Research graph
References from Cell-type-specific proteostasis networks differ across developing human organs. Local targets link to admitted publications; unresolved targets remain external evidence.
The little prince (translated by Katherine Woods)
1974 · External reference
Diversity in the origins of proteostasis networks–a driver for protein function in evolution
10.1038/nrm3542 · 2013 · External reference
Biological and chemical approaches to diseases of proteostasis deficiency
10.1146/annurev.biochem.052308.114844 · 2009 · External reference
Adapting proteostasis for disease intervention
10.1126/science.1141448 · 2008 · External reference
A comprehensive enumeration of the human proteostasis network. 2. Components of the autophagy-lysosome pathway
2023 · External reference
The proteostasis boundary in misfolding diseases of membrane traffic
10.1016/j.febslet.2009.07.014 · 2009 · External reference
A chaperome subnetwork safeguards proteostasis in aging and neurodegenerative disease
10.1016/j.celrep.2014.09.042 · 2014 · External reference
Systems-wide proteomic analysis in mammalian cells reveals conserved, functional protein turnover
10.1021/pr101183k · 2011 · External reference
ER stress affects processing of MHC class I-associated peptides
10.1186/1471-2172-10-10 · 2009 · External reference
Building an antibody factory: a job for the unfolded protein response
10.1038/ni1149 · 2005 · External reference
Chaperone networks are shaped by cellular differentiation and identity
10.1016/j.tcb.2021.11.001 · 2022 · External reference
Shaping proteostasis at the cellular, tissue, and organismal level
10.1083/jcb.201612111 · 2017 · External reference
The landscape of molecular chaperones across human tissues reveals a layered architecture of core and variable chaperones
10.1038/s41467-021-22369-9 · 2021 · External reference
Interplay of proteostasis capacity and protein aggregation: implications for cellular function and disease
10.1016/j.jmb.2024.168615 · 2024 · External reference
The proteostasis network and its decline in ageing
10.1038/s41580-019-0101-y · 2019 · External reference
Quality control: maintaining molecular order and preventing cellular chaos
10.1016/j.molcel.2022.04.002 · 2022 · External reference
Structural analyses define the molecular basis of clusterin chaperone function
10.1038/s41594-025-01631-4 · 2025 · External reference
Protein degradation on the global scale
10.1016/j.molcel.2022.02.027 · 2022 · External reference
The nature and extent of contributions by defective ribosome products to the HLA peptidome
10.1073/pnas.1321902111 · 2014 · External reference
Regulation of organismal proteostasis by transcellular chaperone signaling
10.1016/j.cell.2013.05.015 · 2013 · External reference
A ribosome-bound quality control complex triggers degradation of nascent peptides and signals translation stress
10.1016/j.cell.2012.10.044 · 2012 · External reference
CAT-tailing as a fail-safe mechanism for efficient degradation of stalled nascent polypeptides
10.1126/science.aam7787 · 2017 · External reference
HSF1 at a glance
10.1242/jcs.132605 · 2014 · External reference
The unfolded protein response governs integrity of the haematopoietic stem-cell pool during stress
10.1038/nature13228 · 2014 · External reference
E2F coregulates an program that essential HSF developmental is distinct from the heat-shock response
10.1101/gad.283317.116 · 2016 · External reference
Evidence for the involvement of mouse heat shock factor 1 in the atypical expression of the HSP70.1 heat shock gene during mouse zygotic genome activation
10.1128/mcb.17.2.778 · 1997 · External reference
Variations in brain defects result from cellular mosaicism in the activation of heat shock signalling
10.1038/ncomms15157 · 2017 · External reference
Heat shock factor 2-like activity in mouse blastocysts
10.1006/dbio.1994.1361 · 1994 · External reference
The pathophysiology of defective proteostasis in the hypothalamus - from obesity to ageing
10.1038/nrendo.2016.107 · 2016 · External reference
Embryonic stem cells: a novel paradigm to study proteostasis?
