Research graph
References from Olfactory Tuft Cells Are Critical to Basal Inflammation, Innate Immune Response to Viral Infection, and Modulation of Quiescent Stem Cell Activation, Proliferation and Differentiation. Local targets link to admitted publications; unresolved targets remain external evidence.
Olfactory Immunology: The Missing Piece in Airway and CNS Defence
10.1038/s41577-023-00972-9 · 2024 · External reference
Neuroimmune Interactions in the Olfactory Epithelium: Maintaining a Sensory Organ at an Immune Barrier Interface
10.1016/j.it.2024.10.005 · 2024 · External reference
Olfactory Perception: Receptors, Cells, and Circuits
10.1016/j.cell.2009.09.015 · 2009 · External reference
A Nasal Cell Atlas Reveals Heterogeneity of Tuft Cells and Their Role in Directing Olfactory Stem Cell Proliferation
10.1126/sciimmunol.abq4341 · 2024 · External reference
Regeneration and Rewiring of Rodent Olfactory Sensory Neurons
2017 · External reference
A Light Microscopy Study of the Migration of Naegleria fowleri From the Nasal Submucosa to the Central Nervous System During the Early Stage of Primary Amebic Meningoencephalitis in Mice
10.1645/0022-3395(2000)086[0050:almsot]2.0.co;2 · 2000 · External reference
Streptococcus pneumoniae Rapidly Translocate From the Nasopharynx Through the Cribriform Plate to Invade the Outer Meninges
10.1128/mbio.01024-22 · 2022 · External reference
Nasal‐Associated Lymphoid Tissue and Olfactory Epithelium as Portals of Entry for Burkholderia pseudomallei in Murine Melioidosis
10.1086/599210 · 2009 · External reference
Heterogeneity of Antiviral Responses in the Upper Respiratory Tract Mediates Differential Non‐Lytic Clearance of Influenza Viruses
10.1016/j.celrep.2020.108103 · 2020 · External reference
SARS‐CoV‐2 Infection of Sustentacular Cells Disrupts Olfactory Signaling Pathways
10.1172/jci.insight.160277 · 2022 · External reference
OR14I1 Is a Receptor for the Human Cytomegalovirus Pentameric Complex and Defines Viral Epithelial Cell Tropism
2019 · External reference
Differential Expression of Mucins in Murine Olfactory Versus Respiratory Epithelium
10.1093/chemse/bjz046 · 2019 · External reference
Apoptosis and Necroptosis as Host Defense Strategies to Prevent Viral Infection
10.1016/j.tcb.2017.05.007 · 2017 · External reference
Non‐Lytic Clearance of Influenza B Virus From Infected Cells Preserves Epithelial Barrier Function
10.1038/s41467-019-08617-z · 2019 · External reference
Olfactory Receptor Neurons Prevent Dissemination of Neurovirulent Influenza A Virus Into the Brain by Undergoing Virus‐Induced Apoptosis
10.1099/0022-1317-83-9-2109 · 2002 · External reference
Distinct Olfactory Mucosal Macrophage Populations Mediate Neuronal Maintenance and Pathogen Defense
10.1016/j.mucimm.2024.07.009 · 2024 · External reference
Mucosal Plasma Cells Are Required to Protect the Upper Airway and Brain From Infection
10.1016/j.immuni.2022.08.017 · 2022 · External reference
Olfactory Receptor Neuronal Dendrites Become Mostly Intra‐Sustentacularly Enwrapped Upon Maturity
10.1111/joa.12777 · 2018 · External reference
Characteristics and Outcome of Influenza‐Associated Encephalopathy/Encephalitis Among Children in a Tertiary Pediatric Hospital in Italy, 2017–2019
10.1186/s12879-019-4636-5 · 2019 · External reference
The Olfactory Nerve: A Shortcut for Influenza and Other Viral Diseases Into the Central Nervous System
10.1002/path.4461 · 2015 · External reference
Disruption of Cellular Proteostasis by H1N1 Influenza A Virus Causes Alpha‐Synuclein Aggregation
10.1073/pnas.1906466117 · 2020 · External reference
Olfactory Transmucosal SARS‐CoV‐2 Invasion as a Port of Central Nervous System Entry in Individuals With COVID‐19
10.1038/s41593-020-00758-5 · 2021 · External reference
T Cell Engagement of Cross‐Presenting Microglia Protects the Brain From a Nasal Virus Infection
10.1126/sciimmunol.abb1817 · 2020 · External reference
Olfactory Impairment in Psychiatric Disorders: Does Nasal Inflammation Impact Disease Psychophysiology?
