Research graph
References from Therapeutic Immune Reprogramming by Rapamycin Attenuates Plaque Inflammation and Lymphoid Immune Responses in Aged Atherosclerotic Mice. Local targets link to admitted publications; unresolved targets remain external evidence.
Disruption of mTORC1 in Macrophages Decreases Chemokine Gene Expression and Atherosclerosis
10.1161/circresaha.114.302313 · 2014 · External reference
Immunosenescence and Its Hallmarks: How to Oppose Aging Strategically? A Review of Potential Options for Therapeutic Intervention
10.3389/fimmu.2019.02247 · 2019 · External reference
Effects of Molecularly Targeted Therapies on Murine Thymus: Highly Selective mTOR Inhibitors Induce Reversible Thymic Involution
10.1186/s40164-016-0044-3 · 2016 · External reference
Sirolimus Treatment Induces Dose‐Dependent Involution of the Thymus With Elevated Cellular Respiration in BALB/c Mice
2022 · External reference
mTOR Regulates Memory CD8 T‐Cell Differentiation
10.1038/nature08155 · 2009 · External reference
Rapamycin Selectively Expands CD4+CD25+FoxP3+ Regulatory T Cells
10.1182/blood-2004-10-3932 · 2005 · External reference
M2 Macrophages as a Potential Target for Antiatherosclerosis Treatment
10.1155/2019/6724903 · 2019 · External reference
Cancer Prevention With Rapamycin
10.18632/oncotarget.28410 · 2023 · External reference
Rapamycin Attenuates Atherosclerosis Induced by Dietary Cholesterol in Apolipoprotein‐Deficient Mice Through a p27Kip1‐Independent Pathway
10.1016/j.atherosclerosis.2003.09.003 · 2004 · External reference
mTOR Regulation and Therapeutic Rejuvenation of Aging Hematopoietic Stem Cells
10.1126/scisignal.2000559 · 2009 · External reference
Rapamycin Regulates Akt and ERK Phosphorylation Through mTORC1 and mTORC2 Signaling Pathways
10.1002/mc.20628 · 2010 · External reference
Regulation of CD8+ T Memory and Exhaustion by the mTOR Signals
10.1038/s41423-023-01064-3 · 2023 · External reference
Single‐Cell RNA‐Seq Reveals the Transcriptional Landscape and Heterogeneity of Aortic Macrophages in Murine Atherosclerosis
10.1161/circresaha.117.312509 · 2018 · External reference
mTORC1 Signaling Regulates Proinflammatory Macrophage Function and Metabolism
10.4049/jimmunol.2100230 · 2021 · External reference
Immunosenescence Accelerates Atherosclerosis Development in AAV‐PCSK9 Mouse Model
10.1007/s11357-025-01768-6 · 2025 · External reference
Rapamycin Decelerates Cellular Senescence
10.4161/cc.8.12.8606 · 2009 · External reference
Microanatomy of the Human Atherosclerotic Plaque by Single‐Cell Transcriptomics
10.1161/circresaha.120.316770 · 2020 · External reference
Cell Cycle Regulation: p53‐p21‐RB Signaling
10.1038/s41418-022-00988-z · 2022 · External reference
Treating Atherosclerosis With Regulatory T Cells
10.1161/atvbaha.114.303568 · 2015 · External reference
The Pim Kinases Control Rapamycin‐Resistant T Cell Survival and Activation
10.1084/jem.20042020 · 2005 · External reference
Oral Rapamycin Attenuates Atherosclerosis Without Affecting the Arterial Responsiveness of Resistance Vessels in Apolipoprotein E‐Deficient Mice
10.1590/s0100-879x2009005000036 · 2009 · External reference
Rapamycin Inhibits GM‐CSF‐Induced Neutrophil Migration
10.1016/s0014-5793(03)00828-7 · 2003 · External reference
Low‐Dose Rapamycin Treatment Increases the Ability of Human Regulatory T Cells to Inhibit Transplant Arteriosclerosis In Vivo
10.1111/j.1600-6143.2012.04065.x · 2012 · External reference
Mammalian Target of Rapamycin Inhibitor Dyslipidemia in Kidney Transplant Recipients
10.1111/j.1600-6143.2008.02272.x · 2008 · External reference
Rapamycin Regulates Macrophage Activation by Inhibiting NLRP3 Inflammasome‐p38 MAPK‐NFκB Pathways in Autophagy‐ and p62‐Dependent Manners
10.18632/oncotarget.17256 · 2017 · External reference
Rapamycin Inhibits Differentiation of Th17 Cells and Promotes Generation of FoxP3+ T Regulatory Cells
10.1016/j.intimp.2007.08.027 · 2007 · External reference
Mechanisms of Cellular Senescence: Cell Cycle Arrest and Senescence Associated Secretory Phenotype
10.3389/fcell.2021.645593 · 2021 · External reference
From ‘Truly Naïve’ to ‘Exhausted Senescent’ T Cells: When Markers Predict Functionality
10.1002/cyto.a.22351 · 2014 · External reference
Mammalian Target of Rapamycin Complex 1 Signalling Is Essential for Germinal Centre Reaction
10.1111/imm.12767 · 2017 · External reference
The Changing Landscape of Atherosclerosis
10.1038/s41586-021-03392-8 · 2021 · External reference
Rapamycin Enhances Long‐Term Hematopoietic Reconstitution of Ex Vivo Expanded Mouse Hematopoietic Stem Cells by Inhibiting Senescence
10.1097/tp.0b013e3182a7fcf8 · 2014 · External reference
