Research graph
References from Caenorhabditis elegans small heat-shock protein HSP-12.6 has a highly specialized protective function towards muscle thick filaments in vivo. Local targets link to admitted publications; unresolved targets remain external evidence.
Alpha-crystallin can function as a molecular chaperone
1992 · External reference
Small heat shock proteins are molecular chaperones
10.1016/s0021-9258(18)53882-5 · 1993 · External reference
Phylogenetic and biochemical studies reveal a potential evolutionary origin of small heat shock proteins of animals from bacterial class A
10.1007/s00239-005-0076-5 · 2006 · External reference
Mechanisms of small heat shock proteins
10.1101/cshperspect.a034025 · 2019 · External reference
Small heat shock proteins and α-crystallins: dynamic proteins with flexible functions
10.1016/j.tibs.2011.11.005 · 2012 · External reference
Decreased lifespan in the absence of expression of the mitochondrial small heat shock protein Hsp22 in Drosophila
10.1074/jbc.c400357200 · 2004 · External reference
Regulation of aging and age-related disease by DAF-16 and heat-shock factor
10.1126/science.1083701 · 2003 · External reference
Insights on human small heat shock proteins and their alterations in diseases
10.3389/fmolb.2022.842149 · 2022 · External reference
The function of small heat-shock proteins and their implication in proteostasis
10.1042/ebc20160010 · 2016 · External reference
Cellular functions and mechanisms of action of small heat shock proteins
10.1146/annurev-micro-020518-115515 · 2019 · External reference
Binding of non-native protein to Hsp25 during heat shock creates a reservoir of folding intermediates for reactivation
10.1093/emboj/16.2.221 · 1997 · External reference
A small heat shock protein stably binds heat-denatured model substrates and can maintain a substrate in a folding-competent state
10.1093/emboj/16.3.659 · 1997 · External reference
Small heat shock proteins sequester misfolding proteins in near-native conformation for cellular protection and efficient refolding
10.1038/ncomms13673 · 2016 · External reference
HspB8 chaperone activity toward poly(Q)-containing proteins depends on its association with Bag3, a stimulator of macroautophagy
10.1074/jbc.m706304200 · 2008 · External reference
Chaperone activity of alpha-crystallins modulates intermediate filament assembly
10.1002/j.1460-2075.1994.tb06339.x · 1994 · External reference
The human genome encodes 10 alpha-crystallin-related small heat shock proteins: HspB1–10
10.1379/1466-1268(2003)8<53:thgecs>2.0.co;2 · 2003 · External reference
Regulation of the levels of small heat-shock proteins during differentiation of C2C12 cells
10.1006/excr.2001.5220 · 2001 · External reference
Muscle develops a specific form of small heat shock protein complex composed of MKBP/HSPB2 and HSPB3 during myogenic differentiation
10.1074/jbc.275.2.1095 · 2000 · External reference
A differentiation transcription factor establishes muscle-specific proteostasis in Caenorhabditis elegans
10.1371/journal.pgen.1006531 · 2016 · External reference
Filamin C dimerisation is regulated by HSPB7
10.1038/s41467-025-58889-x · 2025 · External reference
Structural basis for the interaction of a human small heat shock protein with the 14-3-3 universal signaling regulator
10.1016/j.str.2016.12.005 · 2017 · External reference
Transducible heat shock protein 20 (HSP20) phosphopeptide alters cytoskeletal dynamics
10.1096/fj.04-2911fje · 2005 · External reference
Small heat-shock protein HSPB3 promotes myogenesis by regulating the lamin B receptor
10.1038/s41419-021-03737-1 · 2021 · External reference
The chaperone activity and substrate spectrum of human small heat shock proteins
10.1074/jbc.m116.760413 · 2017 · External reference
HSPB7 is the most potent polyQ aggregation suppressor within the HSPB family of molecular chaperones
10.1093/hmg/ddq398 · 2010 · External reference
Caenorhabditis elegans small heat-shock proteins Hsp12.2 and Hsp12.3 form tetramers and have no chaperone-like activity