10.1038/s41398-022-02081-y · 2022 · External reference
Injury Activates Transient Olfactory Stem Cell States With Diverse Lineage Capacities
10.1016/j.stem.2017.10.014 · 2017 · External reference
Frontline Science: Conversion of Neutrophils Into Atypical Ly6G(+) SiglecF(+) Immune Cells With Neurosupportive Potential in Olfactory Neuroepithelium
10.1002/jlb.1hi0620-190rr · 2021 · External reference
Deconstructing Olfactory Stem Cell Trajectories at Single‐Cell Resolution
10.1016/j.stem.2017.04.003 · 2017 · External reference
Is TrpM5 a Reliable Marker for Chemosensory Cells? Multiple Types of Microvillous Cells in the Main Olfactory Epithelium of Mice
10.1186/1471-2202-9-115 · 2008 · External reference
Transcriptional Profiling Reveals Potential Involvement of Microvillous TRPM5‐Expressing Cells in Viral Infection of the Olfactory Epithelium
10.1186/s12864-021-07528-y · 2021 · External reference
TRPM5‐Expressing Microvillous Cells in the Main Olfactory Epithelium
10.1186/1471-2202-9-114 · 2008 · External reference
Cholinergic Microvillous Cells in the Mouse Main Olfactory Epithelium and Effect of Acetylcholine on Olfactory Sensory Neurons and Supporting Cells
10.1152/jn.00186.2011 · 2011 · External reference
Microvillous Cells in the Olfactory Epithelium Express Elements of the Solitary Chemosensory Cell Transduction Signaling Cascade
10.1371/journal.pone.0202754 · 2018 · External reference
Skn‐1a/Pou2f3 Is Required for the Generation of Trpm5‐Expressing Microvillous Cells in the Mouse Main Olfactory Epithelium
10.1186/1471-2202-15-13 · 2014 · External reference
Intestinal Epithelial Tuft Cells Initiate Type 2 Mucosal Immunity to Helminth Parasites
10.1038/nature16527 · 2016 · External reference
Tuft‐Cell‐Derived IL‐25 Regulates an Intestinal ILC2‐Epithelial Response Circuit
10.1038/nature16161 · 2016 · External reference
Gastric Tuft Cells Express DCLK1 and Are Expanded in Hyperplasia
10.1007/s00418-011-0831-1 · 2011 · External reference
Tuft Cell Formation Reflects Epithelial Plasticity in Pancreatic Injury: Implications for Modeling Human Pancreatitis
10.3389/fphys.2020.00088 · 2020 · External reference
A Revised Airway Epithelial Hierarchy Includes CFTR‐Expressing Ionocytes
10.1038/s41586-018-0393-7 · 2018 · External reference
G Protein Subunit Gγ13‐Mediated Signaling Pathway Is Critical to the Inflammation Resolution and Functional Recovery of Severely Injured Lungs
10.7554/elife.92956.3 · 2024 · External reference
Ultrastructural Characteristics of Tuft Cells in Mouse Gallbladder Epithelium
10.1159/000144796 · 1977 · External reference
Thymic Tuft Cells Promote an IL‐4‐Enriched Medulla and Shape Thymocyte Development
10.1038/s41586-018-0345-2 · 2018 · External reference
Activation of Intestinal Tuft Cell‐Expressed Sucnr1 Triggers Type 2 Immunity in the Mouse Small Intestine
10.1073/pnas.1720758115 · 2018 · External reference
Tuft Cells, Taste‐Chemosensory Cells, Orchestrate Parasite Type 2 Immunity in the Gut
10.1126/science.aaf1648 · 2016 · External reference
Infection by the Parasitic Helminth Trichinella Spiralis Activates a Tas2r‐Mediated Signaling Pathway in Intestinal Tuft Cells
10.1073/pnas.1812901116 · 2019 · External reference
Tuft‐Cell‐Derived Leukotrienes Drive Rapid Anti‐Helminth Immunity in the Small Intestine but Are Dispensable for Anti‐Protist Immunity
10.1016/j.immuni.2020.02.005 · 2020 · External reference
A Metabolite‐Triggered Tuft Cell‐ILC2 Circuit Drives Small Intestinal Remodeling
10.1016/j.cell.2018.05.014 · 2018 · External reference
Tuft Cells in the Intestine, Immunity and Beyond
10.1038/s41575-024-00978-1 · 2024 · External reference