Moderate Autophagy Inhibits Vascular Smooth Muscle Cell Senescence to Stabilize Progressed Atherosclerotic Plaque via the mTORC1/ULK1/ATG13 Signal Pathway
10.1155/2017/3018190 · 2017 · External reference
A Single Rapamycin Dose Protects Against Late‐Stage Experimental Cerebral Malaria via Modulation of Host Immunity, Endothelial Activation and Parasite Sequestration
10.1186/s12936-017-2092-5 · 2017 · External reference
Rapamycin Unbalances the Polarization of Human Macrophages to M1
10.1111/imm.12126 · 2013 · External reference
10.1152/physrev.00016.2024
10.1152/physrev.00016.2024 · External reference
Identification of Cellular Senescence‐Specific Genes by Comparative Transcriptomics
10.1038/srep31758 · 2016 · External reference
Rapamycin Attenuates Atherosclerotic Plaque Progression in Apolipoprotein E Knockout Mice: Inhibitory Effect on Monocyte Chemotaxis
10.1097/01.fjc.0000177985.14305.15 · 2005 · External reference
The Principal Target of Rapamycin‐Induced p70s6k Inactivation Is a Novel Phosphorylation Site Within a Conserved Hydrophobic Domain
10.1002/j.1460-2075.1995.tb00212.x · 1995 · External reference
IL‐21 Shapes Germinal Center Polarization via Light Zone B Cell Selection and Cyclin D3 Upregulation
10.1084/jem.20221653 · 2023 · External reference
Regulation of T Cells by mTOR: The Known Knowns and the Known Unknowns
10.1016/j.it.2014.11.005 · 2014 · External reference
CD4(+)CD25(High)CD127(Low) Regulatory T Cells in Patients With Stable Angina and Their Dynamics After Intracoronary Sirolimus‐Eluting Stent Implantation
10.1016/j.humimm.2011.03.015 · 2011 · External reference
Cellular Senescence and Tumor Suppressor Gene p16
10.1002/ijc.27316 · 2011 · External reference
Low Frequency of IL‐10+ B Cells in Patients With Atherosclerosis Is Related With Inflammatory Condition
10.1016/j.heliyon.2020.e03441 · 2020 · External reference
mTOR as a Senescence Manipulation Target: A Forked Road
10.1016/bs.acr.2021.02.002 · 2021 · External reference
Prolonged Rapamycin Treatment Inhibits mTORC2 Assembly and Akt/PKB
10.1016/j.molcel.2006.03.029 · 2006 · External reference
A New Gene Set Identifies Senescent Cells and Predicts Senescence‐Associated Pathways Across Tissues
10.1038/s41467-022-32552-1 · 2022 · External reference
New Insights Into the Role of Mtor Signaling in the Cardiovascular System
10.1161/circresaha.117.311147 · 2018 · External reference
Effect of Rapamycin on Aging and Age‐Related Diseases—Past and Future
10.1007/s11357-020-00274-1 · 2020 · External reference
Extracellular Mechanisms of Neutrophils in Immune Cell Crosstalk
10.4110/in.2023.23.e38 · 2023 · External reference
10.1093/cvr/cvad099
10.1093/cvr/cvad099 · External reference
Adaptive Immunity and Atherosclerosis: Aging at Its Crossroads
10.3389/fimmu.2024.1350471 · 2024 · External reference
Mechanisms Underlying Neutrophil‐Mediated Monocyte Recruitment
10.1182/blood-2009-06-221630 · 2009 · External reference
Combined Application of Rapamycin and Atorvastatin Improves Lipid Metabolism in Apolipoprotein E‐Deficient Mice With Chronic Kidney Disease
10.5483/bmbrep.2021.54.3.136 · 2021 · External reference
Treg‐Mediated Suppression of Atherosclerosis Requires MYD88 Signaling in DCs
10.1172/jci64617 · 2013 · External reference
Expression of Senescence Marker TIGIT Identifies Polyfunctional Donor‐Reactive CD4+ T Cells Preferentially Lost After Kidney Transplantation
10.3389/fimmu.2021.656846 · 2021 · External reference
Selective Clearance of Macrophages in Atherosclerotic Plaques by Autophagy
10.1016/j.jacc.2006.09.047 · 2007 · External reference
The Metabolic Signature of Macrophage Responses
10.3389/fimmu.2019.01462 · 2019 · External reference
Thymus‐Derived CD4+CD8+ Cells Reside in Mediastinal Adipose Tissue and the Aortic Arch
10.4049/jimmunol.2100208 · 2021 · External reference
Lupus‐Associated Atypical Memory B Cells Are mTORC1‐Hyperactivated and Functionally Dysregulated
2019 · External reference
Rapamycin Immunomodulation Utilizes Time‐Dependent Alterations of Lymph Node Architecture, Leukocyte Trafficking, and Gut Microbiome
10.1172/jci.insight.186505 · 2025 · External reference
Age‐Related Gene Alteration in Naïve and Memory T Cells Using Precise Age‐Tracking Model
10.3389/fcell.2020.624380 · 2021 · External reference
mTOR Promotes Antiviral Humoral Immunity by Differentially Regulating CD4 Helper T Cell and B Cell Responses
2017 · External reference
Constitutive Reductions in mTOR Alter Cell Size, Immune Cell Development, and Antibody Production
10.1182/blood-2010-05-287821 · 2010 · External reference
Aging and Cardiovascular Disease: Current Status and Challenges
10.31083/j.rcm2304135 · 2022 · External reference
