References

How the shapes of seeds can influence pathology

10.1016/j.nbd.2017.03.011 · 2018 · External reference

α-synuclein strains: does amyloid conformation explain the heterogeneity of synucleinopathies?

10.3390/biom11070931 · 2021 · External reference

Neurodegenerative disease tauopathies

10.1146/annurev-pathmechdis-051222-120750 · 2024 · External reference

α-Synuclein conformational strains spread, seed and target neuronal cells differentially after injection into the olfactory bulb

10.1186/s40478-019-0859-3 · 2019 · External reference

Cellular and pathological heterogeneity of primary tauopathies

10.1186/s13024-021-00476-x · 2021 · External reference

Prions

1998 · External reference

A general model of prion strains and their pathogenicity

10.1126/science.1138718 · 2007 · External reference

Mammalian prions and their wider relevance in neurodegenerative diseases

10.1038/nature20415 · 2016 · External reference

Yeast prions: evolution of the prion concept

10.4161/pri.1.2.4664 · 2007 · External reference

Genesis and variability of [PSI] prion factors in Saccharomyces cerevisiae

10.1093/genetics/144.4.1375 · 1996 · External reference

Two new polymorphic structures of human full-length alpha-synuclein fibrils solved by cryo-electron microscopy

10.7554/elife.48907 · 2019 · External reference

Molecular pathology of neurodegenerative diseases by cryo-EM of amyloids

10.1038/s41586-023-06437-2 · 2023 · External reference

A structural basis for prion strain diversity

10.1038/s41589-022-01229-7 · 2023 · External reference

Single-cell expression predicts neuron-specific protein homeostasis networks

10.1098/rsob.230386 · 2024 · External reference

Shaping proteostasis at the cellular, tissue, and organismal level

10.1083/jcb.201612111 · 2017 · External reference

Chaperone networks are shaped by cellular differentiation and identity

10.1016/j.tcb.2021.11.001 · 2022 · External reference

Structural polymorphism of α-synuclein fibrils alters the pathway of Hsc70-mediated disaggregation

2025 · External reference

Internalized SNCA/α-synuclein fibrils become truncated and resist degradation in neurons while glial cells rapidly degrade SNCA fibrils

10.1080/15548627.2025.2579147 · 2026 · External reference

Prion protein biology

10.1016/s0092-8674(00)81163-0 · 1998 · External reference

Eight prion strains have PrP(Sc) molecules with different conformations

10.1038/2654 · 1998 · External reference

Conformational variations in an infectious protein determine prion strain differences

10.1038/nature02392 · 2004 · External reference

Protein-only transmission of three yeast prion strains

10.1038/nature02391 · 2004 · External reference

2.7 A cryo-EM structure of ex vivo RML prion fibrils

10.1038/s41467-022-30457-7 · 2022 · External reference

Prion strains viewed through the lens of cryo-EM

10.1007/s00441-022-03676-z · 2023 · External reference

Structural biology of ex vivo mammalian prions

10.1016/j.jbc.2022.102181 · 2022 · External reference

Structural and functional characterization of two alpha-synuclein strains

10.1038/ncomms3575 · 2013 · External reference

Nanomechanical properties of distinct fibrillar polymorphs of the protein α-synuclein

10.1038/srep37970 · 2016 · External reference

Multiple isoforms of human microtubule-associated protein tau: sequences and localization in neurofibrillary tangles of Alzheimer's disease

10.1016/0896-6273(89)90210-9 · 1989 · External reference

Heparin-induced tau filaments are polymorphic and differ from those in Alzheimer's and Pick's diseases

10.7554/elife.43584 · 2019 · External reference

Atomic force microscopy imaging and nanomechanical properties of six tau isoform assemblies

10.1016/j.bpj.2020.10.045 · 2020 · External reference

Stepwise proteolysis liberates tau fragments that nucleate the Alzheimer-like aggregation of full-length tau in a neuronal cell model

2007 · External reference

Physiological C-terminal truncation of α-synuclein potentiates the prion-like formation of pathological inclusions

10.1074/jbc.ra118.005603 · 2018 · External reference

Molecular features of human pathological tau distinguish tauopathy-associated dementias

10.1016/j.cell.2025.12.036 · 2026 · External reference

α-synuclein is phosphorylated in synucleinopathy lesions

10.1038/ncb748 · 2002 · External reference

Pseudophosphorylation and glycation of tau protein enhance but do not trigger fibrillization in vitro

