Research graph
References from Immune Mechanisms and Translational Therapeutic Challenges in Type 1 Diabetes. Local targets link to admitted publications; unresolved targets remain external evidence.
A Comprehensive Review of Novel Advances in Type 1 Diabe‐ Tes Mellitus
10.1111/1753-0407.70120 · 2025 · External reference
10.1007/s40124‐025‐00351‐z
10.1007/s40124‐025‐00351‐z · External reference
Neoepitopes at the Crossroads of Immunometabolism: Metabolic Remodeling of Antigen Presentation in Type 1 Diabetes
10.3389/fimmu.2026.1744422 · 2026 · External reference
The β‐Cell in Type 1 Diabetes Pathogenesis: A Victim of Circumstances or an Instigator of Tragic Events?
10.2337/dbi21-0036 · 2022 · External reference
Current Perspectives and the Future of Disease‐Modifying Therapies in Type 1 Diabetes
10.4239/wjd.v16.i1.99496 · 2025 · External reference
An Anti‐CD3 Antibody, Teplizumab, in Relatives at Risk for Type 1 Diabetes
10.1056/nejmoa1902226 · 2019 · External reference
Toward a Cure for Diabetes: iPSC and ESC‐Derived Islet Cell Transplantation Trials
10.1111/jdi.14366 · 2025 · External reference
Fifty Years of HLA‐Associated Type 1 Diabetes Risk: History, Current Knowledge, and Future Directions
10.3389/fimmu.2024.1457213 · 2024 · External reference
Protein Tyrosine Phosphatases and Type 1 Diabetes: Genetic and Functional Implications of PTPN2 and PTPN22
10.1900/rds.2012.9.188 · 2012 · External reference
Genetic Modifiers of Thymic Selection and Central Tolerance in Type 1 Diabetes
10.3389/fimmu.2022.889856 · 2022 · External reference
The IL‐2/IL‐2R System: From Basic Science to Therapeutic Applications to Enhance Immune Regulation
10.1007/s12026-013-8452-5 · 2013 · External reference
Advances in Knowledge of Candidate Genes Acting at the Beta‐Cell Level in the Pathogenesis of T1DM
10.3389/fendo.2020.00119 · 2020 · External reference
Environmental Mechanisms Influencing the Pathogenesis and Progression of Type 1 Diabetes
10.3390/ijms262311613 · 2025 · External reference
The Role of Viral Infections in the Immunopathogenesis of Type 1 Diabetes Mellitus: A Narrative Review
10.3390/biology14080981 · 2025 · External reference
Persistent Coxsackievirus B Infection and Pathogenesis of Type 1 Diabetes Mellitus
10.1038/s41574-022-00688-1 · 2022 · External reference
Detection of Enterovirus RNA in Pancreas and Lymphoid Tissues of Organ Donors With Type 1 Diabetes
10.1007/s00125-025-06359-w · 2025 · External reference
Autoreactive T Cells in Type 1 Diabetes
10.1172/jci94549 · 2017 · External reference
Induction of Islet Autoimmunity to Defective Ribosomal Product of the Insulin Gene as Neoantigen After Anti‐Cancer Immunotherapy Leading to Autoimmune Diabetes
10.3389/fimmu.2024.1384406 · 2024 · External reference
A Microenvironment‐Driven, HLA‐II‐Associated Insulin Neoantigen Elicits Persistent Memory T Cell Activation in Diabetes
10.1038/s41590-025-02343-z · 2026 · External reference
Modifying Enzymes Are Elicited by ER Stress, Generating Epitopes That Are Selectively Recognized by CD4(+) T Cells in Patients With Type 1 Diabetes
10.2337/db17-1166 · 2018 · External reference
Citrullination and PAD Enzyme Biology in Type 1 Diabetes ‐ Regulators of Inflammation, Autoimmunity, and Pathology
10.3389/fimmu.2021.678953 · 2021 · External reference
