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References from Klotho Deficiency Impairs Distal Potassium Homeostasis Through <scp>mTORC1</scp> ‐Dependent Suppression of <scp>ROMK</scp>. Local targets link to admitted publications; unresolved targets remain external evidence.
Hyperkalemia and Its Association With Mortality, Cardiovascular Events, Hospitalizations, and Intensive Care Unit Admissions in a Population‐Based Retrospective Cohort
10.1016/j.ekir.2021.02.038 · 2021 · External reference
The Prevalence of Hyperkalemia in the United States
10.1080/03007995.2018.1433141 · 2018 · External reference
The Prevalence and Risk Factors of Hyperkalemia in the Outpatient Setting
10.1155/2024/5694131 · 2024 · External reference
The Aging Kidney
10.1038/ki.2008.319 · 2008 · External reference
Pathophysiology of the Aging Kidney and Therapeutic Interventions
10.1038/hr.2012.159 · 2012 · External reference
Regulation of Potassium Homeostasis
10.2215/cjn.08580813 · 2015 · External reference
Establishment of Sandwich ELISA for Soluble Alpha‐Klotho Measurement: Age‐Dependent Change of Soluble Alpha‐Klotho Levels in Healthy Subjects
10.1016/j.bbrc.2010.06.110 · 2010 · External reference
Soluble Serum Klotho Levels in Healthy Subjects. Comparison of Two Different Immunoassays
10.1016/j.clinbiochem.2013.05.046 · 2013 · External reference
References Values of Soluble α‐Klotho Serum Levels Using an Enzyme‐Linked Immunosorbent Assay in Healthy Adults Aged 18–85 Years
10.3390/jcm11092415 · 2022 · External reference
Mutation of the Mouse Klotho Gene Leads to a Syndrome Resembling Ageing
10.1038/36285 · 1997 · External reference
Salt Causes Aging‐Associated Hypertension via Vascular Wnt5a Under Klotho Deficiency
2020 · External reference
The Emerging Role of Klotho in Clinical Nephrology
10.1093/ndt/gfs160 · 2012 · External reference
Loss of Klotho Contributes to Kidney Injury by Derepression of Wnt/β‐Catenin Signaling
10.1681/asn.2012080865 · 2013 · External reference
Removal of Sialic Acid Involving Klotho Causes Cell‐Surface Retention of TRPV5 Channel via Binding to Galectin‐1
10.1073/pnas.0803223105 · 2008 · External reference
Regulation of Renal Outer Medullary Potassium Channel and Renal K (+) Excretion by Klotho
10.1124/mol.109.055780 · 2009 · External reference
A Comprehensive Guide to the ROMK Potassium Channel: Form and Function in Health and Disease
10.1152/ajprenal.00181.2009 · 2009 · External reference
Potassium Homeostasis and Management of Dyskalemia in Kidney Diseases: Conclusions From a Kidney Disease: Improving Global Outcomes (KDIGO) Controversies Conference
10.1016/j.kint.2019.09.018 · 2020 · External reference
Activation of mTORC1 in Collecting Ducts Causes Hyperkalemia
10.1681/asn.2013030225 · 2014 · External reference
mTORC2 Regulates Renal Tubule Sodium Uptake by Promoting ENaC Activity
10.1172/jci73935 · 2015 · External reference
Soluble Klotho Improves Hepatic Glucose and Lipid Homeostasis in Type 2 Diabetes
10.1016/j.omtm.2020.08.002 · 2020 · External reference
mTORC1‐Induced Bone Marrow‐Derived Mesenchymal Stem Cell Exhaustion Contributes to the Bone Abnormalities in Klotho‐Deficient Mice of Premature Aging
10.1089/scd.2022.0243 · 2023 · External reference
Inorganic Phosphate Activates the AKT/mTORC1 Pathway and Shortens the Life Span of an α‑Klotho‐Deficient Model
