydrogen sulfide negative Salmonella and their implication for standard culture-based identification
10.1016/j.jfp.2025.100549 · 2025 · External reference
Plasma hydrogen sulfide: a biomarker of Alzheimer's disease and related dementias
10.1002/alz.12305 · 2021 · External reference
Trimethylamine N-oxide (TMAO) in human health
2021 · External reference
Assessment of trimethylamine-N-oxide at the blood-cerebrospinal fluid barrier: results from 290 lumbar punctures
2020 · External reference
The gut microbiome-derived metabolite trimethylamine N-oxide modulates neuroinflammation and cognitive function with aging
10.1007/s11357-020-00257-2 · 2021 · External reference
Association between levels of trimethylamine N-oxide and cognitive dysfunction: a systematic review and meta-analysis
10.7717/peerj.20000 · 2025 · External reference
TMAO promotes dementia progression by mediating the PI3K/Akt/mTOR pathway
10.1016/j.tice.2023.102034 · 2023 · External reference
Elevated serum trimethylamine N-oxide (TMAO) and trimethyllysine in patients with amyotrophic lateral sclerosis (ALS): an exploratory case-control study
10.1016/j.ibneur.2026.02.006 · 2026 · External reference
The gut microbiota-derived metabolite trimethylamine N-oxide is elevated in Alzheimer's disease
10.1186/s13195-018-0451-2 · 2018 · External reference
TMAO accelerates cellular aging by disrupting endoplasmic reticulum integrity and mitochondrial unfolded protein response
10.1007/s00018-024-05546-z · 2025 · External reference
Trimethylamine N-oxide (TMAO) and cancer risk: insights into a possible link
10.1016/j.biopha.2025.118592 · 2025 · External reference
The role of the Mediterranean diet in reducing the risk of cognitive impairment, dementia, and Alzheimer's disease: a meta-analysis
10.1007/s11357-024-01488-3 · 2025 · External reference
Habitual natto consumption is inversely associated with mild cognitive impairment and depressive symptoms in older Japanese adults: a cross-sectional study
10.1016/j.nutres.2026.04.009 · 2026 · External reference
Fecal microbiota transplantation in Alzheimer's disease: mechanistic insights through the microbiota-gut-brain axis and therapeutic prospects
10.3390/microorganisms13081956 · 2025 · External reference
The role of probiotics, prebiotics, and postbiotics: cellular and molecular pathways activated on glial cells in Alzheimer's disease
10.3389/fnins.2025.1598011 · 2025 · External reference
Probiotics for Alzheimer's disease: a systematic review
10.3390/nu14010020 · 2021 · External reference
Precise probiotic therapy: advances, bottlenecks, and the road to microbiome-informed nutrition
10.1080/19490976.2026.2623359 · 2026 · External reference
Efficacy of probiotic supplementation in influencing cognitive function in Alzheimer's disease: a systematic review and meta-analysis
10.1111/1750-3841.70037 · 2025 · External reference
