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References from The mitochondrial chaperone HSPD1 folds MTHFD2 independently of its co-chaperone HSPE1. Local targets link to admitted publications; unresolved targets remain external evidence.
Multifaceted mitochondria: moving mitochondrial science beyond function and dysfunction
10.1038/s42255-023-00783-1 · 2023 · External reference
Mitochondria are required for antigen-specific T cell activation through reactive oxygen species signaling
10.1016/j.immuni.2012.10.020 · 2013 · External reference
Mitochondrial phosphoenolpyruvate carboxykinase regulates metabolic adaptation and enables glucose-independent tumor growth
10.1016/j.molcel.2015.08.013 · 2015 · External reference
Metabolic reprogramming and cancer progression
10.1126/science.aaw5473 · 2020 · External reference
HSP60 chaperone deficiency disrupts the mitochondrial matrix proteome and dysregulates cholesterol synthesis
10.1016/j.molmet.2024.102009 · 2024 · External reference
Mitochondrial bioenergetics of breast cancer
10.1016/j.mito.2024.101951 · 2024 · External reference
Cancer drug-tolerant persister cells: from biological questions to clinical opportunities
10.1038/s41568-024-00737-z · 2024 · External reference
What is cancer metabolism?
10.1016/j.cell.2023.01.038 · 2023 · External reference
Metabolic reprogramming: a cancer hallmark even Warburg did not anticipate
10.1016/j.ccr.2012.02.014 · 2012 · External reference
Chaperone-protease networks in mitochondrial protein homeostasis
10.1016/j.bbamcr.2012.06.005 · 2013 · External reference
Mitochondrial enzymes are protected from stress-induced aggregation by mitochondrial chaperones and the Pim1/LON protease
10.1091/mbc.e10-08-0718 · 2011 · External reference
Landscape of the mitochondrial Hsp90 metabolome in tumours
10.1038/ncomms3139 · 2013 · External reference
Chaperone networks are shaped by cellular differentiation and identity
10.1016/j.tcb.2021.11.001 · 2022 · External reference
Pan-cancer analysis of mitochondria chaperone-client co-expression reveals chaperone functional partitioning
10.3390/cancers12040825 · 2020 · External reference
Ecological network analysis reveals cancer-dependent chaperone-client interaction structure and robustness in the mitochondria
10.1038/s41467-023-41906-2 · 2023 · External reference
Crystal structure of the human mitochondrial chaperonin symmetrical football complex
10.1073/pnas.1411718112 · 2015 · External reference
An inventory of interactors of the human HSP60/HSP10 chaperonin in the mitochondrial matrix space
10.1007/s12192-020-01080-6 · 2020 · External reference
KHS101 disrupts energy metabolism in human glioblastoma cells and reduces tumor growth in mice
10.1126/scitranslmed.aar2718 · 2018 · External reference
Metabolic impairment of non-small cell lung cancers by mitochondrial HSPD1 targeting
10.1186/s13046-021-02049-8 · 2021 · External reference
Knockdown of heat shock protein family D member 1 (HSPD1) promotes proliferation and migration of ovarian cancer cells via disrupting the stability of mitochondrial 3-oxoacyl-ACP synthase (OXSM)
10.1186/s13048-023-01184-4 · 2023 · External reference
Mitochondrial proteostatic stress disrupts mitoribosome biogenesis and translation
2025 · External reference
Inactivation of the hereditary spastic paraplegia-associated Hspd1 gene encoding the Hsp60 chaperone results in early embryonic lethality in mice
10.1007/s12192-010-0194-x · 2010 · External reference
Gene set knowledge discovery with Enrichr
10.1002/cpz1.90 · 2021 · External reference
Enrichr: a comprehensive gene set enrichment analysis web server 2016 update
10.1093/nar/gkw377 · 2016 · External reference
Enrichr: interactive and collaborative HTML5 gene list enrichment analysis tool
