Research graph
References from Amylin Receptor Signalling in the Laterodorsal Tegmental Nucleus Controls Food Intake Through Projections to the Ventral Tegmental Area. Local targets link to admitted publications; unresolved targets remain external evidence.
Reasons for Discontinuation of GLP1 Receptor Agonists: Data From a Real‐World Cross‐Sectional Survey of Physicians and Their Patients With Type 2 Diabetes
10.2147/dmso.s141235 · 2017 · External reference
Tirzepatide for Obesity Treatment and Diabetes Prevention
10.1056/nejmoa2410819 · 2025 · External reference
Physiology of the Weight‐Loss Plateau in Response to Diet Restriction, GLP‐1 Receptor Agonism, and Bariatric Surgery
10.1002/oby.24027 · 2024 · External reference
Once‐Weekly Semaglutide in Adults With Overweight or Obesity
10.1056/nejmoa2032183 · 2021 · External reference
Longer‐Term Liraglutide Administration at the Highest Dose Approved for Obesity Increases Reward‐Related Orbitofrontal Cortex Activation in Response to Food Cues: Implications for Plateauing Weight Loss in Response to Anti‐Obesity Therapies
10.1111/dom.13827 · 2019 · External reference
Structural and Mechanistic Insights Into Dual Activation of Cagrilintide in Amylin and Calcitonin Receptors
10.1038/s41401-025-01635-2 · 2025 · External reference
Novel Pharmaceuticals in Appetite Regulation: Exploring Emerging Gut Peptides and Their Pharmacological Prospects
10.1002/prp2.1243 · 2024 · External reference
DACRA Induces Profound Weight Loss, Satiety Control, and Increased Mitochondrial Respiratory Capacity in Adipose Tissue
2024 · External reference
The Dual Amylin and Calcitonin Receptor Agonist KBP‐336 Elicits a Unique Combination of Weight Loss, Antinociception and Bone Protection ‐ a Novel Disease‐Modifying Osteoarthritis Drug
10.1186/s13075-024-03361-2 · 2024 · External reference
Improved Metabolic Efficacy of a Dual Amylin and Calcitonin Receptor Agonist When Combined With Semaglutide or Empagliflozin
10.1016/j.ejphar.2022.175397 · 2023 · External reference
Dual Amylin and Calcitonin Receptor Agonist Treatment Improves Insulin Sensitivity and Increases Muscle‐Specific Glucose Uptake Independent of Weight Loss
10.1016/j.biopha.2023.114969 · 2023 · External reference
KBP‐066A, a Long‐Acting Dual Amylin and Calcitonin Receptor Agonist, Induces Weight Loss and Improves Glycemic Control in Obese and Diabetic Rats
10.1016/j.molmet.2021.101282 · 2021 · External reference
A Novel Dual Amylin and Calcitonin Receptor Agonist, KBP‐089, Induces Weight Loss Through a Reduction in Fat, but Not Lean Mass, While Improving Food Preference
10.1111/bph.13723 · 2017 · External reference
KBP‐088, a Novel DACRA With Prolonged Receptor Activation, Is Superior to Davalintide in Terms of Efficacy on Body Weight
10.1152/ajpendo.00514.2015 · 2016 · External reference
Coadministered Cagrilintide and Semaglutide in Adults With Overweight or Obesity
10.1056/nejmoa2502081 · 2025 · External reference
Implications of Amylin Receptor Agonism: Integrated Neurohormonal Mechanisms and Therapeutic Applications
2009 · External reference
The Role of Amylin in the Control of Energy Homeostasis
10.1152/ajpregu.00703.2009 · 2010 · External reference
Amylin Secretion From the Rat Pancreas and Its Selective Loss After Streptozotocin Treatment
10.1172/jci114528 · 1990 · External reference
Amylin—Its Role in the Homeostatic and Hedonic Control of Eating and Recent Developments of Amylin Analogs to Treat Obesity
10.1016/j.molmet.2017.11.009 · 2018 · External reference
Incretins and Amylin: Neuroendocrine Communication Between the Gut, Pancreas, and Brain in Control of Food Intake and Blood Glucose
10.1146/annurev-nutr-071812-161201 · 2014 · External reference
In Vitro Autoradiographic Localization of Amylin Binding Sites in Rat Brain
10.1016/0306-4522(94)90388-3 · 1994 · External reference
High Affinity Amylin Binding Sites in Rat Brain
10.1016/s0026-895x(25)13212-4 · 1993 · External reference
Comparative Immunohistochemical Distribution of Amylin‐Like and Calcitonin Gene Related Peptide Like Immunoreactivity in the Rat Central Nervous System
10.1139/y95-131 · 1995 · External reference
Salmon Calcitonin Distributes Into the Arcuate Nucleus to a Subset of NPY Neurons in Mice
10.1016/j.neuropharm.2020.107987 · 2020 · External reference
Endogenous VMH Amylin Signaling Is Required for Full Leptin Signaling and Protection From Diet‐Induced Obesity
10.1152/ajpregu.00462.2015 · 2016 · External reference
Brainstem Mechanisms of Amylin‐Induced Anorexia
