Research graph
References from Dietary CoQ10 Ameliorates Age‐Related Megakaryocyte Dysfunction via COPS3 ‐Mediated Activation of Autophagy. Local targets link to admitted publications; unresolved targets remain external evidence.
CoQ10 Augments Rosuvastatin Neuroprotective Effect in a Model of Global Ischemia via Inhibition of NF‐κB/JNK3/Bax and Activation of Akt/FOXO3A/Bim Cues
10.3389/fphar.2017.00735 · 2017 · External reference
Cardiovascular Mortality and N‐Terminal‐proBNP Reduced After Combined Selenium and Coenzyme Q10 Supplementation: A 5‐Year Prospective Randomized Double‐Blind Placebo‐Controlled Trial Among Elderly Swedish Citizens
10.1016/j.ijcard.2012.04.156 · 2013 · External reference
Improving the Anti‐Ageing Activity of Coenzyme Q10 Through Protransfersome‐Loaded Emulgel
10.1038/s41598-021-04708-4 · 2022 · External reference
Effects of Coenzyme Q10 Supplementation on Physical Function Adaptations to High‐Intensity Interval Training in Older Adults
10.3390/nu17243959 · 2025 · External reference
CoQ10 and Aging
10.3390/biology8020028 · 2019 · External reference
Natural Distribution and Occurrence of Coenzyme Q Homologues
10.3109/09687689009025839 · 1990 · External reference
Klotho, Stem Cells, and Aging
2015 · External reference
Revisiting the COP9 Signalosome as a Transcriptional Regulator
10.1038/embor.2009.33 · 2009 · External reference
ROS‐Mediated Platelet Generation: A Microenvironment‐Dependent Manner for Megakaryocyte Proliferation, Differentiation, and Maturation
10.1038/cddis.2013.253 · 2013 · External reference
Endogenous Coenzyme Q Content and Exogenous Bioavailability in D. melanogaster
10.1016/j.heliyon.2024.e37854 · 2024 · External reference
Autophagy and Aging: Keeping That Old Broom Working
10.1016/j.tig.2008.10.002 · 2008 · External reference
Critical Shifts in Lipid Metabolism Promote Megakaryocyte Differentiation and Proplatelet Formation
10.1038/s44161-023-00325-8 · 2023 · External reference
The Paradox of Coenzyme Q(10) in Aging
10.3390/nu11092221 · 2019 · External reference
Global Projections of Heat Exposure of Older Adults
10.1038/s41467-024-47197-5 · 2024 · External reference
Inflammageing: Chronic Inflammation in Ageing, Cardiovascular Disease, and Frailty
10.1038/s41569-018-0064-2 · 2018 · External reference
Association Between Genetic Variants in the Coenzyme Q10 Metabolism and Coenzyme Q10 Status in Humans
10.1186/1756-0500-4-245 · 2011 · External reference
Hyperaldosteronism in Klotho‐Deficient Mice
10.1152/ajprenal.00233.2010 · 2010 · External reference
Coenzyme q10 Therapy
10.1159/000360101 · 2014 · External reference
Autophagy: A Key Regulator of Homeostasis and Disease: An Overview of Molecular Mechanisms and Modulators
10.3390/cells11152262 · 2022 · External reference
Coenzyme Q10 Affects Expression of Genes Involved in Cell Signalling, Metabolism and Transport in Human CaCo‐2 Cells
10.1016/j.biocel.2004.11.017 · 2005 · External reference
Aging and Aging‐Related Diseases: From Molecular Mechanisms to Interventions and Treatments
10.1038/s41392-022-01251-0 · 2022 · External reference
Coenzyme Q10 and Cardiovascular Diseases
10.3390/antiox10060906 · 2021 · External reference
Coenzyme Q10 as a Therapy for Mitochondrial Disease
10.1016/j.biocel.2014.01.020 · 2014 · External reference
Coenzyme Q10 in Mitochondrial and Lysosomal Disorders
10.3390/jcm10091970 · 2021 · External reference
Coenzyme Q(10) Supplementation in Aging and Disease
10.3389/fphys.2018.00044 · 2018 · External reference
Metabolic Targets of Coenzyme Q10 in Mitochondria
10.3390/antiox10040520 · 2021 · External reference
CoQ(10) Enhances PGC1α and Increases Expression of Mitochondrial Antioxidant Proteins in Chronically Ischemic Swine Myocardium
10.1186/s12986-019-0418-8 · 2019 · External reference
Age‐Related Diseases and Clinical and Public Health Implications for the 85 Years Old and Over Population
10.3389/fpubh.2017.00335 · 2017 · External reference
Coenzyme Q10 Protects Astrocytes From ROS‐Induced Damage Through Inhibition of Mitochondria‐Mediated Cell Death Pathway
10.7150/ijbs.10174 · 2015 · External reference
The Autophagy Research in Electron Microscopy
10.1186/s42649-019-0012-6 · 2019 · External reference
Flow Cytometric Analysis of Thiazole Orange Uptake by Platelets: A Diagnostic Aid in the Evaluation of Thrombocytopenic Disorders
10.1182/blood.v75.1.116.116 · 1990 · External reference
Isolation of Mouse Megakaryocyte Progenitors
2021 · External reference
The Role of Coenzyme Q in Mitochondrial Electron Transport
10.1016/j.mito.2007.03.009 · 2007 · External reference
