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References from HSP60 and HSP10 depletion provoke distinct biological responses. Local targets link to admitted publications; unresolved targets remain external evidence.
Chaperone networks are shaped by cellular differentiation and identity
10.1016/j.tcb.2021.11.001 · 2022 · External reference
Chaperone families and interactions in metazoa
10.1042/ebc20160004 · 2016 · External reference
Human clearance systems have a layered architecture across tissues and cell types that supports varied proteome compositions
10.1080/15548627.2025.2580035 · 2026 · External reference
The landscape of molecular chaperones across human tissues reveals a layered architecture of core and variable chaperones
10.1038/s41467-021-22369-9 · 2021 · External reference
The structural basis of protein folding and its links with human disease
10.1098/rstb.2000.0758 · 2001 · External reference
MitCHAP-60 and hereditary spastic paraplegia SPG-13 arise from an inactive hsp60 chaperonin that fails to fold the ATP synthase β-subunit
10.1038/s41598-019-48762-5 · 2019 · External reference
Mitochondrial chaperone code: just warming up
10.1016/j.cstres.2024.05.002 · 2024 · External reference
Ecological network analysis reveals cancer-dependent chaperone-client interaction structure and robustness
10.1038/s41467-023-41906-2 · 2023 · External reference
Pan-cancer analysis of mitochondria chaperone-client co-expression reveals chaperone functional partitioning
10.3390/cancers12040825 · 2020 · External reference
Structural basis for active single and double ring complexes in human mitochondrial Hsp60-Hsp10 chaperonin
10.1038/s41467-020-15698-8 · 2020 · External reference
In situ characterization of mitochondrial Hsp60-Hsp10 chaperone complex under folding stress
10.1126/sciadv.adw6064 · 2025 · External reference
Structural remodeling of the mitochondrial protein biogenesis machinery under proteostatic stress
10.1126/sciadv.aed3579 · 2026 · External reference
The GroEL–GroES chaperonin machine: a nano-cage for protein folding
10.1016/j.tibs.2015.07.009 · 2016 · External reference
Mitochondrial proteostatic stress disrupts mitoribosome biogenesis and translation
2025 · External reference
Asymmetric apical domain states of mitochondrial Hsp60 coordinate substrate engagement and chaperonin assembly
10.1038/s41594-024-01352-0 · 2024 · External reference
HSF1 remodels mitochondrial biogenesis and function in cancer cells via TIMM17A
2025 · External reference
Protein folding in the central cavity of the GroEL–GroES chaperonin complex
10.1038/379420a0 · 1996 · External reference
GroEL and CCT are catalytic unfoldases mediating out-of-cage polypeptide refolding without ATP
10.1073/pnas.1219867110 · 2013 · External reference
Allosteric mechanisms in chaperonin machines
10.1021/acs.chemrev.5b00556 · 2016 · External reference
Role of the chaperonin cofactor Hsp10 in protein folding and sorting in yeast mitochondria
10.1083/jcb.126.2.305 · 1994 · External reference
Identification of in vivo substrates of the yeast mitochondrial chaperonins reveals overlapping but non-identical requirement for hsp60 and hsp10
10.1093/emboj/17.20.5868 · 1998 · External reference
Identification of HSPE1 as a new actionable cancer vulnerability leads to an innovative and effective combination therapy for pancreatic ductal adenocarcinoma
10.1186/s12943-026-02587-9 · 2026 · External reference
Role of human HSPE1 for OPA1 processing independent of HSPD1
10.1016/j.isci.2023.106067 · 2023 · External reference
Cytosolic trapping of a mitochondrial heat shock protein is an early pathological event in synucleinopathies
10.1016/j.celrep.2019.06.009 · 2019 · External reference
Heat shock protein 10 as a chaperone modulating α-synuclein amyloid fibril formation
10.1002/pro.70452 · 2026 · External reference
HSP10 as a chaperone for neurodegenerative amyloid fibrils
10.3389/fnins.2022.902600 · 2022 · External reference
The mitochondrial chaperone HSPD1 folds MTHFD2 independently of its co-chaperone HSPE1
2026 · External reference
A cytosolic surveillance mechanism activates the mitochondrial UPR
10.1038/s41586-023-06142-0 · 2023 · External reference
The transcription factor ATF5 mediates a mammalian mitochondrial UPR
10.1016/j.cub.2016.06.002 · 2016 · External reference
Multi-omics analysis identifies ATF4 as a key regulator of the mitochondrial stress response in mammals
10.1083/jcb.201702058 · 2017 · External reference
Mitochondrial unfolded protein response controls matrix pre-RNA processing and translation
10.1038/nature18302 · 2016 · External reference
The Hsp60 folding machinery is crucial for manganese superoxide dismutase folding and function
10.3109/10715762.2013.858147 · 2014 · External reference
Quantitation of acyl-CoA and acylcarnitine esters accumulated during abnormal mitochondrial fatty acid oxidation
10.1016/s0021-9258(18)54444-6 · 1991 · External reference
Effects of a mutation in the HSPE1 gene encoding the mitochondrial co-chaperonin HSP10 and its potential association with a neurological and developmental disorder
10.3389/fmolb.2016.00065 · 2016 · External reference
The matrix peptide exporter HAF-1 signals a mitochondrial UPR by activating the transcription factor ZC376.7 in C. elegans
10.1016/j.molcel.2010.01.015 · 2010 · External reference
Mitochondrial dysfunction, aging, and the mitochondrial unfolded protein response in Caenorhabditis elegans
10.1093/genetics/iyac160 · 2022 · External reference
Heat shock protein 27 kDa expression and phosphorylation regulates endothelial cell migration
10.1096/fasebj.12.14.1481 · 1998 · External reference
Actin cytoskeleton and small heat shock proteins: how do they interact?
10.1379/1466-1268(2002)007<0167:acashs>2.0.co;2 · 2002 · External reference
HSP60 chaperone deficiency disrupts the mitochondrial matrix proteome and dysregulates cholesterol synthesis
10.1016/j.molmet.2024.102009 · 2024 · External reference
Nuclear and cytosolic J-domain proteins provide synergistic control of Hsf1 at distinct phases of the heat shock response
10.7554/elife.107157 · 2025 · External reference
Nuclear import carrier Hikeshi cooperates with HSP70 to promote murine oligodendrocyte differentiation and CNS myelination
10.1016/j.devcel.2023.09.002 · 2023 · External reference
Reflux of endoplasmic reticulum proteins to the cytosol inactivates tumor suppressors
10.15252/embr.202051412 · 2021 · External reference
Inactivation of the hereditary spastic paraplegia-associated Hspd1 gene encoding the Hsp60 chaperone results in early embryonic lethality in mice
10.1007/s12192-010-0194-x · 2010 · External reference
Small heat-shock protein HSPB3 promotes myogenesis by regulating the lamin B receptor
10.1038/s41419-021-03737-1 · 2021 · External reference
HSP60 and HSP10 depletion provoke distinct biological responses
2026 · External reference