10.1016/j.physbeh.2010.03.001 · 2010 · External reference
Pedunculopontine and Laterodorsal Tegmental Nuclei Contain Distinct Populations of Cholinergic, Glutamatergic and GABAergic Neurons in the Rat
10.1111/j.1460-9568.2008.06576.x · 2009 · External reference
Distribution of Pontomesencephalic Cholinergic Neurons Projecting to Substantia Nigra Differs Significantly From Those Projecting to Ventral Tegmental Area
10.1523/jneurosci.15-09-05859.1995 · 1995 · External reference
A Non‐Canonical GABAergic Pathway to the VTA Promotes Unconditioned Freezing
10.1038/s41380-022-01765-7 · 2022 · External reference
Optogenetic Excitation of LDTg Axons in the VTA Reinforces Operant Responding in Rats
10.1016/j.brainres.2015.04.021 · 2015 · External reference
Operant Responding for Optogenetic Excitation of LDTg Inputs to the VTA Requires D1 and D2 Dopamine Receptor Activation in the NAcc
10.1016/j.bbr.2017.06.045 · 2017 · External reference
Optogenetic Excitation in the Ventral Tegmental Area of Glutamatergic or Cholinergic Inputs From the Laterodorsal Tegmental Area Drives Reward
10.1111/ejn.13436 · 2017 · External reference
GLP‐1 Receptor Signaling in the Laterodorsal Tegmental Nucleus Attenuates Cocaine Seeking by Activating GABAergic Circuits That Project to the VTA
10.1038/s41380-020-00957-3 · 2021 · External reference
Glutamate Inputs From the Laterodorsal Tegmental Nucleus to the Ventral Tegmental Area Are Essential for the Induction of Cocaine Sensitization in Male Mice
10.1007/s00213-022-06209-2 · 2022 · External reference
Afferent and Efferent Connections of the Laterodorsal Tegmental Nucleus in the Rat
10.1016/0361-9230(90)90072-8 · 1990 · External reference
Glucagon‐Like Peptide‐1 Receptor Signaling in the Lateral Dorsal Tegmental Nucleus Regulates Energy Balance
10.1038/npp.2017.225 · 2018 · External reference
Amylin Acts in the Lateral Dorsal Tegmental Nucleus to Regulate Energy Balance Through Gamma‐Aminobutyric Acid Signaling
10.1016/j.biopsych.2016.12.028 · 2017 · External reference
Ghrelin Administration Into Tegmental Areas Stimulates Locomotor Activity and Increases Extracellular Concentration of Dopamine in the Nucleus Accumbens
10.1111/j.1369-1600.2006.00041.x · 2007 · External reference
Amylin Modulates the Mesolimbic Dopamine System to Control Energy Balance
10.1038/npp.2014.180 · 2015 · External reference
GPR‐160 Receptor Signaling in the Dorsal Vagal Complex of Male Rats Modulates Meal Microstructure and CART‐Mediated Hypophagia
10.3390/nu15102268 · 2023 · External reference
GDF15 Induces Anorexia Through Nausea and Emesis
10.1016/j.cmet.2019.12.004 · 2020 · External reference
Calcitonin Receptor Signaling in Nucleus Accumbens D1R‐ and D2R‐Expressing Medium Spiny Neurons Bidirectionally Alters Opioid Taking in Male Rats
10.1038/s41386-023-01634-z · 2023 · External reference
Laterodorsal Tegmentum‐Ventral Tegmental Area Projections Encode Positive Reinforcement Signals
10.1002/jnr.24931 · 2021 · External reference
Nicotine Aversion Is Mediated by GABAergic Interpeduncular Nucleus Inputs to Laterodorsal Tegmentum
10.1038/s41467-018-04654-2 · 2018 · External reference
An Amylin and Calcitonin Receptor Agonist Modulates Alcohol Behaviors by Acting on Reward‐Related Areas in the Brain
10.1016/j.pneurobio.2020.101969 · 2021 · External reference
Sex Differences in the Efficacy of Glucagon‐Like Peptide‐1 Receptor Agonists for Weight Reduction: A Systematic Review and Meta‐Analysis
10.1111/1753-0407.70063 · 2025 · External reference
Sex Differences in the Efficacy of GLP‐1 Receptor Agonists: A Systematic Review and Meta‐Analysis of Cardiovascular and Renal Outcome Trials
10.1111/dom.70123 · 2025 · External reference
Input‐Specific Control of Reward and Aversion in the Ventral Tegmental Area
10.1038/nature11527 · 2012 · External reference
Laterodorsal Tegmental Projections to Identified Cell Populations in the Rat Ventral Tegmental Area
10.1002/cne.20417 · 2005 · External reference
Neurotensin Afferents of the Ventral Tegmental Area in the Rat: [1] Re‐Examination of Their Origins and [2] Responses to Acute Psychostimulant and Antipsychotic Drug Administration
10.1111/j.1460-9568.2006.04928.x · 2006 · External reference
The Neurobiology of Food Intake in an Obesogenic Environment
10.1017/s0029665112000602 · 2012 · External reference
Western Diet Consumption and Cognitive Impairment: Links to Hippocampal Dysfunction and Obesity
10.1016/j.physbeh.2010.12.003 · 2011 · External reference
