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References from Inhibiting Glutaminase Reverses Senescence‐Associated Mitochondrial Dysfunction and Skeletal Muscle Decline. Local targets link to admitted publications; unresolved targets remain external evidence.
Mitochondrial Function Is Impaired in the Skeletal Muscle of Pre‐Frail Elderly
10.1038/s41598-018-26944-x · 2018 · External reference
Regulation of Senescence Traits by MAPKs
10.1007/s11357-020-00183-3 · 2020 · External reference
p38 MAPK in Glucose Metabolism of Skeletal Muscle: Beneficial or Harmful?
10.3390/ijms21186480 · 2020 · External reference
Role of Mitochondrial DNA Mutations in Human Aging: Implications for the Central Nervous System and Muscle
10.1002/ana.410430212 · 1998 · External reference
Mitochondrial Pathways in Sarcopenia of Aging and Disuse Muscle Atrophy
10.1515/hsz-2012-0247 · 2013 · External reference
Striking Denervation of Neuromuscular Junctions Without Lumbar Motoneuron Loss in Geriatric Mouse Muscle
10.1371/journal.pone.0028090 · 2011 · External reference
Mitochondrial Dysfunction: Roles in Skeletal Muscle Atrophy
10.1186/s12967-023-04369-z · 2023 · External reference
Inhibition of Glutaminolysis Restores Mitochondrial Function in Senescent Stem Cells
10.1016/j.celrep.2022.111744 · 2022 · External reference
Proline Restores Mitochondrial Function and Reverses Aging Hallmarks in Senescent Cells
10.1016/j.celrep.2024.113738 · 2024 · External reference
Skeletal Muscle Mitochondrial Energetics Are Associated With Maximal Aerobic Capacity and Walking Speed in Older Adults
10.1093/gerona/gls196 · 2013 · External reference
Replicative Senescence: A Critical Review
10.1016/j.mad.2004.07.010 · 2004 · External reference
Glutamine: Metabolism and Immune Function, Supplementation and Clinical Translation
10.3390/nu10111564 · 2018 · External reference
Sarcopenia
10.1016/s0140-6736(19)31138-9 · 2019 · External reference
The Role of Inflammation in Age‐Related Sarcopenia
10.3389/fphys.2017.01045 · 2017 · External reference
Mitochondrial Biogenesis During Skeletal Muscle Regeneration
10.1152/ajpendo.00343.2001 · 2002 · External reference
The Role of Mitochondria in Aging of Skeletal Muscle
10.1007/s10522-007-9121-7 · 2008 · External reference
Aging Impairs Skeletal Muscle Mitochondrial Bioenergetic Function
10.1093/gerona/gln048 · 2009 · External reference
Mouse Models to Disentangle the Hallmarks of Human Aging
10.1161/circresaha.118.312204 · 2018 · External reference
Aging Changes in Satellite Cells and Their Functions
10.2174/1874609811104030279 · 2011 · External reference
Mitochondrial Dysfunction Induces Muscle Atrophy During Prolonged Inactivity: A Review of the Causes and Effects
10.1016/j.abb.2018.11.005 · 2019 · External reference
Crosstalk Between Mitogen‐Activated Protein Kinases and Mitochondria in Cardiac Diseases: Therapeutic Perspectives
10.1016/j.pharmthera.2014.05.013 · 2014 · External reference
Senolysis by Glutaminolysis Inhibition Ameliorates Various Age‐Associated Disorders
10.1126/science.abb5916 · 2021 · External reference
Short‐Term Dietary Reduction of Branched‐Chain Amino Acids Reduces Meal‐Induced Insulin Secretion and Modifies Microbiome Composition in Type 2 Diabetes: A Randomized Controlled Crossover Trial
10.1093/ajcn/nqz191 · 2019 · External reference
Glutamine Supplementation Stimulates Protein‐Synthetic and Inhibits Protein‐Degradative Signaling Pathways in Skeletal Muscle of Diabetic Rats
10.1371/journal.pone.0050390 · 2012 · External reference
Sarcopenia: Aging‐Related Loss of Muscle Mass and Function
10.1152/physrev.00061.2017 · 2019 · External reference
Mitochondrial Dysfunction in Cell Senescence and Aging
10.1172/jci158447 · 2022 · External reference
Senescence Atlas Reveals an Aged‐Like Inflamed Niche That Blunts Muscle Regeneration
10.1038/s41586-022-05535-x · 2023 · External reference
The Decline in Skeletal Muscle Mass With Aging Is Mainly Attributed to a Reduction in Type II Muscle Fiber Size
10.1016/j.exger.2013.02.012 · 2013 · External reference
