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References from Differential proteostasis imbalance and the molecular basis of distinct synucleinopathies and tauopathies. Local targets link to admitted publications; unresolved targets remain external evidence.
Unresolved reference
1999 · External reference
From covalent transition states in chemistry to noncovalent in biology: from β- to Φ-value analysis of protein folding
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Principles of protein folding, misfolding and aggregation
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Heparin and other glycosaminoglycans stimulate the formation of amyloid fibrils from α-synuclein in vitro
10.1021/bi011711s · 2002 · External reference
Rapid assembly of Alzheimer-like paired helical filaments from microtubule-associated protein tau monitored by fluorescence in solution
10.1021/bi980537d · 1998 · External reference
RNA stimulates aggregation of microtubule-associated protein tau into Alzheimer-like paired helical filaments
10.1016/s0014-5793(96)01386-5 · 1996 · External reference
Metal-triggered structural transformations, aggregation, and fibrillation of human α-synuclein. A possible molecular link between Parkinson's disease and heavy metal exposure
10.1074/jbc.m105343200 · 2001 · External reference
Insights into the molecular mechanisms of Alzheimer's and Parkinson's diseases with molecular simulations: understanding the roles of artificial and pathological missense mutations in intrinsically disordered proteins related to pathology
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Supersaturation is a major driving force for protein aggregation in neurodegenerative diseases
10.1016/j.tips.2014.12.004 · 2015 · External reference
Unresolved reference
1975 · External reference
Liquid–liquid phase separation in disease
10.1146/annurev-genet-112618-043527 · 2019 · External reference
Biomolecular condensates at the nexus of cellular stress, protein aggregation disease and ageing
10.1038/s41580-020-00326-6 · 2021 · External reference
Protein phase separation: a new phase in cell biology
10.1016/j.tcb.2018.02.004 · 2018 · External reference
Liquid–liquid phase separation in biology
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Half a century of amyloids: past, present and future
10.1039/c9cs00199a · 2020 · External reference
The molecular basis of amyloidosis
10.1007/s000180050107 · 1997 · External reference
Nucleotide hydrolysis regulates the dynamics of actin filaments and microtubules
10.1098/rstb.1992.0048 · 1992 · External reference
Phenotypic manifestation of α-synuclein strains derived from Parkinson's disease and multiple system atrophy in human dopaminergic neurons
10.1038/s41467-021-23682-z · 2021 · External reference
Supersaturation-dependent formation of amyloid fibrils
10.3390/molecules27144588 · 2022 · External reference
Acceleration of the depolymerization of amyloid β fibrils by ultrasonication
10.1016/j.bbapap.2013.08.013 · 2013 · External reference
Tau and neurodegeneration
10.1002/cm.21812 · 2024 · External reference
The synucleinopathies: twenty years on
10.3233/jpd-179005 · 2017 · External reference
Burden of 375 diseases and injuries, risk-attributable burden of 88 risk factors, and healthy life expectancy in 204 countries and territories, including 660 subnational locations, 1990–2023: a systematic analysis for the Global Burden of Disease Study 2023
10.1016/s0140-6736(25)01637-x · 2025 · External reference
Neuropathology underlying clinical variability in patients with synucleinopathies
10.1007/s00401-011-0852-9 · 2011 · External reference
Unraveling the clinical–pathological correlations of subjects with isolated and mixed neurodegenerative processes in the National Alzheimer's Coordinating Center dataset
10.1093/jnen/nlae134 · 2025 · External reference
Basal forebrain cholinergic system in the dementias: vulnerability, resilience, and resistance
10.1111/jnc.15471 · 2021 · External reference
Life on the edge: a link between gene expression levels and aggregation rates of human proteins
10.1016/j.tibs.2007.03.005 · 2007 · External reference
Staging of brain pathology related to sporadic Parkinson's disease
10.1016/s0197-4580(02)00065-9 · 2003 · External reference
Silver staining method for demonstrating Lewy bodies in Parkinson's disease and argyrophilic oligodendrocytes in multiple system atrophy
10.1016/s0165-0270(98)00173-3 · 1999 · External reference
Unresolved reference
2025 · External reference
Local protein synthesis at synapses: a driver for synapse diversification