10.1186/1471-2105-14-128 · 2013 · External reference
Metabolic enzyme expression highlights a key role for MTHFD2 and the mitochondrial folate pathway in cancer
10.1038/ncomms4128 · 2014 · External reference
Massive mining of publicly available RNA-seq data from human and mouse
10.1038/s41467-018-03751-6 · 2018 · External reference
Targeting mitochondrial metabolism for precision medicine in cancer
10.1038/s41418-022-01022-y · 2022 · External reference
mTORC1 induces purine synthesis through control of the mitochondrial tetrahydrofolate cycle
10.1126/science.aad0489 · 2016 · External reference
One-carbon metabolism in health and disease
10.1016/j.cmet.2016.08.009 · 2017 · External reference
Targeting MTHFD2 to exploit cancer-specific metabolism and the DNA damage response
10.1158/0008-5472.can-23-1290 · 2024 · External reference
One-carbon metabolism supports S-adenosylmethionine and histone methylation to drive inflammatory macrophages
10.1016/j.molcel.2019.06.039 · 2019 · External reference
Histone methylation dynamics and gene regulation occur through the sensing of one-carbon metabolism
10.1016/j.cmet.2015.08.024 · 2015 · External reference
Quantitative flux analysis reveals folate-dependent NADPH production
10.1038/nature13236 · 2014 · External reference
p53 deficiency induces MTHFD2 transcription to promote cell proliferation and restrain DNA damage
10.1073/pnas.2019822118 · 2021 · External reference
Mitochondrial matrix proteases: quality control and beyond
10.1111/febs.15964 · 2022 · External reference
GroEL and CCT are catalytic unfoldases mediating out-of-cage polypeptide refolding without ATP
10.1073/pnas.1219867110 · 2013 · External reference
Structural basis for active single and double ring complexes in human mitochondrial Hsp60-Hsp10 chaperonin
10.1038/s41467-020-15698-8 · 2020 · External reference
Identification of in vivo substrates of the yeast mitochondrial chaperonins reveals overlapping but non-identical requirement for hsp60 and hsp10
10.1093/emboj/17.20.5868 · 1998 · External reference
MitCHAP-60 and hereditary spastic paraplegia SPG-13 arise from an inactive hsp60 chaperonin that fails to fold the ATP synthase β-subunit
10.1038/s41598-019-48762-5 · 2019 · External reference
Transcriptomic and proteomic landscape of mitochondrial dysfunction reveals secondary coenzyme Q deficiency in mammals
10.7554/elife.30952 · 2017 · External reference
HSF1 remodels mitochondrial biogenesis and function in cancer cells via TIMM17A
2025 · External reference
Tracing compartmentalized NADPH metabolism in the cytosol and mitochondria of mammalian cells
10.1016/j.molcel.2014.05.008 · 2014 · External reference
Serine-glycine-one-carbon metabolism: the hidden Achilles heel of MYCN-amplified neuroblastoma?
10.1158/0008-5472.can-19-1816 · 2019 · External reference
Pharmacological targeting of MTHFD2 suppresses acute myeloid leukemia by inducing thymidine depletion and replication stress
10.1038/s43018-022-00331-y · 2022 · External reference
Metabolic impairment of non-small cell lung cancers by mitochondrial HSPD1 targeting
10.1186/s13046-021-02049-8 · 2021 · External reference
YY1-Upregulated MTHFD2 drives non-small cell lung cancer progression through the regulation of LRRK2
10.1002/jbt.70504 · 2025 · External reference
A mitochondrial unfolded protein response inhibitor suppresses prostate cancer growth in mice via HSP60
10.1172/jci149906 · 2022 · External reference
PEBP1 amplifies mitochondrial dysfunction-induced integrated stress response
10.7554/elife.102852.2 · 2025 · External reference
Supplementary material from: The mitochondrial chaperone HSPD1 folds MTHFD2 independently of its co-chaperone HSPE1
2026 · External reference