10.1074/jbc.m405527200 · 2004 · External reference

Strain-specified relative conformational stability of the scrapie prion protein

10.1110/ps.39201 · 2001 · External reference

Assembly of recombinant tau into filaments identical to those of Alzheimer's disease and chronic traumatic encephalopathy

10.7554/elife.76494 · 2022 · External reference

The physical basis of how prion conformations determine strain phenotypes

10.1038/nature04922 · 2006 · External reference

Human Tau isoforms assemble into ribbon-like fibrils that display polymorphic structure and stability

10.1074/jbc.m110.145318 · 2010 · External reference

Distinct differences in prion-like seeding and aggregation between Tau protein variants provide mechanistic insights into tauopathies

10.1074/jbc.m117.815357 · 2018 · External reference

Cellular handling of protein aggregates by disaggregation machines

10.1016/j.molcel.2018.01.004 · 2018 · External reference

Molecular chaperones in protein folding and proteostasis

10.1038/nature10317 · 2011 · External reference

Adapting proteostasis for disease intervention

10.1126/science.1141448 · 2008 · External reference

Differentiation drives widespread rewiring of the neural stem cell chaperone network

10.1016/j.molcel.2020.03.009 · 2020 · External reference

Molecular and cellular mechanisms of selective vulnerability in neurodegenerative diseases

10.1038/s41583-024-00806-0 · 2024 · External reference

Proteostasis of organelles in aging and disease

10.1111/febs.70439 · 2026 · External reference

The proteostasis network and its decline in ageing

10.1038/s41580-019-0101-y · 2019 · External reference

The biology of proteostasis in aging and disease

10.1146/annurev-biochem-060614-033955 · 2015 · External reference

Stress-response hormesis and aging: “that which does not kill us makes us stronger”

10.1016/j.cmet.2008.01.001 · 2008 · External reference

Multiple stressors in Caenorhabditis elegans induce stress hormesis and extended longevity

10.1093/gerona/57.3.b109 · 2002 · External reference

Hormetic heat stress and HSF-1 induce autophagy to improve survival and proteostasis in C. elegans

10.1038/ncomms14337 · 2017 · External reference

The HSP70 chaperone machinery: J proteins as drivers of functional specificity

10.1038/nrm2941 · 2010 · External reference

HSP90 at the hub of protein homeostasis: emerging mechanistic insights

10.1038/nrm2918 · 2010 · External reference

Recognition and processing of ubiquitin-protein conjugates by the proteasome

10.1146/annurev.biochem.78.081507.101607 · 2009 · External reference

Cargo recognition and degradation by selective autophagy

10.1038/s41556-018-0037-z · 2018 · External reference

Nucleotide exchange factors for Hsp70 molecular chaperones: GrpE, Hsp110/Grp170, HspBP1/Sil1, and BAG domain proteins

10.1007/978-3-031-14740-1_1 · 2023 · External reference

Increased proteasome activity in human embryonic stem cells is regulated by PSMD11

10.1038/nature11468 · 2012 · External reference

RPN-6 determines C. elegans longevity under proteotoxic stress conditions

10.1038/nature11315 · 2012 · External reference

Collapse of proteostasis represents an early molecular event in Caenorhabditis elegans aging

2009 · External reference

Repression of the heat shock response is a programmed event at the onset of reproduction

10.1016/j.molcel.2015.06.027 · 2015 · External reference

Molecular chaperones: a double-edged sword in neurodegenerative diseases

10.3389/fnagi.2020.581374 · 2020 · External reference

Human Hsp70 disaggregase reverses Parkinson's-linked α-synuclein amyloid fibrils

10.1016/j.molcel.2015.07.012 · 2015 · External reference

Complete suppression of Htt fibrilization and disaggregation of Htt fibrils by a trimeric chaperone complex

10.15252/embj.201797212 · 2017 · External reference

Molecular chaperones: structure of a protein disaggregase

10.1016/j.cub.2003.12.051 · 2004 · External reference

Role of the chaperone protein Hsp104 in propagation of the yeast prion-like factor [psi+]

10.1126/science.7754373 · 1995 · External reference

Amyloid conformation-dependent disaggregation in a reconstituted yeast prion system