New Insight Into the Causes, Consequences, and Correction of Hematopoietic Stem Cell Aging
10.1016/j.exphem.2023.07.002 · 2023 · External reference
Coenzyme Q10 and Xenobiotic Metabolism: An Overview
10.3390/ijms26125788 · 2025 · External reference
Coenzyme Q10, Ageing and the Nervous System: An Overview
2022 · External reference
The Effect of Coenzyme Q10 on Morbidity and Mortality in Chronic Heart Failure: Results From Q‐SYMBIO: A Randomized Double‐Blind Trial
2014 · External reference
Cyclin D‐Cdk4 Is Regulated by GATA‐1 and Required for Megakaryocyte Growth and Polyploidization
10.1182/blood-2006-11-059378 · 2007 · External reference
The COPS3‐FOXO3 Positive Feedback Loop Regulates Autophagy to Promote Cisplatin Resistance in Osteosarcoma
10.1080/15548627.2022.2150003 · 2023 · External reference
Inhibition of Oxidative Stress by Coenzyme Q10 Increases Mitochondrial Mass and Improves Bioenergetic Function in Optic Nerve Head Astrocytes
10.1038/cddis.2013.341 · 2013 · External reference
Historical Landmarks of Autophagy Research
10.1038/cr.2013.169 · 2013 · External reference
Coenzyme Q10 Supplementation Modulates NFκB and Nrf2 Pathways in Exercise Training
2016 · External reference
The Roles of Coenzyme Q in Disease: Direct and Indirect Involvement in Cellular Functions
10.3390/ijms23010128 · 2021 · External reference
Autophagy, Aging, and Age‐Related Neurodegeneration
10.1016/j.neuron.2024.09.015 · 2025 · External reference
BubR1 Insufficiency Drives Transcriptomic Alterations and Pathology Associated With Cardiac Aging and Heart Failure
10.1111/acel.70160 · 2025 · External reference
COP9 Signalosome: Discovery, Conservation, Activity, and Function
10.1111/jipb.12903 · 2020 · External reference
Dose Translation From Animal to Human Studies Revisited
10.1096/fj.07-9574lsf · 2008 · External reference
Cardiovascular Risks Associated With Gender and Aging
10.3390/jcdd6020019 · 2019 · External reference
LC3‐positive structures are prominent in autophagy‐deficient cells
10.1038/s41598-019-46657-z · 2019 · External reference
Age‐Dependent Loss of Mitochondrial Function in Epithelial Tissue Can be Reversed by Coenzyme Q10
10.1155/2018/6354680 · 2018 · External reference
Autophagy and Its Consequences for Platelet Biology
10.1016/j.thromres.2022.08.019 · 2023 · External reference
Dietary Coenzyme Q10 Supplementation Alters Platelet Size and Inhibits Human Vitronectin (CD51/CD61) Receptor Expression
10.1097/00005344-199701000-00003 · 1997 · External reference
Coenzyme Q10 and Heart Failure: A State‐Of‐The‐Art Review
2016 · External reference
The COP9 Signalosome Inhibits Cullin‐RING E3 Ubiquitin Ligases Independently of Its Deneddylase Activity
10.1080/19336934.2018.1429858 · 2018 · External reference
CoQ10 Ameliorates Mitochondrial Dysfunction in Diabetic Nephropathy Through Mitophagy
10.1530/joe-18-0578 · 2019 · External reference
Megakaryocytic Dysfunction in Immune Thrombocytopenia Is Linked to Autophagy
10.1186/s12935-019-0779-0 · 2019 · External reference
Megakaryocyte Polyploidization: Role in Platelet Production
10.1080/09537104.2019.1667497 · 2020 · External reference
Coenzyme Q10 Attenuates Human Platelet Aggregation Induced by SARS‐CoV‐2 Spike Protein via Reducing Oxidative Stress in Vitro
10.3390/ijms232012345 · 2022 · External reference
Mitochondria in Oxidative Stress, Inflammation and Aging: From Mechanisms to Therapeutic Advances
10.1038/s41392-025-02253-4 · 2025 · External reference
Coenzyme Q10 Ameliorates Pancreatic Fibrosis via the ROS‐Triggered mTOR Signaling Pathway
10.1155/2019/8039694 · 2019 · External reference
Coenzyme Q10 Upregulates Platelet cAMP/PKA Pathway and Attenuates Integrin αIIbβ3 Signaling and Thrombus Growth
10.1002/mnfr.201900662 · 2019 · External reference
Coenzyme Q10 Attenuates Platelet Integrin αIIbβ3 Signaling and Platelet Hyper‐Reactivity in ApoE‐Deficient Mice
10.1039/c9fo01686d · 2020 · External reference
Apoptosis in Megakaryocytes: Safeguard and Threat for Thrombopoiesis
10.3389/fimmu.2022.1025945 · 2023 · External reference
Coenzyme Q10 Inhibits the Aging of Mesenchymal Stem Cells Induced by D‐Galactose Through Akt/mTOR Signaling
10.1155/2015/867293 · 2015 · External reference
COPS3 Inhibition Promotes Cell Proliferation Blockage and Anoikis via Regulating PFKFB3 in Osteosarcoma Cancer Cells
10.1016/j.ejphar.2023.175799 · 2023 · External reference
Novel Oncogene COPS3 Interacts With Beclin1 and Raf‐1 to Regulate Metastasis of Osteosarcoma Through Autophagy
10.1186/s13046-018-0791-6 · 2018 · External reference
Autophagy in Adult Stem Cell Homeostasis, Aging, and Disease Therapy
10.1186/s13619-025-00224-2 · 2025 · External reference