Heterotrimeric G Protein Subunit Ggamma13 Is Critical to Olfaction
10.1523/jneurosci.5563-12.2013 · 2013 · External reference
Dysplastic Epithelial Repair Promotes the Tissue Residence of Lymphocytes to Inhibit Alveolar Regeneration Post Viral Infection
10.1016/j.stem.2025.12.005 · 2026 · External reference
Matrix Metalloprotease‐Mediated Cleavage of Neural Glial‐Related Cell Adhesion Molecules Activates Quiescent Olfactory Stem Cells via EGFR
10.1016/j.mcn.2020.103552 · 2020 · External reference
Notch Signaling Regulates Lgr5+ Olfactory Epithelium Progenitor/Stem Cell Turnover and Mediates Recovery of Lesioned Olfactory Epithelium in Mouse Model
10.1002/stem.2837 · 2018 · External reference
Contribution of Olfactory Neural Stem Cells to Tissue Maintenance and Regeneration
10.1038/nn1882 · 2007 · External reference
Invasion and Persistence of the Neuroadapted Influenza Virus A/WSN/33 in the Mouse Olfactory System
10.1089/088282403322396208 · 2003 · External reference
Long‐Term In Vitro Expansion of a Human Fetal Pancreas Stem Cell That Generates All Three Pancreatic Cell Lineages
10.1016/j.cell.2024.10.044 · 2024 · External reference
p63 Regulates Olfactory Stem Cell Self‐Renewal and Differentiation
10.1016/j.neuron.2011.09.009 · 2011 · External reference
DeltaNp63 Regulates Stem Cell Dynamics in the Mammalian Olfactory Epithelium
10.1523/jneurosci.0681-11.2011 · 2011 · External reference
Transcription Factor p63 Controls the Reserve Status but Not the Stemness of Horizontal Basal Cells in the Olfactory Epithelium
2015 · External reference
Intestinal Tuft Cell Subtypes Represent Successive Stages of Maturation Driven by Crypt‐Villus Signaling Gradients
10.1038/s41467-025-61878-9 · 2025 · External reference
Intestinal Tuft Cells: Morphology, Function, and Implications for Human Health
10.1146/annurev-physiol-042022-030310 · 2024 · External reference
Tuft Cell Acetylcholine Is Released Into the Gut Lumen to Promote Anti‐Helminth Immunity
10.1016/j.immuni.2024.04.018 · 2024 · External reference
Tuft Cell‐Derived Acetylcholine Promotes Epithelial Chloride Secretion and Intestinal Helminth Clearance
10.1016/j.immuni.2024.03.023 · 2024 · External reference
Tuft Cells Utilize Taste Signaling Molecules to Respond to the Pathobiont Microbe Ruminococcus gnavus in the Proximal Colon
10.3389/fimmu.2023.1259521 · 2023 · External reference
A Genetic Model of Chronic Rhinosinusitis‐Associated Olfactory Inflammation Reveals Reversible Functional Impairment and Dramatic Neuroepithelial Reorganization
10.1523/jneurosci.4507-09.2010 · 2010 · External reference
An In Vitro Model of Acute Horizontal Basal Cell Activation Reveals Gene Regulatory Networks Underlying the Nascent Activation Phase
10.1016/j.stemcr.2024.06.011 · 2024 · External reference
Respiratory Viral Infections Awaken Metastatic Breast Cancer Cells in Lungs
10.1038/s41586-025-09332-0 · 2025 · External reference
Asymmetric Histone Inheritance Regulates Olfactory Stem Cell Fates During Regeneration
10.1038/s41467-026-70987-y · 2026 · External reference
Tuft Cell IL‐17RB Restrains IL‐25 Bioavailability and Reveals Context‐Dependent ILC2 Hypoproliferation
10.1038/s41590-025-02104-y · 2025 · External reference
Frontline Science: Conversion of Neutrophils Into Atypical Ly6G(+) SiglecF(+) Immune Cells With Neurosupportive Potential in Olfactory Neuroepithelium
10.1002/jlb.1hi0620-190rr · ExternalCitation · doi-reference
The Olfactory Nerve: A Shortcut for Influenza and Other Viral Diseases Into the Central Nervous System
10.1002/path.4461 · ExternalCitation · doi-reference
