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References from Prodh2‐Mediated Mitochondrial Stress Drives TNF ‐α‐Induced Myoblast Dysfunction and Sarcopenia in COPD. Local targets link to admitted publications; unresolved targets remain external evidence.
Chronic Obstructive Pulmonary Disease and Associated Factors in Arba Minch Health and Demographic Surveillance Site, 2020
10.2147/copd.s319721 · 2021 · External reference
Cytosolic Self‐DNA‐A Potential Source of Chronic Inflammation in Aging
10.3390/cells10123544 · 2021 · External reference
Mitochondrial DNA Release and cGAS‐STING Activation: Emerging Insights Into Anti‐Tumor Immunity
10.1016/j.prp.2025.156158 · 2025 · External reference
CTRP13‐Mediated Effects on Endothelial Cell Function and Their Potential Role in Obesity
10.3390/cells13151291 · 2024 · External reference
SIRT1 Pathway in Parkinson's Disease: A Faraway Snapshot but So Close
10.1007/s10787-022-01125-5 · 2023 · External reference
Interplay Between Proline Metabolism and ROS in the Fine Tuning of Root‐Meristem Size in Arabidopsis
2022 · External reference
Sarcopenia Correlates With Systemic Inflammation in COPD
10.2147/copd.s130790 · 2017 · External reference
The New Insight Into the Role of Hydroxyproline in Metabolism of Cancer Cells
10.3389/fcell.2025.1556770 · 2025 · External reference
Mitochondrial Damage and Activation of the STING Pathway Lead to Renal Inflammation and Fibrosis
10.1016/j.cmet.2019.08.003 · 2019 · External reference
A Novel Function for Hydroxyproline Oxidase in Apoptosis Through Generation of Reactive Oxygen Species *
10.1074/jbc.m702181200 · 2008 · External reference
Liver‐Secreted Extracellular Vesicles Promote Cirrhosis‐Associated Skeletal Muscle Injury Through mtDNA‐cGAS/STING Axis
10.1002/advs.202410439 · 2025 · External reference
YAP/TAZ‐Mediated Nuclear Membrane Rupture in Promoting Senescence of Skeletal Muscle Associated With COPD
10.1186/s12931-025-03170-4 · 2025 · External reference
PRODH2‐Mediated Metabolism in the Bone Microenvironment Promotes Breast Cancer Metastasis
10.1158/0008-5472.can-24-4391 · 2025 · External reference
TNF‐α Induces Premature Senescence in Tendon Stem Cells via the NF‐κB and p53/p21/Cyclin E/CDK2 Signaling Pathways
10.3892/ijmm.2025.5581 · 2025 · External reference
Mitochondrial DNA Mutations Induce Mitochondrial Dysfunction, Apoptosis and Sarcopenia in Skeletal Muscle of Mitochondrial DNA Mutator Mice
10.1371/journal.pone.0011468 · 2010 · External reference
Celecoxib Attenuates Hindlimb Unloading‐Induced Muscle Atrophy via Suppressing Inflammation, Oxidative Stress and ER Stress by Inhibiting STAT3
10.1007/s10787-024-01454-7 · 2024 · External reference
Role of Nrf2 and Exercise in Alleviating COPD‐Induced Skeletal Muscle Dysfunction
10.1177/17534666231208633 · 2023 · External reference
Mitophagy Curtails Cytosolic mtDNA‐Dependent Activation of cGAS/STING Inflammation During Aging
10.1038/s41467-024-45044-1 · 2024 · External reference
NSAIDs Induce Proline Dehydrogenase/Proline Oxidase‐Dependent and Independent Apoptosis in MCF7 Breast Cancer Cells
10.3390/ijms23073813 · 2022 · External reference
Glycine and N‐Acetylcysteine (GlyNAC) Supplementation in Older Adults Improves Glutathione Deficiency, Oxidative Stress, Mitochondrial Dysfunction, Inflammation, Insulin Resistance, Endothelial Dysfunction, Genotoxicity, Muscle Strength, and Cognition: Results of a Pilot Clinical Trial
10.1002/ctm2.372 · 2021 · External reference
Oxidized Mitochondrial DNA Activates the cGAS‐STING Pathway in the Neuronal Intrinsic Immune System After Brain Ischemia‐Reperfusion Injury
10.1016/j.neurot.2024.e00368 · 2024 · External reference
Calprotectin Is a Circulating Biomarker and Potential Therapeutic Target for Sarcopenia in Chronic Obstructive Pulmonary Disease
10.1002/jcsm.70196 · 2026 · External reference
Cancerous Conditions Accelerate the Aging of Skeletal Muscle via Mitochondrial DNA Damage
10.3390/ijms25137060 · 2024 · External reference
Sarcopenia as a Treatable Trait in COPD: From Mechanisms to Management
10.1016/j.rmed.2025.108401 · 2025 · External reference
Recent Advances in Dermal Fibroblast Senescence and Skin Aging: Unraveling Mechanisms and Pioneering Therapeutic Strategies
10.3389/fphar.2025.1592596 · 2025 · External reference
Role of Nutrition in Patients With Coexisting Chronic Obstructive Pulmonary Disease and Sarcopenia
10.3389/fnut.2023.1214684 · 2023 · External reference
Mitochondrial DNA Release in Innate Immune Signaling
10.1146/annurev-biochem-032620-104401 · 2023 · External reference
Mechanisms Linking COPD to Type 1 and 2 Diabetes Mellitus: Is There a Relationship Between Diabetes and COPD?