10.1111/febs.13810 · 2017 · External reference
The intrinsic proteostasis network of stem cells
10.1016/j.ceb.2020.08.005 · 2020 · External reference
Lessons in longevity from blood stem cells under protein stress
10.1016/j.tcb.2025.06.006 · 2026 · External reference
Plasma cell differentiation requires the transcription factor XBP-1
10.1038/35085509 · 2001 · External reference
The special unfolded protein response in plasma cells
10.1111/imr.13012 · 2021 · External reference
Glucose regulated protein 94 is required for muscle differentiation through its control of the autocrine production of insulin-like growth factors
10.1016/j.bbamcr.2009.11.005 · 2010 · External reference
HSP-4/BiP expression in secretory cells is regulated by a developmental program and not by the unfolded protein response
10.1371/journal.pbio.3000196 · 2019 · External reference
Regulation of B cell differentiation by intracellular membrane-associated proteins and microRNAs: role in the antibody response
10.3389/fimmu.2015.00537 · 2015 · External reference
A differentiation transcription factor establishes muscle-specific proteostasis in Caenorhabditis elegans
10.1371/journal.pgen.1006531 · 2016 · External reference
HLH-1 modulates muscle proteostasis during Caenorhabditis elegans larval development
10.3389/fcell.2022.920569 · 2022 · External reference
Differentiation drives widespread rewiring of the neural stem cell chaperone network
10.1016/j.molcel.2020.03.009 · 2020 · External reference
In vivo regulation of Grp78/BiP transcription in the embryonic heart: role of the endoplasmic reticulum stress response element and GATA-4
10.1074/jbc.m505784200 · 2006 · External reference
Small heat-shock protein HSPB3 promotes myogenesis by regulating the lamin B receptor
10.1038/s41419-021-03737-1 · 2021 · External reference
Olfactory experience primes the heat shock transcription factor HSF-1 to enhance the expression of molecular chaperones in C. elegans
10.1126/scisignal.aan4893 · 2017 · External reference
Regulation of the cellular heat shock response in Caenorhabditis elegans by thermosensory neurons
10.1126/science.1156093 · 2008 · External reference
Neuronal serotonin release triggers the heat shock response in C. elegans in the absence of temperature increase
10.1016/j.cub.2014.11.040 · 2015 · External reference
The cell-non-autonomous nature of electron transport chain-mediated longevity
10.1016/j.cell.2010.12.016 · 2011 · External reference
The mitochondrial unfolded protein response is mediated cell-non-autonomously by retromer-dependent wnt signaling
10.1016/j.cell.2018.06.029 · 2018 · External reference
A PQM-1-mediated response triggers transcellular chaperone signaling and regulates organismal proteostasis
10.1016/j.celrep.2018.05.093 · 2018 · External reference
Ketogenic diet attenuates aging-associated myocardial remodeling and dysfunction in mice
10.1016/j.exger.2020.111058 · 2020 · External reference
Ceramide mediates vascular dysfunction in diet-induced obesity by PP2A-mediated dephosphorylation of the eNOS-Akt complex
10.2337/db11-1399 · 2012 · External reference
Gene bookmarking by the heat shock transcription factor programs the insulin-like signaling pathway
10.1016/j.molcel.2021.09.022 · 2021 · External reference
Early life changes in histone landscape protect against age-associated amyloid toxicities through HSF-1-dependent regulation of lipid metabolism
10.1038/s43587-023-00537-4 · 2024 · External reference
Proteomics. Tissue-based map of the human proteome
10.1126/science.1260419 · 2015 · External reference
The Hsp70 chaperone system: distinct roles in erythrocyte formation and maintenance
10.3324/haematol.2019.233056 · 2021 · External reference
The evolution of cell types in animals: emerging principles from molecular studies
10.1038/nrg2416 · 2008 · External reference
Inferring cell type innovations by phylogenetic methods-concepts, methods, and limitations
10.1002/jez.b.22657 · 2015 · External reference
Evolution of cellular differentiation: from hypotheses to models
10.1016/j.tree.2020.07.013 · 2021 · External reference
The Human Cell Atlas
10.7554/elife.27041 · 2017 · External reference