Notch Signaling Regulates Lgr5+ Olfactory Epithelium Progenitor/Stem Cell Turnover and Mediates Recovery of Lesioned Olfactory Epithelium in Mouse Model
10.1002/stem.2837 · ExternalCitation · doi-reference
Gastric Tuft Cells Express DCLK1 and Are Expanded in Hyperplasia
10.1007/s00418-011-0831-1 · ExternalCitation · doi-reference
Olfactory Perception: Receptors, Cells, and Circuits
10.1016/j.cell.2009.09.015 · ExternalCitation · doi-reference
A Metabolite‐Triggered Tuft Cell‐ILC2 Circuit Drives Small Intestinal Remodeling
10.1016/j.cell.2018.05.014 · ExternalCitation · doi-reference
Long‐Term In Vitro Expansion of a Human Fetal Pancreas Stem Cell That Generates All Three Pancreatic Cell Lineages
10.1016/j.cell.2024.10.044 · ExternalCitation · doi-reference
Heterogeneity of Antiviral Responses in the Upper Respiratory Tract Mediates Differential Non‐Lytic Clearance of Influenza Viruses
10.1016/j.celrep.2020.108103 · ExternalCitation · doi-reference
Tuft‐Cell‐Derived Leukotrienes Drive Rapid Anti‐Helminth Immunity in the Small Intestine but Are Dispensable for Anti‐Protist Immunity
10.1016/j.immuni.2020.02.005 · ExternalCitation · doi-reference
Mucosal Plasma Cells Are Required to Protect the Upper Airway and Brain From Infection
10.1016/j.immuni.2022.08.017 · ExternalCitation · doi-reference
Tuft Cell‐Derived Acetylcholine Promotes Epithelial Chloride Secretion and Intestinal Helminth Clearance
10.1016/j.immuni.2024.03.023 · ExternalCitation · doi-reference
Tuft Cell Acetylcholine Is Released Into the Gut Lumen to Promote Anti‐Helminth Immunity
10.1016/j.immuni.2024.04.018 · ExternalCitation · doi-reference
Neuroimmune Interactions in the Olfactory Epithelium: Maintaining a Sensory Organ at an Immune Barrier Interface
10.1016/j.it.2024.10.005 · ExternalCitation · doi-reference
Matrix Metalloprotease‐Mediated Cleavage of Neural Glial‐Related Cell Adhesion Molecules Activates Quiescent Olfactory Stem Cells via EGFR
10.1016/j.mcn.2020.103552 · ExternalCitation · doi-reference
Distinct Olfactory Mucosal Macrophage Populations Mediate Neuronal Maintenance and Pathogen Defense
10.1016/j.mucimm.2024.07.009 · ExternalCitation · doi-reference
p63 Regulates Olfactory Stem Cell Self‐Renewal and Differentiation
10.1016/j.neuron.2011.09.009 · ExternalCitation · doi-reference
Deconstructing Olfactory Stem Cell Trajectories at Single‐Cell Resolution
10.1016/j.stem.2017.04.003 · ExternalCitation · doi-reference
Injury Activates Transient Olfactory Stem Cell States With Diverse Lineage Capacities
10.1016/j.stem.2017.10.014 · ExternalCitation · doi-reference
Dysplastic Epithelial Repair Promotes the Tissue Residence of Lymphocytes to Inhibit Alveolar Regeneration Post Viral Infection
10.1016/j.stem.2025.12.005 · ExternalCitation · doi-reference
An In Vitro Model of Acute Horizontal Basal Cell Activation Reveals Gene Regulatory Networks Underlying the Nascent Activation Phase
10.1016/j.stemcr.2024.06.011 · ExternalCitation · doi-reference
Apoptosis and Necroptosis as Host Defense Strategies to Prevent Viral Infection
10.1016/j.tcb.2017.05.007 · ExternalCitation · doi-reference
Tuft‐Cell‐Derived IL‐25 Regulates an Intestinal ILC2‐Epithelial Response Circuit
10.1038/nature16161 · ExternalCitation · doi-reference
Intestinal Epithelial Tuft Cells Initiate Type 2 Mucosal Immunity to Helminth Parasites
10.1038/nature16527 · ExternalCitation · doi-reference
Contribution of Olfactory Neural Stem Cells to Tissue Maintenance and Regeneration
10.1038/nn1882 · ExternalCitation · doi-reference
Olfactory Impairment in Psychiatric Disorders: Does Nasal Inflammation Impact Disease Psychophysiology?