10.1111/jnc.70308 · 2025 · External reference
The integrated stress response in the brain: cell type-specific functions in health and neurological disorders
10.1016/j.tins.2025.08.002 · 2025 · External reference
An ultrasensitive spatial tissue proteomics workflow exceeding 100 proteomes per day
10.1016/j.mcpro.2025.101489 · 2025 · External reference
New multiomic studies shed light on cellular diversity and neuronal susceptibility in Parkinson's disease
10.1002/mds.30097 · 2025 · External reference
Understanding the molecular diversity of synapses
10.1038/s41583-024-00888-w · 2025 · External reference
A tissue-specific atlas of protein–protein associations enables prioritization of candidate disease genes
10.1038/s41587-025-02659-z · 2025 · External reference
Atlas of proteomic signatures of brain structure and its links to brain disorders
10.1038/s41467-025-60185-7 · 2025 · External reference
The X-ray interpretation of denaturation, the structure of the seed globulins
10.1042/bj0292351 · 1935 · External reference
Unresolved reference
1999 · External reference
Structures for amyloid fibrils
10.1111/j.1742-4658.2005.05025.x · 2005 · External reference
Role of intermolecular forces in defining material properties of protein nanofibrils
10.1126/science.1150057 · 2007 · External reference
Nanomechanical properties of distinct fibrillar polymorphs of the protein α-synuclein
10.1038/srep37970 · 2016 · External reference
Atomic force microscopy imaging and nanomechanical properties of six tau isoform assemblies
10.1016/j.bpj.2020.10.045 · 2020 · External reference
Inverse correlation between amyloid stiffness and size
10.1021/jacs.8b10142 · 2019 · External reference
α-Synuclein induces both positive mean curvature and negative Gaussian curvature in membranes
10.1021/ja208316h · 2012 · External reference
α-Synuclein-induced membrane remodeling is driven by binding affinity, partition depth, and interleaflet order asymmetry
10.1021/ja5016958 · 2014 · External reference
α-Synuclein promotes dilation of the exocytotic fusion pore
10.1038/nn.4529 · 2017 · External reference
Remodeling of lipid vesicles into cylindrical micelles by α-synuclein in an extended α-helical conformation
10.1074/jbc.m112.365817 · 2012 · External reference
α-Synuclein has a high affinity for packing defects in a bilayer membrane: a thermodynamics study
10.1074/jbc.m401076200 · 2004 · External reference
α-Synuclein senses lipid packing defects and induces lateral expansion of lipids leading to membrane remodeling
10.1074/jbc.m113.478297 · 2013 · External reference
α-Synuclein and ALPS motifs are membrane curvature sensors whose contrasting chemistry mediates selective vesicle binding
10.1083/jcb.201011118 · 2011 · External reference
Membrane curvature induction and tubulation are common features of synucleins and apolipoproteins
10.1074/jbc.m110.139576 · 2010 · External reference
α-Synuclein in synaptic function and dysfunction
10.1016/j.tins.2022.11.007 · 2023 · External reference
The role of α-synuclein in SNARE-mediated synaptic vesicle fusion
10.1016/j.jmb.2022.167775 · 2023 · External reference
Nuclear transport deficits in tau-related neurodegenerative diseases
10.3389/fneur.2020.01056 · 2020 · External reference
Structure, microtubule interactions, and phosphorylation of tau protein
10.1111/j.1749-6632.1996.tb34407.x · 1996 · External reference
Tau and membranes: interactions that promote folding and condensation
10.3389/fcell.2021.725241 · 2021 · External reference
Functional alterations to the nigrostriatal system in mice lacking all three members of the synuclein family
10.1523/jneurosci.6194-10.2011 · 2011 · External reference
Inhibition of neuronal maturation in primary hippocampal neurons from tau deficient mice
10.1242/jcs.114.6.1179 · 2001 · External reference
αβγ-Synuclein triple knockout mice reveal age-dependent neuronal dysfunction
10.1073/pnas.1005005107 · 2010 · External reference
Altered microtubule organization in small-calibre axons of mice lacking tau protein
10.1038/369488a0 · 1994 · External reference
The physiological role of α-synuclein and its relationship to Parkinson's disease
10.1111/jnc.14810 · 2019 · External reference
Protein aggregation and neurodegenerative disease
10.1038/nm1066 · 2004 · External reference
Protein aggregation can inhibit clathrin-mediated endocytosis by chaperone competition
10.1073/pnas.1321811111 · 2014 · External reference
α-Synuclein assemblies sequester neuronal α3-Na+/K+-ATPase and impair Na+ gradient