The MHC‐II Peptidome of Pancreatic Islets Identifies Key Features of Autoimmune Peptides
10.1038/s41590-020-0623-7 · 2020 · External reference
Hybrid Insulin Peptide Isomers Spontaneously Form in Pancreatic Beta‐Cells From an Aspartic Anhydride Intermediate
10.1016/j.jbc.2023.105264 · 2023 · External reference
Identifying New Hybrid Insulin Peptides (HIPs) in Type 1 Diabetes
10.3389/fimmu.2021.667870 · 2021 · External reference
Using Mass Spectrometry to Identify Neoantigens in Autoimmune Diseases: The Type 1 Diabetes Example
10.1016/j.smim.2023.101730 · 2023 · External reference
Mechanisms in Endocrinology: Alternative Splicing: The New Frontier in Diabetes Research
10.1530/eje-15-0916 · 2016 · External reference
Recognition of mRNA Splice Variant and Secretory Granule Epitopes by CD4+ T Cells in Type 1 Diabetes
10.2337/db22-0191 · 2023 · External reference
Molecular Mimicry at the Gut‐Immune Interface: A Mechanistic Link to Type 1 Diabetes
10.1111/imm.70091 · 2026 · External reference
Central Role for Interleukin‐2 in Type 1 Diabetes
10.2337/db11-1213 · 2011 · External reference
Persistent Organic Pollutants and β‐Cell Toxicity: A Comprehensive Review
10.1152/ajpendo.00358.2021 · 2022 · External reference
Damage‐Associated Molecular Patterns in Inflammatory Diseases
10.4110/in.2018.18.e27 · 2018 · External reference
From Microbes to Metabolites: Advances in Gut Microbiome Research in Type 1 Diabetes
10.3390/metabo15020138 · 2025 · External reference
Endocrine Disrupting Chemicals and Type 1 Diabetes
10.3390/ijms21082937 · 2020 · External reference
Cytokines in Type 1 Diabetes: Mechanisms of Action and Immunotherapeutic Targets
10.1002/cti2.1122 · 2020 · External reference
Double Deficiency in IL‐17 and IFN‐γ Signalling Significantly Suppresses the Development of Diabetes in the NOD Mouse
10.1007/s00125-013-2935-8 · 2013 · External reference
The Heterogeneity of Type 1 Diabetes: Implications for Pathogenesis, Prevention, and Treatment‐2024 Diabetes, Diabetes Care, and Diabetologia Expert Forum
10.1007/s00125-025-06462-y · 2025 · External reference
Generating Long‐Lived CD8(+) T‐Cell Memory: Insights From Epigenetic Programs
10.1002/eji.201545550 · 2016 · External reference
Islet Autoimmunity in Human Type 1 Diabetes: Initiation and Progression From the Perspective of the Beta Cell
10.1007/s00125-023-05970-z · 2023 · External reference
Immune Cell Trafficking to the Islets During Type 1 Diabetes
10.1111/cei.13353 · 2019 · External reference
Pro‐Inflammatory Cytokines Induce Cell Death, Inflammatory Responses, and Endoplasmic Reticulum Stress in Human iPSC‐Derived Beta Cells
10.1186/s13287-019-1523-3 · 2020 · External reference
Integrin Regulated Autoimmune Disorders: Understanding the Role of Mechanical Force in Autoimmunity
10.3389/fcell.2022.852878 · 2022 · External reference
Beta Cell and Immune Cell Interactions in Autoimmune Type 1 Diabetes: How They Meet and Talk to Each Other
10.1016/j.molmet.2022.101565 · 2022 · External reference
Piezo1 Mechanosensing Regulates Integrin‐Dependent Chemotactic Migration in Human T Cells
10.7554/elife.91903.3 · 2024 · External reference
Piezo1 in Immune Cells: From Mechanosensation to Immunoregulation
10.3389/fimmu.2026.1827414 · 2026 · External reference
Pericyte Dysfunction and Impaired Vasomotion Are Hallmarks of Islets During the Pathogenesis of Type 1 Diabetes