10.1038/s41398-022-02081-y · ExternalCitation · doi-reference
Non‐Lytic Clearance of Influenza B Virus From Infected Cells Preserves Epithelial Barrier Function
10.1038/s41467-019-08617-z · ExternalCitation · doi-reference
Intestinal Tuft Cell Subtypes Represent Successive Stages of Maturation Driven by Crypt‐Villus Signaling Gradients
10.1038/s41467-025-61878-9 · ExternalCitation · doi-reference
Asymmetric Histone Inheritance Regulates Olfactory Stem Cell Fates During Regeneration
10.1038/s41467-026-70987-y · ExternalCitation · doi-reference
Tuft Cells in the Intestine, Immunity and Beyond
10.1038/s41575-024-00978-1 · ExternalCitation · doi-reference
Olfactory Immunology: The Missing Piece in Airway and CNS Defence
10.1038/s41577-023-00972-9 · ExternalCitation · doi-reference
Thymic Tuft Cells Promote an IL‐4‐Enriched Medulla and Shape Thymocyte Development
10.1038/s41586-018-0345-2 · ExternalCitation · doi-reference
A Revised Airway Epithelial Hierarchy Includes CFTR‐Expressing Ionocytes
10.1038/s41586-018-0393-7 · ExternalCitation · doi-reference
Respiratory Viral Infections Awaken Metastatic Breast Cancer Cells in Lungs
10.1038/s41586-025-09332-0 · ExternalCitation · doi-reference
Tuft Cell IL‐17RB Restrains IL‐25 Bioavailability and Reveals Context‐Dependent ILC2 Hypoproliferation
10.1038/s41590-025-02104-y · ExternalCitation · doi-reference
Olfactory Transmucosal SARS‐CoV‐2 Invasion as a Port of Central Nervous System Entry in Individuals With COVID‐19
10.1038/s41593-020-00758-5 · ExternalCitation · doi-reference
Activation of Intestinal Tuft Cell‐Expressed Sucnr1 Triggers Type 2 Immunity in the Mouse Small Intestine
10.1073/pnas.1720758115 · ExternalCitation · doi-reference
Infection by the Parasitic Helminth Trichinella Spiralis Activates a Tas2r‐Mediated Signaling Pathway in Intestinal Tuft Cells
10.1073/pnas.1812901116 · ExternalCitation · doi-reference
Disruption of Cellular Proteostasis by H1N1 Influenza A Virus Causes Alpha‐Synuclein Aggregation
10.1073/pnas.1906466117 · ExternalCitation · doi-reference
Nasal‐Associated Lymphoid Tissue and Olfactory Epithelium as Portals of Entry for Burkholderia pseudomallei in Murine Melioidosis
10.1086/599210 · ExternalCitation · doi-reference
Invasion and Persistence of the Neuroadapted Influenza Virus A/WSN/33 in the Mouse Olfactory System
10.1089/088282403322396208 · ExternalCitation · doi-reference
Differential Expression of Mucins in Murine Olfactory Versus Respiratory Epithelium
10.1093/chemse/bjz046 · ExternalCitation · doi-reference
Olfactory Receptor Neurons Prevent Dissemination of Neurovirulent Influenza A Virus Into the Brain by Undergoing Virus‐Induced Apoptosis
10.1099/0022-1317-83-9-2109 · ExternalCitation · doi-reference
Olfactory Receptor Neuronal Dendrites Become Mostly Intra‐Sustentacularly Enwrapped Upon Maturity
10.1111/joa.12777 · ExternalCitation · doi-reference
Tuft Cells, Taste‐Chemosensory Cells, Orchestrate Parasite Type 2 Immunity in the Gut
10.1126/science.aaf1648 · ExternalCitation · doi-reference
T Cell Engagement of Cross‐Presenting Microglia Protects the Brain From a Nasal Virus Infection
10.1126/sciimmunol.abb1817 · ExternalCitation · doi-reference
A Nasal Cell Atlas Reveals Heterogeneity of Tuft Cells and Their Role in Directing Olfactory Stem Cell Proliferation
