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References from More than the ‘master regulator of cytosolic proteostasis’: new roles for HSF1 in promoting tissue health. Local targets link to admitted publications; unresolved targets remain external evidence.
Activating protein factor binds in vitro to upstream control sequences in heat shock gene chromatin
10.1038/311081a0 · 1984 · External reference
A Drosophila RNA polymerase II transcription factor binds to the regulatory site of an hsp70 gene
10.1016/0092-8674(84)90323-4 · 1984 · External reference
E2F coregulates an essential HSF developmental program that is distinct from the heat-shock response
10.1101/gad.283317.116 · 2016 · External reference
Multiple functions of Drosophila heat shock transcription factor in vivo
10.1093/emboj/16.9.2452 · 1997 · External reference
Hsf1 promotes hematopoietic stem cell fitness and proteostasis in response to ex vivo culture stress and aging
10.1016/j.stem.2021.07.009 · 2021 · External reference
Impaired hippocampal spinogenesis and neurogenesis and altered affective behavior in mice lacking heat shock factor 1
10.1073/pnas.1016424108 · 2011 · External reference
Lack of maternal Heat Shock Factor 1 results in multiple cellular and developmental defects, including mitochondrial damage and altered redox homeostasis, and leads to reduced survival of mammalian oocytes and embryos
10.1016/j.ydbio.2009.12.037 · 2010 · External reference
Rethinking HSF1 in stress, development, and organismal health
10.1016/j.tcb.2017.08.002 · 2017 · External reference
A guide to heat shock factors as multifunctional transcriptional regulators
10.1111/febs.70139 · 2025 · External reference
Regulation of heat shock transcription factors and their roles in physiology and disease
10.1038/nrm.2017.73 · 2018 · External reference
Heat shock factors: integrators of cell stress, development and lifespan
10.1038/nrm2938 · 2010 · External reference
The diversity of plant heat stress transcription factors
10.1016/j.tplants.2007.08.014 · 2007 · External reference
Heat shock transcription factors in development and disease
10.1242/dmm.052700 · 2026 · External reference
Heterotrimerization of heat-shock factors 1 and 2 provides a transcriptional switch in response to distinct stimuli
10.1091/mbc.e08-08-0864 · 2009 · External reference
Human heat shock factors 1 and 2 are differentially activated and can synergistically induce hsp70 gene transcription
1994 · External reference
Heat shock factor 2 (HSF2) contributes to inducible expression of hsp genes through interplay with HSF1
10.1074/jbc.m607556200 · 2007 · External reference
Heat shock factor 2 is a stress-responsive mediator of neuronal migration defects in models of fetal alcohol syndrome
10.15252/emmm.201303311 · 2014 · External reference
The proteasome inhibitor bortezomib is a potent inducer of zinc finger AN1-type domain 2a gene expression: role of heat shock factor 1 (HSF1)-heat shock factor 2 (HSF2) heterocomplexes
10.1074/jbc.m113.513242 · 2014 · External reference
Heat shock transcription factor 1 localizes to sex chromatin during meiotic repression
10.1074/jbc.m110.157552 · 2010 · External reference
Crosstalk between HSF1 and HSF2 during the heat shock response in mouse testes
10.1016/j.biocel.2014.10.006 · 2014 · External reference
HSF2 cooperates with HSF1 to drive a transcriptional program critical for the malignant state
10.1126/sciadv.abj6526 · 2022 · External reference
Molecular mechanisms of heat shock factor 1 regulation
10.1016/j.tibs.2021.10.004 · 2022 · External reference
Hsf1 on a leash – controlling the heat shock response by chaperone titration
10.1016/j.yexcr.2020.112246 · 2020 · External reference
Mammalian heat shock response and mechanisms underlying its genome-wide transcriptional regulation
10.1016/j.molcel.2016.02.025 · 2016 · External reference
HSF1Base: a comprehensive database of HSF1 (Heat Shock Factor 1) target genes
10.3390/ijms20225815 · 2019 · External reference
The biology of proteostasis in aging and disease
10.1146/annurev-biochem-060614-033955 · 2015 · External reference
Regulation of aging and age-related disease by DAF-16 and heat-shock factor
10.1126/science.1083701 · 2003 · External reference
Regulation of longevity in Caenorhabditis elegans by heat shock factor and molecular chaperones
10.1091/mbc.e03-07-0532 · 2004 · External reference
Collapse of proteostasis represents an early molecular event in Caenorhabditis elegans aging
10.1073/pnas.0902882106 · 2009 · External reference
Repression of the heat shock response is a programmed event at the onset of reproduction