Tracing the history of cell types
10.7554/elife.90447 · 2023 · External reference
The origin and evolution of cell types
10.1038/nrg.2016.127 · 2016 · External reference
Cell type ontologies of the Human Cell Atlas
10.1038/s41556-021-00787-7 · 2021 · External reference
The Human Cell Atlas from a cell census to a unified foundation model
10.1038/s41586-024-08338-4 · 2025 · External reference
A prenatal skin atlas reveals immune regulation of human skin morphogenesis
10.1038/s41586-024-08002-x · 2024 · External reference
A human embryonic limb cell atlas resolved in space and time
10.1038/s41586-023-06806-x · 2024 · External reference
A multi-omic atlas of human embryonic skeletal development
10.1038/s41586-024-08189-z · 2024 · External reference
Human Cell Atlas and cell-type authentication for regenerative medicine
10.1038/s12276-020-0421-1 · 2020 · External reference
UMAP: uniform manifold approximation and projection
10.21105/joss.00861 · 2018 · External reference
HSF-1 is involved in attenuating the release of inflammatory cytokines induced by LPS through regulating autophagy
10.1097/shk.0000000000000118 · 2014 · External reference
The stress response regulator HSF1 modulates natural killer cell anti-tumour immunity
10.1038/s41556-024-01490-z · 2024 · External reference
FoxO proteins restrain osteoclastogenesis and bone resorption by attenuating H2O2 accumulation
10.1038/ncomms4773 · 2014 · External reference
The role of reactive oxygen species in bone cell physiology and pathophysiology
10.1016/j.bonr.2023.101664 · 2023 · External reference
Enhanced lysosomal degradation maintains the quiescent state of neural stem cells
10.1038/s41467-019-13203-4 · 2019 · External reference
Notch-induced endoplasmic reticulum-associated degradation governs mouse thymocyte beta-selection
10.7554/elife.69975 · 2021 · External reference
The origin, molecular regulation and therapeutic potential of myogenic stem cell populations
10.1111/j.1469-7580.2009.01138.x · 2009 · External reference
The potential of muscle stem cells
10.1016/s1534-5807(01)00049-1 · 2001 · External reference
Pax3 and Pax7 play essential safeguard functions against environmental stress-induced birth defects
10.1016/j.devcel.2015.02.006 · 2015 · External reference
Limb development: a paradigm of gene regulation
10.1038/nrg.2016.167 · 2017 · External reference
Single-cell sequencing reveals dissociation-induced gene expression in tissue subpopulations
10.1038/nmeth.4437 · 2017 · External reference
The coupling of alternative splicing and nonsense-mediated mRNA decay
10.1007/978-0-387-77374-2_12 · 2007 · External reference
Plasticity of the differentiated state
10.1126/science.2414846 · 1985 · External reference
Viable offspring derived from fetal and adult mammalian cells
10.1038/385810a0 · 1997 · External reference
Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors
10.1016/j.cell.2006.07.024 · 2006 · External reference
Dedifferentiation, transdifferentiation and reprogramming: three routes to regeneration
10.1038/nrm3043 · 2011 · External reference
Searching chromatin for stem cell identity
10.1016/j.cell.2006.04.004 · 2006 · External reference
Breaking out of the mold: diversity within adult stem cells and their niches
10.1016/j.gde.2006.08.003 · 2006 · External reference
Germline stem cells
10.1101/cshperspect.a002642 · 2011 · External reference
Stem cells and their niches: integrated units that maintain Drosophila tissues
10.1101/sqb.2008.73.023 · 2008 · External reference
p53: defender of lineage fidelity and foe of plasticity in cancer and regeneration
10.1016/j.trecan.2026.02.004 · 2026 · External reference
Loss of colonic fidelity enables multilineage plasticity and metastasis
10.1038/s41586-025-09125-5 · 2025 · External reference
Brahma safeguards canalization of cardiac mesoderm differentiation
10.1038/s41586-021-04336-y · 2022 · External reference
RB constrains lineage fidelity and multiple stages of tumour progression and metastasis
10.1038/s41586-019-1172-9 · 2019 · External reference
Pathway-specific canalization and plasticity of gene expression during C. elegans dauer development
10.1016/j.isci.2026.115058 · 2026 · External reference
