Research graph
References from Efficacy and Safety of Crisugabalin for Inadequately Controlled Diabetic Peripheral Neuropathic Pain: A Randomized, Active‐Controlled, Phase 2 Trial. Local targets link to admitted publications; unresolved targets remain external evidence.
Global, Regional, and National Burden of Diabetes From 1990 to 2021, With Projections of Prevalence to 2050: A Systematic Analysis for the Global Burden of Disease Study 2021
10.1016/s0140-6736(23)01301-6 · 2023 · External reference
National Burden and Risk Factors of Diabetes Mellitus in China From 1990 to 2021: Results From the Global Burden of Disease Study 2021
10.1111/1753-0407.70012 · 2024 · External reference
Global, Regional, and National Burden of Disorders Affecting the Nervous System, 1990–2021: A Systematic Analysis for the Global Burden of Disease Study 2021
10.1016/s1474-4422(24)00038-3 · 2024 · External reference
The Global and Regional Burden of Diabetic Peripheral Neuropathy
10.1038/s41582-024-01041-y · 2025 · External reference
Pathogenesis, Diagnosis and Clinical Management of Diabetic Sensorimotor Peripheral Neuropathy
10.1038/s41574-021-00496-z · 2021 · External reference
Painful and Non‐Painful Diabetic Neuropathy, Diagnostic Challenges and Implications for Future Management
10.1093/brain/awab079 · 2021 · External reference
Diabetic Peripheral Neuropathy: Epidemiology, Diagnosis, and Pharmacotherapy
10.1016/j.clinthera.2018.04.001 · 2018 · External reference
Diabetic Neuropathy: Clinical Manifestations and Current Treatments
10.1016/s1474-4422(12)70065-0 · 2012 · External reference
Terpenoids: A Promising Traditional Chinese Medicine for Neuropathic Pain Relief
10.1016/j.phrs.2025.107789 · 2025 · External reference
Evidence‐Based Treatment of Painful Diabetic Neuropathy: A Systematic Review
2022 · External reference
Painful Diabetic Neuropathy: The Role of Ion Channels
10.1016/j.biopha.2024.116417 · 2024 · External reference
Comparison of Amitriptyline Supplemented With Pregabalin, Pregabalin Supplemented With Amitriptyline, and Duloxetine Supplemented With Pregabalin for the Treatment of Diabetic Peripheral Neuropathic Pain (OPTION‐DM): A Multicentre, Double‐Blind, Randomised Crossover Trial
10.1016/s0140-6736(22)01472-6 · 2022 · External reference
Pregabalin for Neuropathic Pain in Adults
2019 · External reference
Calcium Channel α2δ1 Subunit Mediates Spinal Hyperexcitability in Pain Modulation
10.1016/j.pain.2006.04.022 · 2006 · External reference
Identification of the α2δ1 Subunit of Voltage‐Dependent Calcium Channels as a Molecular Target for Pain Mediating the Analgesic Actions of Pregabalin
10.1073/pnas.0409066103 · 2006 · External reference
Pharmacology and Mechanism of Action of HSK16149, a Selective Ligand of α2δ Subunit of Voltage‐Gated Calcium Channel With Analgesic Activity in Animal Models of Chronic Pain
10.1124/jpet.120.000315 · 2021 · External reference
Binding Characteristics and Analgesic Effects of Mirogabalin, a Novel Ligand for the α2δ Subunit of Voltage‐Gated Calcium Channels
10.1124/jpet.117.247551 · 2018 · External reference
Crisugabalin, a Ligand for the α2δ Subunit of Voltage‐Gated Calcium Channels, Exhibits no Obvious Abuse Potential in Rodents
10.1016/j.pbb.2025.174015 · 2025 · External reference
Ducky Mouse Phenotype of Epilepsy and Ataxia Is Associated With Mutations in the Cacna2d2 Gene and Decreased Calcium Channel Current in Cerebellar Purkinje Cells
10.1523/jneurosci.21-16-06095.2001 · 2001 · External reference
Entla, a Novel Epileptic and Ataxic Cacna2d2 Mutant of the Mouse
10.1074/jbc.m308778200 · 2004 · External reference
GABA Analogue HSK16149 in Chinese Patients With Diabetic Peripheral Neuropathic Pain: A Phase 3 Randomized Clinical Trial