10.1016/s0014-5793(98)00917-x · 1998 · External reference
Unique structural features of a novel class of small heat shock proteins
10.1074/jbc.272.19.12847 · 1997 · External reference
The cytoprotective sequestration activity of small heat shock proteins is evolutionarily conserved
10.1083/jcb.202202149 · 2022 · External reference
Widespread protein aggregation as an inherent part of aging in C. elegans
10.1371/journal.pbio.1000450 · 2010 · External reference
Widespread proteome remodeling and aggregation in aging C. elegans
10.1016/j.cell.2015.03.032 · 2015 · External reference
Genes that act downstream of DAF-16 to influence the lifespan of Caenorhabditis elegans
10.1038/nature01789 · 2003 · External reference
Transcriptional targets of DAF-16 insulin signaling pathway protect C. elegans from extreme hypertonic stress
10.1152/ajpcell.00451.2004 · 2005 · External reference
Integrative analysis of the Caenorhabditis elegans genome by the modENCODE Project
10.1126/science.1196914 · 2010 · External reference
Changes in gene expression associated with developmental arrest and longevity in Caenorhabditis elegans
10.1101/gr.184401 · 2001 · External reference
Analysis of long-lived C. elegans daf-2 mutants using serial analysis of gene expression
10.1101/gr.3274805 · 2005 · External reference
A fasting-responsive signaling pathway that extends life span in C. elegans
10.1016/j.celrep.2012.12.018 · 2013 · External reference
Signalling through RHEB-1 mediates intermittent fasting-induced longevity in C. elegans
10.1038/nature07583 · 2009 · External reference
Human myocytes are protected from titin aggregation-induced stiffening by small heat shock proteins
10.1083/jcb.201306077 · 2014 · External reference
Translocation of molecular chaperones to the titin springs is common in skeletal myopathy patients and affects sarcomere function
10.1186/s40478-017-0474-0 · 2017 · External reference
Gene CATCHR–gene cloning and tagging for Caenorhabditis elegans using yeast homologous recombination: a novel approach for the analysis of gene expression
10.1093/nar/gni164 · 2005 · External reference
Sleep neuron depolarization promotes protective gene expression changes and FOXO activation
10.1016/j.cub.2022.04.012 · 2022 · External reference
Comparison of the small heat shock proteins αb-crystallin, MKBP, HSP25, HSP20, and cvHSP in heart and skeletal muscle
10.1007/s00418-004-0711-z · 2000 · External reference
αB-crystallin modulates protein aggregation of abnormal desmin
10.1161/01.res.0000102401.77712.ed · 2003 · External reference
A hemidesmosome-to-cytoplasm translocation of small heat shock proteins provides immediate protection against heat stress
10.1016/j.celrep.2020.108410 · 2020 · External reference
Destabilizing protein polymorphisms in the genetic background direct phenotypic expression of mutant SOD1 toxicity
10.1371/journal.pgen.1000399 · 2009 · External reference
Progressive disruption of cellular protein folding in models of polyglutamine diseases
10.1126/science.1124514 · 2006 · External reference
Nonsense mRNA suppression via nonstop decay
10.7554/elife.33292 · 2018 · External reference
The Caenorhabditis elegans unc-78 gene encodes a homologue of actin-interacting protein 1 required for organized assembly of muscle actin filaments
10.1083/jcb.152.6.1313 · 2001 · External reference
UNC-87 isoforms, Caenorhabditis elegans calponin-related proteins, interact with both actin and myosin and regulate actomyosin contractility
10.1091/mbc.e14-10-1483 · 2015 · External reference
Assemblages of multiple thick filaments in nematode mutants
10.1007/bf01567911 · 1987 · External reference
Myosin and paramyosin of Caenorhabditis elegans embryos assemble into nascent structures distinct from thick filaments and multi-filament assemblages
10.1083/jcb.122.4.845 · 1993 · External reference
The SH3 domain of UNC-89 (obscurin) interacts with paramyosin, a coiled-coil protein, in Caenorhabditis elegans muscle