10.1016/j.celrep.2023.112913 · 2023 · External reference
Diabetes as a Pancreatic Microvascular Disease‐A Pericytic Perspective
10.1369/00221554241236535 · 2024 · External reference
Zonulin, Regulation of Tight Junctions, and Autoimmune Diseases
10.1111/j.1749-6632.2012.06538.x · 2012 · External reference
Zonulin Upregulation Is Associated With Increased Gut Permeability in Subjects With Type 1 Diabetes and Their Relatives
10.2337/db05-1593 · 2006 · External reference
The Protective Effect of the Intestinal Microbiota in Type‐1 Diabetes in NOD Mice Is Limited to a Time Window in Early Life
10.3389/fendo.2024.1425235 · 2024 · External reference
Host‐Microbiota Interactions Shaping T‐Cell Response and Tolerance in Type 1 Diabetes
10.3389/fimmu.2022.974178 · 2022 · External reference
Unconventional Immune Cells in the Gut Mucosal Barrier: Regulation by Symbiotic Microbiota
10.1038/s12276-023-01088-9 · 2023 · External reference
The Role for Gut Permeability in the Pathogenesis of Type 1 Diabetes—A Solid or Leaky Concept?
10.1111/pedi.12305 · 2015 · External reference
Mechanisms Regulating Intestinal Barrier Integrity and Its Pathological Implications
10.1038/s12276-018-0126-x · 2018 · External reference
Aire Mediates Tolerance to Insulin Through Thymic Trimming of High‐Affinity T Cell Clones
10.1073/pnas.2320268121 · 2024 · External reference
Central and Peripheral Autoantigen Presentation in Immune Tolerance
10.1111/j.0019-2805.2003.01804.x · 2004 · External reference
Physiological Beta Cell Death Triggers Priming of Self‐Reactive T Cells by Dendritic Cells in a Type‐1 Diabetes Model
10.1084/jem.20030966 · 2003 · External reference
Thymic Self‐Antigen Expression for Immune Tolerance and Surveillance
10.1186/s41232-022-00211-z · 2022 · External reference
Aire Unleashes Stalled RNA Polymerase to Induce Ectopic Gene Expression in Thymic Epithelial Cells
10.1073/pnas.1119351109 · 2012 · External reference
Thymic Epithelial Cells Co‐Opt Lineage‐Defining Transcription Factors to Eliminate Autoreactive T Cells
10.1016/j.cell.2022.05.018 · 2022 · External reference
The Self‐Obsession of T Cells: How TCR Signaling Thresholds Affect Fate ‘Decisions’ and Effector Function
10.1038/ni.2938 · 2014 · External reference
Why Must T Cells be Cross‐Reactive?
10.1038/nri3279 · 2012 · External reference
The Origin of Autoimmune Diseases: Is There a Role for Ancestral HLA‐II Haplotypes in Immune Hyperactivity
10.3389/fimmu.2025.1710571 · 2025 · External reference
The Contribution of Natural Selection to Present‐Day Susceptibility to Chronic Inflammatory and Autoimmune Disease
10.1016/j.coi.2014.09.008 · 2014 · External reference
Detection and Characterization of CD8(+) Autoreactive Memory Stem T Cells in Patients With Type 1 Diabetes
10.2337/db17-1390 · 2018 · External reference
Autoimmune CD8+ T Cells in Type 1 Diabetes: From Single‐Cell RNA Sequencing to T‐Cell Receptor Redirection
10.3389/fendo.2024.1377322 · 2024 · External reference
Circulating β Cell‐Specific CD8(+) T Cells Restricted by High‐Risk HLA Class I Molecules Show Antigen Experience in Children With and at Risk of Type 1 Diabetes
10.1111/cei.13391 · 2020 · External reference
The Many Faces of Islet Antigen‐Specific CD8 T Cells: Clues to Clinical Outcome in Type 1 Diabetes
10.1111/imcb.12437 · 2021 · External reference