10.1126/sciimmunol.abq4341 · ExternalCitation · doi-reference
Streptococcus pneumoniae Rapidly Translocate From the Nasopharynx Through the Cribriform Plate to Invade the Outer Meninges
10.1128/mbio.01024-22 · ExternalCitation · doi-reference
Intestinal Tuft Cells: Morphology, Function, and Implications for Human Health
10.1146/annurev-physiol-042022-030310 · ExternalCitation · doi-reference
Cholinergic Microvillous Cells in the Mouse Main Olfactory Epithelium and Effect of Acetylcholine on Olfactory Sensory Neurons and Supporting Cells
10.1152/jn.00186.2011 · ExternalCitation · doi-reference
Ultrastructural Characteristics of Tuft Cells in Mouse Gallbladder Epithelium
10.1159/000144796 · ExternalCitation · doi-reference
SARS‐CoV‐2 Infection of Sustentacular Cells Disrupts Olfactory Signaling Pathways
10.1172/jci.insight.160277 · ExternalCitation · doi-reference
Skn‐1a/Pou2f3 Is Required for the Generation of Trpm5‐Expressing Microvillous Cells in the Mouse Main Olfactory Epithelium
10.1186/1471-2202-15-13 · ExternalCitation · doi-reference
TRPM5‐Expressing Microvillous Cells in the Main Olfactory Epithelium
10.1186/1471-2202-9-114 · ExternalCitation · doi-reference
Is TrpM5 a Reliable Marker for Chemosensory Cells? Multiple Types of Microvillous Cells in the Main Olfactory Epithelium of Mice
10.1186/1471-2202-9-115 · ExternalCitation · doi-reference
Transcriptional Profiling Reveals Potential Involvement of Microvillous TRPM5‐Expressing Cells in Viral Infection of the Olfactory Epithelium
10.1186/s12864-021-07528-y · ExternalCitation · doi-reference
Characteristics and Outcome of Influenza‐Associated Encephalopathy/Encephalitis Among Children in a Tertiary Pediatric Hospital in Italy, 2017–2019
10.1186/s12879-019-4636-5 · ExternalCitation · doi-reference
Microvillous Cells in the Olfactory Epithelium Express Elements of the Solitary Chemosensory Cell Transduction Signaling Cascade
10.1371/journal.pone.0202754 · ExternalCitation · doi-reference
DeltaNp63 Regulates Stem Cell Dynamics in the Mammalian Olfactory Epithelium
10.1523/jneurosci.0681-11.2011 · ExternalCitation · doi-reference
A Genetic Model of Chronic Rhinosinusitis‐Associated Olfactory Inflammation Reveals Reversible Functional Impairment and Dramatic Neuroepithelial Reorganization
10.1523/jneurosci.4507-09.2010 · ExternalCitation · doi-reference
Heterotrimeric G Protein Subunit Ggamma13 Is Critical to Olfaction
10.1523/jneurosci.5563-12.2013 · ExternalCitation · doi-reference
A Light Microscopy Study of the Migration of Naegleria fowleri From the Nasal Submucosa to the Central Nervous System During the Early Stage of Primary Amebic Meningoencephalitis in Mice
10.1645/0022-3395(2000)086[0050:almsot]2.0.co;2 · ExternalCitation · doi-reference
Tuft Cells Utilize Taste Signaling Molecules to Respond to the Pathobiont Microbe Ruminococcus gnavus in the Proximal Colon
10.3389/fimmu.2023.1259521 · ExternalCitation · doi-reference
Tuft Cell Formation Reflects Epithelial Plasticity in Pancreatic Injury: Implications for Modeling Human Pancreatitis
10.3389/fphys.2020.00088 · ExternalCitation · doi-reference
G Protein Subunit Gγ13‐Mediated Signaling Pathway Is Critical to the Inflammation Resolution and Functional Recovery of Severely Injured Lungs
10.7554/elife.92956.3 · ExternalCitation · doi-reference