10.3390/medicina58081030 · 2022 · External reference
Circulating Mitochondrial DNA at the Crossroads of Mitochondrial Dysfunction and Inflammation During Aging and Muscle Wasting Disorders
10.1089/rej.2017.1989 · 2018 · External reference
Elephant TP53‐RETROGENE 9 Induces Transcription‐Independent Apoptosis at the Mitochondria
10.1038/s41420-023-01348-7 · 2023 · External reference
P53 Family Members Modulate the Expression of PRODH, but Not PRODH2, via Intronic p53 Response Elements
10.1371/journal.pone.0069152 · 2013 · External reference
TNF‐Alpha Impairs Regulation of Muscle Oxidative Phenotype: Implications for Cachexia?
2010 · External reference
Ornithine‐Delta‐Aminotransferase and Proline Dehydrogenase Genes Play a Role in Non‐Host Disease Resistance by Regulating Pyrroline‐5‐Carboxylate Metabolism‐Induced Hypersensitive Response
10.1111/j.1365-3040.2012.02492.x · 2012 · External reference
Impact of Pre‐Sarcopenia and Sarcopenia on Biological and Functional Outcomes in Individuals With Chronic Obstructive Pulmonary Disease: A Cross‐Sectional Study
10.12873/441sepulveda · 2024 · External reference
Triple Therapy in COPD: Can We Welcome the Reduction in Cardiovascular Risk and Mortality?
10.3389/fmed.2022.816843 · 2022 · External reference
Genetic Cause and Prevalence of Hydroxyprolinemia
10.1007/s10545-016-9940-2 · 2016 · External reference
Global Metabolic Profiling Identifies a Pivotal Role of Proline and Hydroxyproline Metabolism in Supporting Hypoxic Response in Hepatocellular Carcinoma
10.1158/1078-0432.ccr-17-1707 · 2018 · External reference
Cigarette Smoke Induces Mitochondrial DNA Damage and Activates cGAS‐STING Pathway: Application to a Biomarker for Atherosclerosis
10.1042/cs20220525 · 2023 · External reference
p53 Regulates the Mitochondrial Immune Checkpoint
10.1016/j.it.2023.03.001 · 2023 · External reference
Gui Qi Zhuang Jin Decoction Ameliorates Mitochondrial Dysfunction in Sarcopenia Mice via AMPK/PGC‐1α/Nrf2 Axis Revealed by a Metabolomics Approach
10.1016/j.phymed.2024.155908 · 2024 · External reference
Nanoplastics Causes Heart Aging/Myocardial Cell Senescence Through the Ca(2+)/mtDNA/cGAS‐STING Signaling Cascade
10.1186/s12951-024-02375-x · 2024 · External reference
Protective Effect of Cornuside on OGD/R Injury in SH‐SY5Y Cells and Its Underlying Mechanism
10.1016/j.brainres.2023.148585 · 2023 · External reference
Integrated Proteomic and Metabolomic Analysis of Muscle Atrophy Induced by Hindlimb Unloading
10.3390/biom15010014 · 2024 · External reference
Mitochondrial DNA‐Activated cGAS‐STING Pathway in Cancer: Mechanisms and Therapeutic Implications
10.1016/j.bbcan.2024.189249 · 2025 · External reference
A Genome‐Scale Gain‐Of‐Function CRISPR Screen in CD8 T Cells Identifies Proline Metabolism as a Means to Enhance CAR‐T Therapy
10.1016/j.cmet.2022.02.009 · 2022 · External reference
Neutrophil Extracellular Traps May Be a Potential Target for Treating Early Brain Injury in Subarachnoid Hemorrhage
10.1007/s12975-021-00909-1 · 2022 · External reference
Recapitulating and Reversing Human Brain Ribosomopathy Defects via the Maladaptive Integrated Stress Response
10.1126/sciadv.adk1034 · 2024 · External reference