10.1091/mbc.e15-09-0675 · 2016 · External reference
UNC-98 and UNC-96 interact with paramyosin to promote its incorporation into thick filaments of Caenorhabditis elegans
10.1091/mbc.e07-07-0723 · 2008 · External reference
Neuronal signaling modulates protein homeostasis in Caenorhabditis elegans post-synaptic muscle cells
10.1101/gad.1575307 · 2007 · External reference
Tensile properties of single desmin intermediate filaments
10.1529/biophysj.107.119826 · 2008 · External reference
Unfolding of titin domains explains the viscoelastic behavior of skeletal myofibrils
10.1016/s0006-3495(01)76116-4 · 2001 · External reference
Mechanical unfolding of cardiac myosin binding protein-C by atomic force microscopy
10.1016/j.bpj.2011.08.030 · 2011 · External reference
Immunochemical localization of myosin heavy chain isoforms and paramyosin in developmentally and structurally diverse muscle cell types of the nematode Caenorhabditis elegans
10.1083/jcb.105.6.2763 · 1987 · External reference
Natural variation in the expression of the heat-shock protein Hsp70 in a population of Drosophila melanogaster and its correlation with tolerance of ecologically relevant thermal stress
1997 · External reference
Modulation of the maladaptive stress response to manage diseases of protein folding
10.1371/journal.pbio.1001998 · 2014 · External reference
Post-embryonic cell lineages of the nematode, Caenorhabditis elegans
10.1016/0012-1606(77)90158-0 · 1977 · External reference
Genetic analysis of muscle development in Caenorhabditis elegans
10.1016/0166-2236(85)90101-8 · 1985 · External reference
The dauer muscle
2013 · External reference
Therapeutic potential of heat shock protein induction for muscular dystrophy and other muscle wasting conditions
10.1098/rstb.2016.0528 · 2017 · External reference
Heat shock proteins: important helpers for the development, maintenance and regeneration of skeletal muscles
10.3390/muscles2020014 · 2023 · External reference
Maintaining proteostasis under mechanical stress
10.15252/embr.202152507 · 2021 · External reference
alphaB-crystallin maintains skeletal muscle myosin enzymatic activity and prevents its aggregation under heat-shock stress
10.1016/j.jmb.2006.02.043 · 2006 · External reference
Small heat shock protein Hsp27 protects myosin S1 from heat-induced aggregation, but not from thermal denaturation and ATPase inactivation
10.1016/j.febslet.2008.03.035 · 2008 · External reference
Proteomics of rimmed vacuoles define new risk allele in inclusion body myositis
10.1002/ana.24847 · 2017 · External reference
A missense mutation in the αb-crystallin chaperone gene causes a desmin-related myopathy
10.1038/1765 · 1998 · External reference
New insights into the protein aggregation pathology in myotilinopathy by combined proteomic and immunolocalization analyses
10.1186/s40478-016-0280-0 · 2016 · External reference
A combined laser microdissection and mass spectrometry approach reveals new disease relevant proteins accumulating in aggregates of filaminopathy patients
10.1074/mcp.m112.023176 · 2013 · External reference
Differential proteomic analysis of abnormal intramyoplasmic aggregates in desminopathy
10.1016/j.jprot.2013.04.026 · 2013 · External reference
Myosinopathies: pathology and mechanisms
10.1007/s00401-012-1024-2 · 2013 · External reference
Etiology of genetic muscle disorders induced by mutations in fast and slow skeletal MyBP-C paralogs
10.1038/s12276-023-00953-x · 2023 · External reference
New cardiac and skeletal protein aggregate myopathy associated with combined MuRF1 and MuRF3 mutations
10.1093/hmg/ddv108 · 2015 · External reference
The genetics of Caenorhabditis elegans
10.1093/genetics/77.1.71 · 1974 · External reference
Investigating the spreading and toxicity of prion-like proteins using the metazoan model organism C. elegans
2015 · External reference
Caenorhabditis elegans small heat-shock protein HSP-12.6 has a highly specialized protective function towards muscle thick filaments in vivo
2026 · External reference