10.1016/j.molcel.2015.06.027 · 2015 · External reference
Stress-induced heat shock protein 70 expression in adrenal cortex: an adrenocorticotropic hormone-sensitive, age-dependent response
10.1073/pnas.88.21.9873 · 1991 · External reference
Multifactorial attenuation of the murine heat shock response with age
2020 · External reference
Disrupted HSF1 regulation in normal and exceptional brain aging
10.1007/s10522-023-10063-w · 2024 · External reference
Stress-inducible regulation of heat shock factor 1 by the deacetylase SIRT1
10.1126/science.1165946 · 2009 · External reference
Cellular proteostasis decline in human senescence
10.1073/pnas.2018138117 · 2020 · External reference
Heat shock factor 1 is a powerful multifaceted modifier of carcinogenesis
10.1016/j.cell.2007.07.020 · 2007 · External reference
Defining the essential function of yeast Hsf1 reveals a compact transcriptional program for maintaining eukaryotic proteostasis
10.1016/j.molcel.2018.01.021 · 2018 · External reference
The Hsp70 chaperone network
10.1038/s41580-019-0133-3 · 2019 · External reference
J-domain protein chaperone circuits in proteostasis and disease
10.1016/j.tcb.2022.05.004 · 2023 · External reference
The HSP90 chaperone machinery
10.1038/nrm.2017.20 · 2017 · External reference
Establishing order through disorder by the Hsp90 molecular chaperone
10.1016/j.jmb.2024.168460 · 2024 · External reference
Catchers of folding gone awry: a tale of small heat shock proteins
10.1016/j.tibs.2024.08.003 · 2024 · External reference
Cellular handling of protein aggregates by disaggregation machines
10.1016/j.molcel.2018.01.004 · 2018 · External reference
Regulation of proteasome assembly and activity in health and disease
10.1038/s41580-018-0040-z · 2018 · External reference
Comprehensive interactome profiling of the human Hsp70 network highlights functional differentiation of J domains
10.1016/j.molcel.2021.04.012 · 2021 · External reference
A quantitative chaperone interaction network reveals the architecture of cellular protein homeostasis pathways
10.1016/j.cell.2014.05.039 · 2014 · External reference
The Hsp90 molecular chaperone governs client proteins by targeting intrinsically disordered regions
10.1016/j.molcel.2023.05.021 · 2023 · External reference
Systems analyses reveal two chaperone networks with distinct functions in eukaryotic cells
10.1016/j.cell.2005.11.039 · 2006 · External reference
The cotranslational function of ribosome-associated Hsp70 in eukaryotic protein homeostasis
10.1016/j.cell.2012.12.001 · 2013 · External reference
Profiling Ssb-nascent chain interactions reveals principles of Hsp70-assisted folding
10.1016/j.cell.2017.06.038 · 2017 · External reference
A ribosome-bound quality control complex triggers degradation of nascent peptides and signals translation stress
10.1016/j.cell.2012.10.044 · 2012 · External reference
Heat shock factor 1 (HSF1) specifically potentiates c-MYC-mediated transcription independently of the canonical heat shock response
10.1016/j.celrep.2023.112557 · 2023 · External reference
HSF-1-mediated cytoskeletal integrity determines thermotolerance and life span
10.1126/science.1253168 · 2014 · External reference
Spatial regulation of the actin cytoskeleton by HSF-1 during aging
10.1091/mbc.e18-06-0362 · 2018 · External reference
Quality control of the mitochondrial proteome
10.1038/s41580-020-00300-2 · 2021 · External reference
Mitochondrial proteins: from biogenesis to functional networks
10.1038/s41580-018-0092-0 · 2019 · External reference
Molecular chaperones Hsp90 and Hsp70 deliver preproteins to the mitochondrial import receptor Tom70
10.1016/s0092-8674(02)01250-3 · 2003 · External reference
Mitochondrial protein-induced stress triggers a global adaptive transcriptional programme
10.1038/s41556-019-0294-5 · 2019 · External reference
MitoStores: chaperone-controlled protein granules store mitochondrial precursors in the cytosol
10.15252/embj.2022112309 · 2023 · External reference
HSF1 remodels mitochondrial biogenesis and function in cancer cells via TIMM17A
2025 · External reference
Ubiquilins chaperone and triage mitochondrial membrane proteins for degradation
10.1016/j.molcel.2016.05.020 · 2016 · External reference
HSF-1 promotes longevity through ubiquilin-1-dependent mitochondrial network remodelling
10.1038/s41467-024-54136-x · 2024 · External reference
The mitochondrial UPR: mechanisms, physiological functions and implications in ageing
10.1038/nrm.2017.110 · 2018 · External reference
Lipid biosynthesis coordinates a mitochondrial-to-cytosolic stress response