The Contribution of Mitochondria to Age‐Related Skeletal Muscle Wasting: A Sex‐Specific Perspective
10.1016/j.lfs.2023.122324 · 2024 · External reference
In Vivo Amelioration of Age‐Associated Hallmarks by Partial Reprogramming
10.1016/j.cell.2016.11.052 · 2016 · External reference
Age‐Related Dysfunction in Proteostasis and Cellular Quality Control in the Development of Sarcopenia
2023 · External reference
Partial Cellular Reprogramming: A Deep Dive Into an Emerging Rejuvenation Technology
10.1111/acel.14039 · 2024 · External reference
Sarcopenia: Molecular Pathways and Potential Targets for Intervention
10.3390/ijms21228844 · 2020 · External reference
Age‐Related Mitochondrial Genotypic and Phenotypic Alterations in Human Skeletal Muscle
10.1016/s0891-5849(01)00517-2 · 2001 · External reference
Human Neuromuscular Structure and Function in Old Age: A Brief Review
10.1016/j.jshs.2013.07.001 · 2013 · External reference
Reversine Ameliorates Hallmarks of Cellular Senescence in Human Skeletal Myoblasts via Reactivation of Autophagy
10.1111/acel.13764 · 2023 · External reference
Methionine adenosyltransferase2A Inhibition Restores Metabolism to Improve Regenerative Capacity and Strength of Aged Skeletal Muscle
10.1038/s41467-023-36483-3 · 2023 · External reference
The Relationship Between Mitochondrial Function and Walking Performance in Older Adults With a Wide Range of Physical Function
10.1016/j.exger.2016.04.002 · 2016 · External reference
Ameliorating the Hallmarks of Cellular Senescence in Skeletal Muscle Myogenic Progenitors In Vitro and In Vivo
10.1126/sciadv.abe5671 · 2021 · External reference
Efficient and High Yield Isolation of Myoblasts From Skeletal Muscle
10.1016/j.scr.2018.05.017 · 2018 · External reference
Decline in Skeletal Muscle Mitochondrial Function With Aging in Humans
10.1073/pnas.0501559102 · 2005 · External reference
Taurine Deficiency as a Driver of Aging
10.1126/science.abn9257 · 2023 · External reference
New Look at the Role of Progerin in Skin Aging
2015 · External reference
The Metabolic Syndrome: Role of Skeletal Muscle Metabolism
10.1080/07853890600888413 · 2006 · External reference
Muscle Mitochondrial Energetics Predicts Mobility Decline in Well‐Functioning Older Adults: The Baltimore Longitudinal Study of Aging
10.1111/acel.13552 · 2022 · External reference
Cellular and Molecular Mechanisms of Stress‐Induced Premature Senescence (SIPS) of Human Diploid Fibroblasts and Melanocytes
10.1016/s0531-5565(00)00180-7 · 2000 · External reference
Protein Restriction and Branched‐Chain Amino Acid Restriction Promote Geroprotective Shifts in Metabolism
10.1111/acel.13626 · 2022 · External reference
Respirometric Profiling of Muscle Mitochondria and Blood Cells Are Associated With Differences in Gait Speed Among Community‐Dwelling Older Adults
10.1093/gerona/glu096 · 2015 · External reference
Methods of Cellular Senescence Induction Using Oxidative Stress
10.1007/978-1-62703-556-9_11 · 2013 · External reference
Progerin‐Induced Replication Stress Facilitates Premature Senescence in Hutchinson‐Gilford Progeria Syndrome
10.1128/mcb.00659-16 · 2017 · External reference
Glutaminase Inhibition With Telaglenastat (CB‐839) Improves Treatment Response in Combination With Ionizing Radiation in Head and Neck Squamous Cell Carcinoma Models
10.1016/j.canlet.2020.12.038 · 2021 · External reference
Mitochondrial Dysfunction Reduces the Activity of KIR2.1 K+ Channel in Myoblasts via Impaired Oxidative Phosphorylation
10.4196/kjpp.2018.22.6.697 · 2018 · External reference
Age‐ and Gender‐Based Differences in Nest‐Building Behavior and Learning and Memory Performance Measured Using a Radial Six‐Armed Water Maze in C57BL/6 Mice
2018 · External reference
Glutaminolysis: A Hallmark of Cancer Metabolism
10.1146/annurev-bioeng-071516-044546 · 2017 · External reference
Targeted Ablation of p38alpha MAPK Suppresses Denervation‐Induced Muscle Atrophy
10.1038/s41598-018-26632-w · 2018 · External reference
Long Term Breeding of the Lmna G609G Progeric Mouse: Characterization of Homozygous and Heterozygous Models
10.1016/j.exger.2019.110784 · 2020 · External reference