10.15252/embj.201591397 · 2015 · External reference
Physico-pathologic mechanisms involved in neurodegeneration: misfolded protein-plasma membrane interactions
10.1016/j.neuron.2017.05.026 · 2017 · External reference
Clustering of tau fibrils impairs the synaptic composition of α3-Na+/K+-ATPase and AMPA receptors
10.15252/embj.201899871 · 2019 · External reference
Prion-like transmission of protein aggregates in neurodegenerative diseases
10.1038/nrm2873 · 2010 · External reference
Prion-like mechanisms in neurodegenerative diseases
10.1038/nrn2786 · 2010 · External reference
Spreading of a prion domain from cell-to-cell by vesicular transport in Caenorhabditis elegans
10.1371/journal.pgen.1003351 · 2013 · External reference
Proximity proteomics reveals unique and shared pathological features between multiple system atrophy and Parkinson's disease
10.1186/s40478-025-01958-5 · 2025 · External reference
Tau interactome and RNA binding proteins in neurodegenerative diseases
10.1186/s13024-022-00572-6 · 2022 · External reference
In situ proximity labeling identifies Lewy pathology molecular interactions in the human brain
10.1073/pnas.2114405119 · 2022 · External reference
Proximity labeling of the tau repeat domain enriches RNA-binding Proteins that are altered in Alzheimer's disease and related tauopathies
10.1016/j.mcpro.2025.101458 · 2025 · External reference
Data in support of the identification of neuronal and astrocyte proteins interacting with extracellularly applied oligomeric and fibrillar α-synuclein assemblies by mass spectrometry
10.1016/j.dib.2016.02.018 · 2016 · External reference
Differential role of C-terminal truncations on alpha-synuclein pathology and Lewy body formation
10.1038/s41531-025-01084-y · 2025 · External reference
Biochemical approaches to assess the impact of post-translational modifications on pathogenic tau conformations using recombinant protein
10.1042/bst20230596 · 2024 · External reference
Structure–function relationship of alpha-synuclein fibrillar polymorphs derived from distinct synucleinopathies
10.1038/s44320-026-00199-5 · 2026 · External reference
Adapting proteostasis for disease intervention
10.1126/science.1141448 · 2008 · External reference
A cellular perspective on conformational disease: the role of genetic background and proteostasis networks
10.1016/j.sbi.2009.11.001 · 2010 · External reference
10.1007/978-1-4419-7002-2_11
10.1007/978-1-4419-7002-2_11 · 2010 · External reference
The heat shock response: systems biology of proteotoxic stress in aging and disease
10.1101/sqb.2012.76.010637 · 2011 · External reference
Shaping proteostasis at the cellular, tissue, and organismal level
10.1083/jcb.201612111 · 2017 · External reference
Phosphorylated tau interactome in the human Alzheimer's disease brain
10.1093/brain/awaa223 · 2020 · External reference
Chaperone networks: tipping the balance in protein folding diseases
10.1016/j.nbd.2010.05.007 · 2010 · External reference
Progressive disruption of cellular protein folding in models of polyglutamine diseases
10.1126/science.1124514 · 2006 · External reference
The role of autophagy in synucleinopathy: clearance versus spread of α-synuclein
10.1080/27694127.2025.2577406 · 2025 · External reference
Tau degradation: the ubiquitin–proteasome system versus the autophagy–lysosome system
10.1016/j.pneurobio.2013.03.001 · 2013 · External reference
Mechanisms of autophagy–lysosome dysfunction in neurodegenerative diseases
10.1038/s41580-024-00757-5 · 2024 · External reference
TNF-α and α-synuclein fibrils differently regulate human astrocyte immune reactivity and impair mitochondrial respiration
10.1016/j.celrep.2021.108895 · 2021 · External reference
Microglial NLRP3 inflammasome activation upon TLR2 and TLR5 ligation by distinct α-synuclein assemblies
10.4049/jimmunol.2100035 · 2021 · External reference
NLRP3 inflammasome activation drives tau pathology.
10.1038/s41586-019-1769-z · 2019 · External reference
Structural polymorphism of α-synuclein fibrils alters the pathway of Hsc70-mediated disaggregation
10.1038/s44318-025-00573-3 · 2025 · External reference
Dissecting aggregation and seeding dynamics of α-Syn polymorphs using the phasor approach to FLIM
10.1038/s42003-022-04289-6 · 2022 · External reference
Disassembly of tau fibrils by the human Hsp70 disaggregation machinery generates small seeding-competent species.
10.1074/jbc.ra120.013478 · 2020 · External reference
Thermodynamic stability modulates chaperone-mediated disaggregation of α-synuclein fibrils
10.1039/d5sc04927j · 2025 · External reference