10.1038/s41589-021-00951-y · 2022 · External reference

Molecular dissection of amyloid disaggregation by human HSP70

10.1038/s41586-020-2904-6 · 2020 · External reference

Metazoan Hsp70 machines use Hsp110 to power protein disaggregation

10.1038/emboj.2012.264 · 2012 · External reference

Protein disaggregation machineries in the human cytosol

10.1016/j.sbi.2023.102735 · 2023 · External reference

Dissecting aggregation and seeding dynamics of α-Syn polymorphs using the phasor approach to FLIM

10.1038/s42003-022-04289-6 · 2022 · External reference

Phosphorylation of α-synuclein fibrils at S129 changes DNAJB1 binding as probed by solid-state NMR

2025 · External reference

Disassembly of Tau fibrils by the human Hsp70 disaggregation machinery generates small seeding-competent species

10.1074/jbc.ra120.013478 · 2020 · External reference

Hsp104 catalyzes formation and elimination of self-replicating Sup35 prion conformers

10.1126/science.1098007 · 2004 · External reference

Hsp70 chaperones as modulators of prion life cycle: novel effects of Ssa and Ssb on the Saccharomyces cerevisiae prion [PSI+]

10.1534/genetics.104.037168 · 2005 · External reference

The prion strain phenomenon: molecular basis and unprecedented features

10.1016/j.bbadis.2006.12.006 · 2007 · External reference

Emergence of multiple prion strains from single isolates of ovine scrapie

10.1099/vir.0.028886-0 · 2011 · External reference

Scrapie strain variation and mutation

10.1093/oxfordjournals.bmb.a072649 · 1993 · External reference

α-synuclein prion strains differentially adapt after passage in mice

10.1371/journal.ppat.1012746 · 2024 · External reference

Mutation and selection of prions

10.1371/journal.ppat.1002582 · 2012 · External reference

Prion strain mutation and selection

10.1126/science.1190815 · 2010 · External reference

Darwinian evolution of prions in cell culture

10.1126/science.1183218 · 2010 · External reference

Contribution of α-synuclein cytopathologies to distinct seeding of misfolded α-synuclein

10.1111/bpa.70024 · 2025 · External reference

Cellular milieu imparts distinct pathological α-synuclein strains in α-synucleinopathies

10.1038/s41586-018-0104-4 · 2018 · External reference

Endocytic vesicle rupture is a conserved mechanism of cellular invasion by amyloid proteins

10.1007/s00401-017-1722-x · 2017 · External reference

Compromised function of the ESCRT pathway promotes endolysosomal escape of tau seeds and propagation of tau aggregation

10.1074/jbc.ra119.009432 · 2019 · External reference

C. elegans models to study the propagation of prions and prion-like proteins

10.3390/biom10081188 · 2020 · External reference

Alpha-synuclein induces lysosomal rupture and cathepsin dependent reactive oxygen species following endocytosis

10.1371/journal.pone.0062143 · 2013 · External reference

Cell-produced α-synuclein is secreted in a calcium-dependent manner by exosomes and impacts neuronal survival

10.1523/jneurosci.5699-09.2010 · 2010 · External reference

Intravesicular localization and exocytosis of α-synuclein and its aggregates

10.1523/jneurosci.0692-05.2005 · 2005 · External reference

Lysosomal dysfunction increases exosome-mediated alpha-synuclein release and transmission

10.1016/j.nbd.2011.01.029 · 2011 · External reference

Autophagy modulates SNCA/α-synuclein release, thereby generating a hostile microenvironment

10.4161/auto.36436 · 2014 · External reference

Tuning Hsp104 specificity to selectively detoxify α-synuclein

10.1016/j.molcel.2023.07.029 · 2023 · External reference

Proteostasis and lysosomal repair deficits in transdifferentiated neurons of Alzheimer's disease

10.1038/s41556-025-01623-y · 2025 · External reference

Progressive disruption of cellular protein folding in models of polyglutamine diseases

10.1126/science.1124514 · 2006 · External reference

A chaperome subnetwork safeguards proteostasis in aging and neurodegenerative disease

10.1016/j.celrep.2014.09.042 · 2014 · External reference

FOXO/4E-BP signaling in Drosophila muscles regulates organism-wide proteostasis during aging

10.1016/j.cell.2010.10.007 · 2010 · External reference