10.1001/jamanetworkopen.2024.25614 · 2024 · External reference
Efficacy and Safety of Crisugabalin (HSK16149) in Adults With Postherpetic Neuralgia: A Phase 3 Randomized Clinical Trial
10.1001/jamadermatol.2024.3410 · 2024 · External reference
Unresolved reference
1999 · External reference
Chinese Expert Consensus on Diagnosis and Treatment of Diabetic Peripheral Neuropathy
2018 · External reference
Reliability, Validity, and Responsiveness of the Daily Sleep Interference Scale Among Diabetic Peripheral Neuropathy and Postherpetic Neuralgia Patients
10.1016/j.jpainsymman.2007.09.016 · 2008 · External reference
A Cross‐Cultural Adaptation and Validation of the Short‐Form McGill Pain Questionnaire‐2: Chinese Version in Patients With Chronic Visceral Pain
10.2147/jpr.s116997 · 2017 · External reference
Estimating an EQ‐5D‐5L Value Set for China
10.1016/j.jval.2016.11.016 · 2017 · External reference
Update on Treating Painful Diabetic Peripheral Neuropathy: A Review of Current US Guidelines With a Focus on the Most Recently Approved Management Options
10.2147/jpr.s442595 · 2024 · External reference
First‐In‐Human Single‐Ascending‐Dose, Multiple‐Dose, and Food Interaction Studies of NRD. E1, an Innovative Nonopioid Therapy for Painful Diabetic Peripheral Neuropathy
10.1002/cpdd.1103 · 2022 · External reference
NRD. E1, an Innovative Non‐Opioid Therapy for Painful Diabetic Peripheral Neuropathy—A Randomized Proof of Concept Study
10.1002/ejp.1989 · 2022 · External reference
Switching From Pregabalin to Mirogabalin in Patients With Peripheral Neuropathic Pain: A Multi‐Center, Prospective, Single‐Arm, Open‐Label Study (MIROP Study)
10.1007/s40122-021-00255-y · 2021 · External reference
Effect of Duloxetine on Neuropathic Pain in Patients Intolerant to Continuous Administration of Pregabalin
10.22603/ssrr.1.2016-0012 · 2017 · External reference
A Phase I Study to Evaluate the Safety, Tolerability, and Pharmacokinetics of a Novel, Potent GABA Analog HSK16149 in Healthy Chinese Subjects
10.3389/fphar.2023.1296672 · 2023 · External reference
Anxiety, Depression and Sleep Disorders in Patients With Diabetic Neuropathic Pain: A Systematic Review
10.1080/14737175.2019.1653760 · 2019 · External reference
How Do Changes in Pain Severity Levels Correspond to Changes in Health Status 3 and Function in Patients With Painful Diabetic Peripheral Neuropathy?
10.1016/j.pain.2009.09.017 · 2010 · External reference
Painful Diabetic Peripheral Neuropathy Study of Chinese Outpatients (PDNSCOPE): A Multicentre Cross‐Sectional Registry Study of Clinical Characteristics and Treatment in Mainland China
10.1007/s40122-021-00281-w · 2021 · External reference
Trends in Pain Medication Initiation Among Patients With Newly Diagnosed Diabetic Peripheral Neuropathy, 2014‐2018
10.1001/jamanetworkopen.2020.35632 · 2021 · External reference
Longitudinal Pattern of Pain Medication Utilization in Peripheral Neuropathy Patients
10.1097/j.pain.0000000000001439 · 2019 · External reference
Risk Factors and Pain Status due to Diabetic Neuropathy in Chronic Long‐Term Diabetic Patients in a Chinese Urban Population
2012 · External reference
A Phase 3, Multicenter, Randomized, Double‐Blind, Placebo‐Controlled 14‐Week Study of Mirogabalin in Chinese Patients With Diabetic Peripheral Neuropathic Pain
10.1007/s40122-024-00617-2 · 2024 · External reference
Unresolved reference
2025 · External reference
Medication Overdose Data Analysis: A Review of Medication Error Reports in the FDA Adverse Event Reporting System (FAERS)
10.1186/s40360-023-00681-y · 2023 · External reference
Unresolved reference
External reference