Autoreactive T Effector Memory Differentiation Mirrors β Cell Function in Type 1 Diabetes
10.1172/jci120555 · 2018 · External reference
Islet‐Resident Memory T Cells Orchestrate the Immunopathogenesis of Type 1 Diabetes Through the FABP4‐CXCL10 Axis
10.1002/advs.202308461 · 2024 · External reference
An Autoimmune Stem‐Like CD8 T Cell Population Drives Type 1 Diabetes
10.1038/s41586-021-04248-x · 2022 · External reference
Targeting Memory T Cells in Type 1 Diabetes
10.1007/s11892-015-0659-5 · 2015 · External reference
The Environmental Determinants of Diabetes in the Young (TEDDY) Study: Study Design
10.1111/j.1399-5448.2007.00269.x · 2007 · External reference
Staging Presymptomatic Type 1 Diabetes: A Scientific Statement of JDRF, the Endocrine Society, and the American Diabetes Association
10.2337/dc15-1419 · 2015 · External reference
New Frontiers in the Treatment of Type 1 Diabetes
10.1016/j.cmet.2019.11.017 · 2020 · External reference
Blood‐Based Signatures in Type 1 Diabetes
10.1007/s00125-015-3843-x · 2016 · External reference
Current and Emerging Assays for Measuring Human T‐Cell Responses Against Beta‐Cell Antigens in Type 1 Diabetes
10.3390/biom15030384 · 2025 · External reference
Screening and Prevention of Type 1 Diabetes: Where Are we?
10.1210/clinem/dgad328 · 2023 · External reference
Teplizumab in Type 1 Diabetes Mellitus: An Updated Review
10.17925/ee.2023.19.2.7 · 2023 · External reference
B‐Lymphocyte Depletion With Rituximab and β‐Cell Function: Two‐Year Results
10.2337/dc13-0626 · 2014 · External reference
The Effect of Low‐Dose IL‐2 and Treg Adoptive Cell Therapy in Patients With Type 1 Diabetes
10.1172/jci.insight.147474 · 2021 · External reference
Type I Interferons as Contextual Regulators of B‐Cell Tolerance in Type 1 Diabetes
10.3390/biom16040563 · 2026 · External reference
Emerging Immunotherapies for Disease Modification of Type 1 Diabetes
10.1007/s40265-025-02150-8 · 2025 · External reference
Learning From Past Failures of Oral Insulin Trials
10.2337/dbi17-0043 · 2018 · External reference
The Fate of Allogeneic Pancreatic Islets Following Intraportal Transplantation: Challenges and Solutions
2018 · External reference
Current Status of Stem Cell Therapy for Type 1 Diabetes: A Critique and a Prospective Consideration
10.1186/s13287-024-03636-0 · 2024 · External reference
Neoepitopes in Type 1 Diabetes: Etiological Insights, Biomarkers and Therapeutic Targets
10.3389/fimmu.2021.667989 · 2021 · External reference
Encapsulation and Immune Protection for Type 1 Diabetes Cell Therapy
10.1016/j.addr.2024.115205 · 2024 · External reference
Islet Transplantation and Encapsulation: An Update on Recent Developments
10.1900/rds.2011.8.51 · 2011 · External reference
An Overview of Engineered Hydrogel‐Based Biomaterials for Improved β‐Cell Survival and Insulin Secretion
10.3389/fbioe.2021.662084 · 2021 · External reference
Immune‐Evasive Beta Cells in Type 1 Diabetes: Innovations in Genetic Engineering, Biomaterials, and Computational Modeling
10.3389/fimmu.2025.1618086 · 2025 · External reference
Allo Beta Cell Transplantation: Specific Features, Unanswered Questions, and Immunological Challenge
10.3389/fimmu.2023.1323439 · 2023 · External reference
10.1038/s41589‐026‐02293‐z
10.1038/s41589‐026‐02293‐z · External reference