10.1016/j.cell.2016.08.027 · 2016 · External reference
Mitochondrial stress restores the heat shock response and prevents proteostasis collapse during aging
10.1016/j.celrep.2017.10.038 · 2017 · External reference
A mitochondrial stress-specific form of HSF1 protects against age-related proteostasis collapse
10.1016/j.devcel.2020.06.038 · 2020 · External reference
Loss of MTCH-1 suppresses age-related proteostasis collapse through the inhibition of programmed cell death factors
10.1016/j.celrep.2022.111690 · 2022 · External reference
IER5 generates a novel hypo-phosphorylated active form of HSF1 and contributes to tumorigenesis
10.1038/srep19174 · 2016 · External reference
HSF1 is required for induction of mitochondrial chaperones during the mitochondrial unfolded protein response
10.1002/2211-5463.12863 · 2020 · External reference
A cytosolic surveillance mechanism activates the mitochondrial UPR
10.1038/s41586-023-06142-0 · 2023 · External reference
Mitochondrial SSBP1 protects cells from proteotoxic stresses by potentiating stress-induced HSF1 transcriptional activity
10.1038/ncomms7580 · 2015 · External reference
Small heat shock proteins operate as molecular chaperones in the mitochondrial intermembrane space
10.1038/s41556-022-01074-9 · 2023 · External reference
Peroxisomes: a nexus for lipid metabolism and cellular signaling
10.1016/j.cmet.2014.01.002 · 2014 · External reference
TOR and heat shock response pathways regulate peroxisome biogenesis during proteotoxic stress
10.1038/s41467-025-65776-y · 2025 · External reference
Protein refolding in peroxisomes is dependent upon an HSF1-regulated function
10.1007/s12192-012-0335-5 · 2012 · External reference
Lack of peroxisomal catalase affects heat shock response in Caenorhabditis elegans
10.26508/lsa.202201737 · 2023 · External reference
The transcriptional coactivator PGC1α protects against hyperthermic stress via cooperation with the heat shock factor HSF1
10.1038/cddis.2016.22 · 2016 · External reference
Celastrol protects against obesity and metabolic dysfunction through activation of a HSF1-PGC1α transcriptional axis
10.1016/j.cmet.2015.08.005 · 2015 · External reference
Direct link between metabolic regulation and the heat-shock response through the transcriptional regulator PGC-1α
10.1073/pnas.1516219112 · 2015 · External reference
Mechanisms of COPII coat assembly and cargo recognition in the secretory pathway
10.1038/s41580-025-00839-y · 2025 · External reference
Mechanisms, regulation and functions of the unfolded protein response
10.1038/s41580-020-0250-z · 2020 · External reference
Order through destruction: how ER-associated protein degradation contributes to organelle homeostasis
10.15252/embj.2021109845 · 2022 · External reference
Identification of a tissue-selective heat shock response regulatory network
10.1371/journal.pgen.1003466 · 2013 · External reference
Heat shock factor-1 alleviates ER-stress in Caenorhabditis elegans
10.1038/s41598-026-43060-3 · 2026 · External reference
The disruption of COPII vesicles activates HSF-1 through SEC-23
10.1093/jmcb/mjaf017 · 2025 · External reference
Heat shock response relieves ER stress
10.1038/emboj.2008.42 · 2008 · External reference
Small heat-shock proteins protect from heat-stroke-associated neurodegeneration
10.1038/nature11417 · 2012 · External reference
Sir2 links the unfolded protein response and the heat shock response in a stress response network
10.1016/j.bbrc.2015.01.021 · 2015 · External reference
ER stress-activated HSF1 governs cancer cell resistance to USP7 inhibitor-based chemotherapy through the PERK pathway
10.3390/ijms25052768 · 2024 · External reference
Lysosomes as dynamic regulators of cell and organismal homeostasis
10.1038/s41580-019-0185-4 · 2020 · External reference
Hormetic heat stress and HSF-1 induce autophagy to improve survival and proteostasis in C. elegans
10.1038/ncomms14337 · 2017 · External reference
The molecular chaperone Hsp90 delivers precursor proteins to the chloroplast import receptor Toc64
10.1038/sj.emboj.7601091 · 2006 · External reference
Interference with plastome gene expression and Clp protease activity in Arabidopsis triggers a chloroplast unfolded protein response to restore protein homeostasis
10.1371/journal.pgen.1007022 · 2017 · External reference
Downregulation of chloroplast RPS1 negatively modulates nuclear heat-responsive expression of HsfA2 and its target genes in Arabidopsis
10.1371/journal.pgen.1002669 · 2012 · External reference
Chloroplast signaling gates thermotolerance in Arabidopsis
10.1016/j.celrep.2018.01.054 · 2018 · External reference