10.1681/asn.2015040446 · 2016 · External reference
Aldosterone Is Essential for Angiotensin II‐Induced Upregulation of Pendrin
10.1681/asn.2017030243 · 2018 · External reference
Two Mineralocorticoid Receptor‐Mediated Mechanisms of Pendrin Activation in Distal Nephrons
10.1681/asn.2019080804 · 2020 · External reference
Fractional Excretion of Potassium in Normal Subjects and in Patients With Hypokalaemia
10.1136/pgmj.71.834.211 · 1995 · External reference
Renal Dysfunction Induced by Kidney‐Specific Gene Deletion of Hsd11b2 as a Primary Cause of Salt‐Dependent Hypertension
10.1161/hypertensionaha.116.08966 · 2017 · External reference
KCNMA1 Encoded Cardiac BK Channels Afford Protection Against Ischemia‐Reperfusion Injury
10.1371/journal.pone.0103402 · 2014 · External reference
mTORC2 Critically Regulates Renal Potassium Handling
10.1172/jci80304 · 2016 · External reference
Klotho Restraining Egr1/TLR4/mTOR Axis to Reducing the Expression of Fibrosis and Inflammatory Cytokines in High Glucose Cultured Rat Mesangial Cells
10.1055/s-0044-101601 · 2019 · External reference
Mammalian Target of Rapamycin Inhibition Decreases Angiotensin II‐Induced Steroidogenesis in HAC15 Human Adrenocortical Carcinoma Cells
10.1210/endocr/bqac185 · 2022 · External reference
Antiaging Gene Klotho Regulates Adrenal CYP11B2 Expression and Aldosterone Synthesis
10.1681/asn.2015010093 · 2016 · External reference
Soluble αKlotho as a Candidate for the Biomarker of Aging
10.1016/j.bbrc.2015.10.018 · 2015 · External reference
Klotho Is a Serum Factor Related to Human Aging
2004 · External reference
10.1101/2024.04.09.587573
10.1101/2024.04.09.587573 · External reference
mTOR Complex 1 Content and Regulation Is Adapted to Animal Longevity
10.3390/ijms23158747 · 2022 · External reference
The Role of the BK Channel in Potassium Homeostasis and Flow‐Induced Renal Potassium Excretion
10.1038/sj.ki.5002369 · 2007 · External reference
Molecular Diversity and Regulation of Renal Potassium Channels
10.1152/physrev.00051.2003 · 2005 · External reference
Rapid Dephosphorylation of the Renal Sodium Chloride Cotransporter in Response to Oral Potassium Intake in Mice
10.1038/ki.2013.14 · 2013 · External reference
Potassium Modulates Electrolyte Balance and Blood Pressure Through Effects on Distal Cell Voltage and Chloride
10.1016/j.cmet.2014.12.006 · 2015 · External reference
Managing Hyperkalemia Caused by Inhibitors of the Renin‐Angiotensin‐Aldosterone System
10.1056/nejmra035279 · 2004 · External reference
Rates of Hyperkalemia After Publication of the Randomized Aldactone Evaluation Study
10.1056/nejmoa040135 · 2004 · External reference
Blood Pressure Effects of Sodium Transport Along the Distal Nephron
10.1016/j.kint.2022.09.009 · 2022 · External reference
Sodium and Potassium Handling by the Aldosterone‐Sensitive Distal Nephron: The Pivotal Role of the Distal and Connecting Tubule
10.1152/ajprenal.00454.2003 · 2004 · External reference
Critical Role of the Mineralocorticoid Receptor in Aldosterone‐Dependent and Aldosterone‐Independent Regulation of ENaC in the Distal Nephron
10.1152/ajprenal.00139.2021 · 2021 · External reference
Treatment of Primary Aldosteronism With mTORC1 Inhibitors
10.1210/jc.2019-00563 · 2019 · External reference
Age‐Related Autonomous Aldosteronism
10.1161/circulationaha.117.028201 · 2017 · External reference
